
Trine Folseraas
- MD; PhD
- +47 23 07 18 19
Education
MD, University of Bergen, 2002
Positions
2013-present, Resident (50%), Section of Gastroeneterology, Division of Cancer Medicine, Surgery and Transplanation, Oslo University Hospital, Rikshospitalet
2009-present, PhD Research fellow (from 2013; 50%), Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet
2007-2008 Resident, Medical Department, Section for Infectious Medicine, Oslo University Hospital, Ullevaal
2006-2007 Resident, Medical Department, Lovisenberg Diakonale Sykehus
2006 Physician (6 months), Doctors Without Borders, Sierra Leone
2005 Diploma in Tropical Medicine (3 months), University of Liverpool
2004-2006 Resident, Medical Department, Lovisenberg Diakonale Sykehus
2003-2004 Internship in Medicine, Surgery and General Practice, Skien/Langesund
Research interests
Primary sclerosing cholangitis. Cancer development in the bile ducts. Complex genetics. Disease mechanisms in autoimmmune disease.
Publications 2020
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110, PubMed 31925805
Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system
Hepatology (in press)
DOI 10.1002/hep.31598, PubMed 33073396
Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation
Hepatology (in press)
DOI 10.1002/hep.31652, PubMed 33226645
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485
Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers
JHEP Rep, 2 (5), 100143
DOI 10.1016/j.jhepr.2020.100143, PubMed 32939446
Publications 2019
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Hepatology, 69 (2), 622-638
DOI 10.1002/hep.30210, PubMed 30102768
Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis
Liver Int., 39 (12), 2230-2237
Pathogenesis, diagnosis and treatment of premalignant and malignant stages of cholangiocarcinoma in primary sclerosing cholangitis
Liver Int, 39 (12), 2230-2237
DOI 10.1111/liv.14180, PubMed 31216595
Publications 2018
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J Surg Oncol, 16 (1), 180
DOI 10.1186/s12957-018-1482-7, PubMed 30185175
Publications 2017
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Am J Pathol, 188 (3), 627-639
DOI 10.1016/j.ajpath.2017.11.010, PubMed 29248458
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Biochim Biophys Acta Mol Basis Dis, 1864 (4 Pt B), 1390-1400
DOI 10.1016/j.bbadis.2017.08.020, PubMed 28844951
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657
Primary sclerosing cholangitis - a comprehensive review
J Hepatol, 67 (6), 1298-1323
DOI 10.1016/j.jhep.2017.07.022, PubMed 28802875
Publications 2016
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
DOI 10.1038/nrgastro.2016.51, PubMed 27095655
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
Nat Genet, 48 (5), 510-8
DOI 10.1038/ng.3528, PubMed 26974007
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nat Genet, 49 (2), 269-273
DOI 10.1038/ng.3745, PubMed 27992413
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol. J., 4 (1), 84-91
Publications 2015
Cancer Risk and Surveillance in Primary Sclerosing Cholangitis
Clin Liver Dis, 20 (1), 79-98
DOI 10.1016/j.cld.2015.08.014, PubMed 26593292
Genetics in PSC: what do the "risk genes" teach us?
Clin Rev Allergy Immunol, 48 (2-3), 154-64
DOI 10.1007/s12016-014-8417-z, PubMed 24736995
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat Commun, 6, 6804
DOI 10.1038/ncomms7804, PubMed 25891430
A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
United European Gastroenterol J, 4 (1), 84-91
DOI 10.1177/2050640615581577, PubMed 26966527
Publications 2014
Fut2 genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis
Aliment Pharmacol Ther, 39 (8), 873-82
DOI 10.1111/apt.12663, PubMed 24612312
Publications 2013
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
DOI 10.1038/ng.2616, PubMed 23603763
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
J Hepatol, 59 (6), 1278-84
DOI 10.1016/j.jhep.2013.08.005, PubMed 23958938
Publications 2012
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342
Publications 2011
To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?
Liver Int, 31 (6), 751-4
DOI 10.1111/j.1478-3231.2011.02471.x, PubMed 21645205
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
DOI 10.1016/j.bpg.2011.09.010, PubMed 22117637
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
DOI 10.1002/hep.24307, PubMed 21425313