The aim of this project is to re-evaluate the role of genetic polymorphisms (SNPs) with respect to the existence of higher order of their organization the haplotypes. Haplotypes may affect expression and protein structure of single genes and gene products, but may also affect whole metabolic pathways by co-inheritance of susceptibility alleles in different genes.
Figure: Chromosomal localization (B) of the selected SNPs for haplotype analysis in the SNP500 database and haplotype frequencies and structures in 4 different SNP 500 populations (A). Linkage disequilibrium between the same SNPs selected for analysis in the SNP500 in 200 breast cancer patients from Norwegian population.
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