Sigrid Skånland’s project group Functional precision medicine for haematologic cancers

There is an unmet need to tailor cancer therapy to each patient's disease. Our research group focuses on developing functional precision medicine for B-cell malignancies, in particular chronic lymphocytic leukemia (CLL). By performing functional analyses such as drug sensitivity screening and single cell signaling analyses directly on the patients' cancer cells, our aim is to identify biomarker signatures that can predict treatment outcomes for the individual patient, and thus guide treatment decisions.

Select publications

1. Yin Y, Athanasiadis P, Karlsen L, Urban A, Xu H, Murali I, Fernandes SM, Arribas AJ, Hilli AK, Taskén K, Bertoni F, Mato AR, Normant E, Brown JR, Tjønnfjord GE, Aittokallio T, Skånland SS. Functional testing to characterize and stratify PI3K inhibitor responses in chronic lymphocytic leukemia. Clinical Cancer Research, 2022, 28(20):4444-4455.
2. Skånland SS and Tjønnfjord GE. Determining drug dose in the era of targeted therapies: playing it (un)safe? Blood Cancer Journal, 2022, 12(8):123.
3. Skånland SS, Inngjerdingen M, Bendiksen H, York J, Spetalen S, Munthe LA, Tjønnfjord GE. Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechansims. An index case. Haematologica, 2022, 107(8):1994-1998.
4. Melvold K, Giliberto M, Karlsen L, Ayuda-Durán P, Hanes R, Holien T, Enserink J, Brown JR, Tjønnfjord GE, Taskén K, Skånland SS. Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies. Mol Oncol, 2022, Mar;16(5):1153-1170.
5. Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K. An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL. Leukemia, 2020, 34(2):478-487.

Contact information

Department of Cancer Immunology, Institute for Cancer Research
Oslo University Hospital, Ullernchausseen 70, 0379 Oslo, Norway