Genotypes and phenotypes responsible for chromosomal instability in relation to tumor progression and clinical outcome
It is of great importance for the cell to precisely coordinate the doubling of the interphase centrosome with nuclear events during the cell cycle and limit the number of centrosomes it contains at the onset of mitosis to two and only two. Abnormal spindle assembly and inappropriate chromosome distribution lead to genomic instability. A vast majority of human cancers are genetically unstable. This instability is most often a chromosomal instability, resulting in abnormal chromosome number and vast chromosomal rearrangements resulting in loss of heterozygosity in many genetic loci. Variation and expression of the genes involved in this checkpoint control, such as bub1, cdc14, stk15 and others are studied in relation to chromosomal instability.