Projects

  • High throughput DNA sequencing of T-cell and B-cell receptors on single cell and bulk cell levels
  • Transcriptome analysis of disease relevant effector immune cells (B cells and T cells)
  • Development of novel diagnostic tools; detection of disease specific effector cells in peripheral blood and development of serological assays for immunoglobulin detection
  • Characterization of models for breakage of B-cell tolerance by use of immunoglobulin knock-in mouse model • Characterization of the autoimmune B-cell response and biology of the autoantigen transglutaminase 2

 

 
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