Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Department of Pharmacology

28 publications found

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO (2018)
Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation
FASEB J, 32 (2), 1059-1069
DOI 10.1096/fj.201700486R, PubMed 29079700

Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS (2018)
Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development
Epilepsia, 59 (10), 1842-1866
DOI 10.1111/epi.14555, PubMed 30368788

Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS (2018)
Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development
Epilepsia, 59 (10), 1811-1841
DOI 10.1111/epi.14557, PubMed 30368792

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Botton MR, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y et al. (2018)
The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals
Clin Pharmacol Ther (in press)
DOI 10.1002/cpt.1323, PubMed 30506689

Eek AK, Strøm BO, Bakkehøi G, Stenberg-Nilsen H (2018)
Anticoagulant-associated adverse drug reactions in 2013-15
Tidsskr Nor Laegeforen, 138 (12)
DOI 10.4045/tidsskr.17.0706, PubMed 30132616

Egeland EJ, Størset E, Robertsen I, Hermann M, Midtvedt K, Gustavsen MT, Klaasen R, Bergan S, Hartmann A, Åsberg A (2018)
The Authors' Reply
Transplantation, 102 (1), e43-e44
DOI 10.1097/TP.0000000000001961, PubMed 28957846

Eide IA, Reinholt FP, Jenssen T, Hartmann A, Schmidt EB, Åsberg A, Bergan S, Brabrand K, Svensson M (2018)
Effects of marine n-3 fatty acid supplementation in renal transplantation: A randomized controlled trial
Am J Transplant (in press)
DOI 10.1111/ajt.15080, PubMed 30125457

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT (2018)
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nat Commun, 9 (1), 621
DOI 10.1038/s41467-018-03061-x, PubMed 29434196

Havig SM, Lea D, Krpo M, Skari RM, Gustavsen I, Høiseth G (2018)
Fatal Adverse Event with Dabigatran in Elderly Patient with Reduced Kidney Function
Basic Clin Pharmacol Toxicol, 123 (2), 221-226
DOI 10.1111/bcpt.12985, PubMed 29438599

Heldal K, Midtvedt K, Hartmann A, Reisaeter AV, Heldal TF, Bergan S, Salvador CL, Åsberg A (2018)
Estimated glomerular filtration rate in stable older kidney transplant recipients-are present algorithms valid? A national cross-sectional cohort study
Transpl Int, 31 (6), 629-638
DOI 10.1111/tri.13137, PubMed 29453878

Henjum K, Quist-Paulsen E, Zetterberg H, Blennow K, Nilsson LNG, Watne LO (2018)
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
J Neuroinflammation, 15 (1), 304
DOI 10.1186/s12974-018-1331-1, PubMed 30390679

Hiis HG, Cosson MV, Dahl CP, Fiane AE, Levy FO, Andersen GØ, Krobert KA (2018)
Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole
Am J Physiol Heart Circ Physiol, 315 (5), H1137-H1147
DOI 10.1152/ajpheart.00208.2018, PubMed 30004809

Hov KR, Neerland BE, Andersen AM, Undseth Ø, Wyller VB, MacLullich AMJ, Skovlund E, Qvigstad E, Wyller TB (2018)
The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses
BMC Pharmacol Toxicol, 19 (1), 29
DOI 10.1186/s40360-018-0218-1, PubMed 29884231

Johannessen Landmark C, Farmen AH, Burns ML, Baftiu A, Lossius MI, Johannessen SI, Tomson T (2018)
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring
Epilepsy Res, 141, 31-37
DOI 10.1016/j.eplepsyres.2018.02.004, PubMed 29453075

Krogstad V, Vethe NT, Robertsen I, Hasvold G, Ose AD, Hermann M, Andersen AM, Chan J, Skauby M, Svensson MHS, Åsberg A, Christensen H (2018)
Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies
Ther Drug Monit, 40 (3), 292-300
DOI 10.1097/FTD.0000000000000510, PubMed 29578937

Krug O, Thomas A, Malerød-Fjeld H, Dehnes Y, Laussmann T, Feldmann I, Sickmann A, Thevis M (2018)
Analysis of new growth promoting black market products
Growth Horm IGF Res, 41, 1-6
DOI 10.1016/j.ghir.2018.05.001, PubMed 29864719

Munkhaugen J, Ruddox V, Halvorsen S, Dammen T, Fagerland MW, Hernæs KH, Vethe NT, Prescott E, Jensen SE, Rødevand O, Jortveit J, Bendz B, Schirmer H, Køber L, Bøtker HE, Larsen AI, Vikenes K, Steigen T, Wiseth R, Pedersen T, Edvardsen T, Otterstad JE, Atar D (2018)
BEtablocker Treatment After acute Myocardial Infarction in revascularized patients without reduced left ventricular ejection fraction (BETAMI): Rationale and design of a prospective, randomized, open, blinded end point study
Am Heart J, 208, 37-46 (in press)
DOI 10.1016/j.ahj.2018.10.005, PubMed 30530121

Müller LD, Opdal MS (2018)
Developing a rapid semi-automated sample preparation with alkaline hydrolysis in a 96-well plate for quantification of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in urine samples by UHPLC-MS/MS
J Pharm Biomed Anal, 161, 296-304
DOI 10.1016/j.jpba.2018.08.045, PubMed 30189411

Narum S (2018)
Fra digitoksin til digoksin
Tidsskr Nor Laegeforen, 138 (15)
DOI 10.4045/tidsskr.18.0700, PubMed 30277041

Nilsen J, Sandlie I, Roopenian DC, Andersen JT (2018)
Animal models for evaluation of albumin-based therapeutics
Curr. Opin. Chem. Eng., 19, 68-76

Reimers A, Berg JA, Burns ML, Brodtkorb E, Johannessen SI, Johannessen Landmark C (2018)
Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines
Drug Des Devel Ther, 12, 271-280
DOI 10.2147/DDDT.S154388, PubMed 29467570

Serkland TT, Nygaard IL, Kvan E, Frost J, Aronsen L, Narum S, Bjånes T (2018)
Immediate telephonic alerting of deviating pharmacological test results
Tidsskr Nor Laegeforen, 138 (18)
DOI 10.4045/tidsskr.18.0776, PubMed 30421739

Skogestad J, Aronsen JM (2018)
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
Front Physiol, 9, 1500
DOI 10.3389/fphys.2018.01500, PubMed 30464746

Stapleton NM, Armstrong-Fisher SS, Andersen JT, van der Schoot CE, Porter C, Page KR, Falconer D, de Haas M, Williamson LM, Clark MR, Vidarsson G, Armour KL (2018)
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport
Mol Immunol, 95, 1-9
DOI 10.1016/j.molimm.2018.01.006, PubMed 29367080

Syvertsen M, Fløgstad I, Enger U, Landmark CJ, Koht J (2018)
Antiepileptic drug withdrawal in juvenile myoclonic epilepsy
Acta Neurol Scand (in press)
DOI 10.1111/ane.13042, PubMed 30378684

Temte V, Kjeldstadli K, Bruun LD, Birdal M, Bachs L, Karinen R, Middelkoop G, Øiestad E, Høiseth G (2018)
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses
J Anal Toxicol (in press)
DOI 10.1093/jat/bky062, PubMed 30517712

Tvete IF, Bjørner T, Skomedal T (2018)
Mental Health and Disability Pension Onset: Changes in Consumption of Antianxiety and Hypnotic Drugs
Health Serv Res Manag Epidemiol, 5, 2333392818792683
DOI 10.1177/2333392818792683, PubMed 30182036

Ulsund AH, Dahl M, Frimurer TM, Manfra O, Schwartz TW, Levy FO, Wessel Andressen K (2018)
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase
FASEB J, fj201800805RR (in press)
DOI 10.1096/fj.201800805RR, PubMed 30508496

 
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