Resources and expertise

Model systems for experimental cancer therapy             

Model systems mimicking human cancers are a prerequisite for functional studies on cancer progression and metastasis, as well as testing of novel treatment options. We have developed patient-derived model systems (cell cultures and xenografts) for breast, prostate and colorectal cancer, sarcoma and melanoma. The models are used for testing novel treatment modalities or drug combinations, or simply for evaluating a particular patient’s likelihood to respond to available drugs (see figure). 

 

Ex vivo drug efficacy testing using patient tumor tissue

 

For testing of immune therapy, we are in the process of developing humanized model systems. We are members of the European Consortium for Patient-derived Xenografts (EurOPDX).

We have experience in drug efficacy testing in PDX models and can advise internal users at Institute for Cancer Research in use of such models and design of appropriate experiments. We can also offer technical assistance in projects. Please contact: GM

 

Bioinformatics:

We are developing bioinformatics resources and solutions, and are providing underpinnings for the implementation of precision cancer medicine at the clinic. We are developing tools for sequence analysis, cancer precision medicine annotation, benchmarking and quality control. We are also aggregating information on national population-wide DNA variation, as well as tools and solutions for handling of sensitive data. We are partner to the RCN-funded ICT Beacon project "BigMed" and the Center of Innovation "BigInsight".

 

Useful links:
Eivind Hovig's research group
Bioinforamtic core facility
Elixir

 

Biobanks:

Biological material from cancer patients represents an important source of knowledge especially when combined with matched clinical follow-up information. Biobank material is used to verify data from model systems, to discover new markers that can be used as prognostic factors or to predict prognosis or treatment response, and to validate molecular tests before initiation of clinical studies.

Useful links:
Prostate Biobank
Hereditary cancer
Colorectal cancer
Lung metastases
Sacroma
Melanoma
Brain metastases

 

Registries:

We use data from national and medical registries and health survey information to validate results from our experimental studies. Data from the Cancer Registry of Norway has been coupled with data from the Norwegian Prescription Database, The Norwegian Patient Registry and the Cause of Death Registry or the Oslo II study. More information is available at helsedata.

 

Institutional equipment in the department:

Technologies

Supplier

Model

Contact person

Detection platforms

 

 

 

   Multimode plate reader

Perkin Elmer

Victor X3

solveig.pettersen@rr-research.no

   Colony Counter

Oxford Optronic

GelCount

hakon.ramberg@rr-research.no

   Automated Western blot

Protein Simple

Peggy Sue

mads.haugland.haugen@rr-research.no

Microscopes

 

 

 

   Fluorescence

Olympus

BX51

siri.juell@rr-research.no

   Brightfield

Zeiss

Axioplan 2

siri.juell@rr-research.no

   Brightfield

Zeiss

Axioskop

siri.juell@rr-research.no

Centrifuges

 

 

 

    Cytospin preparation

Gemini BV

Hettich Universal 30F

siri.juell@rr-research.no

    Ultracentrifuge

Beckman Coultier

Avanti J-25 I

tove.Oyjord@rr-research.no

    Ultracentrifuge

Beckman Coultier

Optima L-90K

tove.Oyjord@rr-research.no

    Ultracentrifuge

Beckman Coultier

Optima Max

tove.Oyjord@rr-research.no

Cell counters

 

 

 

   Automated cell counter 

LifeTechnologies/ThermoFisher

Countess™ II Automated Cell Counter

 

   Automated cell counter 

ChemoMetec

Nucleocounter NC-200

hakon.ramberg@rr-research.no

   Particle counter

Beckman Coultier

Coultier Z1

hakon.ramberg@rr-research.no

Other instrumentation

 

 

 

   Laser Microdissection (LMD)

 

Leica LMD6000

hakon.ramberg@rr-research.no

   Tissue homogenizer

Bertin Instruments

Precellys Evolution with Cryolyse

mads.haugland.haugen@rr-research.no

   Cell pick

 

CP0001

 

MaxMat Robot

Erba Diagnostics

 

Nikolai.engedal@rr-research.no

 

 
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