Ludvig Sollid's group Functional Immunogenetics

Ludvig Sollid
Group leader

We study coeliac disease to understand the interplay between genetic and environmental factors in chronic inflammatory disorders.

Our group is striving to understand what happens when the body's defense from disease, the immune system, directly or indirectly causes harm to the body.

Coeliac disease, rheumatoid arthritis, type 1 (insulin dependent) diabetes, and multiple sclerosis are examples of autoimmune disorders of a chronic inflammatory nature.

We are concentrating on coeliac disease as a model to understand the molecular mechanisms leading to chronic inflammatory disease.

Research in the group has lead to a better understanding of the molecular basis of coeliac disease, but has also revealed general principles of immune regulation that are applicable to other immune mediated disorders.

The research group is part of the K.G. Jebsen Coeliac Disease Research Centre. In the period 2007 - 2017 the research group was part of the Centre for Immune Regulation (CIR), a Centre of Excellence established by the Research Council of Norway.

The research group is located at the Department of Immunology at OUS-Rikshospitalet and is part of the University of Oslo and the Oslo University Hospital.

Our group, at the Institute of Immunology (IMMI), is striving to understand what happens when the body's defence from disease, the immune system, directly or indirectly causes harm to the body. Coeliac disease, rhematoid arthritis, type 1 (insulin-dependent) diabetes, and multiple sclerosis are examples of autoimmune disorders of a chronic inflammatory nature.

People with coeliac disease get sick when they eat bread or other gluten containing food. We are concentrating on coeliac disease as a model to understand the molecular mechanisms leading to chronic inflammatory disease. In particular, we focus on how certain variants of HLA molecules predispose to disease development. We are working in the fields of cell biology, genetics, biochemistry and protein chemistry. We are interested in the relationship between environmental factors (including gluten) and inherited (genetic) factors. As our research has lead to a better understanding of the molecular basis of coeliac disease, we are approaching other immune mediated diseases with some of the same tools that we use to explore coeliac disease. Rheumatoid arthritis has therefore become another focus for our research. The group is participating in EU and nationally funded projects.

 
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