Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Cardiology B (Div Med)

56 publications found

Agewall S (2020)
Focus on subpopulations of atrial fibrillation patients
Eur Heart J Cardiovasc Pharmacother, 6 (3), 131-132
DOI 10.1093/ehjcvp/pvaa034, PubMed 32412082

Atar D, Berge E, Le Heuzey JY, Virdone S, Camm AJ, Steffel J, Gibbs H, Goldhaber SZ, Goto S, Kayani G, Misselwitz F, Stepinska J, Turpie AGG, Bassand JP, Kakkar AK, GARFIELD-AF Investigators (2020)
The association between patterns of atrial fibrillation, anticoagulation, and cardiovascular events
Europace, 22 (2), 195-204
DOI 10.1093/europace/euz292, PubMed 31747004

Aulokken TM, Parkar AP, Markussen TV, Ashraf H, Mynarek GK, Nes H, Muller F, Schubert M, Jorgensen A, Blomberg SM, Bjornerheim R, Klow NE, Hopp E (2020)
Imaging of patients with COVID-19
Tidsskr. Nor. Laegeforen., 140 (8), 756-760

Berntsen KS, Raastad T, Marstein H, Kirkhus E, Merckoll E, Cumming KT, Flatø B, Sjaastad I, Sanner H (2020)
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: A Controlled Cross-Sectional Study
Arthritis Rheumatol, 72 (5), 837-848
DOI 10.1002/art.41174, PubMed 31746550

Bittner VA, Szarek M, Aylward PE, Bhatt DL, Diaz R, Edelberg JM, Fras Z, Goodman SG, Halvorsen S, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Moriarty PM, Moryusef A, Pordy R, Roe MT, Sinnaeve P, Tsimikas S, Vogel R, White HD, Zahger D, Zeiher AM, Steg PG, Schwartz GG et al. (2020)
Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
J Am Coll Cardiol, 75 (2), 133-144
DOI 10.1016/j.jacc.2019.10.057, PubMed 31948641

Bjørkavoll-Bergseth M, Kleiven Ø, Auestad B, Eftestøl T, Oskal K, Nygård M, Skadberg Ø, Aakre KM, Melberg T, Gjesdal K, Ørn S (2020)
Duration of Elevated Heart Rate Is an Important Predictor of Exercise-Induced Troponin Elevation
J Am Heart Assoc, 9 (4), e014408
DOI 10.1161/JAHA.119.014408, PubMed 32065043

Bogsrud MP, Øyri LKL, Halvorsen S, Atar D, Leren TP, Holven KB (2020)
Prevalence of genetically verified familial hypercholesterolemia among young (<45 years) Norwegian patients hospitalized with acute myocardial infarction
J Clin Lipidol, 14 (3), 339-345
DOI 10.1016/j.jacl.2020.04.002, PubMed 32418822

Bratseth V, Margeirsdottir HD, Chiva-Blanch G, Heier M, Solheim S, Arnesen H, Dahl-Jørgensen K, Seljeflot I (2020)
Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study
J Diabetes Res, 2020, 7216863
DOI 10.1155/2020/7216863, PubMed 32309448

Bratseth V, Margeirsdottir HD, Heier M, Solheim S, Arnesen H, Dahl-Jørgensen K, Seljeflot I (2020)
Procoagulant activity in children and adolescents on intensive insulin therapy
Pediatr Diabetes, 21 (3), 496-504
DOI 10.1111/pedi.12978, PubMed 31943582

Butt N, Bache-Mathiesen LK, Ushakova A, Nordrehaug JE, Jensen SE, Munk PS, Danchin N, Dubois-Rande JL, Hansen HS, Paganelli F, Corvoisier PL, Firat H, Erlinge D, Atar D, Larsen AI (2020)
Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size
Eur Heart J Acute Cardiovasc Care, 2048872620923641
DOI 10.1177/2048872620923641, PubMed 32403934

Cadilhac DA, Kim J, Wilsno A, Berge E, Patel A, Ali M, Saver J, Christensen H, Cuche M, Crews S, Wu O, Provoyeur M, McMeekin P, Durand-Zaleski I, Ford GA, Muhlemann N, Bath PM, Abdul-Rahim AH, Sunnerhagen K, Meretoja A, Thijs V, Weimar C, Massaro A, Ranta A, Lees KR et al. (2020)
Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group
Eur. Stroke J., 2396987319897466

Chieffo A, Stefanini GG, Price S, Barbato E, Tarantini G, Karam N, Moreno R, Buchanan GL, Gilard M, Halvorsen S, Huber K, James S, Neumann FJ, Möllmann H, Roffi M, Tavazzi G, Mauri Ferré J, Windecker S, Dudek D, Baumbach A (2020)
EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic
Eur Heart J, 41 (19), 1839-1851
DOI 10.1093/eurheartj/ehaa381, PubMed 32405641

Danielsen SO, Moons P, Leegaard M, Solheim S, Tønnessen T, Lie I (2020)
Facilitators of and barriers to reducing thirty-day readmissions and improving patient-reported outcomes after surgical aortic valve replacement: a process evaluation of the AVRre trial
BMC Health Serv Res, 20 (1), 256
DOI 10.1186/s12913-020-05125-5, PubMed 32220252

Drexel H, Rosano GMC, Lewis BS, Huber K, Vonbank A, Dopheide JF, Mader A, Niessner A, Savarese G, Wassmann S, Agewall S (2020)
The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid and diabetes trials
Eur Heart J Cardiovasc Pharmacother, 6 (2), 97-103
DOI 10.1093/ehjcvp/pvz029, PubMed 31298686

Frankenstein L, Seide S, Täger T, Jensen K, Fröhlich H, Clark AL, Seiz M, Katus HA, Nee P, Uhlmann L, Naci H, Atar D (2020)
Relative Efficacy of Spironolactone, Eplerenone, and cAnRenone in patients with Chronic Heart failure (RESEARCH): a systematic review and network meta-analysis of randomized controlled trials
Heart Fail Rev, 25 (2), 161-171
DOI 10.1007/s10741-019-09832-y, PubMed 31364027

Gjesdal K (2020)
Langtids EKG: Riktig bruk er viktig
Tidsskr Nor Laegeforen, 140 (5)
DOI 10.4045/tidsskr.20.0200, PubMed 32238969

Godolphin PJ, Bath PM, Partlett C, Berge E, Brown MM, Eliasziw M, Sandset PM, Serena J, Montgomery AA (2020)
Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification
Eur. Stroke J., 2396987320910047

Gorenek B, Halvorsen S, Kudaiberdieva G, Bueno H, Van Gelder IC, Lettino M, Marin F, Masip J, Mueller C, Okutucu S, Poess J, Potpara TS, Price S, Lip GYH (2020)
Atrial fibrillation in acute heart failure: A position statement from the Acute Cardiovascular Care Association and European Heart Rhythm Association of the European Society of Cardiology
Eur Heart J Acute Cardiovasc Care, 2048872619894255
DOI 10.1177/2048872619894255, PubMed 31976747

Gorog DA, Price S, Sibbing D, Baumbach A, Capodanno D, Gigante B, Halvorsen S, Huber K, Lettino M, Leonardi S, Morais J, Rubboli A, Siller-Matula JM, Storey RF, Vranckx P, Rocca B (2020)
Antithrombotic therapy in patients with acute coronary syndrome complicated by cardiogenic shock or out-of-hospital cardiac arrest: a Joint Position Paper from the European Society of Cardiology (ESC) Working Group on Thrombosis, in association with the Acute Cardiovascular Care Association (ACCA) and European Association of Percutaneous Cardiovascular Interventions (EAPCI)
Eur Heart J Cardiovasc Pharmacother (in press)
DOI 10.1093/ehjcvp/pvaa009, PubMed 32049278

Gustavsen A, Njerve IU, Sitras V, Haugen G, Tollofsrud PA, Akkok CA (2020)
A young woman with a transfusion-related pregnancy complication
Tidsskr. Nor. Laegeforen., 140 (1), 58-61

Gustavsen A, Njerve IU, Sitras V, Haugen G, Tølløfsrud PA, Akkök ÇA (2020)
A young woman with a transfusion-related pregnancy complication
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.19.0117, PubMed 31948214

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Hollan I, Ronda N, Dessein P, Agewall S, Karpouzas G, Tamargo J, Niessner A, Savarese G, Rosano G, Kaski JC, Wassmann S, Meroni PL (2020)
Lipid management in rheumatoid arthritis: a position paper of the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology
Eur Heart J Cardiovasc Pharmacother, 6 (2), 104-114
DOI 10.1093/ehjcvp/pvz033, PubMed 31397840

Holte KB, Svanteson M, Hanssen KF, Sveen KA, Seljeflot I, Solheim S, Sell DR, Monnier VM, Berg TJ (2020)
Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study
PLoS One, 15 (5), e0233174
DOI 10.1371/journal.pone.0233174, PubMed 32401813

Jortveit J, Halvorsen S, Langorgen J (2020)
Preventive drugs after a heart attack delivered from a pharmacy
Tidsskr. Nor. Laegeforen., 140 (4), 355-360

Jortveit J, Halvorsen S, Langørgen J (2020)
Pharmacy-dispensed drugs for secondary prevention after myocardial infarction
Tidsskr Nor Laegeforen, 140 (4)
DOI 10.4045/tidsskr.19.0416, PubMed 32192264

Jortveit J, Pripp AH, Langørgen J, Halvorsen S (2020)
Incidence, risk factors and outcome of young patients with myocardial infarction
Heart (in press)
DOI 10.1136/heartjnl-2019-316067, PubMed 32111640

Kluge KE, Langseth MS, Opstad TB, Pettersen AÅ, Arnesen H, Tønnessen T, Seljeflot I, Helseth R (2020)
Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease
Mediators Inflamm, 2020, 5080743
DOI 10.1155/2020/5080743, PubMed 32308555

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ et al. (2020)
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Eur Heart J, 41 (3), 407-477
DOI 10.1093/eurheartj/ehz425, PubMed 31504439

Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G (2020)
Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project
J Hypertens (in press)
DOI 10.1097/HJH.0000000000002479, PubMed 32516290

Kristensen AMD, Bovin A, Zwisler AD, Cerquira C, Torp-Pedersen C, Bøtker HE, Gustafsson I, Veien KT, Thomsen KK, Olsen MH, Larsen ML, Nielsen OW, Hildebrandt P, Foghmar S, Jensen SE, Lange T, Sehested T, Jernberg T, Atar D, Ibanez B, Prescott E (2020)
Design and rationale of the Danish trial of beta-blocker treatment after myocardial infarction without reduced ejection fraction: study protocol for a randomized controlled trial
Trials, 21 (1), 415
DOI 10.1186/s13063-020-4214-6, PubMed 32446298

Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Trøseid M, Vestad B, Skårdal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138

Langseth MS, Helseth R, Ritschel V, Hansen CH, Andersen GØ, Eritsland J, Halvorsen S, Fagerland MW, Solheim S, Arnesen H, Seljeflot I, Opstad TB (2020)
Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction
Sci Rep, 10 (1), 5007
DOI 10.1038/s41598-020-61971-7, PubMed 32193509

Mahfoud F, Azizi M, Ewen S, Pathak A, Ukena C, Blankestijn PJ, Böhm M, Burnier M, Chatellier G, Durand Zaleski I, Grassi G, Joner M, Kandzari DE, Kirtane A, Kjeldsen SE, Lobo MD, Lüscher TF, McEvoy JW, Parati G, Rossignol P, Ruilope L, Schlaich MP, Shahzad A, Sharif F, Sharp ASP et al. (2020)
Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies
Eur Heart J, 41 (16), 1588-1599
DOI 10.1093/eurheartj/ehaa121, PubMed 32211888

Malhotra K, Katsanos AH, Goyal N, Tayal A, Gensicke H, Mitsias PD, De Marchis GM, Berge E, Alexandrov AW, Alexandrov AV, Tsivgoulis G (2020)
Intravenous thrombolysis in patients with chronic kidney disease: A systematic review and meta-analysis
Neurology (in press)
DOI 10.1212/WNL.0000000000009756, PubMed 32554767

Mayerhofer CCK, Kummen M, Holm K, Broch K, Awoyemi A, Vestad B, Storm-Larsen C, Seljeflot I, Ueland T, Bohov P, Berge RK, Svardal A, Gullestad L, Yndestad A, Aukrust P, Hov JR, Trøseid M (2020)
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943

Mehlum MH, Liestøl K, Kjeldsen SE, Wyller TB, Julius S, Rothwell PM, Mancia G, Parati G, Weber MA, Berge E (2020)
Blood Pressure-Lowering Profiles and Clinical Effects of Angiotensin Receptor Blockers Versus Calcium Channel Blockers
Hypertension, 75 (6), 1584-1592
DOI 10.1161/HYPERTENSIONAHA.119.14443, PubMed 32336236

Nakstad ER, Stær-Jensen H, Wimmer H, Henriksen J, Alteheld LH, Reichenbach A, Drægni T, Šaltytė-Benth J, Wilson JA, Etholm L, Øijordsbakken M, Eritsland J, Seljeflot I, Jacobsen D, Andersen GØ, Lundqvist C, Sunde K (2020)
Late awakening, prognostic factors and long-term outcome in out-of-hospital cardiac arrest - results of the prospective Norwegian Cardio-Respiratory Arrest Study (NORCAST)
Resuscitation, 149, 170-179
DOI 10.1016/j.resuscitation.2019.12.031, PubMed 31926258

Okin PM, Hille DA, Wachtell K, Kjeldsen SE, Julius S, Devereux RB (2020)
On-treatment HDL cholesterol predicts incident atrial fibrillation in hypertensive patients with left ventricular hypertrophy
Blood Press, 1-8 (in press)
DOI 10.1080/08037051.2020.1782171, PubMed 32586143

Opstad TB, Kalstad AA, Holte KB, Berg TJ, Solheim S, Arnesen H, Seljeflot I (2020)
Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease
Rejuvenation Res
DOI 10.1089/rej.2019.2258, PubMed 31805818

Pope MK, Ghanima W, Atar D (2020)
Intensification of antithrombotic therapy for chronic atherosclerosis
Tidsskr Nor Laegeforen, 140 (10)
DOI 10.4045/tidsskr.20.0066, PubMed 32602309

Prestgaard E, Mariampillai J, Engeseth K, Erikssen J, Bodegård J, Liestøl K, Kjeldsen S, Grundvold I, Berge E (2020)
Change in Body Weight and Long-Term Risk of Stroke and Death in Healthy Men
Stroke, 51 (5), 1435-1441
DOI 10.1161/STROKEAHA.119.027233, PubMed 32268850

Rutherford OW, Jonasson C, Ghanima W, Söderdahl F, Halvorsen S (2020)
Comparison of dabigatran, rivaroxaban, and apixaban for effectiveness and safety in atrial fibrillation: a nationwide cohort study
Eur Heart J Cardiovasc Pharmacother, 6 (2), 75-85
DOI 10.1093/ehjcvp/pvz086, PubMed 31942972

Sandven I, Eritsland J, Abdelnoor M (2020)
Remote Ischemic Conditioning in Patients with Acute Coronary Syndromes: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Clin Epidemiol, 12, 595-605
DOI 10.2147/CLEP.S249785, PubMed 32606985

Savarese G, Reiner MF, Uijl A, D'Amario D, Agewall S, Atar D, Baumgartner I, Borghi C, De Carlo M, Drexel H, Kaski JC, Kjeldsen KP, Kucher N, Lund LH, Niessner A, Semb AG, Schmidt TA, Sulzgruber P, Tamargo J, Vitale C, Wassmann S, Aboyans V, Lewis BS (2020)
Antithrombotic therapy and major adverse limb events in patients with chronic lower extremity arterial disease: systematic review and meta-analysis from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy in Collaboration with the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases
Eur Heart J Cardiovasc Pharmacother, 6 (2), 86-93
DOI 10.1093/ehjcvp/pvz036, PubMed 31392312

Steen T (2020)
Pacemakers for young patients – not so fast
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.19.0794, PubMed 31948213

Stensjøen AL, Hommerstad A, Halvorsen S, Arheden H, Engblom H, Erlinge D, Larsen AI, Sejersten Ripa M, Clemmensen P, Atar D, Hall TS (2020)
Worst lead ST deviation and resolution of ST elevation at one hour for prediction of myocardial salvage, infarct size, and microvascular obstruction in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention
Ann Noninvasive Electrocardiol, e12784 (in press)
DOI 10.1111/anec.12784, PubMed 32592427

Tancin Lambert A, Kong XY, Ratajczak-Tretel B, Atar D, Russell D, Skjelland M, Bjerkeli V, Skagen K, Coq M, Schordan E, Firat H, Halvorsen B, Aamodt AH (2020)
Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study
Cerebrovasc Dis Extra, 10 (1), 11-20
DOI 10.1159/000504529, PubMed 32028277

Trøseid M, Andersen GØ, Broch K, Hov JR (2020)
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353

Tschiderer L, Seekircher L, Klingenschmid G, Izzo R, Baldassarre D, Iglseder B, Calabresi L, Liu J, Price JF, Bae JH, Brouwers FP, de Groot E, Schmidt C, Bergström G, Aşçi G, Gresele P, Okazaki S, Kapellas K, Landecho MF, Sattar N, Agewall S, Zou ZY, Byrne CD, Nanayakkara PWB, Papagianni A et al. (2020)
The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale
Gerontology, 1-13 (in press)
DOI 10.1159/000508498, PubMed 32610336

Täger T, Atar D, Agewall S, Katus HA, Grundtvig M, Cleland JGF, Clark AL, Fröhlich H, Frankenstein L (2020)
Comparative efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for cardiovascular outcomes in type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
Heart Fail Rev
DOI 10.1007/s10741-020-09954-8, PubMed 32314085

Willeit P, Tschiderer L, Allara E, Reuber K, Seekircher L, Gao L, Liao X, Lonn E, Gerstein HC, Yusuf S, Brouwers FP, Asselbergs FW, van Gilst W, Anderssen SA, Grobbee DE, Kastelein JJP, Visseren FLJ, Ntaios G, Hatzitolios AI, Savopoulos C, Nieuwkerk PT, Stroes E, Walters M, Higgins P, Dawson J et al. (2020)
Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients
Circulation (in press)
DOI 10.1161/CIRCULATIONAHA.120.046361, PubMed 32546049

Ødegaard KM, Hallén J, Lirhus SS, Melberg HO, Halvorsen S (2020)
Incidence, prevalence, and mortality of heart failure: a nationwide registry study from 2013 to 2016
ESC Heart Fail
DOI 10.1002/ehf2.12773, PubMed 32530563

Aaløkken TM, Parkar AP, Markussen TV, Ashraf H, Mynarek GK, Nes H, Müller F, Schubert M, Jørgensen A, Blomberg SM, Bjørnerheim R, Kløw NE, Hopp E (2020)
Diagnostic imaging of COVID-19 patients
Tidsskr Nor Laegeforen, 140 (8)
DOI 10.4045/tidsskr.20.0332, PubMed 32463192

Aamodt AH, Bjørk MH, Tronvik EA, Buanes EA, Stovner LJ, Atar D (2020)
Do ACE inhibitors and angiotensin receptor antagonists increase the risk of severe COVID-19?
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0411, PubMed 32549022

Aamodt IT, Lycholip E, Celutkiene J, von Lueder T, Atar D, Falk RS, Hellesø R, Jaarsma T, Strömberg A, Lie I (2020)
Self-Care Monitoring of Heart Failure Symptoms and Lung Impedance at Home Following Hospital Discharge: Longitudinal Study
J Med Internet Res, 22 (1), e15445
DOI 10.2196/15445, PubMed 31909717

 
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