
Maja Radulovic
- Project Leader, Senior scientist (Research Council of Norway)
- +47 22 78 14 91
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Maja is in charge of the Project Mechanisms and importance of lysosome repair
From the news:
In this News and Views article Lysosomes enlist endoplasmic reticulum microdomains for repair | Nature Cell Biology ,Zhengyand An at al. comment on recently published work on how DFCP1-containing ER microdomains mediate lysosomal membrane repair
Maja Radulovic uncovers new mechanism of lysosomal membrane repair
Radulovic and Stenmark with lysosome review in Nature Reviews Molecular Cell Biology
Highlighted in the journal Science: Fixing leaky lysosomes
Maja Radulovic first author on EMBO J article: An ER for damaged lysosomes
Vietri, Radulovic and Stenmark with Nature Review about ESCRT proteins in membrane dynamics
EMBO J paper from Maja Radulovic: Repair of damaged lysosomes keeps cells alive.
Publications 2026
DFCP1-containing ER microdomains mediate lysosomal membrane repair
Nat Cell Biol (in press)
DOI 10.1038/s41556-026-02062-z, PubMed 42744858
Publications 2025
Lysosomal membrane homeostasis and its importance in physiology and disease
Nat Rev Mol Cell Biol, 27 (1), 71-87
DOI 10.1038/s41580-025-00873-w, PubMed 40759742
Publications 2024
Lysophagy prevents neurotoxic aggregate transmission
Proc Natl Acad Sci U S A, 121 (3), e2321181121
DOI 10.1073/pnas.2321181121, PubMed 38190545
Publications 2023
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525
Publications 2022
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828
Publications 2021
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy
Biochem Pharmacol, 194, 114837
DOI 10.1016/j.bcp.2021.114837, PubMed 34780750
Sealing holes in cellular membranes
EMBO J, 40 (7), e106922
DOI 10.15252/embj.2020106922, PubMed 33644904
Publications 2020
LRRK2 to the rescue of damaged endomembranes
EMBO J, 39 (18), e106162
DOI 10.15252/embj.2020106162, PubMed 32803793
Publications 2019
The many functions of ESCRTs
Nat Rev Mol Cell Biol, 21 (1), 25-42
DOI 10.1038/s41580-019-0177-4, PubMed 31705132
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282
Publications 2018
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966
ESCRTs in membrane sealing
Biochem Soc Trans, 46 (4), 773-778
DOI 10.1042/BST20170435, PubMed 29903934
Homocysteine regulates fatty acid and lipid metabolism in yeast
J Biol Chem, 293 (15), 5544-5555
DOI 10.1074/jbc.M117.809236, PubMed 29414770
Publications 2016
Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism
J Biol Chem, 291 (22), 11865-75
DOI 10.1074/jbc.M115.705541, PubMed 27036938
Publications 2015
Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast
Biochim Biophys Acta, 1851 (11), 1450-64
DOI 10.1016/j.bbalip.2015.08.003, PubMed 26275961
Publications 2013
The emergence of lipid droplets in yeast: current status and experimental approaches
Curr Genet, 59 (4), 231-42
DOI 10.1007/s00294-013-0407-9, PubMed 24057105