
Sachin Kumar Singh
- Proteomics Data Analyst; PhD
- +47230 73807
Sachin started working as head engineer in Proteomics facility in November 2019. He received PhD from University of Karlsruhe Germany in 2015. His PhD was on deciphering in vivo proteome and transcriptome changes over time upon inflammation in zebrafish. Soon after his PhD, He received scientia fellow’s post-doctorate research fellowship (2015-17) to move University of Oslo. He has expertise in Proteomics, PTM-proteomics, Pathway analysis (Meta-Core), R biconductors. He has keen interest in proteomic method development and bioinformatics.
Publications:
Publications from 2016 and onwards: see below.
Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress.
Purushothaman S, Saxena S, Meghah V, Meena Lakshmi MG, Singh SK, Brahmendra Swamy CV, Idris MM.
J Sleep Res. 2015 Aug;24(4):458-65. doi: 10.1111/jsr.12287. Epub 2015 Feb 27.
PMID: 25726855
Array tomography: characterizing FAC-sorted populations of zebrafish immune cells by their 3D ultrastructure.
Wacker I, Chockley P, Bartels C, Spomer W, Hofmann A, Gengenbach U, Singh S, Thaler M, Grabher C, Schröder RR.
J Microsc. 2015 Aug;259(2):105-113. doi: 10.1111/jmi.12223. Epub 2015 Jan 21.
PMID: 25611576
Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation.
Singh SK, Aravamudhan S, Armant O, Krüger M, Grabher C.
Fish Shellfish Immunol. 2014 Sep;40(1):217-24. doi: 10.1016/j.fsi.2014.06.035. Epub 2014 Jul 8.
PMID: 25014315
Proteome mapping of adult zebrafish marrow neutrophils reveals partial cross species conservation to humanperipheral neutrophils.
Singh SK, Sethi S, Aravamudhan S, Krüger M, Grabher C.
PLoS One. 2013 Sep 3;8(9):e73998. doi: 10.1371/journal.pone.0073998. eCollection 2013.
PMID: 24019943
Proteome map of the neural complex of the tunicate Ciona intestinalis, the closest living relative to vertebrates.
Saxena S, Dupont S, Meghah V, Lakshmi MG, Singh SK, Swamy CV, Idris MM.
Proteomics. 2013 Mar;13(5):860-5. doi: 10.1002/pmic.201200148. Epub 2013 Jan 30.
PMID:23300126
Proteomic analysis of zebrafish caudal fin regeneration.
Saxena S, Singh SK, Lakshmi MG, Meghah V, Bhatti B, Swamy CV, Sundaram CS, Idris MM.
Mol Cell Proteomics. 2012 Jun;11(6):M111.014118. doi: 10.1074/mcp.M111.014118. Epub 2012 Jan 25.
PMID:22278371
Hydrogen peroxide in inflammation: messenger, guide, and assassin.
Wittmann C, Chockley P, Singh SK, Pase L, Lieschke GJ, Grabher C.
Adv Hematol. 2012;2012:541471. doi: 10.1155/2012/541471. Epub 2012 Jun 12.
PMID: 22737171
Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis.
Singh SK, Saxena S, Meena Lakshmi MG, Saxena P, Idris MM.
Zebrafish. 2011 Dec;8(4):183-9. doi: 10.1089/zeb.2011.0711.
PMID:22181661
Proteome profile of zebrafish kidney.
Saxena S, Singh SK, Lakshmi MG, Meghah V, Sundaram CS, Swamy CV, Idris MM.
J Proteomics. 2011 Nov 18;74(12):2937-47. doi: 10.1016/j.jprot.2011.07.021. Epub 2011 Aug 4.
PMID: 21839869
Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis.
Singh SK, Sundaram CS, Shanbhag S, Idris MM.
Zebrafish. 2010 Jun;7(2):169-77. doi: 10.1089/zeb.2010.0657.
PMID: 20528263
Publications 2025
The use of three-dimensional primary human myospheres to explore skeletal muscle effects of in vivo krill oil supplementation
In Vitro Model, 4 (2), 145-155
DOI 10.1007/s44164-025-00087-6, PubMed 40708816
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end
Commun Biol, 8 (1), 810
DOI 10.1038/s42003-025-08249-8, PubMed 40419755
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
Nat Metab (in press)
DOI 10.1038/s42255-025-01367-x, PubMed 41028912
Publications 2024
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
iScience, 27 (7), 110185
DOI 10.1016/j.isci.2024.110185, PubMed 39015150
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Nature, 628 (8009), 844-853
DOI 10.1038/s41586-024-07260-z, PubMed 38570685
Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
NPJ Syst Biol Appl, 10 (1), 73
DOI 10.1038/s41540-024-00402-z, PubMed 38997321
Publications 2023
Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism
Biomedicines, 11 (11)
DOI 10.3390/biomedicines11112908, PubMed 38001909
Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization
J Infect, 86 (5), 489-492
DOI 10.1016/j.jinf.2023.02.024, PubMed 36822413
Publications 2022
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178
Publications 2021
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality
Toxicol Sci, 183 (1), 154-169
DOI 10.1093/toxsci/kfab075, PubMed 34129049
Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients
Proteomics Clin Appl, 15 (6), e2100022
DOI 10.1002/prca.202100022, PubMed 34510746
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015
Publications 2020
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632
Publications 2018
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines
Int J Mol Sci, 19 (12)
DOI 10.3390/ijms19124123, PubMed 30572598
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4
Biochemistry, 57 (26), 3807-3816
DOI 10.1021/acs.biochem.8b00120, PubMed 29812912
Publications 2016
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Nucleic Acids Res, 44 (22), 10588-10602
DOI 10.1093/nar/gkw785, PubMed 27638884