Nicholas Paul Casey

  • Postdoc; PhD, Msc
  • +47 22 78 23 16

FIGHT KIDS CANCER (IMAGINE)

 Education:

2005-2010: Ph.D., Disciplines of Medicine and Pathology, University of Tasmania

1995-2000: Master of Science (Research), Department of Zoology, La Trobe University, Australia

1991-1994: Bachelor of Science (Honours)Honours B.Sc., Biology, Department of Anatomy, University of Queensland

Research interests/projects:

- Development of CAR

Work experience:

2019/present: Postdoctoral Fellow, Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, Norway

2017/2019: Postdoctoral Fellow, Section Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, Norway

2016/2017: Specialist Editor, Cactus Communications

2012/2016: Postdoctoral Fellow, Ehime University Graduate School of Medicine, Toon, Japan

2009/2011: Postdoctoral Fellow, Department of Hematology, University of Washington, USA

2008/2009: Research Assistant,   University of Tasmania Clinical School, Australia

2004/2005: Visiting Scholar, National Medical Centre, Hungary

2002: Visiting Scholar, Semmelweis University of Medicine, Hungary

 Grant and awards:

-July 2012 – JSPS Postdoctoral Fellowship for Foreign Researchers

-May 2011 – David Collins Leukaemia Foundation Grant

-Mar. 2009 – Overseas Postdoctoral Fellowship from the Children’s Hospital, Westmead, Sydney, Australia

-Oct. 2008 – Menzies Research Institute Student Travel Grant

-Sept. 2007 – David Collins Leukaemia Foundation Professional Development Grant

-August 2003 – University of Tasmania Strategic Postgraduate Scholarship

 

 

 

Publications 2024

Casey NP, Kleinmanns K, Forcados C, Gelebart PF, Joaquina S, Lode M, Benard E, Kaveh F, Caulier B, Helgestad Gjerde C, García de Jalón E, Warren DJ, Lindemann K, Rokkones E, Davidson B, Myhre MR, Kvalheim G, Bjørge L, McCormack E, Inderberg EM, Wälchli S (2024)
Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16
J Immunother Cancer, 12 (4)
DOI 10.1136/jitc-2023-008179, PubMed 38604812

Publications 2023

Beck C, Casey NP, Persiconi I, Moharrami NN, Sike A, Jin Y, Kyte JA (2023)
Development of a TGFβ-IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy
Biomedicines, 11 (2)
DOI 10.3390/biomedicines11020459, PubMed 36830995

Casey NP, Klee CH, Fåne A, Caulier B, Graczyk-Jarzynka A, Krawczyk M, Fidyt K, Josefsson SE, Köksal H, Dillard P, Patkowska E, Firczuk M, Smeland EB, Winiarska M, Myklebust JH, Inderberg EM, Wälchli S (2023)
Efficient chimeric antigen receptor targeting of a central epitope of CD22
J Biol Chem, 299 (7), 104883
DOI 10.1016/j.jbc.2023.104883, PubMed 37269947

Klee CH, Villatoro A, Casey NP, Inderberg EM, Wälchli S (2023)
In vitro re-challenge of CAR T cells
Methods Cell Biol, 183, 335-353
DOI 10.1016/bs.mcb.2023.06.003, PubMed 38548418

Mensali N, Köksal H, Joaquina S, Wernhoff P, Casey NP, Romecin P, Panisello C, Rodriguez R, Vimeux L, Juzeniene A, Myhre MR, Fåne A, Ramírez CC, Maggadottir SM, Duru AD, Georgoudaki AM, Grad I, Maturana AD, Gaudernack G, Kvalheim G, Carcaboso AM, de Alava E, Donnadieu E, Bruland ØS, Menendez P et al. (2023)
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
Nat Commun, 14 (1), 3375
DOI 10.1038/s41467-023-39097-x, PubMed 37291203

Publications 2022

Forcados C, Joaquina S, Casey NP, Caulier B, Wälchli S (2022)
How CAR T Cells Breathe
Cells, 11 (9)
DOI 10.3390/cells11091454, PubMed 35563759

Publications 2021

Dillard P, Casey N, Pollmann S, Vernhoff P, Gaudernack G, Kvalheim G, Wälchli S, Inderberg EM (2021)
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
Oncoimmunology, 10 (1), 1936757
DOI 10.1080/2162402X.2021.1936757, PubMed 34235003

Publications 2020

Benard E, Casey NP, Inderberg EM, Wälchli S (2020)
SJI 2020 special issue: A catalogue of Ovarian Cancer targets for CAR therapy
Scand J Immunol, 92 (4), e12917
DOI 10.1111/sji.12917, PubMed 32557659

Casey NP, Kyte JA, Fujiwara H (2020)
Use of RNA Interference with TCR Transfer to Enhance Safety and Efficiency
Methods Mol Biol, 2115, 327-349
DOI 10.1007/978-1-0716-0290-4_18, PubMed 32006409

Publications 2018

Casey N, Fujiwara H, Azuma T, Murakami Y, Yoshimitsu M, Masamoto I, Nawa Y, Yamanouchi J, Narumi H, Yakushijin Y, Hato T, Yasukawa M (2018)
An unusual, CD4 and CD8 dual-positive, CD25 negative, tumor cell phenotype in a patient with adult T-cell leukemia/lymphoma
Leuk Lymphoma, 59 (11), 2740-2742
DOI 10.1080/10428194.2018.1439168, PubMed 29465309

Publications 2016

Casey NP, Fujiwara H, Ochi T, Yasukawa M (2016)
Novel immunotherapy for adult T-cell leukemia/lymphoma: Targeting aurora kinase A
Oncoimmunology, 5 (11), e1239006
DOI 10.1080/2162402X.2016.1239006, PubMed 27999761

Casey NP, Fujiwara H, Tanimoto K, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M (2016)
A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy
PLoS One, 11 (6), e0156896
DOI 10.1371/journal.pone.0156896, PubMed 27271876

Tanaka H, Fujiwara H, Ochi F, Tanimoto K, Casey N, Okamoto S, Mineno J, Kuzushima K, Shiku H, Sugiyama T, Barrett AJ, Yasukawa M (2016)
Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia
Clin Cancer Res, 22 (17), 4405-16
DOI 10.1158/1078-0432.CCR-15-2714, PubMed 27091408

Publications 2012

Casey NP, Woods GM (2012)
Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid
J RNAi Gene Silencing, 8, 464-9
PubMed 23300507

Publications 2006

Brózik A, Casey NP, Hegedus C, Bors A, Kozma A, Andrikovics H, Geiszt M, Német K, Magócsi M (2006)
Reduction of Bcr-Abl function leads to erythroid differentiation of K562 cells via downregulation of ERK
Ann N Y Acad Sci, 1090, 344-54
DOI 10.1196/annals.1378.038, PubMed 17384279

Publications 2003

Casey N, Selwood L (2003)
Removal of the shell coat affects maintenance of epithelia in blastocysts of the Brushtail Possum in vitro
Cells Tissues Organs, 173 (1), 21-45
DOI 10.1159/000068215, PubMed 12566625

Publications 2002

Casey NP, Martinus R, Selwood L (2002)
Outer egg coats of the marsupial conceptus: secretion and protein composition
Mol Reprod Dev, 62 (2), 181-94
DOI 10.1002/mrd.10073, PubMed 11984828

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