Mazyar Yazdani

  • Senior Scientist; PhD

Education

  • 2009-2014: PhD in Integrative Biology - Toxicology, Department of Biosciences, University of Oslo, Norway

Thesis: In vitro, in ovo and in vivo models for cytotoxicity, oxidative stress, neurotoxicity and DNA damage

Committee: Ketil Hylland, Ragnhild Paulsen & Tor Gjøen   (Collaborator: Gunnar Brunborg, Norwegian Institute of Public Health)

Affiliation

– Associated member of:

Research Summary

Dr. Yazdani, a toxicologist, began his research career by studying the mechanisms of action of hazardous substances, with emphasis on oxidative stress induction and in vitro (cell culture) method development. He later linked the role of oxidative stress to pathophysiology of dry eye disease and treatment of corneal epithelial (limbal) stem cell deficiency. Currently, as a core member of the Metabolomics & Metabolic Molecular Biology group, he is investigating the role of metabolic changes in health and disease. The main goal is to better understand the mechanisms underlying disease development using mass spectrometry-based metabolomics and lipidomics. Apart from these, Mazyar has always had a keen interest in biological role and effects of oxygen. He is interested in both empirical and conceptual research (Read more here). 

Selected projects

Mazyar is involved in several projects (on eye, brain, blood, etc.), but his main fields of interest are ophthalmology and neurology. Some examples:

Dry eye disease (e.g., Yazdani et al 2021a), Kearns–Sayre syndrome (e.g., Salvador et al 2023), Pyridoxine-dependent epilepsy (e.g., Böhm et al 2022) & Neurotoxicity (e.g., Mathisen et al 2013).

Highlights

Current PhD students

  • Fredrik Fineide, Since 2024, Optimization of current dry eye disease treatment regimens through artificial intelligence
  • Morten Gundersen, Since 2023, Metabolomic profile in tear film samples of patients with or without dry eye disease before and after cataract surgery
  • Madhavi bhandari, Since 2021, Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease

Work Experience

  • 2021-to date: Metabolomics Group, Oslo University Hospital (OUS) - Rikshospitalet, Oslo
  • 2017-2020: Regenerative Medicine Group, Oslo University Hospital (OUS) - Ullevål Sykehus, Oslo
  • 2016: Health Effects Group, Norwegian Institute for Air Research (NILU), Kjeller + Norwegian Dry Eye Clinic (TØK), Oslo
  • 2015: Toxicology Group and Ecotoxicology Group, Norwegian Food Safety Authority (Mattilsynet), Ås
  • 2009-2014: Toxicology Group, University of Oslo (UiO), Oslo
  • 2006-2009: Ecotoxicology Group, University of Putra (UPM), Malaysia

Links

NB: Visit our NEWS PAGE for the latest updates and the Galleries (Links: 1, 2, 3 & 4) for social events!

 

Publications 2021

Skogvold HB, Yazdani M, Sandas EM, Vassli AO, Kristensen E, Haarr D, Rootwelt H, Elgstoen KBP (2021)
A pioneer study on human 3-nitropropionic acid intoxication: Contributions from metabolomics
J. Appl. Toxicol.
DOI 10.1002/jat.4259

Yazdani M, Elgstoen KBP (2021)
Is oxidative stress an overlooked player in pyridoxine-dependent epilepsy? A focused review
Seizure, 91, 369-373
DOI 10.1016/j.seizure.2021.07.014

Yazdani M, Elgstoen KBP, Utheim TP (2021)
Eye Make-up Products and Dry Eye Disease: A Mini Review
Curr. Eye Res.
DOI 10.1080/02713683.2021.1966476

Yazdani M, Fiskadal J, Chen XJ, Utheim OA, Raeder S, Vitelli V, Utheim TP (2021)
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort
J. Clin. Med., 10 (4), 884
DOI 10.3390/jcm10040884

Publications 2020

Gautvik KM, Gunther CC, Prijatelj V, Medina-Gomez C, Shevroja E, Rad LH, Yazdani M, Lindalen E, Valland H, Gautvik VT, Olstad OK, Holden M, Rivadeneira F, Utheim TP, Reppe S (2020)
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J. Bone Miner. Res., 35 (6), 1065-1076
DOI 10.1002/jbmr.3974

Tashbayev B, Utheim TP, Utheim OA, Raeder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen XJ (2020)
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x

Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP (2020)
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul. Surf., 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002

Yazdani M (2020)
Comparative toxicity of selected PAHs in rainbow trout hepatocytes: genotoxicity, oxidative stress and cytotoxicity
Drug Chem. Toxicol., 43 (1), 71-78
DOI 10.1080/01480545.2018.1497054

Yazdani M, Shahdadfar A, Reppe S, Sapkota D, Vallenari EM, Lako M, Connon CJ, Figueiredo FC, Utheim TP (2020)
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914

Publications 2019

Yazdani M, Chen XJ, Tashbayev B, Utheim OA, Raeder S, Hua YJ, Eidet JR, Stojanovic A, Dartt DA, Utheim TP (2019)
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients
Curr. Eye Res., 44 (9), 941-947
DOI 10.1080/02713683.2019.1604972

Yazdani M, Elgstoen KBP, Rootwelt H, Shahdadfar A, Utheim OA, Utheim TP (2019)
Tear Metabolomics in Dry Eye Disease: A Review
Int. J. Mol. Sci., 20 (15), 3755
DOI 10.3390/ijms20153755

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3), 245
DOI 10.3390/cells8030245

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy
Bioengineering-Basel, 6 (4), 97
DOI 10.3390/bioengineering6040097

Publications 2018

Yazdani M, Chen XJ, Tashbayev B, Utheim OA, Raeder S, Lagli N, Stojanovic A, Dartt DA, Utheim TP (2018)
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort
Curr. Eye Res., 43 (12), 1465-1470
DOI 10.1080/02713683.2018.1514055

Publications 2017

Gabelova A, El Yamani N, Alonso TI, Buliakova B, Srancikova A, Babelova A, Pran ER, Fjellsbo LM, Elje E, Yazdani M, Silva MJ, Dusinska M (2017)
Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles
Mutagenesis, 32 (1), 193-202
DOI 10.1093/mutage/gew045

Publications 2016

Yazdani M, Andresen AMS, Gjoen T (2016)
Short-term effect of bisphenol-a on oxidative stress responses in Atlantic salmon kidney cell line: a transcriptional study
Toxicol. Mech. Methods, 26 (4), 295-300
DOI 10.1080/15376516.2016.1177864

Yazdani M, Hylland K (2016)
A Kinetic Study of Reactive Oxygen Species in Rainbow Trout Hepatocytes by Fluorometry
J. Environ. Pathol. Toxicol. Oncol., 35 (4), 291-297
DOI 10.1615/JEnvironPatholToxicolOncol.2016016184

Publications 2015

Yazdani M (2015)
Concerns in the application of fluorescent probes DCDHF-DA, DHR 123 and DHE to measure reactive oxygen species in vitro
Toxicol. Vitro, 30 (1), 578-582
DOI 10.1016/j.tiv.2015.08.010

Yazdani M, Paulsen RE, Gjoen T, Hylland K (2015)
Reactive Oxygen Species and Cytotoxicity in Rainbow Trout Hepatocytes: Effects of Medium and Incubation Time
Bull. Environ. Contam. Toxicol., 94 (2), 193-198
DOI 10.1007/s00128-014-1433-0

Publications 2013

Mathisen GH, Yazdani M, Rakkestad KE, Aden PK, Bodin J, Samuelsen M, Nygaard UC, Goverud IL, Gaarder M, Loberg EM, Bolling AK, Becher R, Paulsen RE (2013)
Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken
Int. J. Dev. Neurosci., 31 (8), 762-769
DOI 10.1016/j.ijdevneu.2013.09.009

Publications 2011

Ellesat KS, Yazdani M, Holth TF, Hylland K (2011)
Species-dependent sensitivity to contaminants: An approach using primary hepatocyte cultures with three marine fish species
Mar. Environ. Res., 72 (4), 216-224
DOI 10.1016/j.marenvres.2011.09.003

Yap CK, Yazdani M, Abdullah F, Tan SG (2011)
Is the high Cu tolerance of Trichoderma atroviride isolated from the Cu-polluted sediment due to adaptation? An in vitro toxicological study
Journal of Sains Malaysiana , 40 (2), 119-124
PublikaID 362

Publications 2010

Yap CK, Fitri M, Yazdani M, Tan SG (2010)
Effects of the metal contaminated soils on the accumulation of heavy metals in the different parts of Centella asiatica: A laboratory study
Journal of Sains Malaysiana, 39 (3), 347-352
PublikaID 360

Yazdani M, Yap CK, Abdullah F, Tan SG (2010)
An in vitro study on the adsorption, absorption and uptake capacity of Zn by using the bioremediator Trichoderma atroviride
EnvironmentAsia, 3 (1), 53-59
PublikaID 361

Publications 2009

Yap CK, Yazdani M (2009)
The identification of point sources in a river receiving industrial metal effluents at the Serdang industrial area, Selangor
Sustainability Science and Management, 4 (2), 18-26
PublikaID 358

Yazdani M, Yap CK, Abdullah F, Tan SG (2009)
Trichoderma atroviride as a bioremediator of Cu pollution: An in vitro study
Toxicological & Environmental Chemistry , 91 (7), 1305-1314
DOI 10.1080/02772240802616510, PublikaID 359

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