Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Division of Cardiovascular and Pulmonary Diseases

35 publications found

Ajmone Marsan N, Michalski B, Cameli M, Podlesnikar T, Manka R, Sitges M, Dweck MR, Haugaa KH (2020)
EACVI survey on standardization of cardiac chambers quantification by transthoracic echocardiography
Eur Heart J Cardiovasc Imaging, 21 (2), 119-123
DOI 10.1093/ehjci/jez297, PubMed 31819943

Alfonso JH, Afanou AK, Holm JØ, Stylianou E (2020)
Skin bioengineering in the diagnosis of occupational protein contact dermatitis
Occup Med (Lond) (in press)
DOI 10.1093/occmed/kqaa005, PubMed 32009172

Andersen ØS, Krogh MR, Boe E, Storsten P, Aalen JM, Larsen CK, Skulstad H, Odland HH, Smiseth OA, Remme EW (2020)
Left Bundle Branch Block Increases Left Ventricular Diastolic Pressure during Tachycardia due to Incomplete Relaxation
J Appl Physiol (1985) (in press)
DOI 10.1152/japplphysiol.01002.2018, PubMed 31999529

Bergh N, Gude E, Bartfay SE, K Andreassen A, Arora S, Dahlberg P, Dellgren G, Gullestad L, Gustafsson F, Karasson K, Rådegran G, Bollano E, Andersson B (2020)
Invasive haemodynamics in de novo everolimus vs. calcineurin inhibitor heart transplant recipients
ESC Heart Fail (in press)
DOI 10.1002/ehf2.12608, PubMed 32059083

Bye A, Klevjer M, Ryeng E, Silva GJJ, Moreira JBN, Stensvold D, Wisløff U (2020)
Identification of novel genetic variants associated with cardiorespiratory fitness
Prog Cardiovasc Dis (in press)
DOI 10.1016/j.pcad.2020.02.001, PubMed 32035127

Dellgren G, Lund TK, Raivio P, Leuckfeld I, Svahn J, Magnusson J, Riise GC (2020)
Design and Rationale of a Scandinavian Multicenter Randomized Study Evaluating if Once-Daily Tacrolimus Versus Twice-Daily Cyclosporine Reduces the 3-year Incidence of Chronic Lung Allograft Dysfunction After Lung Transplantation (ScanCLAD Study)
Adv Ther (in press)
DOI 10.1007/s12325-020-01224-1, PubMed 31993943

Duchenne J, Aalen JM, Cvijic M, Larsen CK, Galli E, Bézy S, Beela AS, Ünlü S, Pagourelias ED, Winter S, Hopp E, Kongsgård E, Donal E, Fehske W, Smiseth OA, Voigt JU (2020)
Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodelling
Eur Heart J Cardiovasc Imaging (in press)
DOI 10.1093/ehjci/jeaa003, PubMed 32031587

Dueland S, Syversveen T, Solheim JM, Solberg S, Grut H, Bjørnbeth BA, Hagness M, Line PD (2020)
Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases
Ann Surg, 271 (2), 212-218
DOI 10.1097/SLA.0000000000003404, PubMed 31188200

Espinoza A, Kerans V, Bugge JF, Skulstad H, Halvorsen PS (2020)
Left Ventricular Function During Epinephrine Stimulation and Hypothermia: Effects at Spontaneous and Paced Heart Rates in a Porcine Model
Ther Hypothermia Temp Manag
DOI 10.1089/ther.2019.0035, PubMed 31916922

Gude E, Hoel TN, Sørensen G, Broch K, Meyer A, Fiane AE (2020)
Long-term continuous flow mechanical biventricular support: 9 years and counting
Interact Cardiovasc Thorac Surg, 30 (1), 81-84
DOI 10.1093/icvts/ivz231, PubMed 31580433

Gustafsson F, Andreassen AK, Andersson B, Eiskjær H, Rådegran G, Gude E, Jansson K, Solbu D, Karason K, Arora S, Dellgren G, Gullestad L, SCHEDULE (Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance) Investigators* (2020)
Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients: Long-term Follow-up From the Randomized SCHEDULE Study
Transplantation, 104 (1), 154-164
DOI 10.1097/TP.0000000000002702, PubMed 30893292

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Kaur S, Shen X, Power A, Ward ML (2020)
Stretch modulation of cardiac contractility: importance of myocyte calcium during the slow force response
Biophys Rev (in press)
DOI 10.1007/s12551-020-00615-6, PubMed 31939110

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ et al. (2020)
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Eur Heart J, 41 (3), 407-477
DOI 10.1093/eurheartj/ehz425, PubMed 31504439

Laerum D, Brustugun OT, Gallefoss F, Falk R, Strand TE, Fjellbirkeland L (2020)
Reduced delays in diagnostic pathways for non-small cell lung cancer after local and National initiatives
Cancer Treat Res Commun, 23, 100168 (in press)
DOI 10.1016/j.ctarc.2020.100168, PubMed 32028190

Larsen CK, Aalen JM, Stokke C, Fjeld JG, Kongsgaard E, Duchenne J, Degtiarova G, Gheysens O, Voigt JU, Smiseth OA, Hopp E (2020)
Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block
Eur Heart J Cardiovasc Imaging, 21 (2), 143-153
DOI 10.1093/ehjci/jez231, PubMed 31599327

Legøy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S (2020)
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Sci Rep, 10 (1), 414
DOI 10.1038/s41598-019-57305-x, PubMed 31942009

Mayerhofer CCK, Kummen M, Holm K, Broch K, Awoyemi A, Vestad B, Storm-Larsen C, Seljeflot I, Ueland T, Bohov P, Berge RK, Svardal A, Gullestad L, Yndestad A, Aukrust P, Hov JR, Trøseid M (2020)
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail (in press)
DOI 10.1002/ehf2.12596, PubMed 31978943

Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 1-12 (in press)
DOI 10.1159/000505318, PubMed 31968347

Nakstad ER, Stær-Jensen H, Wimmer H, Henriksen J, Alteheld LH, Reichenbach A, Drægni T, Šaltytė-Benth J, Wilson JA, Etholm L, Øijordsbakken M, Eritsland J, Seljeflot I, Jacobsen D, Andersen GØ, Lundqvist C, Sunde K (2020)
Late awakening, prognostic factors and long-term outcome in out-of-hospital cardiac arrest - results of the prospective Norwegian Cardio-Respiratory Arrest Study (NORCAST)
Resuscitation (in press)
DOI 10.1016/j.resuscitation.2019.12.031, PubMed 31926258

Nelson LM, Andreassen AK, Arora S, Andersson B, Gude E, Eiskjaer H, Rådegran G, Dellgren G, Gullestad L, Gustafsson F (2020)
Mild acute cellular rejection and development of cardiac allograft vasculopathy assessed by intravascular ultrasound and coronary angiography in heart transplant recipients-a SCHEDULE trial substudy
Transpl Int (in press)
DOI 10.1111/tri.13577, PubMed 31958178

Norekvål TM, Allore HG, Bendz B, Bjorvatn C, Borregaard B, Brørs G, Deaton C, Fålun N, Hadjistavropoulos H, Hansen TB, Igland S, Larsen AI, Palm P, Pettersen TR, Rasmussen TB, Schjøtt J, Søgaard R, Valaker I, Zwisler AD, Rotevatn S, CONCARD Investigators (2020)
Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI)
BMJ Open, 10 (2), e031995
DOI 10.1136/bmjopen-2019-031995, PubMed 32054625

Peersen K, Otterstad JE, Sverre E, Perk J, Gullestad L, Moum T, Dammen T, Munkhaugen J (2020)
Medical and Psychosocial Factors Associated With Low Physical Activity and Increasing Exercise Level After a Coronary Event
J Cardiopulm Rehabil Prev, 40 (1), 35-40
DOI 10.1097/HCR.0000000000000399, PubMed 30720643

Pezel T, Coisne A, Mahmoud-Elsayed H, Mandoli GE, Elgamal SM, Podlesnikar T, Cameli M, Grapsa J, Lafitte S, Edvardsen T, Donal E, Dreyfus J (2020)
EACVI communication paper: first international young dedicated multimodal cardiovascular imaging simulation education event organized by the ESC
Eur Heart J Cardiovasc Imaging, 21 (2), 124-126
DOI 10.1093/ehjci/jez299, PubMed 31834376

Rodriguez-Palomares JF, Edvardsen T, Almeida AG, Petersen SE (2020)
EuroCMR 2019 highlights
Eur Heart J Cardiovasc Imaging, 21 (2), 127-131
DOI 10.1093/ehjci/jez307, PubMed 31821461

Ross S, Nestaas E, Kongsgaard E, Odland HH, Haland TF, Hopp E, Haugaa KH, Edvardsen T (2020)
Septal contraction predicts acute haemodynamic improvement and paced QRS width reduction in cardiac resynchronization therapy
Eur Heart J Cardiovasc Imaging (in press)
DOI 10.1093/ehjci/jez315, PubMed 31925420

Schalit I, Espinoza A, Pettersen FJ, Snartland S, Ringdal ML, Hoel TN, Skulstad H, Fosse E, Fiane AE, Halvorsen PS (2020)
Detection of Thromboembolic Events and Pump Thrombosis in HeartWare HVAD Using Accelerometer in a Porcine Model
ASAIO J, 66 (1), 38-48
DOI 10.1097/MAT.0000000000000954, PubMed 30688692

Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC (2020)
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun (in press)
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888

Skjølsvik ET, Hasselberg NE, Dejgaard LA, Lie ØH, Andersen K, Holm T, Edvardsen T, Haugaa KH (2020)
Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype
J Am Heart Assoc, 9 (2), e012937
DOI 10.1161/JAHA.119.012937, PubMed 31957533

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2020)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686

Storsten P, Aalen JM, Boe E, Remme EW, Gjesdal O, Larsen CK, Andersen ØS, Eriksen M, Kongsgaard E, Duchenne J, Voigt JU, Smiseth OA, Skulstad H (2020)
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging (in press)
DOI 10.1016/j.jcmg.2019.11.016, PubMed 31954643

Sverre E, Peersen K, Weedon-Fekjær H, Perk J, Gjertsen E, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J (2020)
Preventable clinical and psychosocial factors predicted two out of three recurrent cardiovascular events in a coronary population
BMC Cardiovasc Disord, 20 (1), 61
DOI 10.1186/s12872-020-01368-6, PubMed 32024471

Thøgersen H, Møller B, Åsli LM, Bhargava S, Kvåle R, Fjellbirkeland L, Robsahm TE, Aaserud S, Babigumira R, Larsen IK (2020)
Waiting times and treatment following cancer diagnosis: comparison between immigrants and the Norwegian host population
Acta Oncol
DOI 10.1080/0284186X.2019.1711167, PubMed 31920119

Törnudd M, Ramström S, Kvitting JE, Alfredsson J, Pihl R, Berg S (2020)
Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors
Platelets
DOI 10.1080/09537104.2020.1719992, PubMed 31992110

Aamodt IT, Lycholip E, Celutkiene J, von Lueder T, Atar D, Falk RS, Hellesø R, Jaarsma T, Strömberg A, Lie I (2020)
Self-Care Monitoring of Heart Failure Symptoms and Lung Impedance at Home Following Hospital Discharge: Longitudinal Study
J Med Internet Res, 22 (1), e15445
DOI 10.2196/15445, PubMed 31909717

 
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