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K.G. Jebsen Coeliac Disease Research Centre

The primary objective of our centre is to translate recent huge advances in the basic understanding of the pathogenesis of coeliac disease to the clinic – to improve disease diagnostics, to implement novel treatments and to identify new therapeutic targets for this common disease.

The secondary objective is to become a clinical research site at the international forefront which will provide optimal patient care and which will be a unique training site for basic scientists and clinicians.

News

  • knuteal Transglutaminase 2 inhibitor shows great promise in clinical trial Sep. 29, 2021 10:44 AM

    Transglutaminase 2 (TG2) activity is essential to induce a pathogenic immune response towards gluten in coeliac disease. In a Phase 2 clinical trial, a daily dose of an irreversible TG2-inhibitor prevented gluten-induced mucosal destruction in coeliac patients that consumed gluten daily for 6 weeks. These findings represents a milestone in the search for treatment options for patients with coeliac disease.

  • Is regular gluten free diet sufficient to curb all anti-gluten immunity? Feb. 17, 2021 10:52 PM

    Proteomics analysis of intestinal tissue biopsies finds that some patients with celiac disease considered to be well treated by regular gluten free diet have ongoing low-level inflammation in the intestine suggestive of ongoing low-level anti-gluten immunity. These patients developed strong intestinal response following 14 -day gluten challenge. We are now investigating whether some patients may still have activated gluten-specific T-cells despite long-term gluten free diet.

Events

Oct. 19, 2021 2:30 PM - 3:30 PM , A2.2068C/D
 
Oct. 20, 2021 4:00 PM - 5:00 PM , Virtual Seminar
Dec. 15, 2021 4:00 PM - 5:00 PM , Virtual Seminar
 
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