Ludvig Sollid's groupFunctional Immunogenetics

Ludvig Sollid
Group leader

We study coeliac disease to understand the interplay between genetic and environmental factors in chronic inflammatory disorders.

Our group is striving to understand what happens when the body's defense from disease, the immune system, directly or indirectly causes harm to the body.

Coeliac disease, rheumatoid arthritis, type 1 (insulin dependent) diabetes, and multiple sclerosis are examples of autoimmune disorders of a chronic inflammatory nature.

We are concentrating on coeliac disease as a model to understand the molecular mechanisms leading to chronic inflammatory disease.

Research in the group has lead to a better understanding of the molecular basis of coeliac disease, but has also revealed general principles of immune regulation that are applicable to other immune mediated disorders.

The research group is part of the K.G. Jebsen Coeliac Disease Research Centre. In the period 2007 - 2017 the research group was part of the Centre for Immune Regulation (CIR), a Centre of Excellence established by the Research Council of Norway.

The research group is located at the Department of Immunology at OUS-Rikshospitalet and is part of the University of Oslo and the Oslo University Hospital.

Projects

  • B cells and the auto-antibody response of coeliac disease.
  • How certain variants of HLA molecules predispose to disease development.
  • Characterisation of how T cells recognise gluten protein, the dietary antigen precipitating coeliac disease.
  • How transglutaminase (TG) 2 mediated post-translational protein modification increases antigenicity.

Links to research group pages at UiO:
Functional immunogenetics
K.G. Jebsen Coeliac Disease Research Centre

Contact information:
Group leader Professor Ludvig M. Sollid Centre for Immune Regulation Department of Immunology Oslo University Hospital Rikshospitalet PO Box 4950 Nydalen NO-0424 Oslo, Norway Tel: +47 23073811 Fax: +47 23073510 E-mail: l.m.sollid@medisin.uio.no