Lene Malerød

  • Senior engineer, lab manager (Institute for Cancer Research)
  • +47 22 78 19 39



From the news:

Escorting receptors for degradation.

Comment in Cell about ESCRT mechanism of membrane involution


©Terje Heiestad/Millimeterpress


Research Interests


Cell division



Cell migration






Publications 2019

Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533

Publications 2018

Malerød L, Le Borgne R, Lie-Jensen A, Eikenes ÅH, Brech A, Liestøl K, Stenmark H, Haglund K (2018)
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
EMBO J, 37 (13)
DOI 10.15252/embj.201797741, PubMed 29858227

Publications 2016

Sundvold H, Sundvold-Gjerstad V, Malerød-Fjeld H, Haglund K, Stenmark H, Malerød L (2016)
Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow
Cell Cycle, 15 (5), 628-43
DOI 10.1080/15384101.2016.1146834, PubMed 27104745

Publications 2015

Egeland EV, Boye K, Pettersen SJ, Haugen MH, Øyjord T, Malerød L, Flatmark K, Mælandsmo GM (2015)
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943

Eikenes ÅH, Malerød L, Christensen AL, Steen CB, Mathieu J, Nezis IP, Liestøl K, Huynh JR, Stenmark H, Haglund K (2015)
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo
PLoS Genet, 11 (1), e1004904
DOI 10.1371/journal.pgen.1004904, PubMed 25635693

Eikenes ÅH, Malerød L, Lie-Jensen A, Sem Wegner C, Brech A, Liestøl K, Stenmark H, Haglund K (2015)
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Development, 142 (23), 4107-18
DOI 10.1242/dev.124370, PubMed 26628094

Publications 2011

Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H (2011)
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
Traffic, 12 (9), 1211-26
DOI 10.1111/j.1600-0854.2011.01220.x, PubMed 21564451

Publications 2010

Kaarbø M, Mikkelsen OL, Malerød L, Qu S, Lobert VH, Akgul G, Halvorsen T, Maelandsmo GM, Saatcioglu F (2010)
PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells
Cell Oncol, 32 (1-2), 11-27
DOI 10.3233/CLO-2009-0487, PubMed 20203370

Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H (2010)
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
Dev Cell, 19 (1), 148-59
DOI 10.1016/j.devcel.2010.06.010, PubMed 20643357

Roxrud I, Stenmark H, Malerød L (2010)
Biol Cell, 102 (5), 293-318
DOI 10.1042/BC20090161, PubMed 20222872

Stuffers S, Malerød L, Schink KO, Corvera S, Stenmark H, Brech A (2010)
Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate
J Histochem Cytochem, 58 (11), 1025-32
DOI 10.1369/jhc.2010.955815, PubMed 20713985

Publications 2009

Malerød L, Stenmark H (2009)
ESCRTing membrane deformation
Cell, 136 (1), 15-7
DOI 10.1016/j.cell.2008.12.029, PubMed 19135881

Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A (2009)
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
Histochem Cell Biol, 133 (1), 41-55
DOI 10.1007/s00418-009-0643-8, PubMed 19830447

Publications 2007

Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerød L, Fisher EM, Isaacs A, Brech A, Stenmark H, Simonsen A (2007)
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J Cell Biol, 179 (3), 485-500
DOI 10.1083/jcb.200702115, PubMed 17984323

Malerød L, Stenmark H (2007)
Curr Biol, 17 (2), R42-3
DOI 10.1016/j.cub.2006.12.009, PubMed 17240322

Malerød L, Stuffers S, Brech A, Stenmark H (2007)
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation
Traffic, 8 (11), 1617-29
DOI 10.1111/j.1600-0854.2007.00630.x, PubMed 17714434

Progida C, Malerød L, Stuffers S, Brech A, Bucci C, Stenmark H (2007)
RILP is required for the proper morphology and function of late endosomes
J Cell Sci, 120 (Pt 21), 3729-37
DOI 10.1242/jcs.017301, PubMed 17959629

Raiborg C, Malerød L, Pedersen NM, Stenmark H (2007)
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking
Exp Cell Res, 314 (4), 801-13
DOI 10.1016/j.yexcr.2007.10.014, PubMed 18031739

Publications 2006

Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H (2006)
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol Biol Cell, 17 (6), 2513-23
DOI 10.1091/mbc.e05-10-0915, PubMed 16554368

Raiborg C, Wesche J, Malerød L, Stenmark H (2006)
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
J Cell Sci, 119 (Pt 12), 2414-24
DOI 10.1242/jcs.02978, PubMed 16720641

Slagsvold T, Pattni K, Malerød L, Stenmark H (2006)
Endosomal and non-endosomal functions of ESCRT proteins
Trends Cell Biol, 16 (6), 317-26
DOI 10.1016/j.tcb.2006.04.004, PubMed 16716591

Publications 2005

Malerød L, Sporstøl M, Juvet LK, Mousavi SA, Gjøen T, Berg T, Roos N, Eskild W (2005)
Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1
Biochem Biophys Res Commun, 336 (4), 1096-105
DOI 10.1016/j.bbrc.2005.08.237, PubMed 16168958

Sporstøl M, Tapia G, Malerød L, Mousavi SA, Berg T (2005)
Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I
Biochem Biophys Res Commun, 331 (4), 1533-41
DOI 10.1016/j.bbrc.2005.04.071, PubMed 15883047

Publications 2004

Mousavi SA, Malerød L, Berg T, Kjeken R (2004)
Clathrin-dependent endocytosis
Biochem J, 377 (Pt 1), 1-16
DOI 10.1042/BJ20031000, PubMed 14505490

Publications 2003

Malerød L, Sporstøl M, Juvet LK, Mousavi A, Gjøen T, Berg T (2003)
Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha
Biochem Biophys Res Commun, 305 (3), 557-65
DOI 10.1016/s0006-291x(03)00819-2, PubMed 12763030

Publications 2002

Malerød L, Juvet LK, Hanssen-Bauer A, Eskild W, Berg T (2002)
Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes
Biochem Biophys Res Commun, 299 (5), 916-23
DOI 10.1016/s0006-291x(02)02760-2, PubMed 12470667

Publications 2001

Malerød L, Juvet K, Gjøen T, Berg T (2001)
The expression of scavenger receptor class B, type I (SR-BI) and caveolin-1 in parenchymal and nonparenchymal liver cells
Cell Tissue Res, 307 (2), 173-80
DOI 10.1007/s00441-001-0476-9, PubMed 11845324

Page visits: 22681