Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2018 from OUS - Department of Neurology
84 publications found
SVM-based Tool to Detect Patients with Multiple Sclerosis Using a Commercial EMG Sensor
PR IEEE SEN ARRAY, 376-379
Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice
ACS Chem Neurosci, 9 (6), 1259-1263
DOI 10.1021/acschemneuro.8b00053, PubMed 29544053
Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography
Org Biomol Chem, 16 (13), 2219-2224
DOI 10.1039/C8OB00184G, PubMed 29546903
Charcot-Marie-Tooth disease type 4C in Norway: Clinical characteristics, mutation spectrum and minimum prevalence
Neuromuscul Disord, 28 (8), 639-645
DOI 10.1016/j.nmd.2018.06.004, PubMed 30001926
Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study
PLoS One, 13 (9), e0203925
DOI 10.1371/journal.pone.0203925, PubMed 30265708
The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence
Front Neurosci, 12, 726
DOI 10.3389/fnins.2018.00726, PubMed 30369866
Automated real-time detection of tonic-clonic seizures using a wearable EMG device
Neurology, 90 (5), e428-e434
DOI 10.1212/WNL.0000000000004893, PubMed 29305441
Supplementary motor area syndrome after surgery for parasagittal meningiomas
Acta Neurochir (Wien), 160 (3), 583-587
DOI 10.1007/s00701-018-3474-3, PubMed 29362933
No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease
Neurobiol Aging, 74, 236.e1-236.e5
DOI 10.1016/j.neurobiolaging.2018.09.022, PubMed 30340792
Multiple Microelectrode Recordings in STN-DBS Surgery for Parkinson's Disease: A Randomized Study
Mov Disord Clin Pract, 5 (3), 296-305
DOI 10.1002/mdc3.12621, PubMed 30009214
Evaluation of long-term antiepileptic drug use in patients with temporal lobe epilepsy: Assessment of risk factors for drug resistance and polypharmacy
Seizure, 61, 63-70
DOI 10.1016/j.seizure.2018.07.011, PubMed 30099235
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study
BMC Neurol, 18 (1), 20
DOI 10.1186/s12883-018-1023-6, PubMed 29466944
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
JAMA Neurol, 75 (11), 1416-1422
DOI 10.1001/jamaneurol.2018.1885, PubMed 30039155
Analysis of shared heritability in common disorders of the brain
Science, 360 (6395)
DOI 10.1126/science.aap8757, PubMed 29930110
The influence of THC:CBD oromucosal spray on driving ability in patients with multiple sclerosis-related spasticity
Brain Behav, 8 (5), e00962
DOI 10.1002/brb3.962, PubMed 29761015
Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study
Int J Bipolar Disord, 6 (1), 19
DOI 10.1186/s40345-018-0128-6, PubMed 30198055
Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension
Brain Res, 1686, 72-82
DOI 10.1016/j.brainres.2018.02.017, PubMed 29477544
Progression of Alzheimer's Disease: A Longitudinal Study in Norwegian Memory Clinics
J Alzheimers Dis, 61 (3), 1221-1232
DOI 10.3233/JAD-170436, PubMed 29254085
Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation
Neuroimage, 186, 497-509
DOI 10.1016/j.neuroimage.2018.11.032, PubMed 30471387
The effect of human herpesvirus 6B infection on the MAPK pathway
Virus Res, 256, 134-141
DOI 10.1016/j.virusres.2018.08.014, PubMed 30130603
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
Cereb Cortex, 28 (8), 2775-2785
DOI 10.1093/cercor/bhx157, PubMed 28655157
Epilepsy in patients with long QT syndrome type 1: A Norwegian family
Epilepsy Behav Case Rep, 10, 118-121
DOI 10.1016/j.ebcr.2018.09.006, PubMed 30406014
Seizure-like episodes and EEG abnormalities in patients with long QT syndrome
Seizure, 61, 214-220
DOI 10.1016/j.seizure.2018.08.020, PubMed 30218808
Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (13), 1919-1926
DOI 10.1177/0333102418764888, PubMed 29517305
Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (14), 2026-2034
DOI 10.1177/0333102418769940, PubMed 29629599
Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus
Glia, 67 (1), 91-100
DOI 10.1002/glia.23528, PubMed 30306658
Pain, psychological distress and motor pattern in women with provoked vestibulodynia (PVD) - symptom characteristics and therapy suggestions
Scand J Pain, 18 (2), 221-227
DOI 10.1515/sjpain-2017-0173, PubMed 29794291
Supporting the Human in Cyber Defence
LECT NOTES COMPUT SC, 10683, 147-162
Anterior thalamic deep brain stimulation in refractory epilepsy: A randomized, double-blinded study
Acta Neurol Scand, 139 (3), 294-304
DOI 10.1111/ane.13047, PubMed 30427061
Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity
Cereb Cortex, 28 (11), 4036-4048
DOI 10.1093/cercor/bhy196, PubMed 30169757
Elevated cerebrospinal fluid protein in POLG-related epilepsy: Diagnostic and prognostic implications
Epilepsia, 59 (8), 1595-1602
DOI 10.1111/epi.14459, PubMed 29920680
International consensus on quality standards for brain health-focused care in multiple sclerosis
Mult Scler, 25 (13), 1809-1818
DOI 10.1177/1352458518809326, PubMed 30381987
Pain Sensitivity and Thermal Detection Thresholds in Young Adults Born Preterm With Very Low Birth Weight or Small for Gestational Age at Term Compared With Controls
J Pain, 19 (8), 873-884
DOI 10.1016/j.jpain.2018.03.001, PubMed 29574049
The Nord-Trøndelag Health Study shows increased prevalence of primary recurrent headaches among adolescents over a four-year period
Scand J Pain, 2 (3), 148-152
DOI 10.1016/j.sjpain.2011.03.002, PubMed 29913741
Formamide as an Unconventional Amine Protecting Group for PET Radiochemistry
Eur. J. Org. Chem., 2018 (27-28), 3701-3704
Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
RSC Adv., 8 (38), 21288-21291
The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study
Eur J Neurol, 25 (9), 1148-e102
DOI 10.1111/ene.13675, PubMed 29747220
Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives
Sleep, 41 (10)
DOI 10.1093/sleep/zsy145, PubMed 30016530
The Standardised Mensendieck Test as a tool for evaluation of movement quality in patients with nonspecific chronic low back pain
Scand J Pain, 18 (2), 203-210
DOI 10.1515/sjpain-2018-0028, PubMed 29794292
Genetic variation in P2RX7 and pain tolerance
Pain, 159 (6), 1064-1073
DOI 10.1097/j.pain.0000000000001188, PubMed 29470314
Sleep duration mediates abdominal and lower-extremity pain after night work in nurses
Int Arch Occup Environ Health, 92 (3), 415-422
DOI 10.1007/s00420-018-1373-9, PubMed 30417278
The association of sleepiness, insomnia, sleep disturbance and pain: a study amongst shiftworking nurses
Sleep Biol. Rhythms, 16 (1), 133-140
Understanding the role of genetic variability in LRRK2 in Indian population
Mov Disord, 34 (4), 496-505
DOI 10.1002/mds.27558, PubMed 30485545
Socio-technical communication: The hybrid space and the OLB model for science-based cyber education
Milit. Psychol., 30 (4), 350-359
European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre-hospital management of stroke
Eur J Neurol, 25 (3), 425-433
DOI 10.1111/ene.13539, PubMed 29218822
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Nat Commun, 9 (1), 2397
DOI 10.1038/s41467-018-04732-5, PubMed 29921915
Effect of modified Atkins diet in adults with drug-resistant focal epilepsy: A randomized clinical trial
Epilepsia, 59 (8), 1567-1576
DOI 10.1111/epi.14457, PubMed 29901816
Pre-hospital thrombolysis of ischemic stroke in the emergency service system-A case report from the Treat-NASPP trial
Acta Anaesthesiol Scand, 63 (3), 410-413
DOI 10.1111/aas.13285, PubMed 30426474
Imaging in Lyme neuroborreliosis
Insights Imaging, 9 (5), 833-844
DOI 10.1007/s13244-018-0646-x, PubMed 30187265
Cyber Officer Profiles and Performance Factors
LECT NOTES ARTIF INT, 10906, 181-190
Ethical challenges in tracheostomy-assisted ventilation in amyotrophic lateral sclerosis
J Neurol, 265 (11), 2730-2736
DOI 10.1007/s00415-018-9054-x, PubMed 30218178
Learning by heart-the relationship between resting vagal tone and metacognitive judgments: a pilot study
Cogn Process, 19 (4), 557-561
DOI 10.1007/s10339-018-0865-6, PubMed 29796847
Proprioceptive loss and the perception, control and learning of arm movements in humans: evidence from sensory neuronopathy
Exp Brain Res, 236 (8), 2137-2155
DOI 10.1007/s00221-018-5289-0, PubMed 29779050
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia
Biochem J, 475 (4), 749-758
DOI 10.1042/BCJ20170814, PubMed 29339464
Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors
EBioMedicine, 39, 401-408
DOI 10.1016/j.ebiom.2018.11.042, PubMed 30503201
Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study
Sleep Med, 50, 175-180
DOI 10.1016/j.sleep.2018.05.037, PubMed 30075393
Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
Mol Psychiatry, 25 (9), 2130-2143
DOI 10.1038/s41380-018-0228-9, PubMed 30171211
Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson's disease
NPJ Parkinsons Dis, 4, 14
DOI 10.1038/s41531-018-0051-7, PubMed 29761156
Assessing genome-wide significance for the detection of differentially methylated regions
Stat Appl Genet Mol Biol, 17 (5)
DOI 10.1515/sagmb-2017-0050, PubMed 30231014
Spastic paraplegia due to SPAST mutations is modified by the underlying mutation and sex
Brain, 141 (12), 3331-3342
DOI 10.1093/brain/awy285, PubMed 30476002
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease
Ann Neurol, 84 (1), 117-129
DOI 10.1002/ana.25274, PubMed 30146727
Guilt and Proneness to Shame: Unethical Behaviour in Vulnerable and Grandiose Narcissism
Eur J Psychol, 14 (1), 28-43
DOI 10.5964/ejop.v14i1.1355, PubMed 29899796
Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
ACS Omega, 3 (7), 7567-7579
DOI 10.1021/acsomega.8b00975, PubMed 30087917
Dopa-responsive dystonia
Tidsskr Nor Laegeforen, 138 (19)
DOI 10.4045/tidsskr.17.0595, PubMed 30497245
The reliability of gait variability measures for individuals with Parkinson's disease and healthy older adults - The effect of gait speed
Gait Posture, 62, 505-509
DOI 10.1016/j.gaitpost.2018.04.011, PubMed 29679922
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511, PubMed 30379917
Group supervision - an unmet need among specialty registrars
Tidsskr Nor Laegeforen, 138 (15)
DOI 10.4045/tidsskr.18.0569, PubMed 30277040
A novel heterozygous variant in ERLIN2 causes autosomal dominant pure hereditary spastic paraplegia
Eur J Neurol, 25 (7), 943-e71
DOI 10.1111/ene.13625, PubMed 29528531
Parent-child communication and timing of interventions are challenges in the Duchenne muscular dystrophy care
Acta Paediatr, 108 (3), 535-540
DOI 10.1111/apa.14537, PubMed 30118557
ULTRA-WIDE-FIELD FUNDUS IMAGING IN THE DIAGNOSIS AND FOLLOW-UP OF SUSAC SYNDROME
Retin Cases Brief Rep, 12 (3), 234-239
DOI 10.1097/ICB.0000000000000470, PubMed 27828899
Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3
Int J Stroke, 13 (7), 759-765
DOI 10.1177/1747493018772733, PubMed 29720045
Homocarnosinosis: A historical update and findings in the SPG11 gene
Acta Neurol Scand, 138 (3), 245-250
DOI 10.1111/ane.12949, PubMed 29732542
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J Am Heart Assoc, 7 (2)
DOI 10.1161/JAHA.117.006479, PubMed 29330254
Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation
J Neurodev Disord, 10 (1), 17
DOI 10.1186/s11689-018-9235-z, PubMed 29788902
Age at Death and Causes of Death in Patients with Huntington Disease in Norway in 1986-2015
J Huntingtons Dis, 7 (1), 77-86
DOI 10.3233/JHD-170270, PubMed 29480207
Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor
Acta Obstet Gynecol Scand, 98 (2), 240-249
DOI 10.1111/aogs.13477, PubMed 30289161
Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis
Mult Scler, 25 (5), 687-698
DOI 10.1177/1352458518765671, PubMed 29542336
Poststroke psychosis: a systematic review
J Neurol Neurosurg Psychiatry, 89 (8), 879-885
DOI 10.1136/jnnp-2017-317327, PubMed 29332009
Factors associated with refractoriness and outcome in an adult status epilepticus cohort
Seizure, 61, 111-118
DOI 10.1016/j.seizure.2018.07.020, PubMed 30125862
Cognitive Performance After a One-Year Multidisciplinary Intensive Rehabilitation Program for Huntington's Disease: An Observational Study
J Huntingtons Dis, 7 (4), 379-389
DOI 10.3233/JHD-180294, PubMed 30320595
Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke: an updated systematic review
Stroke Vasc Neurol, 3 (1), 28-33
DOI 10.1136/svn-2017-000112, PubMed 29600005
Availability of secondary prevention services after stroke in Europe: An ESO/SAFE survey of national scientific societies and stroke experts
Eur Stroke J, 4 (2), 110-118
DOI 10.1177/2396987318816136, PubMed 31259259
Migraine and stroke
Tidsskr Nor Laegeforen, 138 (4)
DOI 10.4045/tidsskr.17.0347, PubMed 29460580
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
Transl Psychiatry, 8 (1), 103
DOI 10.1038/s41398-018-0151-5, PubMed 29795193