The Research lab (Head: G. Kvalheim, Project Leaders: E.M. Inderberg and S. Wälchli) relies on the clinical trials patient biobank established by G. Gaudernack (Prof. emeritus, mentor). This represents an inestimable source of information about the patients’ response to immunological treatments over the years. Furthermore, the patient material can be re-analyzed and therapeutic molecules isolated. Indeed, selected material from “good responders” (cured patients) is characterized by molecular biology techniques and studied to reach the pre-clinical stage (in vivo assays). In addition, the scientific team is also developing novel tools to improve immunotherapy. The research lab can undertake basic studies independently. It possesses a fully functional molecular biology lab, cell culture hoods including a retroviral one, different high tech analysis instruments (flow cytometer, fluorescent microscope) and the access to the core facilities of the ICR including the animal facility.
Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy
Cancer Immunol Immunother, 68 (8), 1235-1243
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection
Immunohorizons, 2 (6), 172-184
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13