Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Neurology

43 publications found

Almekhlafi MA, Kunz WG, Menon BK, McTaggart RA, Jayaraman MV, Baxter BW, Heck D, Frei D, Derdeyn CP, Takagi T, Aamodt AH, Fragata IMR, Hill MD, Demchuk AM, Goyal M (2019)
Imaging of Patients with Suspected Large-Vessel Occlusion at Primary Stroke Centers: Available Modalities and a Suggested Approach
AJNR Am J Neuroradiol, 40 (3), 396-400
DOI 10.3174/ajnr.A5971, PubMed 30705072

Bandres-Ciga S, Saez-Atienzar S, Bonet-Ponce L, Billingsley K, Vitale D, Blauwendraat C, Gibbs JR, Pihlstrøm L, Gan-Or Z, International Parkinson's Disease Genomics Consortium (IPDGC), Cookson MR, Nalls MA, Singleton AB (2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
Mov Disord, 34 (4), 460-468
DOI 10.1002/mds.27614, PubMed 30675927

Barclay K, Carruthers R, Traboulsee A, Bass AD, LaGanke C, Bertolotto A, Boster A, Celius EG, de Seze J, Cruz DD, Habek M, Lee JM, Limmroth V, Meuth SG, Oreja-Guevara C, Pagnotta P, Vos C, Ziemssen T, Baker DP, Wijmeersch BV (2019)
Best Practices for Long-Term Monitoring and Follow-Up of Alemtuzumab-Treated MS Patients in Real-World Clinical Settings
Front Neurol, 10, 253
DOI 10.3389/fneur.2019.00253, PubMed 30967831

Berge T, Eriksson A, Brorson IS, Høgestøl EA, Berg-Hansen P, Døskeland A, Mjaavatten O, Bos SD, Harbo HF, Berven F (2019)
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Clin Proteomics, 16, 19
DOI 10.1186/s12014-019-9241-5, PubMed 31080378

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J et al. (2019)
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
Mov Disord (in press)
DOI 10.1002/mds.27659, PubMed 30957308

Bøen E, Hjørnevik T, Hummelen B, Elvsåshagen T, Moberget T, Holtedahl JE, Babovic A, Hol PK, Karterud S, Malt UF (2019)
Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder
Acta Psychiatr Scand, 139 (3), 256-268
DOI 10.1111/acps.12997, PubMed 30552759

Børte S, Zwart JA, Stensland SØ, Hagen K, Winsvold BS (2019)
Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
Cephalalgia, 333102419828989 (in press)
DOI 10.1177/0333102419828989, PubMed 30714392

Fjeld OR, Grøvle L, Helgeland J, Småstuen MC, Solberg TK, Zwart JA, Grotle M (2019)
Complications, reoperations, readmissions, and length of hospital stay in 34 639 surgical cases of lumbar disc herniation
Bone Joint J, 101-B (4), 470-477
DOI 10.1302/0301-620X.101B4.BJJ-2018-1184.R1, PubMed 30929479

Flengsrud K, Toft M, Dietrichs E (2019)
Essensiell tremor
Tidsskr Nor Laegeforen, 139 (8)
DOI 10.4045/tidsskr.18.0904, PubMed 31062562

Grøvle L, Fjeld OR, Haugen AJ, Helgeland J, Småstuen MC, Solberg TK, Zwart JA, Grotle M (2019)
The Rates of LSS Surgery in Norwegian Public Hospitals: A Threefold Increase From 1999 to 2013
Spine (Phila Pa 1976), 44 (6), E372-E378
DOI 10.1097/BRS.0000000000002858, PubMed 30234811

Hagberg G, Fure B, Sandset EC, Thommessen B, Ihle-Hansen H, Øksengård AR, Nygård S, Wyller TB, Ihle-Hansen H (2019)
Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: secondary analysis of a randomized controlled trial, a 7-year follow-up study
Vasc Health Risk Manag, 15, 11-18
DOI 10.2147/VHRM.S191873, PubMed 30799926

Hagen K, Hopstock LA, Elise Eggen A, Mathiesen EB, Nilsen KB (2019)
Does insomnia modify the association between C-reactive protein and migraine? The Tromsø Study 2015-2016
Cephalalgia, 333102418825370 (in press)
DOI 10.1177/0333102418825370, PubMed 30862180

Hogestol EA, Kaufmann T, Nygaard G, Beyer MK, Sowa P, Nordvik JE, Kolskar K, Richard G, Andreassen OA, Harbo HF, Westlye LT (2019)
Cross-Sectional and Longitudinal MRI Brain Scans Reveal Accelerated Brain Aging in Multiple Sclerosis
Front. Neurol., 10, 450

Hov MR, Røislien J, Lindner T, Zakariassen E, Bache KCG, Solyga VM, Russell D, Lund CG (2019)
Stroke severity quantification by critical care physicians in a mobile stroke unit
Eur J Emerg Med, 26 (3), 194-198
DOI 10.1097/MEJ.0000000000000529, PubMed 29239899

Høgestøl EA, Nygaard GO, Alnæs D, Beyer MK, Westlye LT, Harbo HF (2019)
Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis
PLoS One, 14 (4), e0210375
DOI 10.1371/journal.pone.0210375, PubMed 30933977

Iqbal Z, Tawamie H, Ba W, Reis A, Halak BA, Sticht H, Uebe S, Kasri NN, Riazuddin S, van Bokhoven H, Abou Jamra R (2019)
Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia
Genet Med (in press)
DOI 10.1038/s41436-018-0415-8, PubMed 30607023

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S et al. (2019)
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Nat Genet, 51 (3), 404-413
DOI 10.1038/s41588-018-0311-9, PubMed 30617256

Jusufovic M, Skagen K, Krohg-Sørensen K, Skjelland M (2019)
Current medical and surgical stroke prevention therapies for patients with carotid artery stenosis
Curr Neurovasc Res (in press)
DOI 10.2174/1567202616666190131162811, PubMed 30706783

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep (in press)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Jørum E, Opstad PK (2019)
A 4-year follow-up of non-freezing cold injury with cold allodynia and neuropathy in 26 naval soldiers
Scand J Pain (in press)
DOI 10.1515/sjpain-2019-0035, PubMed 30939119

Kristoffersen ES, Winsvold BS, Faiz KW (2019)
Prestige of neurological disorders among future neurologists in Norway
Acta Neurol Scand, 139 (6), 555-558
DOI 10.1111/ane.13087, PubMed 30851195

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B et al. (2019)
Biological and clinical insights from genetics of insomnia symptoms
Nat Genet, 51 (3), 387-393
DOI 10.1038/s41588-019-0361-7, PubMed 30804566

Li J, Yang SC, Moullaali TJ, Chen R, Woodward M, Carcel C, Delcourt C, Sandset EC, Anderson C, Chen G, Wang X (2019)
Sex differences in blood pressure after stroke: a systematic review and meta-analysis
J Hypertens (in press)
DOI 10.1097/HJH.0000000000002116, PubMed 31058800

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, 23andMe Research Team, HUNT All-In Psychiatry, Choquet H, Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR et al. (2019)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Nat Genet, 51 (2), 237-244
DOI 10.1038/s41588-018-0307-5, PubMed 30643251

Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M, Lampert A (2019)
The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients
Pain, 160 (6), 1327-1341
DOI 10.1097/j.pain.0000000000001511, PubMed 30720580

Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, Ness TV, Moberget T, Elvsåshagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT (2019)
Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations
Cereb Cortex, 29 (2), 875-891
DOI 10.1093/cercor/bhy291, PubMed 30475994

Nordstrand SEH, Hansen BH, Rootwelt T, Karlsen TI, Swanson D, Nilsen KB, Knudsen S (2019)
Psychiatric symptoms in patients with post-H1N1 narcolepsy type 1 in Norway
Sleep, 42 (4)
DOI 10.1093/sleep/zsz008, PubMed 30649483

Quist-Paulsen E, Kran AB, Lindland ES, Ellefsen K, Sandvik L, Dunlop O, Ormaasen V (2019)
To what extent can clinical characteristics be used to distinguish encephalitis from encephalopathy of other causes? Results from a prospective observational study
BMC Infect Dis, 19 (1), 80
DOI 10.1186/s12879-018-3570-2, PubMed 30669985

Reynolds RH, Botía J, Nalls MA, International Parkinson’s Disease Genomics Consortium (IPDGC), System Genomics of Parkinson’s Disease (SGPD), Hardy J, Gagliano Taliun SA, Ryten M (2019)
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
NPJ Parkinsons Dis, 5, 6
DOI 10.1038/s41531-019-0076-6, PubMed 31016231

Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I et al. (2019)
GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
Sci Rep, 9 (1), 7013
DOI 10.1038/s41598-019-43458-2, PubMed 31065058

Rosic B, Dukefoss DB, Åbjørsbråten KS, Tang W, Jensen V, Ottersen OP, Enger R, Nagelhus EA (2019)
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression
Glia, 67 (6), 1113-1121
DOI 10.1002/glia.23604, PubMed 30791140

Rydning SL, Koht J, Sheng Y, Sowa P, Hjorthaug HS, Wedding IM, Erichsen AK, Hovden IA, Backe PH, Tallaksen CME, Vigeland MD, Selmer KK (2019)
Biallelic POLR3A variants confirmed as a frequent cause of hereditary ataxia and spastic paraparesis
Brain, 142 (4), e12
DOI 10.1093/brain/awz041, PubMed 30847471

Rødevand L, Steen NE, Elvsåshagen T, Quintana DS, Reponen EJ, Mørch RH, Lunding SH, Vedal TSJ, Dieset I, Melle I, Lagerberg TV, Andreassen OA (2019)
Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade
Acta Psychiatr Scand, 139 (4), 348-360
DOI 10.1111/acps.13008, PubMed 30697685

Rønning OM, Logallo N, Thommessen B, Tobro H, Novotny V, Kvistad CE, Aamodt AH, Næss H, Waje-Andreassen U, Thomassen L (2019)
Tenecteplase Versus Alteplase Between 3 and 4.5 Hours in Low National Institutes of Health Stroke Scale
Stroke, 50 (2), 498-500
DOI 10.1161/STROKEAHA.118.024223, PubMed 30602354

Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, Dawson TM, Rosenthal LS, Houlden H, Pletnikova O, Troncoso J, Scholz SW (2019)
Assessment of APOE in atypical parkinsonism syndromes
Neurobiol Dis, 127, 142-146 (in press)
DOI 10.1016/j.nbd.2019.02.016, PubMed 30798004

Skagen K, Hetlevik SO, Zamani M, Lilleby V, Skjelland M (2019)
Preclinical Carotid Atherosclerosis in Patients With Juvenile-Onset Mixed Connective Tissue Disease
J Stroke Cerebrovasc Dis, 28 (5), 1295-1301
DOI 10.1016/j.jstrokecerebrovasdis.2019.01.027, PubMed 30772156

Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A et al. (2019)
Genome-wide association study identifies 30 loci associated with bipolar disorder
Nat Genet, 51 (5), 793-803
DOI 10.1038/s41588-019-0397-8, PubMed 31043756

Wang X, Sandset EC, Moullaali TJ, Chen G, Song L, Carcel C, Delcourt C, Woodward M, Robinson T, Chalmers J, Arima H, Anderson CS, INTERACT2 Investigators (2019)
Determinants of the high admission blood pressure in mild-to-moderate acute intracerebral hemorrhage
J Hypertens (in press)
DOI 10.1097/HJH.0000000000002056, PubMed 31085948

Zak N, Bøen E, Boye B, Andreassen OA, Doan NT, Malt UF, Westlye LT, Elvsåshagen T (2019)
Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II
Bipolar Disord (in press)
DOI 10.1111/bdi.12771, PubMed 30864260

Ørstavik K (2019)
Oliver Sacks – om anger, nevrolitterær glede og empati
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.18.0663, PubMed 30969042

Aamodt AH, Bjork MH, Alstadhaug KB, Eldoen G, Dueland AN, Poole T, Hagen K, Vetvik KG, Ofte HK, Sonnervik J, Kristoffersen ES, Winsvold BS, Lundqvist C, Sagabraten SO (2019)
Practical management of headache
Tidsskr. Nor. Laegeforen., 139 (7), 617-620

Aamodt AH, Bjørk MH, Alstadhaug KB, Eldøen G, Dueland AN, Poole T, Hagen K, Vetvik KG, Ofte HK, Sønnervik J, Kristoffersen ES, Winsvold BS, Lundqvist C, Sagabråten SO (2019)
Practical management of headache
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.18.0837, PubMed 30969051

Aas M, Elvsåshagen T, Westlye LT, Kaufmann T, Athanasiu L, Djurovic S, Melle I, van der Meer D, Martin-Ruiz C, Steen NE, Agartz I, Andreassen OA (2019)
Telomere length is associated with childhood trauma in patients with severe mental disorders
Transl Psychiatry, 9 (1), 97
DOI 10.1038/s41398-019-0432-7, PubMed 30898995

 
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