Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2019 from OUS - Department of Pharmacology
40 publications found
Identification of potential carcinogenic and chemopreventive effects of prescription drugs: a protocol for a Norwegian registry-based study
BMJ Open, 9 (4), e028504
DOI 10.1136/bmjopen-2018-028504, PubMed 30962244
Safety aspects of antiepileptic drugs-a population-based study of adverse effects relative to changes in utilisation
Eur J Clin Pharmacol, 75 (8), 1153-1160
DOI 10.1007/s00228-019-02678-1, PubMed 31001654
Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
Cell Transplant, 28 (12), 1603-1613
DOI 10.1177/0963689719872488, PubMed 31512504
Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study
Blood Press, 29 (2), 123-134
DOI 10.1080/08037051.2019.1684817, PubMed 31718316
Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host Microbe, 25 (4), 617-629.e7
DOI 10.1016/j.chom.2019.02.016, PubMed 30926239
Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report
Ther Drug Monit, 41 (3), 261-307
DOI 10.1097/FTD.0000000000000640, PubMed 31045868
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing
J Anal Toxicol, 43 (5), 369-377
DOI 10.1093/jat/bky083, PubMed 30615130
Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
PLoS One, 14 (6), e0218110
DOI 10.1371/journal.pone.0218110, PubMed 31173603
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun Biol, 2, 394
DOI 10.1038/s42003-019-0641-x, PubMed 31701023
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response
J Mol Cell Cardiol, 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017, PubMed 31009605
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals
Clin Pharmacol Ther, 105 (6), 1477-1491
DOI 10.1002/cpt.1323, PubMed 30506689
TRIM21-From Intracellular Immunity to Therapy
Front Immunol, 10, 2049
DOI 10.3389/fimmu.2019.02049, PubMed 31555278
Interdisciplinary medication review to improve pharmacotherapy for patients with intellectual disabilities
Int J Clin Pharm, 41 (6), 1516-1525
DOI 10.1007/s11096-019-00914-3, PubMed 31729635
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study
Scand J Prim Health Care, 37 (1), 30-40
DOI 10.1080/02813432.2019.1569424, PubMed 30822254
Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence
Epilepsia, 60 (5), e58-e62
DOI 10.1111/epi.14734, PubMed 30980675
Sexual function in people with epilepsy: Similarities and differences with the general population
Epilepsia, 60 (9), 1984-1992
DOI 10.1111/epi.16311, PubMed 31407332
Challenges in epilepsy-The perspective of Norwegian epilepsy patients
Acta Neurol Scand, 140 (1), 40-47
DOI 10.1111/ane.13098, PubMed 30963535
Refractory epilepsy and nonadherence to drug treatment
Epilepsia Open, 4 (4), 618-623
DOI 10.1002/epi4.12367, PubMed 31819918
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
Sci Rep, 9 (1), 4600
DOI 10.1038/s41598-019-40999-4, PubMed 30872722
Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Res, 155, 106148
DOI 10.1016/j.eplepsyres.2019.05.016, PubMed 31195184
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy
Epilepsy Behav, 98 (Pt A), 110-116
DOI 10.1016/j.yebeh.2019.05.021, PubMed 31330379
A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients
Ther Drug Monit, 41 (1), 11-18
DOI 10.1097/FTD.0000000000000580, PubMed 30633722
A novel direct method to determine adherence to atorvastatin therapy in patients with coronary heart disease
Br J Clin Pharmacol, 85 (12), 2878-2885
DOI 10.1111/bcp.14122, PubMed 31495943
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
EMBO J, 38 (21), e101365
DOI 10.15252/embj.2018101365, PubMed 31468569
Therapeutic drug monitoring of gabapentin in various indications
Acta Neurol Scand, 139 (5), 446-454
DOI 10.1111/ane.13075, PubMed 30710348
Pharmacokinetic Variability and Clinical Use of Lacosamide in Children and Adolescents in Denmark and Norway
Ther Drug Monit, 41 (3), 340-347
DOI 10.1097/FTD.0000000000000599, PubMed 30688870
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes
Sci Rep, 9 (1), 18021
DOI 10.1038/s41598-019-54226-7, PubMed 31792234
Targeting B-cell malignancies with the beta-emitting anti-CD37 radioimmunoconjugate 177Lu-NNV003
Eur J Nucl Med Mol Imaging, 46 (11), 2311-2321
DOI 10.1007/s00259-019-04417-1, PubMed 31309259
Statin-associated muscle symptoms in coronary patients: design of a randomized study
Scand Cardiovasc J, 53 (3), 162-168
DOI 10.1080/14017431.2019.1612085, PubMed 31030568
Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice
Basic Res Cardiol, 114 (3), 26
DOI 10.1007/s00395-019-0734-1, PubMed 31016449
Glial activation and inflammation along the Alzheimer's disease continuum
J Neuroinflammation, 16 (1), 46
DOI 10.1186/s12974-019-1399-2, PubMed 30791945
The Neonatal Fc Receptor (FcRn): A Misnomer?
Front Immunol, 10, 1540
DOI 10.3389/fimmu.2019.01540, PubMed 31354709
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose-a randomized controlled trial
Addiction, 114 (5), 859-867
DOI 10.1111/add.14552, PubMed 30644628
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319
Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of high-grade pseudomyxoma peritonei
Clin Exp Metastasis, 36 (6), 511-518
DOI 10.1007/s10585-019-09991-0, PubMed 31541325
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses
J Anal Toxicol, 43 (2), 104-111
DOI 10.1093/jat/bky062, PubMed 30517712
Prevalence, risk factors, and type of sleep apnea in patients with paroxysmal atrial fibrillation
Int J Cardiol Heart Vasc, 26, 100447
DOI 10.1016/j.ijcha.2019.100447, PubMed 32140547
Tacrolimus Can Be Reliably Measured With Volumetric Absorptive Capillary Microsampling Throughout the Dose Interval in Renal Transplant Recipients
Ther Drug Monit, 41 (5), 607-614
DOI 10.1097/FTD.0000000000000655, PubMed 31584926
A Method for Direct Monitoring of Atorvastatin Adherence in Cardiovascular Disease Prevention: Quantification of the Total Exposure to Parent Drug and Major Metabolites Using 2-Channel Chromatography and Tandem Mass Spectrometry
Ther Drug Monit, 41 (1), 19-28
DOI 10.1097/FTD.0000000000000578, PubMed 30633723
Critical appraisal of adverse effects reporting in the 'Treatment for Adolescents With Depression Study (TADS)'
BMJ Open, 9 (3), e026089
DOI 10.1136/bmjopen-2018-026089, PubMed 30878988