Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Pharmacology

46 publications found

Amrutkar M, Vethe NT, Verbeke CS, Aasrum M, Finstadsveen AV, Sántha P, Gladhaug IP (2020)
Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123628, PubMed 33287390

Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, The Cannabinoids International Experts Panel, Collaborators (2020)
Epilepsy and cannabidiol: a guide to treatment
Epileptic Disord, 22 (1), 1-14
DOI 10.1684/epd.2020.1141, PubMed 32096470

Åsberg A, Bergan S, Bjørkto MH, Mjøen G, Varberg Reisæter A, Robertsen I, Midtvedt K (2020)
Severe Mycophenolate Intoxication in a Solid Organ Transplant Recipient-No Intervention Actually Needed
Transplant Direct, 6 (10), e609
DOI 10.1097/TXD.0000000000001058, PubMed 33062842

Azevedo C, Nilsen J, Grevys A, Nunes R, Andersen JT, Sarmento B (2020)
Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin
J Control Release, 327, 161-173
DOI 10.1016/j.jconrel.2020.08.005, PubMed 32771477

Bejder J, Breenfeldt Andersen A, Bonne TC, Piil JF, Hagen LCH, Dehnes Y, Eibye KH, Nybo L, Nordsborg NB (2020)
Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists
Med Sci Sports Exerc, 52 (5), 1169-1175
DOI 10.1249/MSS.0000000000002217, PubMed 31809408

Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT (2020)
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243

Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Perucca P, Tomson T, White HS (2020)
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development
Epilepsia, 61 (11), 2340-2364
DOI 10.1111/epi.16725, PubMed 33190243

Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Perucca P, Tomson T, White HS (2020)
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). II. Drugs in more advanced clinical development
Epilepsia, 61 (11), 2365-2385
DOI 10.1111/epi.16726, PubMed 33165915

Caddy SL, Vaysburd M, Papa G, Wing M, O'Connell K, Stoycheva D, Foss S, Terje Andersen J, Oxenius A, James LC (2020)
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
EMBO J, e106228
DOI 10.15252/embj.2020106228, PubMed 33258165

Caddy SL, Vaysburd M, Wing M, Foss S, Andersen JT, O'Connell K, Mayes K, Higginson K, Iturriza-Gómara M, Desselberger U, James LC (2020)
Intracellular neutralisation of rotavirus by VP6-specific IgG
PLoS Pathog, 16 (8), e1008732
DOI 10.1371/journal.ppat.1008732, PubMed 32750093

Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M (2020)
Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease
Front Immunol, 11, 602547
DOI 10.3389/fimmu.2020.602547, PubMed 33424849

Edwin TH, Henjum K, Nilsson LNG, Watne LO, Persson K, Eldholm RS, Saltvedt I, Halaas NB, Selbæk G, Engedal K, Strand BH, Knapskog AB (2020)
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Alzheimers Dement (Amst), 12 (1), e12128
DOI 10.1002/dad2.12128, PubMed 33313376

Egeland EJ, Witczak BJ, Zaré HK, Christensen H, Åsberg A, Robertsen I (2020)
Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End-Stage Renal Disease
Clin Pharmacol Ther, 108 (4), 866-873
DOI 10.1002/cpt.1875, PubMed 32356565

Elens L, Langman LJ, Hesselink DA, Bergan S, Moes DJAR, Molinaro M, Venkataramanan R, Lemaitre F (2020)
Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2: Considerations Regarding Therapeutic Drug Monitoring and Drug-Drug Interactions
Ther Drug Monit, 42 (3), 360-368
DOI 10.1111/ajt.15874, PubMed 32304488

Farcas M, Inngjerdingen M (2020)
Natural killer cell-derived extracellular vesicles in cancer therapy
Scand J Immunol, 92 (4), e12938
DOI 10.1111/sji.12938, PubMed 32697853

Fjeld H, Kjeldstadli K, Steinbakk M (2020)
Antibiotic dosage - theory and practice
Tidsskr. Nor. Laegeforen., 140 (13), 1359-1363

Franco V, Gatti G, Mazzucchelli I, Marchiselli R, Fattore C, Rota P, Galimberti CA, Capovilla G, Beccaria F, De Giorgis V, Johannessen Landmark C, Perucca E (2020)
Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy
Epilepsia, 61 (7), e79-e84
DOI 10.1111/epi.16584, PubMed 32562438

Gustavsen MT, Midtvedt K, Robertsen I, Woillard JB, Debord J, Klaasen RA, Vethe NT, Bergan S, Åsberg A (2020)
Fasting Status and Circadian Variation Must be Considered When Performing AUC-based Therapeutic Drug Monitoring of Tacrolimus in Renal Transplant Recipients
Clin Transl Sci, 13 (6), 1327-1335
DOI 10.1111/cts.12833, PubMed 32652886

Gustavsen MT, Midtvedt K, Vethe NT, Robertsen I, Bergan S, Åsberg A (2020)
Tacrolimus Area Under the Concentration Versus Time Curve Monitoring, Using Home-Based Volumetric Absorptive Capillary Microsampling
Ther Drug Monit, 42 (3), 407-414
DOI 10.1097/FTD.0000000000000697, PubMed 31479042

Halaas NB, Henjum K, Blennow K, Dakhil S, Idland AV, Nilsson LN, Sederevicius D, Vidal-Piñeiro D, Walhovd KB, Wyller TB, Zetterberg H, Watne LO, Fjell AM (2020)
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex, 30 (4), 2295-2306
DOI 10.1093/cercor/bhz240, PubMed 31812991

Heger K, Lund C, Larsen Burns M, Bjørnvold M, Sætre E, Johannessen SI, Johannessen Landmark C (2020)
A retrospective review of changes and challenges in the use of antiseizure medicines in Dravet syndrome in Norway
Epilepsia Open, 5 (3), 432-441
DOI 10.1002/epi4.12413, PubMed 32913951

Hemmersbach P (2020)
The Probenecid-story - A success in the fight against doping through out-of-competition testing
Drug Test Anal, 12 (5), 589-594
DOI 10.1002/dta.2727, PubMed 31797550

Henjum K, Årskog V, Jendresen CB, Fladby T, Torp R, Nilsson LNG (2020)
Analyzing microglial-associated Aβ in Alzheimer's disease transgenic mice with a novel mid-domain Aβ-antibody
Sci Rep, 10 (1), 10590
DOI 10.1038/s41598-020-67419-2, PubMed 32601313

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS (2020)
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity
J Exp Med, 217 (10)
DOI 10.1084/jem.20200359, PubMed 32658257

Jang W, Adams CE, Liu H, Zhang C, Levy FO, Andressen KW, Lambert NA (2020)
An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling
Proc Natl Acad Sci U S A, 117 (48), 30755-30762
DOI 10.1073/pnas.2010801117, PubMed 33199589

Jessen S, Becker V, Rzeppa S, Backer V, Bengtsen K, Hullstein I, Dehnes Y, Hostrup M (2020)
Pharmacokinetics of salmeterol and its main metabolite α-hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance-trained men: Implications for doping control
Drug Test Anal
DOI 10.1002/dta.2978, PubMed 33210444

Johannessen Landmark C, Heger K, Lund C, Burns ML, Bjørnvold M, Sætre E, Johannessen SI (2020)
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome
Ther Drug Monit, 42 (5), 744-753
DOI 10.1097/FTD.0000000000000781, PubMed 32558674

Johannessen Landmark C, Johannessen SI, Patsalos PN (2020)
Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
Expert Opin Drug Metab Toxicol, 16 (3), 227-238
DOI 10.1080/17425255.2020.1724956, PubMed 32054370

Klaasen RA, Bergan S, Bremer S, Hole K, Nordahl CB, Andersen AM, Midtvedt K, Skauby MH, Vethe NT (2020)
Pharmacodynamic assessment of mycophenolic acid in resting and activated target cell population during the first year after renal transplantation
Br J Clin Pharmacol, 86 (6), 1100-1112
DOI 10.1111/bcp.14218, PubMed 31925806

Knapskog AB, Henjum K, Idland AV, Eldholm RS, Persson K, Saltvedt I, Watne LO, Engedal K, Nilsson LNG (2020)
Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Sci Rep, 10 (1), 15886
DOI 10.1038/s41598-020-72878-8, PubMed 32985583

Kristiansen O, Vethe NT, Peersen K, Fagerland MW, Sverre E, Jensen EP, Lindberg M, Gjertsen E, Gullestad L, Perk J, Dammen T, Bergan S, Husebye E, Otterstad JE, Munkhaugen J (2020)
Effect of atorvastatin on muscle symptoms in coronary heart disease patients with self-perceived statin muscle side-effects: a randomized, double blinded crossover trial
Eur Heart J Cardiovasc Pharmacother (in press)
DOI 10.1093/ehjcvp/pvaa076, PubMed 32609361

Kvamsøe MM, Hansen KR, Skadberg Ø, Vethe NT, Brede C (2020)
Salting Out-Assisted Liquid-Liquid Extraction for Liquid Chromatography-Tandem Mass Spectrometry Measurement of Tacrolimus, Sirolimus, Everolimus, and Cyclosporine a in Whole Blood
Ther Drug Monit, 42 (5), 695-701
DOI 10.1097/FTD.0000000000000794, PubMed 32701594

Lang GP, Ndongson-Dongmo B, Lajqi T, Brodhun M, Han Y, Wetzker R, Frasch MG, Bauer R (2020)
Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice-role of phosphoinositide 3-kinase gamma
J Neuroinflammation, 17 (1), 292
DOI 10.1186/s12974-020-01954-7, PubMed 33028343

Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE (2020)
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
MAbs, 12 (1), 1686319
DOI 10.1080/19420862.2019.1686319, PubMed 31671278

Lemaitre F, Vethe NT, D'Avolio A, Tron C, Robertsen I, De Winter B, Denicolo A, Koch BCP, Venkataramanan R, Van Gelder T, Brunet M, Bergan S, Hesselink DA, Wallemacq P (2020)
Measuring Intracellular Concentrations of Calcineurin Inhibitors: Expert Consensus from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Expert Panel
Ther Drug Monit, 42 (5), 665-670
DOI 10.1097/FTD.0000000000000780, PubMed 32520841

Mullen J, Baekken LV, Törmäkangas T, Ekström L, Ericsson M, Hullstein IR, Schulze JJ (2020)
Inter-individual variation of the urinary steroid profiles in Swedish and Norwegian athletes
Drug Test Anal, 12 (6), 720-730
DOI 10.1002/dta.2778, PubMed 32052600

Saidu NEB, Bonini C, Dickinson A, Grce M, Inngjerdingen M, Koehl U, Toubert A, Zeiser R, Galimberti S (2020)
New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions
Front Immunol, 11, 578314
DOI 10.3389/fimmu.2020.578314, PubMed 33162993

Schrottmaier WC, Salzmann M, Badrnya S, Mussbacher M, Kral-Pointner JB, Morava S, Pirabe A, Brunnthaler L, Yaiw KC, Heber UM, Pereyra D, Andersen JT, Bergthaler A, Söderberg-Nauclér C, Karlsson MCI, Assinger A, Forsell MNE (2020)
Platelets mediate serological memory to neutralize viruses in vitro and in vivo
Blood Adv, 4 (16), 3971-3976
DOI 10.1182/bloodadvances.2020001786, PubMed 32841338

Skauby RH, Gustavsen MT, Andersen AM, Bjerre A, Åsberg A, Midtvedt K, Vethe NT, Bergan S (2020)
Prednisolone and Prednisone Pharmacokinetics in Adult Renal Transplant Recipients
Ther Drug Monit (in press)
DOI 10.1097/FTD.0000000000000835, PubMed 33181621

Solheim SA, Jessen S, Mørkeberg J, Thevis M, Dehnes Y, Eibye K, Hostrup M, Nordsborg NB (2020)
Single-dose administration of clenbuterol is detectable in dried blood spots
Drug Test Anal, 12 (9), 1366-1372
DOI 10.1002/dta.2872, PubMed 32495983

Solheim SA, Mørkeberg J, Dehnes Y, Hullstein I, Juul A, Upners EN, Nordsborg NB (2020)
Changes in blood parameters after intramuscular testosterone ester injections - Implications for anti-doping
Drug Test Anal, 12 (8), 1019-1030
DOI 10.1002/dta.2803, PubMed 32307878

Solheim SA, Mørkeberg J, Juul A, Freiesleben SY, Upners EN, Dehnes Y, Nordsborg NB (2020)
An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men
Front Physiol, 11, 563620
DOI 10.3389/fphys.2020.563620, PubMed 33071818

Svendsen T, Brodtkorb E, Baftiu A, Lossius MI, Nakken KO, Johannessen SI, Johannessen Landmark C (2020)
Clinical experience combined with therapeutic drug monitoring of lacosamide
Acta Neurol Scand, 141 (4), 279-286
DOI 10.1111/ane.13206, PubMed 31853958

Torp HA, Nystoyl B (2020)
Neutropenia in treatment with antipsychotics
Tidsskr. Nor. Laegeforen., 140 (8), 793-795

Westergren T, Narum S, Klemp M (2020)
Adverse effects information in clinical guidelines on pharmacological treatment of depression in children and adolescents: a systematic review
BMJ Open, 10 (7), e036412
DOI 10.1136/bmjopen-2019-036412, PubMed 32690742

 
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