DNA microarrays allow measurements of thousands of genes or genetic loci in single experiments. We are using DNA microarrays for measurements of both gene expression (RNA levels) and DNA copy numbers.

Expression analyses are in our ongoing projects mostly performed by use of Affymetrix exon microarrays or by the Applied Biosystems platform. We also have data sets obtained by custom designed microarrays on the Nimblegen platform, Agilent oligo microarays (Figure below), and in-house cDNA arrays.

Our lab ("Molecular Cancer Genetics Group") was part of a "CGED - Centre for Gene Expression and Discovery" as a collaboration with Applied Biosystems from may 2005- august 2007.

DNA copy number analyses (array-CGH): we currently apply both Nimblegen arrays with 385 000 measurements along the genome, and also in-house made BAC-arrays. In array-CGH, we hybridise differentially labelled DNA onto specific DNA sequences printed in a microarray format, as compared to "chromosomal CGH" where the DNA is hybridised onto metaphase slides.