Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2019 from OUS - Department of Microbiology
43 publications found
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323
Additive manufacturing of laminar flow cells for single-molecule experiments
Sci Rep, 9 (1), 16784
DOI 10.1038/s41598-019-53151-z, PubMed 31727950
Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Nucleic Acids Res, 47 (2), 779-793
DOI 10.1093/nar/gky1184, PubMed 30496516
The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein
J Biol Chem, 294 (42), 15480-15494
DOI 10.1074/jbc.RA119.008318, PubMed 31484725
Experiences from multiplex PCR diagnostics of faeces in hospitalised patients: clinical significance of Enteropathogenic Escherichia coli (EPEC) and culture negative campylobacter
BMC Infect Dis, 19 (1), 630
DOI 10.1186/s12879-019-4271-1, PubMed 31315581
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097
A man in his 80s with arthritis and persistent fever
Tidsskr Nor Laegeforen, 139 (13)
DOI 10.4045/tidsskr.18.0546, PubMed 31556531
Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis
Front Immunol, 10, 2186
DOI 10.3389/fimmu.2019.02186, PubMed 31636628
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
BMJ, 367, l5654
DOI 10.1136/bmj.l5654, PubMed 31619437
Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data
BMC Infect Dis, 19 (1), 281
DOI 10.1186/s12879-019-3900-z, PubMed 30909883
Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country
Proc Natl Acad Sci U S A, 116 (29), 14599-14605
DOI 10.1073/pnas.1900959116, PubMed 31262808
Going low to reach high: Small-scale ChIP-seq maps new terrain
Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465
DOI 10.1002/wsbm.1465, PubMed 31478357
Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women
Thromb Res, 184, 1-7
DOI 10.1016/j.thromres.2019.10.005, PubMed 31677448
The impact of age on risk assessment, therapeutic practice and outcome in candidemia
Infect Dis (Lond), 51 (6), 425-434
DOI 10.1080/23744235.2019.1595709, PubMed 31010380
Expanding the activity spectrum of antiviral agents
Drug Discov Today, 24 (5), 1224-1228
DOI 10.1016/j.drudis.2019.04.006, PubMed 30980905
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213
PML Bodies in Mitosis
Cells, 8 (8)
DOI 10.3390/cells8080893, PubMed 31416160
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533
Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
RSC Adv., 9 (63), 37092-37100
Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans
J Phys Chem B, 123 (10), 2270-2279
DOI 10.1021/acs.jpcb.8b11448, PubMed 30789732
Immunity to varicella zoster virus among pregnant women in the Norwegian Mother and Child Cohort Study
PLoS One, 14 (8), e0221084
DOI 10.1371/journal.pone.0221084, PubMed 31408478
Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
PLoS One, 14 (9), e0223074
DOI 10.1371/journal.pone.0223074, PubMed 31557254
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Nat Commun, 10 (1), 5460
DOI 10.1038/s41467-019-13394-w, PubMed 31784530
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast
J Biol Chem, 294 (49), 18784-18795
DOI 10.1074/jbc.RA119.009721, PubMed 31676685
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765
HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors
BMC Med, 17 (1), 4
DOI 10.1186/s12916-018-1241-1, PubMed 30616632
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
Sci Rep, 9 (1), 13249
DOI 10.1038/s41598-019-49550-x, PubMed 31519943
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131
To what extent can clinical characteristics be used to distinguish encephalitis from encephalopathy of other causes? Results from a prospective observational study
BMC Infect Dis, 19 (1), 80
DOI 10.1186/s12879-018-3570-2, PubMed 30669985
Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning
Sci Rep, 9 (1), 16158
DOI 10.1038/s41598-019-52570-2, PubMed 31695095
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
DNA Repair (Amst), 81, 102665
DOI 10.1016/j.dnarep.2019.102665, PubMed 31327582
Imported visceral leishmaniasis and immunosuppression in seven Norwegian patients
Trop Dis Travel Med Vaccines, 5, 16
DOI 10.1186/s40794-019-0092-x, PubMed 31463070
The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics
Clin Microbiol Infect, 26 (4), 492-498
DOI 10.1016/j.cmi.2019.09.004, PubMed 31525517
Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide
Antimicrob Agents Chemother, 63 (6)
DOI 10.1128/AAC.02681-18, PubMed 30858213
Whole genome sequencing of Salmonella Chester reveals geographically distinct clusters, Norway, 2000 to 2016
Euro Surveill, 24 (4)
DOI 10.2807/1560-7917.ES.2019.24.4.1800186, PubMed 30696528
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
Neurodegener Dis, 19 (1), 22-34
DOI 10.1159/000500091, PubMed 31167196
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
Proteins, 88 (3), 440-448
DOI 10.1002/prot.25821, PubMed 31587363
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet, 28 (18), 3043-3052
DOI 10.1093/hmg/ddz114, PubMed 31131398
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catalysis Today, 0, 1-6 (in press)
DOI 10.1016/j.cattod.2019.12.031, PublikaID 337
Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J Immunol, 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382, PubMed 31427442
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318