Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Section of Preventive Medicine

33 publications found

Bang CN, Greve AM, La Cour M, Boman K, Gohlke-Bärwolf C, Ray S, Pedersen T, Rossebø A, Okin PM, Devereux RB, Wachtell K (2015)
Effect of Randomized Lipid Lowering With Simvastatin and Ezetimibe on Cataract Development (from the Simvastatin and Ezetimibe in Aortic Stenosis Study)
Am J Cardiol, 116 (12), 1840-4
DOI 10.1016/j.amjcard.2015.09.026, PubMed 26602073

Braamskamp MJ, Stefanutti C, Langslet G, Drogari E, Wiegman A, Hounslow N, Kastelein JJ, PASCAL Study Group (2015)
Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk
J Pediatr, 167 (2), 338-43.e5
DOI 10.1016/j.jpeds.2015.05.006, PubMed 26059337

Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, Stein EA, Kastelein JJP (2015)
Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study
J Clin Lipidol, 9 (6), 741-750
DOI 10.1016/j.jacl.2015.07.011, PubMed 26687694

Fadl Elmula FE, Jin Y, Yang WY, Thijs L, Lu YC, Larstorp AC, Persu A, Sapoval M, Rosa J, Widimský P, Jacobs L, Renkin J, Petrák O, Chatellier G, Shimada K, Widimský J, Kario K, Azizi M, Kjeldsen SE, Staessen JA, European Network Coordinating Research On Renal Denervation (ENCOReD) Consortium (2015)
Meta-analysis of randomized controlled trials of renal denervation in treatment-resistant hypertension
Blood Press, 24 (5), 263-74
DOI 10.3109/08037051.2015.1058595, PubMed 26194721

Fadl Elmula FE, Rebora P, Talvik A, Salerno S, Miszkowska-Nagórna E, Liu X, Heinpalu-Kuum M, Comotti T, Larstorp AC, Rostrup M, Świerblewska E, Valsecchi MG, Kjeldsen SE, Viigimaa M, Narkiewicz K, Parati G, Laurent S, BEtter control of blood pressure in hypertensive pAtients monitored Using the HOTMAN sYstem (BEAUTY) Study Investigators (2015)
A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients
J Hypertens, 33 (12), 2534-45
DOI 10.1097/HJH.0000000000000749, PubMed 26485460

Gerdts E, Rossebø AB, Pedersen TR, Cioffi G, Lønnebakken MT, Cramariuc D, Rogge BP, Devereux RB (2015)
Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate Aortic Valve Stenosis
Circ Cardiovasc Imaging, 8 (11), e003644; discussion e003644
DOI 10.1161/CIRCIMAGING.115.003644, PubMed 26489804

Holme I, Kjeldsen SE (2015)
Long-term survival in the randomized trial of drug treatment in mild to moderate hypertension of the Oslo study 1972-3
Eur J Intern Med, 26 (2), 123-6
DOI 10.1016/j.ejim.2015.01.013, PubMed 25681139

Holme I, Tonstad S (2015)
Survival in elderly men in relation to midlife and current BMI
Age Ageing, 44 (3), 434-9
DOI 10.1093/ageing/afu202, PubMed 25609234

Ikdahl E, Hisdal J, Rollefstad S, Olsen IC, Kvien TK, Pedersen TR, Semb AG (2015)
Rosuvastatin improves endothelial function in patients with inflammatory joint diseases, longitudinal associations with atherosclerosis and arteriosclerosis: results from the RORA-AS statin intervention study
Arthritis Res Ther, 17, 279
DOI 10.1186/s13075-015-0795-y, PubMed 26445924

Jiménez-Ruiz CA, Andreas S, Lewis KE, Tonnesen P, van Schayck CP, Hajek P, Tonstad S, Dautzenberg B, Fletcher M, Masefield S, Powell P, Hering T, Nardini S, Tonia T, Gratziou C (2015)
Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit
Eur Respir J, 46 (1), 61-79
DOI 10.1183/09031936.00092614, PubMed 25882805

Kastelein JJ, Besseling J, Shah S, Bergeron J, Langslet G, Hovingh GK, Al-Saady N, Koeijvoets M, Hunter J, Johnson-Levonas AO, Fable J, Sapre A, Mitchel Y (2015)
Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study
Lancet, 385 (9983), 2153-61
DOI 10.1016/S0140-6736(14)62115-2, PubMed 25743173

Kastelein JJ, Ginsberg HN, Langslet G, Hovingh GK, Ceska R, Dufour R, Blom D, Civeira F, Krempf M, Lorenzato C, Zhao J, Pordy R, Baccara-Dinet MT, Gipe DA, Geiger MJ, Farnier M (2015)
ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
Eur Heart J, 36 (43), 2996-3003
DOI 10.1093/eurheartj/ehv370, PubMed 26330422

Kjeldsen SE, Berge E, Bangalore S, Messerli FH, Mancia G, Holzhauer B, Hua TA, Zappe D, Zanchetti A, Weber MA, Julius S (2015)
No evidence for a J-shaped curve in treated hypertensive patients with increased cardiovascular risk: The VALUE trial
Blood Press, 25 (2), 83-92
DOI 10.3109/08037051.2015.1106750, PubMed 26511535

Koopal C, Retterstøl K, Sjouke B, Hovingh GK, Ros E, de Graaf J, Dullaart RP, Bertolini S, Visseren FL (2015)
Vascular risk factors, vascular disease, lipids and lipid targets in patients with familial dysbetalipoproteinemia: a European cross-sectional study
Atherosclerosis, 240 (1), 90-7
DOI 10.1016/j.atherosclerosis.2015.02.046, PubMed 25768710

Krogh HW, Mundal L, Holven KB, Retterstøl K (2015)
Patients with familial hypercholesterolaemia are characterized by presence of cardiovascular disease at the time of death
Eur Heart J, 37 (17), 1398-405
DOI 10.1093/eurheartj/ehv602, PubMed 26586781

Langslet G, Bogsrud MP, Halvorsen I, Fjeldstad H, Retterstøl K, Veierød MB, Ose L (2015)
Long-term follow-up of young adults with familial hypercholesterolemia after participation in clinical trials during childhood
J Clin Lipidol, 9 (6), 778-785
DOI 10.1016/j.jacl.2015.08.008, PubMed 26687698

Langslet G, Emery M, Wasserman SM (2015)
Evolocumab (AMG 145) for primary hypercholesterolemia
Expert Rev Cardiovasc Ther, 13 (5), 477-88
DOI 10.1586/14779072.2015.1030395, PubMed 25824308

Narverud I, van Lennep JR, Christensen JJ, Versmissen J, Gran JM, Iversen PO, Aukrust P, Halvorsen B, Ueland T, Ulven SM, Ose L, Veierød MB, Sijbrands E, Retterstøl K, Holven KB (2015)
Maternal inheritance does not predict cholesterol levels in children with familial hypercholesterolemia
Atherosclerosis, 243 (1), 155-60
DOI 10.1016/j.atherosclerosis.2015.09.014, PubMed 26386212

Okin PM, Hille DA, Wachtell K, Kjeldsen SE, Boman K, Dahlöf B, Devereux RB (2015)
Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation
J Hypertens, 33 (7), 1480-6
DOI 10.1097/HJH.0000000000000559, PubMed 25799208

Pihlstrøm H, Dahle DO, Mjøen G, Pilz S, März W, Abedini S, Holme I, Fellström B, Jardine AG, Holdaas H (2015)
Increased risk of all-cause mortality and renal graft loss in stable renal transplant recipients with hyperparathyroidism
Transplantation, 99 (2), 351-9
DOI 10.1097/TP.0000000000000583, PubMed 25594550

Preiss D, Campbell RT, Murray HM, Ford I, Packard CJ, Sattar N, Rahimi K, Colhoun HM, Waters DD, LaRosa JC, Amarenco P, Pedersen TR, Tikkanen MJ, Koren MJ, Poulter NR, Sever PS, Ridker PM, MacFadyen JG, Solomon SD, Davis BR, Simpson LM, Nakamura H, Mizuno K, Marfisi RM, Marchioli R et al. (2015)
The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials
Eur Heart J, 36 (24), 1536-46
DOI 10.1093/eurheartj/ehv072, PubMed 25802390

Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ, ODYSSEY LONG TERM Investigators (2015)
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
N Engl J Med, 372 (16), 1489-99
DOI 10.1056/NEJMoa1501031, PubMed 25773378

Rollefstad S, Ikdahl E, Hisdal J, Kvien TK, Pedersen TR, Semb AG (2015)
Association of Chest Pain and Risk of Cardiovascular Disease with Coronary Atherosclerosis in Patients with Inflammatory Joint Diseases
Front Med (Lausanne), 2, 80
DOI 10.3389/fmed.2015.00080, PubMed 26618159

Rollefstad S, Ikdahl E, Hisdal J, Olsen IC, Holme I, Hammer HB, Smerud KT, Kitas GD, Pedersen TR, Kvien TK, Semb AG (2015)
Rosuvastatin-Induced Carotid Plaque Regression in Patients With Inflammatory Joint Diseases: The Rosuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and Other Inflammatory Joint Diseases Study
Arthritis Rheumatol, 67 (7), 1718-28
DOI 10.1002/art.39114, PubMed 25778850

Sabatine MS, Giugliano RP, Keech A, Honarpour N, Wang H, Liu T, Wasserman SM, Scott R, Sever PS, Pedersen TR (2015)
Rationale and design of the Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk trial
Am Heart J, 173, 94-101
DOI 10.1016/j.ahj.2015.11.015, PubMed 26920601

Schernthaner G, Durán-Garcia S, Hanefeld M, Langslet G, Niskanen L, Östgren CJ, Malvolti E, Hardy E (2015)
Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION)
Diabetes Obes Metab, 17 (7), 630-8
DOI 10.1111/dom.12461, PubMed 25761977

Skårn SN, Eggesbø HB, Flaa A, Kjeldsen SE, Rostrup M, Brunborg C, Reims HM, Aksnes TA (2015)
Predictors of abdominal adipose tissue compartments: 18-year follow-up of young men with and without family history of diabetes
Eur J Intern Med, 29, 26-31
DOI 10.1016/j.ejim.2015.11.027, PubMed 26712453

Skårn SN, Flaa A, Kjeldsen SE, Rostrup M, Brunborg C, Reims HM, Fossum E, Høieggen A, Aksnes TA (2015)
Family history of hypertension and serum triglycerides predict future insulin sensitivity: a 17-year follow-up study of young men
J Hypertens, 33 (9), 1845-51; discussion 1852
DOI 10.1097/HJH.0000000000000632, PubMed 26103130

Skårn SN, Flaa A, Kjeldsen SE, Rostrup M, Brunborg C, Reims HM, Fossum E, Høieggen A, Aksnes TA (2015)
High screening blood pressure at young age predicts future masked hypertension: A 17 year follow-up study
Blood Press, 24 (3), 131-8
DOI 10.3109/21695717.2015.1030889, PubMed 25901999

Stoekenbroek RM, Boekholdt SM, Fayyad R, Laskey R, Tikkanen MJ, Pedersen TR, Hovingh GK, Incremental Decrease in End Points Through Aggressive Lipid Lowering Study Group (2015)
High-dose atorvastatin is superior to moderate-dose simvastatin in preventing peripheral arterial disease
Heart, 101 (5), 356-62
DOI 10.1136/heartjnl-2014-306906, PubMed 25595417

Strohmaier S, Røysland K, Hoff R, Borgan Ø, Pedersen TR, Aalen OO (2015)
Dynamic path analysis - a useful tool to investigate mediation processes in clinical survival trials
Stat Med, 34 (29), 3866-87
DOI 10.1002/sim.6598, PubMed 26278111

Vishram JK, Dahlöf B, Devereux RB, Ibsen H, Kjeldsen SE, Lindholm LH, Mancia G, Okin PM, Rothwell PM, Wachtell K, Olsen MH (2015)
Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage: a LIFE substudy
J Hypertens, 33 (12), 2422-30
DOI 10.1097/HJH.0000000000000739, PubMed 26378687

Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, Ose L, Averna M, Boileau C, Borén J, Bruckert E, Catapano AL, Defesche JC, Descamps OS, Hegele RA, Hovingh GK, Humphries SE, Kovanen PT, Kuivenhoven JA, Masana L, Nordestgaard BG, Pajukanta P, Parhofer KG, Raal FJ, Ray KK et al. (2015)
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment
Eur Heart J, 36 (36), 2425-37
DOI 10.1093/eurheartj/ehv157, PubMed 26009596

 
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