Ludvig Sollid's group: Functional Immunogenetics
In the gluten-induced enteropathy celiac disease, the main genetic and environmental risk factors are identified. Extensive knowledge on the intestinal adaptive immune response and development of reagents (MCH class II tetramers, labelled B-cell antigen) allows the specific labelling and analysis of disease relevant effector cells. These assets enable us to study disease-relevant cells, both at population and single cell level. The ability to study immune cells over time in response to controlled antigenic exposure (gluten challenge) give us insight into how and why chronic (auto-)immunity may develop in celiac disease and possibly also other MCH class II restricted autoimmune diseases.