Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Department of Pharmacology

39 publications found

Baftiu A, Johannessen Landmark C, Nikaj V, Neslein IL, Johannessen SI, Perucca E (2015)
Availability of antiepileptic drugs across Europe
Epilepsia, 56 (12), e191-7
DOI 10.1111/epi.13210, PubMed 26477534

Bakke SS, Feng YZ, Nikolić N, Kase ET, Moro C, Stensrud C, Damlien L, Ludahl MO, Sandbu R, Solheim BM, Rustan AC, Hjelmesæth J, Thoresen GH, Aas V (2015)
Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjects
PLoS One, 10 (3), e0119556
DOI 10.1371/journal.pone.0119556, PubMed 25790476

Beiske GA, Holmøy T, Beiske AG, Johannessen SI, Johannessen Landmark C (2015)
Antiepileptic and Antidepressive Polypharmacy in Patients with Multiple Sclerosis
Mult Scler Int, 2015, 317859
DOI 10.1155/2015/317859, PubMed 26221541

Bergan S, Bremer S, Vethe NT (2015)
Drug target molecules to guide immunosuppression
Clin Biochem, 49 (4-5), 411-8
DOI 10.1016/j.clinbiochem.2015.10.001, PubMed 26453533

Bernard JP, Khiabani HZ, Hilberg T, Karinen R, Slørdal L, Waal H, Mørland J (2015)
Characteristics of methadone-related fatalities in Norway
J Forensic Leg Med, 36, 114-20
DOI 10.1016/j.jflm.2015.09.011, PubMed 26439870

Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS (2015)
Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)
Epilepsy Res, 111, 85-141
DOI 10.1016/j.eplepsyres.2015.01.001, PubMed 25769377

Bremer S, Fløisand Y, Brinch L, Gedde-Dahl T, Bergan S (2015)
Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning
Ther Drug Monit, 37 (4), 493-500
DOI 10.1097/FTD.0000000000000180, PubMed 25565670

Cehajic I, Bergan S, Bjordal K (2015)
Pharmacist assessment of drug-related problems on an oncology ward
Eur. J. Hosp. Pharm.-Sci. Pract., 22 (4), 194-197

de Graav GN, Bergan S, Baan CC, Weimar W, van Gelder T, Hesselink DA (2015)
Therapeutic Drug Monitoring of Belatacept in Kidney Transplantation
Ther Drug Monit, 37 (5), 560-7
DOI 10.1097/FTD.0000000000000179, PubMed 25551406

Fagermoen E, Sulheim D, Winger A, Andersen AM, Gjerstad J, Godang K, Rowe PC, Saul JP, Skovlund E, Wyller VB (2015)
Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial
BMC Pediatr, 15, 117
DOI 10.1186/s12887-015-0428-2, PubMed 26357864

Feng YZ, Nikolić N, Bakke SS, Kase ET, Guderud K, Hjelmesæth J, Aas V, Rustan AC, Thoresen GH (2015)
Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise
Am J Physiol Cell Physiol, 308 (7), C548-56
DOI 10.1152/ajpcell.00314.2014, PubMed 25608533

Hjelmeland K, Gustavsen I, Bernard JP, Mørland J (2015)
Can a simple clinical test detect impairment of zopiclone and alcohol? - A randomized controlled trial
Forensic Sci Int, 248, 129-33
DOI 10.1016/j.forsciint.2014.12.028, PubMed 25617762

Hovda KE, Gadeholt G, Evtodienko V, Jacobsen D (2015)
A novel bedside diagnostic test for methanol poisoning using dry chemistry for formate
Scand J Clin Lab Invest, 75 (7), 610-4
DOI 10.3109/00365513.2015.1066847, PubMed 26203958

Hullstein IR, Malerod-Fjeld H, Dehnes Y, Hemmersbach P (2015)
Black market products confiscated in Norway 2011-2014 compared to analytical findings in urine samples
Drug Test Anal, 7 (11-12), 1025-9
DOI 10.1002/dta.1900, PubMed 26607218

Haase CB, Backer V, Kalsen A, Rzeppa S, Hemmersbach P, Hostrup M (2015)
The influence of exercise and dehydration on the urine concentrations of salbutamol after inhaled administration of 1600 µg salbutamol as a single dose in relation to doping analysis
Drug Test Anal, 8 (7), 613-20
DOI 10.1002/dta.1828, PubMed 26044066

Impellizzeri AA, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S (2015)
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
DOI 10.3389/fnbeh.2015.00092, PubMed 26005408

Jabeen S, Holmboe L, Alnæs GI, Andersen AM, Hall KS, Kristensen VN (2015)
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate
Pharmacogenomics J, 15 (5), 385-90
DOI 10.1038/tpj.2015.11, PubMed 25778468

Johannessen Landmark C, Beiske G, Baftiu A, Burns ML, Johannessen SI (2015)
Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice
Seizure, 28, 88-91
DOI 10.1016/j.seizure.2015.02.017, PubMed 25758302

Kase ET, Feng YZ, Badin PM, Bakke SS, Laurens C, Coue M, Langin D, Gaster M, Thoresen GH, Rustan AC, Moro C (2015)
Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals
Biochim Biophys Acta, 1851 (9), 1194-201
DOI 10.1016/j.bbalip.2015.03.005, PubMed 25819461

Kaupang Å, Paulsen SM, Steindal CC, Ravna AW, Sylte I, Halvorsen TG, Thoresen GH, Hansen TV (2015)
Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618
Eur J Med Chem, 94, 229-36
DOI 10.1016/j.ejmech.2015.03.006, PubMed 25768705

Kloster-Jensen K, Vethe NT, Bremer S, Abadpour S, Korsgren O, Foss A, Bergan S, Scholz H (2015)
Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro
Transpl Int, 28 (10), 1152-61
DOI 10.1111/tri.12617, PubMed 26046470

Kong XY, Kase ET, Herskedal A, Schjalm C, Damme M, Nesset CK, Thoresen GH, Rustan AC, Eskild W (2015)
Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver
PLoS One, 10 (6), e0129402
DOI 10.1371/journal.pone.0129402, PubMed 26047317

Kringen MK (2015)
Analysis of Copy Number Variation by Pyrosequencing® Using Paralogous Sequences
Methods Mol Biol, 1315, 115-21
DOI 10.1007/978-1-4939-2715-9_9, PubMed 26103895

Kringen MK, Stormo C, Berg JP, Terry SF, Vocke CM, Rizvi S, Hendig D, Piehler AP (2015)
Copy number variation in the ATP-binding cassette transporter ABCC6 gene and ABCC6 pseudogenes in patients with pseudoxanthoma elasticum
Mol Genet Genomic Med, 3 (3), 233-7
DOI 10.1002/mgg3.137, PubMed 26029710

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW (2015)
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem Neurosci, 6 (7), 1206-18
DOI 10.1021/cn500339p, PubMed 25706089

Nordal K, Øiestad EL, Enger A, Christophersen AS, Vindenes V (2015)
Detection Times of Diazepam, Clonazepam, and Alprazolam in Oral Fluid Collected From Patients Admitted to Detoxification, After High and Repeated Drug Intake
Ther Drug Monit, 37 (4), 451-60
DOI 10.1097/FTD.0000000000000174, PubMed 25549207

Olberg DE, Hausner SH, Bauer N, Klaveness J, Indrevoll B, Andressen KW, Dahl M, Levy FO, Sutcliffe JL, Haraldsen I (2015)
Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats
MedChemComm, 6 (4), 708-714

Opdal MS, Arnesen M, Müller LD, Hullstein I, Sayed K, Brørs O, Kringen M, Sagedal S, Gjesdal K, Krajci P (2015)
Effects of Hemodialysis on Methadone Pharmacokinetics and QTc
Clin Ther, 37 (7), 1594-9
DOI 10.1016/j.clinthera.2015.04.009, PubMed 25963997

Robertsen I, Vethe NT, Midtvedt K, Falck P, Christensen H, Åsberg A (2015)
Closer to the Site of Action: Everolimus Concentrations in Peripheral Blood Mononuclear Cells Correlate Well With Whole Blood Concentrations
Ther Drug Monit, 37 (5), 675-80
DOI 10.1097/FTD.0000000000000185, PubMed 25565673

Robertsen I, Åsberg A, Ingerø AO, Vethe NT, Bremer S, Bergan S, Midtvedt K (2015)
Use of generic tacrolimus in elderly renal transplant recipients: precaution is needed
Transplantation, 99 (3), 528-32
DOI 10.1097/TP.0000000000000384, PubMed 25148382

Rogeberg M, Almdahl IS, Wettergreen M, Nilsson LN, Fladby T (2015)
Isobaric Quantification of Cerebrospinal Fluid Amyloid-β Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration
J Proteome Res, 14 (11), 4834-43
DOI 10.1021/acs.jproteome.5b00668, PubMed 26452689

Rogeberg M, Wettergreen M, Nilsson LN, Fladby T (2015)
Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid
Biochimie, 113, 86-92
DOI 10.1016/j.biochi.2015.03.022, PubMed 25866191

Rzeppa S, Heinrich G, Hemmersbach P (2015)
Analysis of anabolic androgenic steroids as sulfate conjugates using high performance liquid chromatography coupled to tandem mass spectrometry
Drug Test Anal, 7 (11-12), 1030-9
DOI 10.1002/dta.1895, PubMed 26472592

Salvador CL, Tøndel C, Mørkrid L, Bjerre A, Brun A, Bolann B, Brackman D, Bergan S (2015)
Glomerular filtration rate measured by iohexol clearance: A comparison of venous samples and capillary blood spots
Scand J Clin Lab Invest, 75 (8), 710-6
DOI 10.3109/00365513.2015.1091091, PubMed 26426851

Størset E, Åsberg A, Skauby M, Neely M, Bergan S, Bremer S, Midtvedt K (2015)
Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study
Transplantation, 99 (10), 2158-66
DOI 10.1097/TP.0000000000000708, PubMed 25886918

Tveteraas IH, Aasrum M, Brusevold IJ, Ødegård J, Christoffersen T, Sandnes D (2015)
Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells
Tumour Biol, 37 (2), 2519-26
DOI 10.1007/s13277-015-4010-1, PubMed 26386720

Ørstavik Ø, Manfra O, Andressen KW, Andersen GØ, Skomedal T, Osnes JB, Levy FO, Krobert KA (2015)
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
DOI 10.1371/journal.pone.0115547, PubMed 25738589

Aasrum M, Tjomsland V, Thoresen GH, De Angelis PM, Christoffersen T, Brusevold IJ (2015)
PI3K is required for both basal and LPA-induced DNA synthesis in oral carcinoma cells
J Oral Pathol Med, 45 (6), 425-32
DOI 10.1111/jop.12384, PubMed 26602326

Aasrum M, Ødegård J, Thoresen GH, Brusevold IJ, Sandnes DL, Christoffersen T (2015)
Gab1 amplifies signaling in response to low-intensity stimulation by HGF
Cell Biol Int, 39 (10), 1177-84
DOI 10.1002/cbin.10511, PubMed 26146811

 
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