Publications
Publications published since 1987 from OUS - Computational Cancer Genomics and Melanoma Systems Biology (Hovig)
386 publications found
Publications 2024
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COSGAP: COntainerized Statistical Genetics Analysis Pipelines
Bioinform Adv, 4 (1), vbae067
DOI 10.1093/bioadv/vbae067, PubMed 38808072 -
Finemap-MiXeR: A variational Bayesian approach for genetic finemapping
PLoS Genet, 20 (8), e1011372
DOI 10.1371/journal.pgen.1011372, PubMed 39146375 -
Evaluation of a combined model of Polygenic Risk Score and mismatch repair genes in the association of colorectal cancer for Norwegian cohort
Tumori, 3008916241303648 (in press)
DOI 10.1177/03008916241303648, PubMed 39654342 -
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762 -
Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways
Mol Oncol (in press)
DOI 10.1002/1878-0261.13726, PubMed 39245677 -
Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)
Prostate, 84 (5), 417-425
DOI 10.1002/pros.24656, PubMed 38193363 -
High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond
J Intern Med, 295 (6), 785-803
DOI 10.1111/joim.13785, PubMed 38698538 -
The SRC-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy
Br J Cancer, 131 (10), 1656-1667
DOI 10.1038/s41416-024-02875-5, PubMed 39390250 -
Corroborating written history with ancient DNA: The case of the Well-man described in an Old Norse saga
iScience, 27 (11), 111076
DOI 10.1016/j.isci.2024.111076, PubMed 39620136 -
A comprehensive characterization of the spectrum of MUTYH germline pathogenic variants in Latin America
Fam Cancer, 23 (4), 507-513
DOI 10.1007/s10689-024-00382-3, PubMed 38687439 -
Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
Nat Genet, 56 (11), 2422-2433
DOI 10.1038/s41588-024-01966-6, PubMed 39472694 -
The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
J Cancer Res Clin Oncol, 150 (2), 56
DOI 10.1007/s00432-023-05514-3, PubMed 38291202 -
The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation
Cancer (in press)
DOI 10.1002/cncr.35666, PubMed 39611336 -
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer
Nat Commun, 15 (1), 9949
DOI 10.1038/s41467-024-54364-1, PubMed 39550375 -
Bilateral Oophorectomy and All-Cause Mortality in Women With BRCA1 and BRCA2 Sequence Variations
JAMA Oncol, 10 (4), 484-492
DOI 10.1001/jamaoncol.2023.6937, PubMed 38421677 -
Incidence of endometrial cancer in BRCA mutation carriers
Gynecol Oncol, 189, 148-155
DOI 10.1016/j.ygyno.2024.07.687, PubMed 39173195 -
To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics
Front Pharmacol, 15, 1419806
DOI 10.3389/fphar.2024.1419806, PubMed 38910881 -
Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy
Cell Commun Signal, 22 (1), 481
DOI 10.1186/s12964-024-01858-6, PubMed 39380098 -
MRI Surveillance and Breast Cancer Mortality in Women With BRCA1 and BRCA2 Sequence Variations
JAMA Oncol, 10 (4), 493-499
DOI 10.1001/jamaoncol.2023.6944, PubMed 38421676 -
Is precision medicine the solution to improve organ preservation in laryngeal/hypopharyngeal cancer? A position paper by the Preserve Research Group
Front Oncol, 14, 1433333
DOI 10.3389/fonc.2024.1433333, PubMed 39165689 -
Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch syndromes
Hered Cancer Clin Pract, 22 (1), 6
DOI 10.1186/s13053-024-00279-3, PubMed 38741120 -
Genetic testing for prevention and treatment of cancer
Tidsskr Nor Laegeforen, 144 (13)
DOI 10.4045/tidsskr.24.0434, PubMed 39498653 -
Commentary on Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank
J Med Genet (in press)
DOI 10.1136/jmg-2024-110385, PubMed 39375027 -
Incidence of peritoneal cancer after oophorectomy among BRCA1 and BRCA2 mutation carriers
J Natl Cancer Inst, 116 (11), 1753-1760
DOI 10.1093/jnci/djae151, PubMed 38937272 -
Roadmap for a European cancer data management and precision medicine infrastructure
Nat Cancer, 5 (3), 367-372
DOI 10.1038/s43018-023-00717-6, PubMed 38321342 -
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
Nucleic Acids Res, 52 (D1), D174-D182
DOI 10.1093/nar/gkad1059, PubMed 37962376 -
Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease
Int J Mol Sci, 25 (10)
DOI 10.3390/ijms25105554, PubMed 38791593 -
Editorial: Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer vol II
Front Oncol, 14, 1448183
DOI 10.3389/fonc.2024.1448183, PubMed 39050580 -
Delineating genotype and parent-of-origin effect on the phenotype in MSH6-associated Lynch syndrome
Genes Chromosomes Cancer, 63 (5), e23237
DOI 10.1002/gcc.23237, PubMed 38722212
Publications 2023
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A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population
Cancers (Basel), 15 (16)
DOI 10.3390/cancers15164124, PubMed 37627152 -
Histology independent drug development - Is this the future for cancer drugs?
Cancer Treat Rev, 123, 102674
DOI 10.1016/j.ctrv.2023.102674, PubMed 38176220 -
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
EClinicalMedicine, 58, 101909
DOI 10.1016/j.eclinm.2023.101909, PubMed 37181409 -
Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Clin Cancer Res, 29 (16), 3026-3036
DOI 10.1158/1078-0432.CCR-23-0416, PubMed 37378632 -
screenwerk: a modular tool for the design and analysis of drug combination screens
Bioinformatics, 39 (1)
DOI 10.1093/bioinformatics/btac840, PubMed 36573326 -
Cancer surveillance for transgender and gender diverse patients with Lynch syndrome: a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Fam Cancer, 22 (4), 437-448
DOI 10.1007/s10689-023-00341-4, PubMed 37341816 -
Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model
Int Immunopharmacol, 126, 111225
DOI 10.1016/j.intimp.2023.111225, PubMed 37988911 -
hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks
PLoS One, 18 (7), e0286330
DOI 10.1371/journal.pone.0286330, PubMed 37467208 -
Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey
Front Oncol, 13, 1141810
DOI 10.3389/fonc.2023.1141810, PubMed 37293588 -
Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement
Hered Cancer Clin Pract, 21 (1), 19
DOI 10.1186/s13053-023-00263-3, PubMed 37821984 -
Comprehensive interrogation of gene lists from genome-scale cancer screens with oncoEnrichR
Int J Cancer, 153 (10), 1819-1828
DOI 10.1002/ijc.34666, PubMed 37551617 -
Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential
Mol Oncol, 17 (11), 2432-2450
DOI 10.1002/1878-0261.13514, PubMed 37622176 -
Clinical testing of transcriptome-wide expression profiles in high-risk localized and metastatic prostate cancer starting androgen deprivation therapy: an ancillary study of the STAMPEDE abiraterone Phase 3 trial
Res Sq
DOI 10.21203/rs.3.rs-2488586/v1, PubMed 36798177 -
Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
BMC Res Notes, 16 (1), 167
DOI 10.1186/s13104-023-06437-5, PubMed 37568187 -
Exploring Stakeholders' Perspectives on Implementing Universal Germline Testing for Colorectal Cancer: Findings From a Clinical Practice Survey
JCO Precis Oncol, 7, e2300440
DOI 10.1200/PO.23.00440, PubMed 37897815 -
The genetic history of Scandinavia from the Roman Iron Age to the present
Cell, 186 (1), 32-46.e19
DOI 10.1016/j.cell.2022.11.024, PubMed 36608656 -
Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients
medRxiv
DOI 10.1101/2023.02.24.23286403, PubMed 36865297 -
Analysis of ATG4C function in vivo
Autophagy, 19 (11), 2912-2933
DOI 10.1080/15548627.2023.2234799, PubMed 37459465
Publications 2022
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Is HLA type a possible cancer risk modifier in Lynch syndrome?
Int J Cancer, 152 (10), 2024-2031
DOI 10.1002/ijc.34312, PubMed 36214792 -
Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway
Cancer Rep (Hoboken), 6 (2), e1736
DOI 10.1002/cnr2.1736, PubMed 36251678 -
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Nat Biotechnol, 40 (11), 1624-1633
DOI 10.1038/s41587-022-01342-x, PubMed 35697807 -
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
Clin Gastroenterol Hepatol, 21 (3), 581-603.e33
DOI 10.1016/j.cgh.2022.12.006, PubMed 36549470 -
Response to Chambuso et al
Genet Med, 24 (5), 1151
DOI 10.1016/j.gim.2022.01.005, PubMed 35216900 -
Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
J Transl Med, 20 (1), 419
DOI 10.1186/s12967-022-03624-z, PubMed 36089578 -
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
J Immunother Cancer, 10 (5)
DOI 10.1136/jitc-2021-004345, PubMed 35613827 -
Transautophagy: Research and Translation of Autophagy Knowledge 2020
Oxid Med Cell Longev, 2022, 9792132
DOI 10.1155/2022/9792132, PubMed 35340207 -
Measuring Autophagic Cargo Flux with Keima-Based Probes
Methods Mol Biol, 2445, 99-115
DOI 10.1007/978-1-0716-2071-7_7, PubMed 34972988 -
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178 -
Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
Trends Pharmacol Sci, 43 (11), 973-985
DOI 10.1016/j.tips.2022.08.009, PubMed 36163057 -
MirGeneDB 2.1: toward a complete sampling of all major animal phyla
Nucleic Acids Res, 50 (D1), D204-D210
DOI 10.1093/nar/gkab1101, PubMed 34850127 -
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963 -
The population genomic legacy of the second plague pandemic
Curr Biol, 32 (21), 4743-4751.e6
DOI 10.1016/j.cub.2022.09.023, PubMed 36182700 -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909 -
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045 -
Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
J Genet Couns, 31 (4), 949-955
DOI 10.1002/jgc4.1567, PubMed 35218578 -
A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer
NAR Cancer, 4 (1), zcab051
DOI 10.1093/narcan/zcab051, PubMed 35047825 -
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
Genet Med, 24 (10), 2208
DOI 10.1016/j.gim.2022.08.005, PubMed 36205748 -
The risks of cancer in older women with BRCA pathogenic variants: How far have we come?
Cancer, 129 (6), 901-907
DOI 10.1002/cncr.34615, PubMed 36571512 -
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Leukemia, 36 (7), 1887-1897
DOI 10.1038/s41375-022-01597-y, PubMed 35643867 -
The Prospective Lynch Syndrome Database: background, design, main results and complete MySQL code
Hered Cancer Clin Pract, 20 (1), 37
DOI 10.1186/s13053-022-00243-z, PubMed 36411472 -
Inherited Cancer Genetic Epidemiology to Improve Precision Medicine
J Clin Med, 11 (3)
DOI 10.3390/jcm11030879, PubMed 35160330 -
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
Hered Cancer Clin Pract, 20 (1), 36
DOI 10.1186/s13053-022-00241-1, PubMed 36182917 -
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Nat Commun, 13 (1), 6283
DOI 10.1038/s41467-022-33933-2, PubMed 36270994 -
AXL inhibition improves BRAF-targeted treatment in melanoma
Sci Rep, 12 (1), 5076
DOI 10.1038/s41598-022-09078-z, PubMed 35332208 -
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529 -
Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach
Hum Mutat, 43 (12), 1921-1944
DOI 10.1002/humu.24449, PubMed 35979650 -
Editorial: Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer
Front Oncol, 12, 1104671
DOI 10.3389/fonc.2022.1104671, PubMed 36601476 -
Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Genome Med, 14 (1), 86
DOI 10.1186/s13073-022-01090-2, PubMed 35948919 -
Contraceptive use and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
Gynecol Oncol, 164 (3), 514-521
DOI 10.1016/j.ygyno.2022.01.014, PubMed 35063280 -
Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru
Cancers (Basel), 14 (22)
DOI 10.3390/cancers14225603, PubMed 36428697
Publications 2021
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Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer
Cancers (Basel), 13 (9)
DOI 10.3390/cancers13092094, PubMed 33925994 -
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development
Prog Chem Org Nat Prod, 115, 59-114
DOI 10.1007/978-3-030-64853-4_2, PubMed 33797641 -
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study
J Clin Med, 10 (13)
DOI 10.3390/jcm10132856, PubMed 34203177 -
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
Front Immunol, 12, 682492
DOI 10.3389/fimmu.2021.682492, PubMed 34290704 -
Recommendations for the FAIRification of genomic track metadata
F1000Res, 10
DOI 10.12688/f1000research.28449.1, PubMed 34249331 -
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma
J Transl Med, 19 (1), 232
DOI 10.1186/s12967-021-02905-3, PubMed 34059094 -
Editorial: Genomic Colocalization and Enrichment Analyses
Front Genet, 11, 617876
DOI 10.3389/fgene.2020.617876, PubMed 33574832 -
Weight Gain and the Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers
Cancer Epidemiol Biomarkers Prev, 30 (11), 2038-2043
DOI 10.1158/1055-9965.EPI-21-0296, PubMed 34426412 -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751 -
Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response
Cancers (Basel), 13 (13)
DOI 10.3390/cancers13133325, PubMed 34283056 -
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
BMC Cancer, 21 (1), 930
DOI 10.1186/s12885-021-08640-8, PubMed 34407780 -
First international workshop of the ATM and cancer risk group (4-5 December 2019)
Fam Cancer, 21 (2), 211-227
DOI 10.1007/s10689-021-00248-y, PubMed 34125377 -
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
Genet Med, 24 (1), 119-129
DOI 10.1016/j.gim.2021.08.016, PubMed 34906479 -
The genetic structure of Norway
Eur J Hum Genet, 29 (11), 1710-1718
DOI 10.1038/s41431-021-00899-6, PubMed 34002043 -
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol., 22 (9), E383 -
Correction to: Letter to the Editor-Recent advances in Lynch syndrome
Fam Cancer, 20 (2), 119
DOI 10.1007/s10689-021-00246-0, PubMed 33792829 -
Towards evidence-based personalised precision medicine for Lynch syndrome
Lancet Oncol, 22 (9), e383
DOI 10.1016/S1470-2045(21)00400-9, PubMed 34478667 -
The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology
J Pers Med, 11 (5)
DOI 10.3390/jpm11050330, PubMed 33922147 -
Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer
Int J Cancer, 149 (11), 1955-1960
DOI 10.1002/ijc.33749, PubMed 34310709 -
The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires
Nat Mach Intell, 3 (11), 936-944
DOI 10.1038/s42256-021-00413-z, PubMed 37396030 -
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
Sci Rep, 11 (1), 9011
DOI 10.1038/s41598-021-87966-6, PubMed 33907223 -
Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Eur J Cancer, 148, 124-133
DOI 10.1016/j.ejca.2021.02.022, PubMed 33743481 -
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Br J Surg, 108 (5), 484-498
DOI 10.1002/bjs.11902, PubMed 34043773 -
Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru
Int J Environ Res Public Health, 18 (4)
DOI 10.3390/ijerph18041470, PubMed 33557277 -
Breast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers
Breast Cancer Res Treat, 187 (2), 515-523
DOI 10.1007/s10549-020-06072-9, PubMed 33423179 -
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy
Cells, 10 (12)
DOI 10.3390/cells10123432, PubMed 34943939 -
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Nat Commun, 12 (1), 5307
DOI 10.1038/s41467-021-25624-1, PubMed 34489465 -
Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial
Front Immunol, 12, 663865
DOI 10.3389/fimmu.2021.663865, PubMed 34046035
Publications 2020
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The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
Int J Cancer, 148 (4), 800-811
DOI 10.1002/ijc.33224, PubMed 32683684 -
Spectrum and Frequency of Tumors, Cancer Risk and Survival in Chilean Families with Lynch Syndrome: Experience of the Implementation of a Registry
J Clin Med, 9 (6)
DOI 10.3390/jcm9061861, PubMed 32549215 -
Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer
Prostate Cancer, 2020, 7673684
DOI 10.1155/2020/7673684, PubMed 32908706 -
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
Genet Med, 23 (4), 705-712
DOI 10.1038/s41436-020-01029-1, PubMed 33257847 -
Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch syndrome tumor spectrum
Int J Cancer, 148 (2), 512-513
DOI 10.1002/ijc.33214, PubMed 32783184 -
Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (9), 1569
DOI 10.1038/s41436-020-0892-4, PubMed 32690931 -
Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database
J Clin Med, 9 (7)
DOI 10.3390/jcm9072290, PubMed 32708519 -
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D132-D141
DOI 10.1093/nar/gkz885, PubMed 31598695 -
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D1172
DOI 10.1093/nar/gkz1016, PubMed 31642479 -
Prevalence of the BRAF p.v600e variant in patients with colorectal cancer from Mexico and its estimated frequency in Latin American and Caribbean populations
J Investig Med, 68 (5), 985-991
DOI 10.1136/jim-2020-001301, PubMed 32184228 -
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology (Basel), 9 (3)
DOI 10.3390/biology9030059, PubMed 32245178 -
Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9
Mol Cancer Res, 18 (10), 1512-1521
DOI 10.1158/1541-7786.MCR-20-0339, PubMed 32611550 -
AR and ERG drive the expression of prostate cancer specific long noncoding RNAs
Oncogene, 39 (30), 5241-5251
DOI 10.1038/s41388-020-1365-6, PubMed 32555329 -
Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among BRCA1 and BRCA2 mutation carriers
Int J Gynecol Cancer, 30 (6), 825-830
DOI 10.1136/ijgc-2019-001141, PubMed 32354794 -
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071719, PubMed 32605315 -
The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care
Hered Cancer Clin Pract, 18, 6
DOI 10.1186/s13053-020-0138-0, PubMed 32190163 -
Correction: Møller, P.; et al. Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift. Cancers 2019, 11, 132
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020410, PubMed 32050665 -
Letter to the Editor-Recent advances in Lynch syndrome
Fam Cancer, 20 (2), 117-118
DOI 10.1007/s10689-020-00200-6, PubMed 32770425 -
Breast cancer survival in Nordic BRCA2 mutation carriers-unconventional association with oestrogen receptor status
Br J Cancer, 123 (11), 1608-1615
DOI 10.1038/s41416-020-01056-4, PubMed 32939053 -
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
JCI Insight, 5 (12)
DOI 10.1172/jci.insight.137495, PubMed 32365348 -
MLH1 intronic variants mapping to + 5 position of splice donor sites lead to deleterious effects on RNA splicing
Fam Cancer, 19 (4), 323-336
DOI 10.1007/s10689-020-00182-5, PubMed 32363481 -
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
Acta Oncol, 59 (7), 733-740
DOI 10.1080/0284186X.2020.1742377, PubMed 32208873 -
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Front Oncol, 10, 523860
DOI 10.3389/fonc.2020.523860, PubMed 33344219 -
The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research
F1000Res, 9
DOI 10.12688/f1000research.24887.1, PubMed 34367618 -
Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD)
Fam Cancer, 20 (1), 35-39
DOI 10.1007/s10689-020-00193-2, PubMed 32507935 -
Structural Variants of poly(alkylcyanoacrylate) Nanoparticles Differentially Affect LC3 and Autophagic Cargo Degradation
J Biomed Nanotechnol, 16 (4), 432-445
DOI 10.1166/jbn.2020.2906, PubMed 32970976 -
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878 -
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858 -
Accuracy and efficiency of germline variant calling pipelines for human genome data
Sci Rep, 10 (1), 20222
DOI 10.1038/s41598-020-77218-4, PubMed 33214604
Publications 2019
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The β2-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Mol Cancer Res, 17 (11), 2154-2168
DOI 10.1158/1541-7786.MCR-18-0605, PubMed 31395667 -
Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer
Endocr Relat Cancer, 26 (4), R211-R235
DOI 10.1530/ERC-18-0579, PubMed 30844748 -
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
Genet Med, 21 (10), 2390-2400
DOI 10.1038/s41436-019-0489-y, PubMed 30918358 -
A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries
Eur J Cancer, 119, 112-121
DOI 10.1016/j.ejca.2019.07.017, PubMed 31442815 -
Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing
Sci Rep, 9 (1), 18555
DOI 10.1038/s41598-019-54517-z, PubMed 31811167 -
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Genet Med, 22 (1), 15-25
DOI 10.1038/s41436-019-0596-9, PubMed 31337882 -
Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
Hered Cancer Clin Pract, 17, 28
DOI 10.1186/s13053-019-0127-3, PubMed 31636762 -
Drivers of AR indifferent anti-androgen resistance in prostate cancer cells
Sci Rep, 9 (1), 13786
DOI 10.1038/s41598-019-50220-1, PubMed 31551480 -
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
Theranostics, 9 (8), 2183-2197
DOI 10.7150/thno.30834, PubMed 31149037 -
Colocalization analyses of genomic elements: approaches, recommendations and challenges
Bioinformatics, 35 (9), 1615-1624
DOI 10.1093/bioinformatics/bty835, PubMed 30307532 -
Oophorectomy and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers
Breast Cancer Res Treat, 175 (2), 443-449
DOI 10.1007/s10549-019-05162-7, PubMed 30756284 -
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609 -
International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation
Br J Cancer, 121 (1), 15-21
DOI 10.1038/s41416-019-0446-1, PubMed 30971774 -
Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift
Cancers (Basel), 11 (2)
DOI 10.3390/cancers11020132, PubMed 30678073 -
Roadmap for a precision-medicine initiative in the Nordic region
Nat Genet, 51 (6), 924-930
DOI 10.1038/s41588-019-0391-1, PubMed 30988515 -
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995 -
Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries
Front Immunol, 10, 2796
DOI 10.3389/fimmu.2019.02796, PubMed 31849974 -
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006 -
Response to Tolva et al
Genet Med, 22 (4), 813-814
DOI 10.1038/s41436-019-0717-5, PubMed 31801985 -
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
Hered Cancer Clin Pract, 17, 8
DOI 10.1186/s13053-019-0106-8, PubMed 30858900 -
The Apparent Genetic Anticipation in PMS2-Associated Lynch Syndrome Families Is Explained by Birth-cohort Effect
Cancer Epidemiol Biomarkers Prev, 28 (6), 1010-1014
DOI 10.1158/1055-9965.EPI-18-0576, PubMed 30824524 -
Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions
Drug Resist Updat, 48, 100662
DOI 10.1016/j.drup.2019.100662, PubMed 31927437
Publications 2018
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Patterns of genomic evolution in advanced melanoma
Nat Commun, 9 (1), 2665
DOI 10.1038/s41467-018-05063-1, PubMed 29991680 -
Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds
Hered Cancer Clin Pract, 16, 4
DOI 10.1186/s13053-018-0086-0, PubMed 29371908 -
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families
Fam Cancer, 17 (1), 141-153
DOI 10.1007/s10689-017-0011-0, PubMed 28608266 -
Identification of genetic variants for clinical management of familial colorectal tumors
BMC Med Genet, 19 (1), 26
DOI 10.1186/s12881-018-0533-9, PubMed 29458332 -
Ancient genomes from Iceland reveal the making of a human population
Science, 360 (6392), 1028-1032
DOI 10.1126/science.aar2625, PubMed 29853688 -
Universal determination of microsatellite instability using BAT26 as a single marker in an Argentine colorectal cancer cohort
Fam Cancer, 17 (3), 395-402
DOI 10.1007/s10689-017-0052-4, PubMed 29128931 -
Mitochondrial mutations associated with hearing and balance disorders
Mutat Res, 810, 39-44
DOI 10.1016/j.mrfmmm.2018.03.003, PubMed 29615272 -
Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers
Int J Epidemiol, 47 (3), 987-997
DOI 10.1093/ije/dyy039, PubMed 29547931 -
Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation
Gynecol Oncol, 150 (1), 85-91
DOI 10.1016/j.ygyno.2018.05.011, PubMed 29793803 -
Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers
JAMA Oncol, 4 (8), 1059-1065
DOI 10.1001/jamaoncol.2018.0211, PubMed 29710224 -
Evaluation of MLH1 variants of unclear significance
Genes Chromosomes Cancer, 57 (7), 350-358
DOI 10.1002/gcc.22536, PubMed 29520894 -
Retraction Note to: The BRCA2 variant c.68-7 T > A is associated with breast cancer
Hered Cancer Clin Pract, 16, 10
DOI 10.1186/s13053-018-0093-1, PubMed 29745381 -
Cancer Risks for PMS2-Associated Lynch Syndrome
J Clin Oncol, 36 (29), 2961-2968
DOI 10.1200/JCO.2018.78.4777, PubMed 30161022 -
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
Int J Cancer, 145 (2), 318-326
DOI 10.1002/ijc.31920, PubMed 30303536 -
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8 (1), 5307
DOI 10.1038/s41598-018-23563-4, PubMed 29593270
Publications 2017
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Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?
BMC Cancer, 17 (1), 406
DOI 10.1186/s12885-017-3365-7, PubMed 28592327 -
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr Pharm Des, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936, PubMed 28699527 -
The rainfall plot: its motivation, characteristics and pitfalls
BMC Bioinformatics, 18 (1), 264
DOI 10.1186/s12859-017-1679-8, PubMed 28521741 -
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924 -
Genome build information is an essential part of genomic track files
Genome Biol, 18 (1), 175
DOI 10.1186/s13059-017-1312-1, PubMed 28911336 -
HPV Genotyping of Modified General Primer-Amplicons Is More Analytically Sensitive and Specific by Sequencing than by Hybridization
PLoS One, 12 (1), e0169074
DOI 10.1371/journal.pone.0169074, PubMed 28045981 -
The BRCA2 variant c.68-7 T>A is associated with breast cancer
Hered Cancer Clin Pract, 15, 20 (Retracted)
DOI 10.1186/s13053-017-0080-y, PubMed 29158857 -
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
Gut, 67 (7), 1306-1316
DOI 10.1136/gutjnl-2017-314057, PubMed 28754778 -
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
BMC Cancer, 17 (1), 29
DOI 10.1186/s12885-016-2992-8, PubMed 28061772 -
Reply to Towfic and others' letter to the editor
Biostatistics, 18 (3), 586-587
DOI 10.1093/biostatistics/kxx001, PubMed 28334081 -
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742 -
Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis
BMC Clin Pathol, 17, 6
DOI 10.1186/s12907-017-0042-3, PubMed 28405177 -
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
BMC Cancer, 17 (1), 623
DOI 10.1186/s12885-017-3599-4, PubMed 28874130 -
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report
Hered Cancer Clin Pract, 15, 18
DOI 10.1186/s13053-017-0078-5, PubMed 29046738 -
GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome
Gigascience, 6 (7), 1-12
DOI 10.1093/gigascience/gix032, PubMed 28459977
Publications 2016
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MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma
Oncotarget, 7 (34), 55128-55140
DOI 10.18632/oncotarget.10422, PubMed 27391157 -
Scanning the mitochondrial genome for mutations by cycling temperature capillary electrophoresis
Mitochondrial DNA A DNA Mapp Seq Anal, 29 (1), 19-30
DOI 10.1080/24701394.2016.1233532, PubMed 27728990 -
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
J Immunol, 196 (3), 1400-11
DOI 10.4049/jimmunol.1501434, PubMed 26746188 -
Galaxy Portal: interacting with the galaxy platform through mobile devices
Bioinformatics, 32 (11), 1743-5
DOI 10.1093/bioinformatics/btw042, PubMed 26819474 -
Profiling networks of distinct immune-cells in tumors
BMC Bioinformatics, 17 (1), 263
DOI 10.1186/s12859-016-1141-3, PubMed 27377892 -
Update on Hereditary Colorectal Cancer
Anticancer Res, 36 (9), 4399-405
DOI 10.21873/anticanres.10983, PubMed 27630275 -
Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization
Sci Rep, 6, 35985
DOI 10.1038/srep35985, PubMed 27786255 -
MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
Front Oncol, 6, 189
DOI 10.3389/fonc.2016.00189, PubMed 27606285 -
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894 -
Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms
Pancreas, 45 (8), 1196-203
DOI 10.1097/MPA.0000000000000610, PubMed 26918873 -
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076 -
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
DOI 10.1038/bjc.2016.278, PubMed 27599042 -
Tp53/p53 status in keratoacanthomas
J Cutan Pathol, 43 (7), 571-8
DOI 10.1111/cup.12713, PubMed 27020606 -
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil Steril, 105 (5), 1170-1179.e5
DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768 -
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database
Gut, 66 (9), 1657-1664
DOI 10.1136/gutjnl-2016-311403, PubMed 27261338 -
Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study
Tumour Biol, 37 (8), 11065-72
DOI 10.1007/s13277-015-4742-y, PubMed 26906551 -
Lynch syndrome in South America: past, present and future
Fam Cancer, 15 (3), 437-45
DOI 10.1007/s10689-016-9903-7, PubMed 27007491
Publications 2015
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A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
Nat Commun, 6, 10001
DOI 10.1038/ncomms10001, PubMed 26647970 -
c-Myb Binding Sites in Haematopoietic Chromatin Landscapes
PLoS One, 10 (7), e0133280
DOI 10.1371/journal.pone.0133280, PubMed 26208222 -
Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis
PLoS One, 10 (3), e0119566
DOI 10.1371/journal.pone.0119566, PubMed 25793388 -
Automated amplicon design suitable for analysis of DNA variants by melting techniques
BMC Res Notes, 8, 667
DOI 10.1186/s13104-015-1624-8, PubMed 26559640 -
Ten modifiers of BRCA1 penetrance validated in a Norwegian series
Hered Cancer Clin Pract, 13 (1), 14
DOI 10.1186/s13053-015-0035-0, PubMed 26052370 -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641 -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252 -
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
Gut, 66 (3), 464-472
DOI 10.1136/gutjnl-2015-309675, PubMed 26657901 -
Methods that remove batch effects while retaining group differences may lead to exaggerated confidence in downstream analyses
Biostatistics, 17 (1), 29-39
DOI 10.1093/biostatistics/kxv027, PubMed 26272994 -
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Blood Cancer J, 5 (3), e299
DOI 10.1038/bcj.2015.24, PubMed 25794135 -
ClusTrack: feature extraction and similarity measures for clustering of genome-wide data sets
PLoS One, 10 (4), e0123261
DOI 10.1371/journal.pone.0123261, PubMed 25879845 -
Investigation of established genetic risk variants for glioma in prediagnostic samples from a population-based nested case-control study
Cancer Epidemiol Biomarkers Prev, 24 (5), 810-6
DOI 10.1158/1055-9965.EPI-14-1106, PubMed 25713050
Publications 2014
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Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15 (1), 449
DOI 10.1186/1471-2164-15-449, PubMed 24912484 -
From proteomes to complexomes in the era of systems biology
Proteomics, 14 (1), 24-41
DOI 10.1002/pmic.201300230, PubMed 24243660 -
Differential protein network analysis of the immune cell lineage
Biomed Res Int, 2014, 363408
DOI 10.1155/2014/363408, PubMed 25309909 -
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis
Int J Mol Med, 35 (1), 24-30
DOI 10.3892/ijmm.2014.1974, PubMed 25333414 -
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699 -
Melanoma brain colonization involves the emergence of a brain-adaptive phenotype
Oncoscience, 1 (1), 82-94
DOI 10.18632/oncoscience.11, PubMed 25593989 -
A statistical model of ChIA-PET data for accurate detection of chromatin 3D interactions
Nucleic Acids Res, 42 (18), e143
DOI 10.1093/nar/gku738, PubMed 25114054 -
HiBrowse: multi-purpose statistical analysis of genome-wide chromatin 3D organization
Bioinformatics, 30 (11), 1620-2
DOI 10.1093/bioinformatics/btu082, PubMed 24511080
Publications 2013
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Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties
Cancer Lett, 344 (1), 28-39
DOI 10.1016/j.canlet.2013.10.036, PubMed 24215866 -
Light-induced mRNA transfection
Methods Mol Biol, 969, 89-100
DOI 10.1007/978-1-62703-260-5_6, PubMed 23296929 -
Light-controlled modulation of gene expression using polyamidoamine formulations
Nucleic Acid Ther, 23 (2), 160-5
DOI 10.1089/nat.2012.0413, PubMed 23530684 -
Predicting physical interactions between protein complexes
Mol Cell Proteomics, 12 (6), 1723-34
DOI 10.1074/mcp.O112.019828, PubMed 23438732 -
Substantial loss of conserved and gain of novel MicroRNA families in flatworms
Mol Biol Evol, 30 (12), 2619-28
DOI 10.1093/molbev/mst155, PubMed 24025793 -
Evaluation of biodegradable peptide carriers for light-directed targeting
Nucleic Acid Ther, 23 (2), 131-9
DOI 10.1089/nat.2012.0403, PubMed 23405950 -
Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling
J Pathol, 230 (1), 59-69
DOI 10.1002/path.4168, PubMed 23335387 -
Molecular profiling of tumor-specific TH1 cells activated in vivo
Oncoimmunology, 2 (5), e24383
DOI 10.4161/onci.24383, PubMed 23762808 -
Handling realistic assumptions in hypothesis testing of 3D co-localization of genomic elements
Nucleic Acids Res, 41 (10), 5164-74
DOI 10.1093/nar/gkt227, PubMed 23571755 -
The Genomic HyperBrowser: an analysis web server for genome-scale data
Nucleic Acids Res, 41 (Web Server issue), W133-41
DOI 10.1093/nar/gkt342, PubMed 23632163 -
Ten simple rules for reproducible computational research
PLoS Comput Biol, 9 (10), e1003285
DOI 10.1371/journal.pcbi.1003285, PubMed 24204232 -
Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer
PLoS One, 8 (6), e66165
DOI 10.1371/journal.pone.0066165, PubMed 23824282 -
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk Lymphoma, 54 (10), 2205-14
DOI 10.3109/10428194.2013.774392, PubMed 23391141
Publications 2012
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Separation principles of cycling temperature capillary electrophoresis
Electrophoresis, 33 (7), 1162-8
DOI 10.1002/elps.201100550, PubMed 22539319 -
Potent gene silencing in vitro at physiological pH using chitosan polymers
Nucleic Acid Ther, 22 (2), 96-102
DOI 10.1089/nat.2011.0335, PubMed 22480314 -
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
PLoS One, 7 (11), e48262
DOI 10.1371/journal.pone.0048262, PubMed 23144859 -
Performance comparison of multiple microarray platforms for gene expression profiling
Methods Mol Biol, 802, 141-55
DOI 10.1007/978-1-61779-400-1_10, PubMed 22130879 -
Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways
Neuroimage, 70, 143-9
DOI 10.1016/j.neuroimage.2012.12.035, PubMed 23274185 -
CellLineMiner: a knowledge portal for human cell lines
Bioinformation, 8 (22), 1119-22
DOI 10.6026/97320630081119, PubMed 23251048 -
Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection
BMC Syst Biol, 6, 11
DOI 10.1186/1752-0509-6-11, PubMed 22316093 -
Understanding the melanocyte distribution in human epidermis: an agent-based computational model approach
PLoS One, 7 (7), e40377
DOI 10.1371/journal.pone.0040377, PubMed 22792296 -
A primer on the current state of microarray technologies
Methods Mol Biol, 802, 3-17
DOI 10.1007/978-1-61779-400-1_1, PubMed 22130870 -
Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
Leuk Lymphoma, 53 (10), 1934-44
DOI 10.3109/10428194.2012.682307, PubMed 22475179
Publications 2011
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Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis
Allergy, 67 (1), 33-40
DOI 10.1111/j.1398-9995.2011.02707.x, PubMed 21919915 -
Light-directed delivery of nucleic acids
Methods Mol Biol, 764, 107-21
DOI 10.1007/978-1-61779-188-8_7, PubMed 21748636 -
A novel photosensitizer for light-controlled gene silencing
Nucleic Acid Ther, 21 (5), 359-67
DOI 10.1089/nat.2011.0309, PubMed 22004417 -
Immunological network signatures of cancer progression and survival
BMC Med Genomics, 4, 28
DOI 10.1186/1755-8794-4-28, PubMed 21453479 -
Introducing Dynamics into the Field of Biosemiotics A Formal Account with Examples from Language and Immunology
Biosemiotics, 4 (1), 5-24
DOI 10.1007/s12304-010-9101-1 -
Identifying elemental genomic track types and representing them uniformly
BMC Bioinformatics, 12, 494
DOI 10.1186/1471-2105-12-494, PubMed 22208806 -
Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer
Clin Cancer Res, 17 (16), 5501-12
DOI 10.1158/1078-0432.CCR-11-0297, PubMed 21737508 -
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
BMC Cancer, 11, 455
DOI 10.1186/1471-2407-11-455, PubMed 22014070 -
The differential disease regulome
BMC Genomics, 12, 353
DOI 10.1186/1471-2164-12-353, PubMed 21736759 -
A mild form of Mucopolysaccharidosis IIIB diagnosed with targeted next-generation sequencing of linked genomic regions
Eur J Hum Genet, 20 (1), 58-63
DOI 10.1038/ejhg.2011.126, PubMed 21712855 -
CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
Genes Immun, 12 (8), 653-62
DOI 10.1038/gene.2011.43, PubMed 21716316
Publications 2010
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Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
J Cell Biol, 188 (5), 629-38
DOI 10.1083/jcb.200905059, PubMed 20194642 -
Light-induced gene expression using messenger RNA molecules
Oligonucleotides, 20 (1), 1-6
DOI 10.1089/oli.2009.0209, PubMed 20038251 -
Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing
Oligonucleotides, 20 (4), 175-82
DOI 10.1089/oli.2010.0230, PubMed 20645877 -
Increased miR-21 expression during human monocyte differentiation into DCs
Front Biosci (Elite Ed), 2 (3), 818-28
DOI 10.2741/e143, PubMed 20515755 -
Impact of DNA physical properties on local sequence bias of human mutation
Hum Mutat, 31 (12), 1316-25
DOI 10.1002/humu.21371, PubMed 20886615 -
Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation
PLoS Comput Biol, 6 (12), e1001032
DOI 10.1371/journal.pcbi.1001032, PubMed 21187905 -
The Genomic HyperBrowser: inferential genomics at the sequence level
Genome Biol, 11 (12), R121
DOI 10.1186/gb-2010-11-12-r121, PubMed 21182759 -
Profiling of miRNA expression and prediction of target genes
Methods Mol Biol, 629, 257-71
DOI 10.1007/978-1-60761-657-3_16, PubMed 20387154
Publications 2009
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Monitoring B cell response to immunoselected phage-displayed peptides by microarrays
Methods Mol Biol, 524, 273-85
DOI 10.1007/978-1-59745-450-6_20, PubMed 19377952 -
Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
Leuk Res, 33 (10), 1379-85
DOI 10.1016/j.leukres.2009.03.028, PubMed 19394083 -
The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts
Nucleic Acids Res, 37 (17), 5749-56
DOI 10.1093/nar/gkp590, PubMed 19617376 -
Large-scale inference of the point mutational spectrum in human segmental duplications
BMC Genomics, 10, 43
DOI 10.1186/1471-2164-10-43, PubMed 19161616 -
Methods for quantitation of gene expression
Front Biosci (Landmark Ed), 14 (2), 552-69
DOI 10.2741/3262, PubMed 19273085 -
The mathematics of tanning
BMC Syst Biol, 3, 60
DOI 10.1186/1752-0509-3-60, PubMed 19505344
Publications 2008
-
Evaluation of various polyethylenimine formulations for light-controlled gene silencing using small interfering RNA molecules
Oligonucleotides, 18 (2), 123-32
DOI 10.1089/oli.2008.0131, PubMed 18637730 -
Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes
Int J Cancer, 123 (6), 1301-10
DOI 10.1002/ijc.23617, PubMed 18548584 -
The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes
Cancer Res, 68 (7), 2514-22
DOI 10.1158/0008-5472.CAN-07-2776, PubMed 18381461 -
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
DOI 10.1186/gb-2008-9-5-r86, PubMed 18500990 -
Cell sampling and global nucleic acid amplification
SEB Exp Biol Ser, 61, 17-36
PubMed 18709735 -
Validation of oligoarrays for quantitative exploration of the transcriptome
BMC Genomics, 9, 258
DOI 10.1186/1471-2164-9-258, PubMed 18513391 -
Expression profiling of microRNAs in cancer cells: technical considerations
Methods Mol Biol, 439, 179-90
DOI 10.1007/978-1-59745-188-8_12, PubMed 18370103 -
A stitch in time: efficient computation of genomic DNA melting bubbles
Algorithms Mol Biol, 3, 10
DOI 10.1186/1748-7188-3-10, PubMed 18637171 -
Segmentation of DNA sequences into twostate regions and melting fork regions
J Phys Condens Matter, 21 (3), 034109
DOI 10.1088/0953-8984/21/3/034109, PubMed 21817254
Publications 2007
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Connectivity can be used to identify key genes in DNA microarray data: a study based on gene expression in nasal polyps before and after treatment with glucocorticoids
Acta Otolaryngol, 127 (10), 1074-9
DOI 10.1080/00016480701200277, PubMed 17851899 -
Photochemically induced gene silencing using small interfering RNA molecules in combination with lipid carriers
Oligonucleotides, 17 (2), 166-73
DOI 10.1089/oli.2007.0076, PubMed 17638521 -
Protein arrays: a versatile toolbox for target identification and monitoring of patient immune responses
Methods Mol Biol, 360, 335-48
DOI 10.1385/1-59745-165-7:335, PubMed 17172738 -
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate
BMC Genomics, 8, 273
DOI 10.1186/1471-2164-8-273, PubMed 17692132 -
Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates
BMC Genomics, 8, 153
DOI 10.1186/1471-2164-8-153, PubMed 17555589 -
The human genomic melting map
PLoS Comput Biol, 3 (5), e93
DOI 10.1371/journal.pcbi.0030093, PubMed 17511513 -
Genetic epidemiology of BRCA mutations--family history detects less than 50% of the mutation carriers
Eur J Cancer, 43 (11), 1713-7
DOI 10.1016/j.ejca.2007.04.023, PubMed 17574839 -
Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs
Biochem Biophys Res Commun, 361 (1), 122-6
DOI 10.1016/j.bbrc.2007.06.177, PubMed 17658482
Publications 2006
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Sampling effects on gene expression data from a human tumour xenograft
Scand. J. Lab. Anim. Sci., 33 (1), 17-30 -
Photochemically induced gene silencing using PNA-peptide conjugates
Oligonucleotides, 16 (2), 145-57
DOI 10.1089/oli.2006.16.145, PubMed 16764538 -
Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
J Mol Biol, 365 (1), 90-108
DOI 10.1016/j.jmb.2006.09.034, PubMed 17054988 -
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies
Nat Biotechnol, 24 (7), 832-40
DOI 10.1038/nbt1217, PubMed 16823376 -
Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling
Nucleic Acids Res, 34 (3), 996-1014
DOI 10.1093/nar/gkj499, PubMed 16473852 -
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
FEBS Lett, 580 (24), 5739-46
DOI 10.1016/j.febslet.2006.09.028, PubMed 17007842 -
MUTYH Mutations Do Not Cause HNPCC or Late Onset Familial Colorectal Cancer
Hered Cancer Clin Pract, 4 (2), 90-3
DOI 10.1186/1897-4287-4-2-90, PubMed 20223013
Publications 2005
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Parallel nanoliter detection of cancer markers using polymer microchips
Lab Chip, 5 (4), 416-20
DOI 10.1039/b415525d, PubMed 15791339 -
Gene-expression profiling in breast cancer
Lancet, 365 (9460), 634-5
DOI 10.1016/S0140-6736(05)17959-8, PubMed 15721457 -
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
DOI 10.1002/ijc.20962, PubMed 15723354 -
Limitations of mRNA amplification from small-size cell samples
BMC Genomics, 6, 147
DOI 10.1186/1471-2164-6-147, PubMed 16253144 -
Partly melted DNA conformations obtained with a probability peak finding method
Phys Rev E Stat Nonlin Soft Matter Phys, 71 (6 Pt 1), 061922
DOI 10.1103/PhysRevE.71.061922, PubMed 16089780 -
Stitchprofiles.uio.no: analysis of partly melted DNA conformations using stitch profiles
Nucleic Acids Res, 33 (Web Server issue), W573-6
DOI 10.1093/nar/gki424, PubMed 15980539
Publications 2004
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BRCA1 mutations in ovarian cancer and borderline tumours in Norway: a nested case-control study
Br J Cancer, 91 (10), 1829-34
DOI 10.1038/sj.bjc.6602199, PubMed 15477862 -
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-82
DOI 10.1002/pmic.200300768, PubMed 15352232 -
Double-sided silicon strip detectors: new applications within genomics and proteomics
Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip., 527 (1-2), 68-72
DOI 10.1016/j.nima.2004.03.063 -
The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
Cell Commun Adhes, 11 (5-6), 155-71
DOI 10.1080/15419060500242877, PubMed 16194882 -
Determination of hereditary mutations in the BRCA1 gene using archived serum samples and capillary electrophoresis
Anal Chem, 76 (15), 4406-9
DOI 10.1021/ac049788k, PubMed 15283579 -
Real-time nucleic acid sequence-based amplification in nanoliter volumes
Anal Chem, 76 (1), 9-14
DOI 10.1021/ac034779h, PubMed 14697026 -
A primer on gene expression and microarrays for machine learning researchers
J Biomed Inform, 37 (4), 293-303
DOI 10.1016/j.jbi.2004.07.002, PubMed 15465482 -
Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 97 (5), 584-91
DOI 10.1016/j.tripleo.2003.11.016, PubMed 15153870 -
FigSearch: a figure legend indexing and classification system
Bioinformatics, 20 (16), 2880-2
DOI 10.1093/bioinformatics/bth316, PubMed 15145804 -
FigSearch: Using maximum entropy classifier to categorize biological figures
2004 IEEE COMPUTATIONAL SYSTEMS BIOINFORMATICS CONFERENCE, PROCEEDINGS, 476-477 -
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
DOI 10.1186/1471-2164-5-10, PubMed 15018648 -
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
J Mol Diagn, 6 (4), 297-307
DOI 10.1016/S1525-1578(10)60525-9, PubMed 15507668 -
Downregulation of tissue factor by RNA interference in human melanoma LOX-L cells reduces pulmonary metastasis in nude mice
Int J Cancer, 112 (6), 994-1002
DOI 10.1002/ijc.20527, PubMed 15386437
Publications 2003
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Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest
Br J Cancer, 88 (12), 1995-2001
DOI 10.1038/sj.bjc.6600998, PubMed 12799648 -
ABI3 mediates expression of the peroxiredoxin antioxidant AtPER1 gene and induction by oxidative stress
Plant Mol Biol, 53 (3), 313-26
DOI 10.1023/b:plan.0000006937.21343.2a, PubMed 14750521 -
Seed 1-cysteine peroxiredoxin antioxidants are not involved in dormancy, but contribute to inhibition of germination during stress
Plant Physiol, 133 (3), 1148-57
DOI 10.1104/pp.103.025916, PubMed 14526116 -
Microarrays and clinical dentistry
J Am Dent Assoc, 134 (4), 456-62
DOI 10.14219/jada.archive.2003.0195, PubMed 12733779 -
S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
Clin Exp Metastasis, 20 (8), 701-11
DOI 10.1023/b:clin.0000006819.21361.03, PubMed 14713104 -
Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance
BMC Genomics, 4 (1), 11
DOI 10.1186/1471-2164-4-11, PubMed 12659661 -
Speed-up of DNA melting algorithm with complete nearest neighbor properties
Biopolymers, 70 (3), 364-76
DOI 10.1002/bip.10495, PubMed 14579309 -
Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data
BMC Bioinformatics, 4, 60
DOI 10.1186/1471-2105-4-60, PubMed 14651757 -
MGraph: graphical models for microarray data analysis
Bioinformatics, 19 (17), 2210-1
DOI 10.1093/bioinformatics/btg298, PubMed 14630649
Publications 2002
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The semantic web and biology
Drug Discov Today, 7 (19), 992
DOI 10.1016/s1359-6446(02)02458-3, PubMed 12546914 -
Associations between gene expressions in breast cancer and patient survival
Hum Genet, 111 (4-5), 411-20
DOI 10.1007/s00439-002-0804-5, PubMed 12384785 -
Analysis of repeatability in spotted cDNA microarrays
Nucleic Acids Res, 30 (14), 3235-44
DOI 10.1093/nar/gkf441, PubMed 12136105 -
Analysis of matched mRNA measurements from two different microarray technologies
Bioinformatics, 18 (3), 405-12
DOI 10.1093/bioinformatics/18.3.405, PubMed 11934739 -
Gene expression levels in different stages of progression in oral squamous cell carcinoma
Proc AMIA Symp, 415-9
PubMed 12474876 -
Gene expression profiling by DNA microarrays and its application to dental research
Oral Oncol, 38 (7), 650-6
DOI 10.1016/s1368-8375(02)00013-1, PubMed 12353490 -
Comparing imperfect measurements with the Bland-Altman technique: application in gene expression analysis
Proc AMIA Symp, 572-6
PubMed 12463888 -
Differential display analysis of breast carcinoma cells enriched by immunomagnetic target cell selection: gene expression profiles in bone marrow target cells
Int J Cancer, 97 (1), 28-33
DOI 10.1002/ijc.1564, PubMed 11774240 -
Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
Oncogene, 21 (57), 8878-84
DOI 10.1038/sj.onc.1205978, PubMed 12483540 -
MArray: analysing single, replicated or reversed microarray experiments
Bioinformatics, 18 (8), 1139-40
DOI 10.1093/bioinformatics/18.8.1139, PubMed 12176840
Publications 2001
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Detection of mutations by denaturing gradient gel electrophoresis
Curr Protoc Hum Genet, Chapter 7, Unit 7.5
DOI 10.1002/0471142905.hg0705s17, PubMed 18428306 -
Optimization of hammerhead ribozymes for the cleavage of S100A4 (CAPL) mRNA
Antisense Nucleic Acid Drug Dev, 11 (2), 67-75
DOI 10.1089/108729001750171272, PubMed 11334142 -
CA 125: the end of the beginning
Tumour Biol, 22 (6), 345-7
DOI 10.1159/000050637, PubMed 11786728 -
A literature network of human genes for high-throughput analysis of gene expression
Nat Genet, 28 (1), 21-8
DOI 10.1038/ng0501-21, PubMed 11326270 -
[New knowledge derived from measurement of gene expression with the DNA microarray method]
Tidsskr Nor Laegeforen, 121 (10), 1229-32
PubMed 11402750 -
Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors
Genes Chromosomes Cancer, 30 (2), 202-6
DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1079>3.0.CO;2-5, PubMed 11135438 -
The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series
Eur J Cancer, 37 (8), 1027-32
DOI 10.1016/s0959-8049(01)00075-2, PubMed 11334729 -
Genetic epidemiology of BRCA1 mutations in Norway
Eur J Cancer, 37 (18), 2428-34
DOI 10.1016/s0959-8049(01)00299-4, PubMed 11720839 -
Detection of mutations by single-strand conformation polymorphism (SSCP) analysis and SSCP-hybrid methods
Curr Protoc Hum Genet, Chapter 7, Unit 7.4
DOI 10.1002/0471142905.hg0704s15, PubMed 18428305
Publications 2000
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Towards Knowledge Discovery from cDNA Microarray Gene Expression Data
Lect. Notes Comput. Sci., 1910, 470-475
Publications 1999
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S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme
Cancer Res, 59 (18), 4702-8
PubMed 10493528 -
BRCA1 1675delA and 1135insA account for one third of Norwegian familial breast-ovarian cancer and are associated with later disease onset than less frequent mutations
Dis Markers, 15 (1-3), 79-84
DOI 10.1155/1999/278269, PubMed 10595257 -
No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
Int J Radiat Biol, 75 (9), 1149-60
DOI 10.1080/095530099139629, PubMed 10528923 -
Penetrances of BRCA1 1675delA and 1135insA with respect to breast cancer and ovarian cancer
Am J Hum Genet, 65 (3), 671-9
DOI 10.1086/302530, PubMed 10441573 -
Three per cent of Norwegian ovarian cancers are caused by BRCA1 1675delA or 1135insA
Eur J Cancer, 35 (5), 779-81
DOI 10.1016/s0959-8049(99)00050-7, PubMed 10505039 -
TP53 as a predictor of response to chemotherapy in breast cancer
ESO SCI UPDATES, 4, 73-88 -
Expression of a novel factor in human breast cancer cells with metastatic potential
Cancer Res, 59 (18), 4675-80
PubMed 10493524 -
Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells
Int J Cancer, 80 (1), 119-25
DOI 10.1002/(sici)1097-0215(19990105)80:1<119::aid-ijc22>3.0.co;2-x, PubMed 9935241 -
Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53
Hum Genet, 104 (1), 15-22
DOI 10.1007/s004390050904, PubMed 10071187
Publications 1998
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Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL
Anticancer Res, 18 (5A), 3299-303
PubMed 9858899 -
Intracellular metabolism of a 2'-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or asfree ribozyme. A study by capillary electrophoresis
Nucleic Acids Res, 26 (18), 4241-8
DOI 10.1093/nar/26.18.4241, PubMed 9722645
Publications 1997
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Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein gene EGP-2
Int J Cancer, 72 (1), 191-6
DOI 10.1002/(sici)1097-0215(19970703)72:1<191::aid-ijc27>3.0.co;2-l, PubMed 9212242 -
A BRCA1 founder mutation, identified with haplotype analysis, allowing genotype/phenotype determination and predictive testing
Eur J Cancer, 33 (14), 2390-2
DOI 10.1016/s0959-8049(97)00328-6, PubMed 9616287 -
Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects
Nucleic Acids Res, 25 (1), 151-7
DOI 10.1093/nar/25.1.151, PubMed 9016527 -
Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma
Int J Cancer, 74 (4), 464-9
DOI 10.1002/(sici)1097-0215(19970822)74:4<464::aid-ijc19>3.0.co;2-9, PubMed 9291441
Publications 1996
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Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation
Nucleic Acids Res, 24 (1), 141-6
DOI 10.1093/nar/24.1.141, PubMed 8594564 -
[Prostate-specific membrane antigen]
Tidsskr Nor Laegeforen, 116 (3), 411-2
PubMed 8638273 -
Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
Br J Cancer, 73 (8), 909-16
DOI 10.1038/bjc.1996.181, PubMed 8611425 -
Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme
Cancer Res, 56 (23), 5490-8
PubMed 8968106 -
CDKN2A (p16INK4A) somatic and germline mutations
Hum Mutat, 7 (4), 294-303
DOI 10.1002/(SICI)1098-1004(1996)7:4<294::AID-HUMU2>3.0.CO;2-9, PubMed 8723678 -
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
Nat Med, 2 (7), 811-4
DOI 10.1038/nm0796-811, PubMed 8673929
Publications 1995
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Semiquantitative polymerase chain reaction for t(14;18) in follicular lymphomas: a colorimetric approach
Lab Invest, 72 (4), 411-8
PubMed 7723279 -
Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and by selection
Hum Mutat, 5 (1), 48-57
DOI 10.1002/humu.1380050107, PubMed 7728149 -
Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1
Br J Cancer, 72 (2), 393-8
DOI 10.1038/bjc.1995.344, PubMed 7640224
Publications 1994
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Database of p53 gene somatic mutations in human tumors and cell lines
Nucleic Acids Res, 22 (17), 3551-5
PubMed 7937055 -
Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma
J Clin Oncol, 12 (5), 925-30
DOI 10.1200/JCO.1994.12.5.925, PubMed 8164043
Publications 1993
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p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179
Publications 1992
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Screening for germ line TP53 mutations in breast cancer patients
Cancer Res, 52 (11), 3234-6
PubMed 1591732 -
No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung
Genes Chromosomes Cancer, 5 (2), 97-103
DOI 10.1002/gcc.2870050202, PubMed 1381957 -
Detection of DNA variation in cancer
Pharmacogenetics, 2 (6), 317-28
DOI 10.1097/00008571-199212000-00011, PubMed 1306133 -
Screening for mutations in human HPRT cDNA using the polymerase chain reaction (PCR) in combination with constant denaturant gel electrophoresis (CDGE)
Mutat Res, 269 (1), 41-53
DOI 10.1016/0027-5107(92)90159-y, PubMed 1381470
Publications 1991
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T-cell receptor tau delta +/CD3+4-8-T- cell acute lymphoblastic leukemias: a distinct subgroup of leukemias in children. A report of five cases
Blood, 77 (9), 2023-30
PubMed 1826854 -
Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations
Proc Natl Acad Sci U S A, 88 (19), 8405-9
DOI 10.1073/pnas.88.19.8405, PubMed 1924299 -
Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection
Mutat Res, 263 (1), 61
DOI 10.1016/0165-7992(91)90036-4, PubMed 2034242 -
Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection
Mutat Res, 262 (1), 63-71
DOI 10.1016/0165-7992(91)90108-g, PubMed 1702518
Publications 1990
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SCREENING FOR BASE MUTATIONS IN THE PAH AND HPRT LOCI USING THE POLYMERASE CHAIN-REACTION (PCR) IN COMBINATION WITH DENATURING GRADIENT GEL-ELECTROPHORESIS (DGGE)
Prog.Clin.Biol.Res., 340, 389-398 -
Screening for base mutations in the PAH and HPRT loci using the polymerase chain reaction (PCR) in combination with denaturing gradient gel electrophoresis (DGGE)
Prog Clin Biol Res, 340A, 389-98
PubMed 2388921
Publications 1989
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Formation of active diphtheria toxin in vitro based on ligated fragments of cloned mutant genes
J Biol Chem, 264 (22), 12747-51
PubMed 2753882 -
FORMATION OF ACTIVE DIPHTHERIA-TOXIN INVITRO BASED ON LIGATED FRAGMENTS OF CLONED MUTANT-GENES
J. Biol. Chem., 264 (22), 12749-12751
Publications 1988
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Detection of base mutations in genomic DNA using denaturing gradient gel electrophoresis (DGGE) followed by transfer and hybridization with gene-specific probes
Mutat Res, 202 (1), 77-83
DOI 10.1016/0027-5107(88)90166-2, PubMed 2903443
Publications 1987
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Chromosome 13 instability and esterase D expression in an osteosarcoma cell line
Cancer Genet Cytogenet, 24 (2), 327-34
DOI 10.1016/0165-4608(87)90115-4, PubMed 2878716