Mutant fractions in 3D Links to Plotly graphs

The mutant fraction of mtDNA distributed in 3-dimensions in 8 different macroscopic samples. Several microtome slices are taken from each tissue sample and subjected to laser capture microdissection. From each 12-micrometer section, 96 LCMD samples are collected and subjected to CTCE.

One orange "bead" (wildtype) in combination with the black circle (mutant) represents mutant fraction in one LCMD spot.

Bubble size legend

 

Mutation analysis by CTCE

 

Microtome slices and pictures, testicular cancer

 

Testicular cancer

Marker P2F1

Marker P2F2

Histogram of marker 1 and 2 

 

Hepatocellular Carcinoma

Marker

Histogram, distribution of wildtype fraction within each LCMD spot

 

Breast cancer

Primary tumor

Lymph node

Liver metastasis

Histogram

 

Bladder cancer

Primary tumor

Marker P2F6

Marker P5F6

 

Lymph node

Marker P2F6

Marker P5F6

Histogram, comparison of mutant fraction of the two markers

 

Colon cancer

Primary tumor

 

 
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