Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Section of Preventive Medicine

41 publications found

Bergmark BA, O'Donoghue ML, Murphy SA, Kuder JF, Ezhov MV, Ceška R, Gouni-Berthold I, Jensen HK, Tokgozoglu SL, Mach F, Huber K, Gaciong Z, Lewis BS, Schiele F, Jukema JW, Pedersen TR, Giugliano RP, Sabatine MS (2020)
An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial
JAMA Cardiol, 5 (6), 709-713
DOI 10.1001/jamacardio.2020.0728, PubMed 32347887

Bergo KK, Larstorp AC, Hoffmann P, Hjørnholm U, Cataliotti A, Høieggen A, Rostrup M, Fadl Elmula FEM (2020)
Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension
Blood Press
DOI 10.1080/08037051.2020.1789446, PubMed 32633141

Bogsrud MP, Øyri LKL, Halvorsen S, Atar D, Leren TP, Holven KB (2020)
Prevalence of genetically verified familial hypercholesterolemia among young (<45 years) Norwegian patients hospitalized with acute myocardial infarction
J Clin Lipidol, 14 (3), 339-345
DOI 10.1016/j.jacl.2020.04.002, PubMed 32418822

Burnier M, Kreutz R, Narkiewicz K, Kjeldsen S, Oparil S, Mancia G (2020)
Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs: is dosing in the evening better than in the morning?
J Hypertens, 38 (8), 1396-1406
DOI 10.1097/HJH.0000000000002532, PubMed 32618895

Christensen JJ, Ulven SM, Thoresen M, Westerman K, Holven KB, Andersen LF (2020)
Associations between dietary patterns and gene expression pattern in peripheral blood mononuclear cells: A cross-sectional study
Nutr Metab Cardiovasc Dis (in press)
DOI 10.1016/j.numecd.2020.06.018, PubMed 32807640

Clemm T, Færden K, Ulvestad B, Lunde LK, Nordby KC (2020)
Dose-response relationship between hand-arm vibration exposure and vibrotactile thresholds among roadworkers
Occup Environ Med, 77 (3), 188-193
DOI 10.1136/oemed-2019-105926, PubMed 31919277

Deedwania P, Murphy SA, Scheen A, Badariene J, Pineda AL, Honarpour N, Keech AC, Sever PS, Pedersen TR, Sabatine MS, Giugliano RP (2020)
Efficacy and Safety of PCSK9 Inhibition With Evolocumab in Reducing Cardiovascular Events in Patients With Metabolic Syndrome Receiving Statin Therapy: Secondary Analysis From the FOURIER Randomized Clinical Trial
JAMA Cardiol (in press)
DOI 10.1001/jamacardio.2020.3151, PubMed 32785614

Ernst G, Watne LO, Rostrup M, Neerland BE (2020)
Delirium in patients with hip fracture is associated with increased heart rate variability
Aging Clin Exp Res (in press)
DOI 10.1007/s40520-019-01447-5, PubMed 31916197

Gaundal L, Myhrstad MCW, Leder L, Byfuglien MG, Gjøvaag T, Rud I, Retterstøl K, Holven KB, Ulven SM, Telle-Hansen VH (2020)
Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for three days: a randomised crossover trial
Br J Nutr, 1-29 (in press)
DOI 10.1017/S0007114520003402, PubMed 32873354

Gencer B, Mach F, Guo J, Im K, Ruzza A, Wang H, Kurtz CE, Pedersen TR, Keech AC, Ott BR, Sabatine MS, Giugliano RP, FOURIER Investigators (2020)
Cognition After Lowering LDL-Cholesterol With Evolocumab
J Am Coll Cardiol, 75 (18), 2283-2293
DOI 10.1016/j.jacc.2020.03.039, PubMed 32381158

Gencer B, Mach F, Murphy SA, De Ferrari GM, Huber K, Lewis BS, Ferreira J, Kurtz CE, Wang H, Honarpour N, Keech AC, Sever PS, Pedersen TR, Sabatine MS, Giugliano RP (2020)
Efficacy of Evolocumab on Cardiovascular Outcomes in Patients With Recent Myocardial Infarction: A Prespecified Secondary Analysis From the FOURIER Trial
JAMA Cardiol, 5 (8), 952-957
DOI 10.1001/jamacardio.2020.0882, PubMed 32432684

Gundem T, Olasveengen TM, Hovda KE, Gaustad K, Schøndorf C, Rostrup M, Frøyshov S, Undseth Ø, Tonby K, Holten AR, Sunde K (2020)
T.M. Gundem og medarbeidere svarer
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0650, PubMed 32900164

Gundem T, Olasveengen TM, Hovda KE, Gaustad K, Schøndorf C, Rostrup M, Frøyshov S, Undseth Ø, Tonby K, Holten AR, Sunde K (2020)
Ventilatory support for hypoxaemic intensive care patients with COVID-19
Tidsskr Nor Laegeforen, 140 (11)
DOI 10.4045/tidsskr.20.0445, PubMed 32815344

Hovland A, Retterstøl K, Mollnes TE, Halvorsen B, Aukrust P, Lappegård KT (2020)
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J
DOI 10.1080/14017431.2020.1775878, PubMed 32500743

Hustad KS, Rundblad A, Ottestad I, Christensen JJ, Holven KB, Ulven SM (2020)
Comprehensive lipid and metabolite profiling in healthy adults with low and high consumption of fatty fish: a cross-sectional study
Br J Nutr, 1-23 (in press)
DOI 10.1017/S0007114520002305, PubMed 32594945

Johannessen TR, Vallersnes OM, Halvorsen S, Larstorp ACK, Mdala I, Atar D (2020)
Pre-hospital One-Hour Troponin in a Low-Prevalence Population of Acute Coronary Syndrome: OUT-ACS study
Open Heart, 7 (2)
DOI 10.1136/openhrt-2020-001296, PubMed 32719074

Johansen N, Tonstad S, Liavaag AH, Selmer RM, Tanbo TG, Michelsen TM (2020)
Risk of cardiovascular disease after preventive salpingo-oophorectomy
Int J Gynecol Cancer, 30 (5), 575-582
DOI 10.1136/ijgc-2019-000856, PubMed 32332121

Langslet G, Hovingh GK, Guyton JR, Baccara-Dinet MT, Letierce A, Manvelian G, Farnier M (2020)
Regional Variations in Alirocumab Dosing Patterns in Patients with Heterozygous Familial Hypercholesterolemia During an Open-Label Extension Study
Cardiovasc Drugs Ther, 34 (4), 515-523
DOI 10.1007/s10557-020-06984-0, PubMed 32363493

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund O, ESC Scientific Document Group (2020)
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Eur Heart J, 41 (1), 111-188
DOI 10.1093/eurheartj/ehz455, PubMed 31504418

Mahfoud F, Azizi M, Ewen S, Pathak A, Ukena C, Blankestijn PJ, Böhm M, Burnier M, Chatellier G, Durand Zaleski I, Grassi G, Joner M, Kandzari DE, Kirtane A, Kjeldsen SE, Lobo MD, Lüscher TF, McEvoy JW, Parati G, Rossignol P, Ruilope L, Schlaich MP, Shahzad A, Sharif F, Sharp ASP et al. (2020)
Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies
Eur Heart J, 41 (16), 1588-1599
DOI 10.1093/eurheartj/ehaa121, PubMed 32211888

Marston NA, Gurmu Y, Melloni GEM, Bonaca M, Gencer B, Sever PS, Pedersen TR, Keech AC, Roselli C, Lubitz SA, Ellinor PT, O'Donoghue ML, Giugliano RP, Ruff CT, Sabatine MS (2020)
The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism
Circulation, 141 (20), 1600-1607
DOI 10.1161/CIRCULATIONAHA.120.046397, PubMed 32223429

Mirza Y, Prestgaard EE, Selmer R, Liestøl K, Grundvold I, Erikssen JE, Kjeldsen SE, Gjesdal K (2020)
Tiårsprediksjon av hjerte- og karsykdom hos friske norske menn basert på NORRISK-2
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0089, PubMed 32900157

Nordstrøm M, Retterstøl K, Hope S, Kolset SO (2020)
Nutritional challenges in children and adolescents with Down syndrome
Lancet Child Adolesc Health, 4 (6), 455-464
DOI 10.1016/S2352-4642(19)30400-6, PubMed 32450124

Norum KR, Remaley AT, Miettinen HE, Strøm EH, Balbo BEP, Sampaio CATL, Wiig I, Kuivenhoven JA, Calabresi L, Tesmer JJ, Zhou M, Ng DS, Skeie B, Karathanasis SK, Manthei KA, Retterstøl K (2020)
Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings
J Lipid Res, 61 (8), 1142-1149
DOI 10.1194/jlr.S120000720, PubMed 32482717

Okin PM, Hille DA, Wachtell K, Kjeldsen SE, Julius S, Devereux RB (2020)
On-treatment HDL cholesterol predicts incident atrial fibrillation in hypertensive patients with left ventricular hypertrophy
Blood Press
DOI 10.1080/08037051.2020.1782171, PubMed 32586143

Olsen T, Øvrebø B, Haj-Yasein N, Lee S, Svendsen K, Hjorth M, Bastani NE, Norheim F, Drevon CA, Refsum H, Vinknes KJ (2020)
Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study
J Transl Med, 18 (1), 122
DOI 10.1186/s12967-020-02288-x, PubMed 32160926

Representatives of the Global Familial Hypercholesterolemia Community, Wilemon KA, Patel J, Aguilar-Salinas C, Ahmed CD, Alkhnifsawi M, Almahmeed W, Alonso R, Al-Rasadi K, Badimon L, Bernal LM, Bogsrud MP, Braun LT, Brunham L, Catapano AL, Cillíková K, Corral P, Cuevas R, Defesche JC, Descamps OS, de Ferranti S, Eiselé JL, Elikir G, Folco E, Freiberger T et al. (2020)
Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action
JAMA Cardiol, 5 (2), 217-229
DOI 10.1001/jamacardio.2019.5173, PubMed 31895433

Rognstad S, Søraas CL, Bergland OU, Høieggen A, Strømmen M, Helland A, Opdal MS (2020)
Establishing Serum Reference Ranges for Antihypertensive Drugs
Ther Drug Monit (in press)
DOI 10.1097/FTD.0000000000000806, PubMed 32881780

Rundblad A, Holven KB, Øyri LKL, Hansson P, Ivan IH, Gjevestad GO, Thoresen M, Ulven SM (2020)
Intake of Fermented Dairy Products Induces a Less Pro-Inflammatory Postprandial Peripheral Blood Mononuclear Cell Gene Expression Response than Non-Fermented Dairy Products: A Randomized Controlled Cross-Over Trial
Mol Nutr Food Res, e2000319 (in press)
DOI 10.1002/mnfr.202000319, PubMed 32844586

Schmidt EB, Hedegaard BS, Retterstøl K (2020)
Familial hypercholesterolaemia: history, diagnosis, screening, management and challenges
Heart (in press)
DOI 10.1136/heartjnl-2019-316276, PubMed 32933999

Sever P, Gouni-Berthold I, Keech A, Giugliano R, Pedersen TR, Im K, Wang H, Knusel B, Sabatine MS, O'Donoghue ML (2020)
LDL-cholesterol lowering with evolocumab, and outcomes according to age and sex in patients in the FOURIER Trial
Eur J Prev Cardiol, UNSP 2047487320902750
DOI 10.1177/2047487320902750, PubMed 32019364

Svendsen K, Jacobs DR, Mørch-Reiersen LT, Garstad KW, Henriksen HB, Telle-Hansen VH, Retterstøl K (2020)
Evaluating the use of the heart age tool in community pharmacies: a 4-week cluster-randomized controlled trial
Eur J Public Health (in press)
DOI 10.1093/eurpub/ckaa048, PubMed 32206810

Svendsen K, Olsen T, Nordstrand Rusvik TC, Ulven SM, Holven KB, Retterstøl K, Telle-Hansen VH (2020)
Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health
Lipids Health Dis, 19 (1), 102
DOI 10.1186/s12944-020-01282-y, PubMed 32438926

Telle-Hansen VH, Christensen JJ, Formo GA, Holven KB, Ulven SM (2020)
A comprehensive metabolic profiling of the metabolically healthy obesity phenotype
Lipids Health Dis, 19 (1), 90
DOI 10.1186/s12944-020-01273-z, PubMed 32386512

Thorsteinsdottir H, Christensen JJ, Holven KB, Tveiterås M, Brun H, Åsberg A, Bjerre A (2020)
Cardiovascular Risk Factors are Inversely Associated With Omega-3 Polyunsaturated Fatty Acid Plasma Levels in Pediatric Kidney Transplant Recipients
J Ren Nutr (in press)
DOI 10.1053/j.jrn.2020.06.002, PubMed 32792219

Tonstad S, Arons C, Rollema H, Berlin I, Hajek P, Fagerström K, Els C, McRae T, Russ C (2020)
Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations
Curr Med Res Opin, 36 (5), 713-730
DOI 10.1080/03007995.2020.1729708, PubMed 32050807

Weider T, Richardson SJ, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2020)
Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis
Thyroid, 30 (3), 432-442
DOI 10.1089/thy.2019.0607, PubMed 31910110

Willeit P, Tschiderer L, Allara E, Reuber K, Seekircher L, Gao L, Liao X, Lonn E, Gerstein HC, Yusuf S, Brouwers FP, Asselbergs FW, van Gilst W, Anderssen SA, Grobbee DE, Kastelein JJP, Visseren FLJ, Ntaios G, Hatzitolios AI, Savopoulos C, Nieuwkerk PT, Stroes E, Walters M, Higgins P, Dawson J et al. (2020)
Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients
Circulation, 142 (7), 621-642
DOI 10.1161/CIRCULATIONAHA.120.046361, PubMed 32546049

Wiviott SD, Giugliano RP, Morrow DA, De Ferrari GM, Lewis BS, Huber K, Kuder JF, Murphy SA, Forni DM, Kurtz CE, Honarpour N, Keech AC, Sever PS, Pedersen TR, Sabatine MS (2020)
Effect of Evolocumab on Type and Size of Subsequent Myocardial Infarction: A Prespecified Analysis of the FOURIER Randomized Clinical Trial
JAMA Cardiol, 5 (7), 787-793
DOI 10.1001/jamacardio.2020.0764, PubMed 32347885

Åkra S, Aksnes TA, Flaa A, Eggesbø HB, Opstad TB, Njerve IU, Seljeflot I (2020)
Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men
Sci Rep, 10 (1), 14055
DOI 10.1038/s41598-020-71109-4, PubMed 32820223

Aakre KM, Omland T, Nordstrand N, Gjevestad ES, Holven KB, Lyngbakken MN, Hjelmesæth J (2020)
Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention
Clin Biochem (in press)
DOI 10.1016/j.clinbiochem.2020.09.006, PubMed 32986994

 
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