Best treatment of multisystem inflammatory syndrome with COVID-19 (MIS-C)
Complicated headache after COVID-19 vaccination
A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers
PREDCOV
Establishment of Interferon-gamma-analysis for accurate detection of SARS-CoV-2 T-cell response
Superinfections in Covid-19 patients in the ICU - before and after dexamethasone
SARS-CoV-2 Immune KTx-study
Aminoacridines with dual SARS-CoV2 antiviral and immunostimulating activity
Risk factors for SARS-CoV-2 infection and hospitalization in children and adolescents in Norway: A nation-wide population-based study.
Monitoring of immunological response to COVID-19 vaccine in lymphoma/leukemia patients treated with anti-CD20 monoclonal antibodies and in patients who have completed allogenic stem cell transplantation
Antibody screening in blood donors
Influence of the COVID-19 pandemic on women with gynecological cancer
Corona virus-related visitation restrictions enforced in ICUs in the Scandinavian countries – what can we learn to meet future challenges?
COVID-19 and labor market participation for young adults with psychosis
Physiotherapy treatment of hospitalised patients with COVID-19 at Oslo University Hospital
Best Available Treatment for Paediatric Inflammatory Syndromes Temporally Associated with SARS-CoV-2 (BATS)
COVID-19 in partients with pituitary disease
MORMOR-COVID: MORbidity and MORtality during the COVID-19 pandemic
Visiting restrain to hospitals; family caregivers of COVID-19 ICU-patients experiences. An exploratory study
Pandemic 2020 - Parental debut in isolation
Cod Liver Oil for COVID-19 Prevention Study
The COVID-19 pandemic and pediatric cancer at Oslo University Hospital
Views of patients with inflammatory bowel disease on the COVID-19 pandemic and the health care service - a Quality study
The incidence of thromboembolic complications in patients admitted with COVID-19 infection
COVID-19 in Pregnancy, Childbirth and Puerperium (COVID-Preg-ChiP Study)
Defining the immune cells that correlate with fatal acute lung injury in COVID-19
NORPLASMA
COVID-19 in the EUSTAR cohort of systemic sclerosis
COVID IgG KTx
Production of "in house" versions of reverse transcriptase and Taq DNA polymerase for use in SARS-CoV-2 assays
The Norwegian study of nervous system manifestations and sequelae in COVID-19 (NeuroCOVID)
Background:
Corona virus (CoV) may not only affect the respiratory system, but also have deleterious effects on the central nervous system. As the number of individuals infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is increasing, more neurologic, neuropsychological and neuropsychiatric symptoms are being reported in COVID-19 patients. COVID-19 may affect the nervous system via four potential mechanisms; direct viral injury of nervous tissue, an excessive immune response in the form of a "cytokine storm”, unintended host immune response effects after an acute infection or as a result of indirect viral injury results from the effects of systemic illness. In addition, the COVID-19 is a significant psychological stressor an may contribute to neuropsychiatric and neuropsychological sequalae. The long-term effect on neurological and neuropsychological functioning.
Primary objective:
To assess the neurological, neuropsychological and neuropsychiatric manifestations of COVID-19 and identify possible post-COVID neurologic, neuropsychological and neuropsychiatric syndromes at follow-up.
The secondary objectives:
To assess at 6 and 12 months´ follow-up:
The rate of stroke, peripheral nervous affection, myopathy, brain MRI pathology, level of blood specific biomarkers, rate of post-COVID-19 related cognitive and/or neuropsychiatric manifestations, the rate of death.
To assess if there is an association between inflammatory markers and neuropsychiatry/neuropsychology, between neuroimaging and neuropsychiatry/neuropsychology or between neurologic examination and neuropsychiatry/neuropsychology.
Methods
Study design: Multi-center prospective observational study of the occurrence of neurological manifestations and sequelae in patients with COVID-19 at 6- and 12-months follow-up.
Project leader:
Visitor bans in hospitals: How are newborn infants affected during the COVID-19 pandemic?
Convalescent plasma therapy for patients with severe COVID-19
COPE - Corona pandemic experiences by patients with psychotic- and bipolar disorders
COVID-19 and geriatric psychiatry health services
Delirium in critically ill patients with SARS-CoV-2 infection
The COVID-19 pandemic: Reactions from the mental health workers
The COVID-19 pandemic: Reactions of acutely ill psychiatric patients
Mental reactions to COVID-19 among adults with heart failure
EuroECMO-COVID
Prospective and retrospective multicenter observational study of COVID-19 patients who receive extracorporeal membrane oxygenation (ECMO) treatment from 87 European intensive care units
Immunoregulatory and antiviral properties of compounds derived from anti-malaria drugs as hydroxychloroquine
COPSYC-19: Consequences for patients with psychosis from the SARS-CoV-2 shut-down
Background
The SARS-CoV-2 virus was declared a global pandemic by the Worlds Health Organization on March 11th 2020. The next day expansive restrictions were enforced by the Norwegian government to reduce spread of the virus. These included closing down schools, kindergartens, sports, universities, encouraging home office wherever possible, strict border control, home quarantine and expansive social distancing. Mental health services were also affected by the restrictions, and consequently face-to-face consultations were replaced by telephone- or video consultations. Inpatients experienced restrictions in the freedom to leave the wards, visits were not permitted and group activities were limited or closed down.
Individuals with psychotic illnesses are generally considered one of the most vulnerable groups within the mental health services, and they often have several comorbid conditions such as depression, anxiety, substance abuse and cognitive impairment. Despite low prevalence, two thirds of all psychiatric hospital days and half of all psychiatric outpatient consultations are linked to psychotic illnesses.
Objectives
The main objective of this study is to investigate how the national shut-down enforced due to the ongoing pandemic has affected individuals receiving treatment for psychotic illnesses at Oslo University Hospital. We will examine the individuals’ subjective experiences of changes in psychotic symptoms, depression, alcohol- and drug abuse, traumatic experiences, quality of life, and functioning in terms of employment or studies. We also aim to examine the individuals’ experiences with the mental health services during the shut-down period, both in terms of quality and accessibility. A secondary objective of the study is to examine therapists’ assessment of the quality of care during the shut-down and the impact this has had on the patient group.
Methods
Participants will be invited to respond to a questionnaire. The questionnaire will be available both online and in paper. Therapists will be invited to respond to an online questionnaire. We will also draw a selection of patient journals to compare the individuals’ responses to what is documented in their journal in order to examine if therapists were able to accurately assess clinical changes in their patients via telephone and video consultations.
Project leader:
Prehospital treatment of "silent hypoxia" in young patients COVID-19
COVID-19 general biobank
Pharmacokinetic population analysis of antiviral drugs in the NOR SOLIDARITY study
Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs
Handling oxygenation targets in adults with COVID-19 associated acute hypoxaemic respiratory failure in the ICU
SARS-CoV-2 and Cancer
Psychological distress and Coping in Psychiatric Patients during COVID-19 pandemic (PsyCo-COVID-19): A cross-sectional study at Oslo University Hospital
Examining COVID19 Course and Outcomes in Patients Previously Diagnosed with Chronic Lymphocytic Leukemia
Laboratory diagnostics for risk stratification in COVID-19
Acute appendicitis at Oslo University Hospital before and after Covid-19 restrictions: Business as usual or delay?
Development of an international questionnaire to assess patient-reported symptoms and concerns related to COVID-19 disease, the COVID-19 QLQ-##
Secure IBD registry. Surveillance epidemiology of Coronavirus (COVID-19) under research exclusion.
Decidual stromal cells (DSC) in treatment of COVID-19 induced respiratory failure
COVID-19 surgery cohort
Use of blood pressure medication and risk of COVID-19 infection and complications
COVID-19 infections in patients with adrenal cortex failure
REACT-NOR - react now! Remote follow-up of relatives of patients with psychosis during the COVID-19 crisis
COVID-19 impact on patient care
Patient-reported outcomes and lung function after hospitalization for COVID-19 infection (PROLIFE)
Use of ultrasound in acute evaluation of patients with suspected COVID-19 infection
Protocol for testing immunological rapid tests for COVID-19
Prevalence of complement activation in COVID-19 patients admitted to OUS
Artificial intelligence to quantify important segments from CT in COVID-19
MINI-Nor Maternal and Infant Immunity against Vaccine Preventable Diseases in Norway
Inhaled NO as a bridge to rapid sequence intubation in COVID-19 related hypoxemia (INOCOV-19)
Splitting one ventilator for multiple patients
Stress responses and health complaints among hospital staff working in intensive care units and clinical wards during the Covid-19 pandemic
Vulnerable patients with personality disorder - consequences of the corona crisis
Sensor based vital signs monitoring of patients with clinical manifestation of Covid 19 disease during home isolation, a randomized feasibility study.
A Norwegian study on views and experiences of health care personnel working in intensive care units during the COVID-19 pandemic.
OVID20: Longitudinal population-based environmental seroepidemiological investigation protocol for COVID-19 virus infection in healthcare workers in an orthopeadic emergency department
COVID-19 and reactions in the Norwegian population
COVID-19 Public Response and Rapid-Cycle Re-Implementation of Activities
Novel vaccine development against COVID-19
Abdominal pain in COVID-19 patients
Outcome of patients >75 with COVID-19 severe acute respiratory insufficiency (SARI)
Both the preliminary reports of critically ill COVID-19 patients in Wuhan (China) and Italy reported a high risk of dying in patients with multimorbidity. Also, very old patients with SARS-CoV-2 infections suffered from high mortality rates. It is, however, unclear if age alone is an independent risk factor, or if co-morbid conditions and frailty trigger the adverse outcome. In non-COVID-19 elderly patients admitted to the ICU, our European research group found that the co-factors are more important than chronological age itself. In patients with COVID-19, pretreatment with AT-2 blockers and ACE-inhibitors, but also nonsteroidal anti-inflammatory drugs such as ibuprofen were suggested to be associated with adverse outcome. Furthermore, some groups reported a higher death rate in patients with concomitant cardiovascular disease and diabetes. This international multicenter study group, therefore, proposes to study the relationship between age, co-morbidities, pretreatment, frailty, and outcomes prospectively in a group of elderly patients receiving critical care for COVID-19. The results of this investigation will be essential to understand which factors can predict mortality in elderly COVID-19 patients to help to detect these patients early. Furthermore, the proposed study will also be a knowledge base necessary to guide triage decisions in the future. With this pandemic likely to continue for 18 months, it is paramount to identify independent risk factors early to facilitate both risk stratification and substantiate necessary triage decisions. The pandemic begins in all European countries now, and decisive action of the research community is needed.