Publications
Publications 2022
Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells
Methods Mol Biol, 2449, 327-348
DOI 10.1007/978-1-0716-2095-3_14, PubMed 35507270
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case
Haematologica (in press)
DOI 10.3324/haematol.2021.280393, PubMed 35236056
Publications 2021
The Norwegian childhood cancer biobank
Cancer Rep (Hoboken), e1555
DOI 10.1002/cnr2.1555, PubMed 34541832
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096
COVID-19 in patients with CLL: improved survival outcomes and update on management strategies
Blood, 138 (18), 1768-1773
DOI 10.1182/blood.2021011841, PubMed 34297826
Overcoming resistance to targeted therapies in chronic lymphocytic leukemia
Blood Adv, 5 (1), 334-343
DOI 10.1182/bloodadvances.2020003423, PubMed 33570649
Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein
Front Immunol, 12, 724361
DOI 10.3389/fimmu.2021.724361, PubMed 34899688
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11
Acta Pharmacol Sin (in press)
DOI 10.1038/s41401-021-00817-y, PubMed 34893686
Publications 2020
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
Blood, 136 (10), 1134-1143
DOI 10.1182/blood.2020006965, PubMed 32688395
Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
Lancet, 395 (10228), 951-961
DOI 10.1016/S0140-6736(19)32983-6, PubMed 32087121
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia
Scand J Immunol, 92 (5), e12931
DOI 10.1111/sji.12931, PubMed 32640099
Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer
Acta Pharmacol Sin, 42 (8), 1298-1310
DOI 10.1038/s41401-020-00544-w, PubMed 33139838
Publications 2019
A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer
Invest New Drugs, 37 (6), 1166-1176
DOI 10.1007/s10637-019-00750-2, PubMed 30825105
Off-label uses of drugs for depression
Eur J Pharmacol, 865, 172732
DOI 10.1016/j.ejphar.2019.172732, PubMed 31622593
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7, PubMed 31471562
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J Immunol, 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660, PubMed 31292214
Publications 2018
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
Oncotarget, 9 (10), 9273-9284
DOI 10.18632/oncotarget.23949, PubMed 29507689
Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
J Vis Exp (140)
DOI 10.3791/58386, PubMed 30346411
In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy
Blood, 132, 4676
DOI 10.1182/blood-2018-99-110357, PublikaID 304
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303
Publications 2016
Insight into the Dual Functions of Bacterial Enhancer-Binding Protein Rrp2 of Borrelia burgdorferi
J Bacteriol, 198 (10), 1543-52
DOI 10.1128/JB.01010-15, PubMed 26977110
Publications 2015
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Haematologica, 101 (2), e59-62
DOI 10.3324/haematol.2015.135590, PubMed 26589914
Publications 2014
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
Biochem J, 460 (3), 399-410
DOI 10.1042/BJ20140040, PubMed 24665965
Publications 2013
BiP negatively affects ricin transport
Toxins (Basel), 5 (5), 969-82
DOI 10.3390/toxins5050969, PubMed 23666197
Publications 2012
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG
Exp Cell Res, 318 (14), 1611-9
DOI 10.1016/j.yexcr.2012.05.014, PubMed 22659621
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
Arterioscler Thromb Vasc Biol, 33 (2), e47-55
DOI 10.1161/ATVBAHA.112.253427, PubMed 23162017
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
PLoS One, 7 (7), e40429
DOI 10.1371/journal.pone.0040429, PubMed 22792315
Publications 2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
Nature, 471 (7340), 637-41
DOI 10.1038/nature09814, PubMed 21455181
Publications 2010
Spatial organization of transmembrane receptor signalling
EMBO J, 29 (16), 2677-88
DOI 10.1038/emboj.2010.175, PubMed 20717138
Publications 2009
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
DOI 10.1371/journal.pone.0005935, PubMed 19529763
β-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
DOI 10.1111/j.1462-5822.2009.01292.x, PubMed 19159388
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
DOI 10.1016/j.cellsig.2009.03.005, PubMed 19289168
Publications 2007
Ribosome binding of a single copy of the SecY complex: implications for protein translocation
Mol Cell, 28 (6), 1083-92
DOI 10.1016/j.molcel.2007.10.034, PubMed 18158904
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
DOI 10.1111/j.1600-0854.2006.00527.x, PubMed 17319803
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
DOI 10.1074/jbc.M610886200, PubMed 17403690
SNX1 and SNX2 mediate retrograde transport of Shiga toxin
Biochem Biophys Res Commun, 358 (2), 566-70
DOI 10.1016/j.bbrc.2007.04.159, PubMed 17498660
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
DOI 10.1091/mbc.e07-06-0565, PubMed 17959827