Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Pharmacology

28 publications found

Andreassen BK, Støer NC, Martinsen JI, Ursin G, Weiderpass E, Thoresen GH, Debernard KB, Karlstad Ø, Pottegard A, Friis S (2019)
Identification of potential carcinogenic and chemopreventive effects of prescription drugs: a protocol for a Norwegian registry-based study
BMJ Open, 9 (4), e028504
DOI 10.1136/bmjopen-2018-028504, PubMed 30962244

Baftiu A, Lima MH, Svendsen K, Larsson PG, Johannessen SI, Landmark CJ (2019)
Safety aspects of antiepileptic drugs-a population-based study of adverse effects relative to changes in utilisation
Eur J Clin Pharmacol, 75 (8), 1153-1160
DOI 10.1007/s00228-019-02678-1, PubMed 31001654

Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC (2019)
Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host Microbe, 25 (4), 617-629.e7
DOI 10.1016/j.chom.2019.02.016, PubMed 30926239

Brunet M, van Gelder T, Åsberg A, Haufroid V, Hesselink DA, Langman L, Lemaitre F, Marquet P, Seger C, Shipkova M, Vinks A, Wallemacq P, Wieland E, Woillard JB, Barten MJ, Budde K, Colom H, Dieterlen MT, Elens L, Johnson-Davis KL, Kunicki PK, MacPhee I, Masuda S, Mathew BS, Millán O et al. (2019)
Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report
Ther Drug Monit, 41 (3), 261-307
DOI 10.1097/FTD.0000000000000640, PubMed 31045868

Bruun LD, Kjeldstadli K, Temte V, Birdal M, Bachs L, Langødegård M, Strand DH, Gaare KI, Øiestad E, Høiseth G (2019)
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing
J Anal Toxicol, 43 (5), 369-377
DOI 10.1093/jat/bky083, PubMed 30615130

Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA (2019)
Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
PLoS One, 14 (6), e0218110
DOI 10.1371/journal.pone.0218110, PubMed 31173603

Cosson MV, Hiis HG, Moltzau LR, Levy FO, Krobert KA (2019)
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response
J Mol Cell Cardiol, 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017, PubMed 31009605

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y et al. (2019)
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals
Clin Pharmacol Ther, 105 (6), 1477-1491
DOI 10.1002/cpt.1323, PubMed 30506689

Havnen GC, Truong MB, Do MH, Heitmann K, Holst L, Nordeng H (2019)
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study
Scand J Prim Health Care, 37 (1), 30-40
DOI 10.1080/02813432.2019.1569424, PubMed 30822254

Henning O, Johannessen Landmark C, Nakken KO, Lossius MI (2019)
Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence
Epilepsia, 60 (5), e58-e62
DOI 10.1111/epi.14734, PubMed 30980675

Henning O, Johannessen Landmark C, Traeen B, Svendsen T, Farmen A, Nakken KO, Lossius M (2019)
Sexual function in people with epilepsy: Similarities and differences with the general population
Epilepsia (in press)
DOI 10.1111/epi.16311, PubMed 31407332

Henning O, Landmark CJ, Henning D, Nakken KO, Lossius MI (2019)
Challenges in epilepsy-The perspective of Norwegian epilepsy patients
Acta Neurol Scand, 140 (1), 40-47
DOI 10.1111/ane.13098, PubMed 30963535

Jendresen C, Digre A, Cui H, Zhang X, Vlodavsky I, Li JP, Nilsson LNG (2019)
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
Sci Rep, 9 (1), 4600
DOI 10.1038/s41598-019-40999-4, PubMed 30872722

Johannessen Landmark C, Fløgstad I, Baftiu A, Syvertsen M, Enger U, Koht J, Johannessen SI (2019)
Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Res, 155, 106148
DOI 10.1016/j.eplepsyres.2019.05.016, PubMed 31195184

Johannessen Landmark C, Fløgstad I, Syvertsen M, Baftiu A, Enger U, Koht J, Johannessen SI (2019)
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Behav, 98 (Pt A), 110-116 (in press)
DOI 10.1016/j.yebeh.2019.05.021, PubMed 31330379

Klaasen RA, Egeland EJ, Chan J, Midtvedt K, Svensson M, Bolstad N, Fellström B, Holdaas H, Åsberg A, Bergan S, Vethe NT, Warren DJ (2019)
A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients
Ther Drug Monit, 41 (1), 11-18
DOI 10.1097/FTD.0000000000000580, PubMed 30633722

Larsen Burns M, Kinge E, Stokke Opdal M, Johannessen SI, Johannessen Landmark C (2019)
Therapeutic drug monitoring of gabapentin in various indications
Acta Neurol Scand, 139 (5), 446-454
DOI 10.1111/ane.13075, PubMed 30710348

Larsen Burns M, Nikanorova M, Baftiu A, Borg Rasmussen J, Johannessen SI, Johannessen Landmark C (2019)
Pharmacokinetic Variability and Clinical Use of Lacosamide in Children and Adolescents in Denmark and Norway
Ther Drug Monit, 41 (3), 340-347
DOI 10.1097/FTD.0000000000000599, PubMed 30688870

Munkhaugen J, Vethe NT, Fagerland MW, Dammen T, Perk J, Gjertsen E, Otterstad JE, Gullestad L, Bergan S, Husebye E (2019)
Statin-associated muscle symptoms in coronary patients: design of a randomized study
Scand Cardiovasc J, 53 (3), 162-168
DOI 10.1080/14017431.2019.1612085, PubMed 31030568

Maaland AF, Heyerdahl H, O'Shea A, Eiriksdottir B, Pascal V, Andersen JT, Kolstad A, Dahle J (2019)
Targeting B-cell malignancies with the beta-emitting anti-CD37 radioimmunoconjugate 177Lu-NNV003
Eur J Nucl Med Mol Imaging (in press)
DOI 10.1007/s00259-019-04417-1, PubMed 31309259

Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R (2019)
Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice
Basic Res Cardiol, 114 (3), 26
DOI 10.1007/s00395-019-0734-1, PubMed 31016449

Nordengen K, Kirsebom BE, Henjum K, Selnes P, Gísladóttir B, Wettergreen M, Torsetnes SB, Grøntvedt GR, Waterloo KK, Aarsland D, Nilsson LNG, Fladby T (2019)
Glial activation and inflammation along the Alzheimer's disease continuum
J Neuroinflammation, 16 (1), 46
DOI 10.1186/s12974-019-1399-2, PubMed 30791945

Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS (2019)
The Neonatal Fc Receptor (FcRn): A Misnomer?
Front Immunol, 10, 1540
DOI 10.3389/fimmu.2019.01540, PubMed 31354709

Skulberg AK, Åsberg A, Khiabani HZ, Røstad H, Tylleskar I, Dale O (2019)
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose-a randomized controlled trial
Addiction, 114 (5), 859-867
DOI 10.1111/add.14552, PubMed 30644628

Temte V, Kjeldstadli K, Bruun LD, Birdal M, Bachs L, Karinen R, Middelkoop G, Øiestad E, Høiseth G (2019)
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses
J Anal Toxicol, 43 (2), 104-111
DOI 10.1093/jat/bky062, PubMed 30517712

Tuv SS, Nordal K, Vethe NT, Bergan S (2019)
Pharmacogenetics in personalised drug therapy
Tidsskr Nor Laegeforen, 139 (8)
DOI 10.4045/tidsskr.19.0055, PubMed 31062549

Vethe NT, Munkhaugen J, Andersen AM, Husebye E, Bergan S (2019)
A Method for Direct Monitoring of Atorvastatin Adherence in Cardiovascular Disease Prevention: Quantification of the Total Exposure to Parent Drug and Major Metabolites Using 2-Channel Chromatography and Tandem Mass Spectrometry
Ther Drug Monit, 41 (1), 19-28
DOI 10.1097/FTD.0000000000000578, PubMed 30633723

Westergren T, Narum S, Klemp M (2019)
Critical appraisal of adverse effects reporting in the 'Treatment for Adolescents With Depression Study (TADS)'
BMJ Open, 9 (3), e026089
DOI 10.1136/bmjopen-2018-026089, PubMed 30878988

 
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