Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Department of Geriatric Medicine

47 publications found

Barca ML, Persson K, Eldholm R, Benth JŠ, Kersten H, Knapskog AB, Saltvedt I, Selbaek G, Engedal K (2017)
Trajectories of depressive symptoms and their relationship to the progression of dementia
J Affect Disord, 222, 146-152
DOI 10.1016/j.jad.2017.07.008, PubMed 28704802

Bieber A, Stephan A, Verbeek H, Verhey F, Kerpershoek L, Wolfs C, de Vugt M, Woods RT, Røsvik J, Selbaek G, Sjölund BM, Wimo A, Hopper L, Irving K, Marques MJ, Gonçalves-Pereira M, Portolani E, Zanetti O, Meyer G (2017)
Access to community care for people with dementia and their informal carers : Case vignettes for a European comparison of structures and common pathways to formal care
Z Gerontol Geriatr, 51 (5), 530-536
DOI 10.1007/s00391-017-1266-7, PubMed 28616816

Broda A, Bieber A, Meyer G, Hopper L, Joyce R, Irving K, Zanetti O, Portolani E, Kerpershoek L, Verhey F, Vugt M, Wolfs C, Eriksen S, Røsvik J, Marques MJ, Gonçalves-Pereira M, Sjölund BM, Woods B, Jelley H, Orrell M, Stephan A, ActifCare Consortium (2017)
Perspectives of policy and political decision makers on access to formal dementia care: expert interviews in eight European countries
BMC Health Serv Res, 17 (1), 518
DOI 10.1186/s12913-017-2456-0, PubMed 28774307

Córdova-Palomera A, Kaufmann T, Persson K, Alnæs D, Doan NT, Moberget T, Lund MJ, Barca ML, Engvig A, Brækhus A, Engedal K, Andreassen OA, Selbæk G, Westlye LT (2017)
Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum
Sci Rep, 7, 40268
DOI 10.1038/srep40268, PubMed 28074926

Doan NT, Engvig A, Persson K, Alnæs D, Kaufmann T, Rokicki J, Córdova-Palomera A, Moberget T, Brækhus A, Barca ML, Engedal K, Andreassen OA, Selbæk G, Westlye LT (2017)
Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum
Sci Rep, 7, 45131
DOI 10.1038/srep45131, PubMed 28338052

Doan NT, Engvig A, Zaske K, Persson K, Lund MJ, Kaufmann T, Cordova-Palomera A, Alnæs D, Moberget T, Brækhus A, Barca ML, Nordvik JE, Engedal K, Agartz I, Selbæk G, Andreassen OA, Westlye LT, Alzheimer's Disease Neuroimaging Initiative (2017)
Distinguishing early and late brain aging from the Alzheimer's disease spectrum: consistent morphological patterns across independent samples
Neuroimage, 158, 282-295
DOI 10.1016/j.neuroimage.2017.06.070, PubMed 28666881

Dourado MCN, Laks J, Kimura NR, Baptista MAT, Barca ML, Engedal K, Tveit B, Johannessen A (2017)
Young-onset Alzheimer dementia: a comparison of Brazilian and Norwegian carers' experiences and needs for assistance
Int J Geriatr Psychiatry, 33 (6), 824-831
DOI 10.1002/gps.4717, PubMed 28370411

Ernst G, Watne LO, Frihagen F, Wyller TB, Dominik A, Rostrup M (2017)
Decreases in heart rate variability are associated with postoperative complications in hip fracture patients
PLoS One, 12 (7), e0180423
DOI 10.1371/journal.pone.0180423, PubMed 28742855

Fjeld KG, Eide H, Mowe M, Hove LH, Willumsen T (2017)
Dental hygiene registration: development, and reliability and validity testing of an assessment scale designed for nurses in institutions
J Clin Nurs, 26 (13-14), 1845-1853
DOI 10.1111/jocn.13452, PubMed 27323699

Fjeld KG, Eide H, Mowe M, Sandvik L, Willumsen T (2017)
A 1-year follow-up of a randomized clinical trial with focus on manual and electric toothbrushes' effect on dental hygiene in nursing homes
Acta Odontol Scand, 76 (4), 257-261
DOI 10.1080/00016357.2017.1416166, PubMed 29239260

Fog AF, Kvalvaag G, Engedal K, Straand J (2017)
Drug-related problems and changes in drug utilization after medication reviews in nursing homes in Oslo, Norway
Scand J Prim Health Care, 35 (4), 329-335
DOI 10.1080/02813432.2017.1397246, PubMed 29096573

Guren E, Figved W, Frihagen F, Watne LO, Westberg M (2017)
Prosthetic joint infection-a devastating complication of hemiarthroplasty for hip fracture
Acta Orthop, 88 (4), 383-389
DOI 10.1080/17453674.2017.1301009, PubMed 28271919

Hall RJ, Watne LO, Cunningham E, Zetterberg H, Shenkin SD, Wyller TB, MacLullich AMJ (2017)
CSF biomarkers in delirium: a systematic review
Int J Geriatr Psychiatry, 33 (11), 1479-1500
DOI 10.1002/gps.4720, PubMed 28585290

Hamre C, Botolfsen P, Tangen GG, Helbostad JL (2017)
Interrater and test-retest reliability and validity of the Norwegian version of the BESTest and mini-BESTest in people with increased risk of falling
BMC Geriatr, 17 (1), 92
DOI 10.1186/s12877-017-0480-x, PubMed 28427332

Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL, COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators (2017)
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women
Am J Respir Cell Mol Biol, 56 (3), 332-341
DOI 10.1165/rcmb.2016-0172OC, PubMed 27854507

Hov KR, Bolstad N, Idland AV, Zetterberg H, Blennow K, Chaudhry FA, Frihagen F, Ræder J, Wyller TB, Watne LO (2017)
Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
DOI 10.1159/000481853, PubMed 29282410

Husebø BS, Flo E, Engedal K (2017)
The Liverpool Care Pathway: discarded in cancer patients but good enough for dying nursing home patients? A systematic review
BMC Med Ethics, 18 (1), 48
DOI 10.1186/s12910-017-0205-x, PubMed 28793905

Idland AV, Wyller TB, Støen R, Dahl GT, Frihagen F, Brækhus A, Hassel B, Watne LO (2017)
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783

Idland AV, Wyller TB, Støen R, Eri LM, Frihagen F, Ræder J, Chaudhry FA, Hansson O, Zetterberg H, Blennow K, Bogdanovic N, Brækhus A, Watne LO (2017)
Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium
J Alzheimers Dis, 55 (1), 371-379
DOI 10.3233/JAD-160461, PubMed 27662296

Ihle-Hansen H, Hagberg G, Fure B, Thommessen B, Fagerland MW, Øksengård AR, Engedal K, Selnes P (2017)
Association between total-Tau and brain atrophy one year after first-ever stroke
BMC Neurol, 17 (1), 107
DOI 10.1186/s12883-017-0890-6, PubMed 28583116

Jason LA, McManimen S, Sunnquist M, Newton JL, Strand EB (2017)
Clinical Criteria Versus a Possible Research Case Definition in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Fatigue, 5 (2), 89-102
DOI 10.1080/21641846.2017.1299077, PubMed 29062593

Jason LA, McManimen S, Sunnquist M, Newton JL, Strand EB (2017)
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia
Neurology (ECronicon), 5 (1), 19-28
PubMed 28713879

Kerpershoek L, de Vugt M, Wolfs C, Woods B, Jelley H, Orrell M, Stephan A, Bieber A, Meyer G, Selbaek G, Handels R, Wimo A, Hopper L, Irving K, Marques M, Gonçalves-Pereira M, Portolani E, Zanetti O, Verhey F, Actifcare Consortium (2017)
Needs and quality of life of people with middle-stage dementia and their family carers from the European Actifcare study. When informal care alone may not suffice
Aging Ment Health, 22 (7), 897-902
DOI 10.1080/13607863.2017.1390732, PubMed 29068697

Kirkhus L, Šaltytė Benth J, Rostoft S, Grønberg BH, Hjermstad MJ, Selbæk G, Wyller TB, Harneshaug M, Jordhøy MS (2017)
Geriatric assessment is superior to oncologists' clinical judgement in identifying frailty
Br J Cancer, 117 (4), 470-477
DOI 10.1038/bjc.2017.202, PubMed 28664916

Knapskog AB, Eldholm RS, Braekhus A, Engedal K, Saltvedt I (2017)
Factors that influence the levels of cerebrospinal fluid biomarkers in memory clinic patients
BMC Geriatr, 17 (1), 210
DOI 10.1186/s12877-017-0611-4, PubMed 28893185

Lebedeva AK, Westman E, Borza T, Beyer MK, Engedal K, Aarsland D, Selbaek G, Haberg AK (2017)
MRI-Based Classification Models in Prediction of Mild Cognitive Impairment and Dementia in Late-Life Depression
Front Aging Neurosci, 9, 13
DOI 10.3389/fnagi.2017.00013, PubMed 28210220

Mjørud M, Engedal K, Røsvik J, Kirkevold M (2017)
Living with dementia in a nursing home, as described by persons with dementia: a phenomenological hermeneutic study
BMC Health Serv Res, 17 (1), 93
DOI 10.1186/s12913-017-2053-2, PubMed 28143535

Molde H, Hynninen KM, Torsheim T, Bendixen AB, Engedal K, Pachana NA, Nordhus IH (2017)
A Bifactor and item response analysis of the geriatric anxiety inventory
Int Psychogeriatr, 29 (10), 1647-1656
DOI 10.1017/S1041610217001004, PubMed 28629480

Myhre J, Bjørnstad Tonga J, Ulstein ID, Høye S, Kvaal K (2017)
The coping experiences of spouses of persons with dementia
J Clin Nurs, 27 (3-4), e495-e502
DOI 10.1111/jocn.14047, PubMed 28833748

Neerland BE, Krogseth M, Juliebø V, Hylen Ranhoff A, Engedal K, Frihagen F, Ræder J, Bruun Wyller T, Watne LO (2017)
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
PLoS One, 12 (7), e0180641
DOI 10.1371/journal.pone.0180641, PubMed 28700610

Nicolaisen M, Moum T, Thorsen K (2017)
Mastery and Depressive Symptoms: How Does Mastery Influence the Impact of Stressors From Midlife to Old Age?
J Aging Health, 30 (7), 1084-1107
DOI 10.1177/0898264317705782, PubMed 28553818

Næss G, Kirkevold M, Hammer W, Straand J, Wyller TB (2017)
Nursing care needs and services utilised by home-dwelling elderly with complex health problems: observational study
BMC Health Serv Res, 17 (1), 645
DOI 10.1186/s12913-017-2600-x, PubMed 28899369

O'connor K, Sunnquist M, Nicholson L, Jason LA, Newton JL, Strand EB (2017)
Energy envelope maintenance among patients with myalgic encephalomyelitis and chronic fatigue syndrome: Implications of limited energy reserves
Chronic Illn, 1742395317746470 (in press)
DOI 10.1177/1742395317746470, PubMed 29231037

Persson K, Barca ML, Cavallin L, Brækhus A, Knapskog AB, Selbæk G, Engedal K (2017)
Comparison of automated volumetry of the hippocampus using NeuroQuant® and visual assessment of the medial temporal lobe in Alzheimer's disease
Acta Radiol, 59 (8), 997-1001
DOI 10.1177/0284185117743778, PubMed 29172642

Persson K, Barca ML, Eldholm RS, Cavallin L, Šaltytė Benth J, Selbæk G, Brækhus A, Saltvedt I, Engedal K (2017)
Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease
Dement Geriatr Cogn Disord, 44 (1-2), 12-24
DOI 10.1159/000477342, PubMed 28614836

Persson K, Bohbot VD, Bogdanovic N, Selbaek G, Braekhus A, Engedal K (2017)
Finding of increased caudate nucleus in patients with Alzheimer's disease
Acta Neurol Scand, 137 (2), 224-232
DOI 10.1111/ane.12800, PubMed 28741672

Persson K, Eldholm RS, Barca ML, Cavallin L, Ferreira D, Knapskog AB, Selbæk G, Brækhus A, Saltvedt I, Westman E, Engedal K (2017)
MRI-assessed atrophy subtypes in Alzheimer's disease and the cognitive reserve hypothesis
PLoS One, 12 (10), e0186595
DOI 10.1371/journal.pone.0186595, PubMed 29036183

Rostoft S (2017)
Integration of Geriatric Assessment in the Care of Patients with Gastrointestinal Malignancies
Visc Med, 33 (4), 275-280
DOI 10.1159/000475452, PubMed 29034256

Rostoft S, Audisio RA (2017)
Recent advances in cancer surgery in older patients
F1000Res, 6, 1242
DOI 10.12688/f1000research.10683.1, PubMed 29034078

Sala-Llonch R, Idland AV, Borza T, Watne LO, Wyller TB, Brækhus A, Zetterberg H, Blennow K, Walhovd KB, Fjell AM (2017)
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
J Alzheimers Dis, 58 (3), 829-840
DOI 10.3233/JAD-161146, PubMed 28505968

Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO (2017)
Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
Alzheimers Res Ther, 9 (1), 57
DOI 10.1186/s13195-017-0279-1, PubMed 28764767

Scheibenbogen C, Freitag H, Blanco J, Capelli E, Lacerda E, Authier J, Meeus M, Castro Marrero J, Nora-Krukle Z, Oltra E, Strand EB, Shikova E, Sekulic S, Murovska M (2017)
The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE
J Transl Med, 15 (1), 162
DOI 10.1186/s12967-017-1263-z, PubMed 28747192

Selbæk G, Janus SIM, Bergh S, Engedal K, Ruths S, Helvik AS, Šaltyte Benth J, Zuidema SU (2017)
Change in psychotropic drug use in Norwegian nursing homes between 2004 and 2011
Int Psychogeriatr, 30 (3), 385-394
DOI 10.1017/S1041610217001788, PubMed 28988552

Strand BH, Wills AK, Langballe EM, Rosness TA, Engedal K, Bjertness E (2017)
Weight Change in Midlife and Risk of Mortality From Dementia up to 35 Years Later
J Gerontol A Biol Sci Med Sci, 72 (6), 855-860
DOI 10.1093/gerona/glw157, PubMed 27510654

Strøm BS, Engedal K, Benth JS, Grov EK (2017)
Effect of the Sonas Programme on Communication in People with Dementia: A Randomized Controlled Trial
Dement Geriatr Cogn Dis Extra, 7 (1), 122-135
DOI 10.1159/000468147, PubMed 28553314

Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F et al. (2017)
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Nat Genet, 49 (5), 801-805
DOI 10.1038/ng.3816, PubMed 28319091

Tevik K, Selbæk G, Engedal K, Seim A, Krokstad S, Helvik AS (2017)
Use of alcohol and drugs with addiction potential among older women and men in a population-based study. The Nord-Trøndelag Health Study 2006-2008 (HUNT3)
PLoS One, 12 (9), e0184428
DOI 10.1371/journal.pone.0184428, PubMed 28886172

 
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