Sachin Kumar Singh

  • Proteomics Data Analyst; PhD
  • +47230 73807

Sachin started working as head engineer in Proteomics facility in November 2019. He received PhD from University of Karlsruhe Germany in 2015. His PhD was on deciphering in vivo proteome and transcriptome changes over time upon inflammation in zebrafish. Soon after his PhD, He received scientia fellow’s post-doctorate research fellowship (2015-17) to move University of Oslo. He has expertise in Proteomics, PTM-proteomics, Pathway analysis (Meta-Core), R biconductors. He has keen interest in proteomic method development and bioinformatics.


Publications:

Publications from 2016 and onwards: see below.

Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress.
Purushothaman S, Saxena S, Meghah V, Meena Lakshmi MG, Singh SK, Brahmendra Swamy CV, Idris MM.
J Sleep Res. 2015 Aug;24(4):458-65. doi: 10.1111/jsr.12287. Epub 2015 Feb 27.
PMID:  25726855

Array tomography: characterizing FAC-sorted populations of zebrafish immune cells by their 3D ultrastructure.
Wacker I, Chockley P, Bartels C, Spomer W, Hofmann A, Gengenbach U, Singh S, Thaler M, Grabher C, Schröder RR.
J Microsc. 2015 Aug;259(2):105-113. doi: 10.1111/jmi.12223. Epub 2015 Jan 21.
PMID: 25611576

Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation.
Singh SK, Aravamudhan S, Armant O, Krüger M, Grabher C.
Fish Shellfish Immunol. 2014 Sep;40(1):217-24. doi: 10.1016/j.fsi.2014.06.035. Epub 2014 Jul 8.
PMID: 25014315

Proteome mapping of adult zebrafish marrow neutrophils reveals partial cross species conservation to humanperipheral neutrophils.
Singh SK, Sethi S, Aravamudhan S, Krüger M, Grabher C.
PLoS One. 2013 Sep 3;8(9):e73998. doi: 10.1371/journal.pone.0073998. eCollection 2013.
PMID: 24019943

Proteome map of the neural complex of the tunicate Ciona intestinalis, the closest living relative to vertebrates.
Saxena S, Dupont S, Meghah V, Lakshmi MG, Singh SK, Swamy CV, Idris MM.
Proteomics. 2013 Mar;13(5):860-5. doi: 10.1002/pmic.201200148. Epub 2013 Jan 30.
PMID:23300126

Proteomic analysis of zebrafish caudal fin regeneration.
Saxena S, Singh SK, Lakshmi MG, Meghah V, Bhatti B, Swamy CV, Sundaram CS, Idris MM.
Mol Cell Proteomics. 2012 Jun;11(6):M111.014118. doi: 10.1074/mcp.M111.014118. Epub 2012 Jan 25.
PMID:22278371

Hydrogen peroxide in inflammation: messenger, guide, and assassin.
Wittmann C, Chockley P, Singh SK, Pase L, Lieschke GJ, Grabher C.
Adv Hematol. 2012;2012:541471. doi: 10.1155/2012/541471. Epub 2012 Jun 12.
PMID: 22737171

Proteome profile of zebrafish Danio rerio olfactory bulb based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis.
Singh SK, Saxena S, Meena Lakshmi MG, Saxena P, Idris MM.
Zebrafish. 2011 Dec;8(4):183-9. doi: 10.1089/zeb.2011.0711.
PMID:22181661

Proteome profile of zebrafish kidney.
Saxena S, Singh SK, Lakshmi MG, Meghah V, Sundaram CS, Swamy CV, Idris MM.
J Proteomics. 2011 Nov 18;74(12):2937-47. doi: 10.1016/j.jprot.2011.07.021. Epub 2011 Aug 4.
PMID: 21839869

Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis.
Singh SK, Sundaram CS, Shanbhag S, Idris MM.
Zebrafish. 2010 Jun;7(2):169-77. doi: 10.1089/zeb.2010.0657.
PMID: 20528263

 

Publications 2025

Dalmao-Fernandez A, Katare PB, Bakke HG, Hamarsland H, Ellefsen S, Singh S, Nyman TA, Kase ET, Rustan AC, Thoresen GH (2025)
The use of three-dimensional primary human myospheres to explore skeletal muscle effects of in vivo krill oil supplementation
In Vitro Model, 4 (2), 145-155
DOI 10.1007/s44164-025-00087-6, PubMed 40708816

Nilsen J, Aaen KH, Benjakul S, Ruso-Julve F, Greiner TU, Bejan D, Stensland M, Singh S, Schlothauer T, Sandlie I, Andersen JT (2025)
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end
Commun Biol, 8 (1), 810
DOI 10.1038/s42003-025-08249-8, PubMed 40419755

Saber SH, Yak N, Yong XLH, Bong YT, Leeson H, Dai CY, Binder T, Lu S, Purushothaman R, Lenaerts AS, Almeida-Souza L, Koludarova L, Er S, Hlushchuk I, Gaudin A, Singh S, Nyman TA, Harmer JR, Zuryn S, Wolvetang E, Talbo GH, Airavaara M, Battersby BJ, van Waardenberg AJ, Anggono V et al. (2025)
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
Nat Metab (in press)
DOI 10.1038/s42255-025-01367-x, PubMed 41028912

Publications 2024

Hilander T, Awadhpersad R, Monteuuis G, Broda KL, Pohjanpelto M, Pyman E, Singh SK, Nyman TA, Crevel I, Taylor RW, Saada A, Balboa D, Battersby BJ, Jackson CB, Carroll CJ (2024)
Supernumerary proteins of the human mitochondrial ribosomal small subunit are integral for assembly and translation
iScience, 27 (7), 110185
DOI 10.1016/j.isci.2024.110185, PubMed 39015150

Kang Y, Hepojoki J, Maldonado RS, Mito T, Terzioglu M, Manninen T, Kant R, Singh S, Othman A, Verma R, Uusimaa J, Wartiovaara K, Kareinen L, Zamboni N, Nyman TA, Paetau A, Kipar A, Vapalahti O, Suomalainen A (2024)
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Nature, 628 (8009), 844-853
DOI 10.1038/s41586-024-07260-z, PubMed 38570685

Lê Quý K, Chernigovskaya M, Stensland M, Singh S, Leem J, Revale S, Yadin DA, Nice FL, Povall C, Minns DH, Galson JD, Nyman TA, Snapkow I, Greiff V (2024)
Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
NPJ Syst Biol Appl, 10 (1), 73
DOI 10.1038/s41540-024-00402-z, PubMed 38997321

Publications 2023

Lunde NN, Osoble NMM, Fernandez AD, Antobreh AS, Jafari A, Singh S, Nyman TA, Rustan AC, Solberg R, Thoresen GH (2023)
Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism
Biomedicines, 11 (11)
DOI 10.3390/biomedicines11112908, PubMed 38001909

Ueland T, Äikäs LAO, Dahl TB, Gregersen I, Olsen MB, Michelsen A, Schanke Y, Holopainen M, Ruhanen H, Singh S, NOR-SOLIDARITY Consortium, Tveita AA, Finbråten AK, Heggelund L, Trøseid M, Dyrhol-Riise AM, Nyman TA, Holven KB, Öörni K, Aukrust P, Halvorsen B (2023)
Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization
J Infect, 86 (5), 489-492
DOI 10.1016/j.jinf.2023.02.024, PubMed 36822413

Publications 2022

Fiorito E, Szybowska P, Haugsten EM, Kostas M, Øy GF, Wiedlocha A, Singh S, Nakken S, Mælandsmo GM, Fletcher JA, Meza-Zepeda LA, Wesche J (2022)
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Br J Cancer, 127 (11), 1939-1953
DOI 10.1038/s41416-022-01973-6, PubMed 36097178

Publications 2021

Hutin D, Long AS, Sugamori K, Shao P, Singh SK, Rasmussen M, Olafsen NE, Pettersen S, Grimaldi G, Grant DM, Matthews J (2021)
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality
Toxicol Sci, 183 (1), 154-169
DOI 10.1093/toxsci/kfab075, PubMed 34129049

Mirlashari MR, Vetlesen A, Nissen-Meyer LSH, Stensland ME, Singh SK, Nyman TA, Hetland G (2021)
Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients
Proteomics Clin Appl, 15 (6), e2100022
DOI 10.1002/prca.202100022, PubMed 34510746

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015

Publications 2020

Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Fløisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM (2020)
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem, 296, 100179
DOI 10.1074/jbc.RA120.015285, PubMed 33303632

Publications 2018

Wang S, Singh SK, Katika MR, Lopez-Aviles S, Hurtado A (2018)
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines
Int J Mol Sci, 19 (12)
DOI 10.3390/ijms19124123, PubMed 30572598

Zhen Y, Haugsten EM, Singh SK, Wesche J (2018)
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4
Biochemistry, 57 (26), 3807-3816
DOI 10.1021/acs.biochem.8b00120, PubMed 29812912

Publications 2016

Fiorito E, Sharma Y, Gilfillan S, Wang S, Singh SK, Satheesh SV, Katika MR, Urbanucci A, Thiede B, Mills IG, Hurtado A (2016)
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Nucleic Acids Res, 44 (22), 10588-10602
DOI 10.1093/nar/gkw785, PubMed 27638884