Publications from OUS - Genetics (Lothe)

300 publications found

Publications 2020

  1. Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok BI, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
    Patient-derived organoids from multiple colorectal cancer liver metastases reveal moderate intra-patient pharmacotranscriptomic heterogeneity
    Clin Cancer Res (in press)
    DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813
  2. Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
    Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
    Mol Oncol, 14 (5), 1016-1027
    DOI 10.1002/1878-0261.12668, PubMed 32171051
  3. Lopes N, Bergsland C, Bruun J, Bjørnslett M, Vieira AF, Mesquita P, Pinto R, Gomes R, Cavadas B, Bennett E, Pereira L, Lothe RA, Almeida R, David L (2020)
    A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis
    Gastric Cancer
    DOI 10.1007/s10120-020-01064-6, PubMed 32215766
  4. Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
    Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
    Blood Adv, 4 (9), 1859-1866
    DOI 10.1182/bloodadvances.2019001325, PubMed 32374878

Publications 2019

  1. Berg KCG, Sveen A, Høland M, Alagaratnam S, Berg M, Danielsen SA, Nesbakken A, Søreide K, Lothe RA (2019)
    Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
    Oncogene, 38 (33), 6109-6122
    DOI 10.1038/s41388-019-0868-5, PubMed 31308487
  2. Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
    Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
    Eur J Surg Oncol, 45 (12), 2340-2346
    DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075
  3. Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
    High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
    Clin Colorectal Cancer, 19 (1), e26-e47
    DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351
  4. Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L (2019)
    Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon
    Cell Death Dis, 10 (11), 818
    DOI 10.1038/s41419-019-2057-4, PubMed 31659152
  5. Carm KT, Hoff AM, Bakken AC, Axcrona U, Axcrona K, Lothe RA, Skotheim RI, Løvf M (2019)
    Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer
    Sci Rep, 9 (1), 13579
    DOI 10.1038/s41598-019-49964-7, PubMed 31537872
  6. Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J (2019)
    Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer
    Ann Oncol, 30 (10), 1622-1629
    DOI 10.1093/annonc/mdz287, PubMed 31504112
  7. Eide PW, Eilertsen IA, Sveen A, Lothe RA (2019)
    Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties
    Int J Cancer, 144 (11), 2843-2853
    DOI 10.1002/ijc.31998, PubMed 30447009
  8. Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A (2019)
    Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
    Cancer Lett, 469, 246-255
    DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167
  9. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (6), 474-482
    DOI 10.1038/s41416-019-0540-4, PubMed 31388185
  10. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Correction: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (9), 807
    DOI 10.1038/s41416-019-0590-7, PubMed 31548598
  11. Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA (2019)
    Combination therapies with HSP90 inhibitors against colorectal cancer
    Biochim Biophys Acta Rev Cancer, 1871 (2), 240-247
    DOI 10.1016/j.bbcan.2019.01.002, PubMed 30708039
  12. Lopes N, Bergsland CH, Bjørnslett M, Pellinen T, Svindland A, Nesbakken A, Almeida R, Lothe RA, David L, Bruun J (2019)
    Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
    Lab Invest, 100 (1), 120-134
    DOI 10.1038/s41374-019-0336-4, PubMed 31641225
  13. Miranda A, Hamilton PT, Zhang AW, Pattnaik S, Becht E, Mezheyeuski A, Bruun J, Micke P, de Reynies A, Nelson BH (2019)
    Cancer stemness, intratumoral heterogeneity, and immune response across cancers
    Proc Natl Acad Sci U S A, 116 (18), 9020-9029
    DOI 10.1073/pnas.1818210116, PubMed 30996127
  14. Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
    Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
    HPB (Oxford), 21 (8), 1017-1023
    DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198
  15. Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
    Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
    ESMO Open, 4 (3), e000523
    DOI 10.1136/esmoopen-2019-000523, PubMed 31321083
  16. Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
    Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
    Oncogenesis, 8 (6), 35
    DOI 10.1038/s41389-019-0141-3, PubMed 31092812
  17. Sveen A, Cremolini C, Dienstmann R (2019)
    Predictive modeling in colorectal cancer: time to move beyond consensus molecular subtypes
    Ann Oncol, 30 (11), 1682-1685
    DOI 10.1093/annonc/mdz412, PubMed 31868904
  18. Sveen A, Kopetz S, Lothe RA (2019)
    Biomarker-guided therapy for colorectal cancer: strength in complexity
    Nat Rev Clin Oncol, 17 (1), 11-32
    DOI 10.1038/s41571-019-0241-1, PubMed 31289352
  19. Totland MZ, Rasmussen NL, Knudsen LM, Leithe E (2019)
    Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
    Cell Mol Life Sci, 77 (4), 573-591
    DOI 10.1007/s00018-019-03285-0, PubMed 31501970
  20. Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K, Tabernero A (2019)
    Connexins in cancer: bridging the gap to the clinic
    Oncogene, 38 (23), 4429-4451
    DOI 10.1038/s41388-019-0741-6, PubMed 30814684

Publications 2018

  1. Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA (2018)
    Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
    Mol Oncol, 12 (9), 1639-1655
    DOI 10.1002/1878-0261.12347, PubMed 29900672
  2. Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2018)
    Prognostic markers for colorectal cancer: estimating ploidy and stroma
    Ann Oncol, 29 (3), 616-623
    DOI 10.1093/annonc/mdx794, PubMed 29293881
  3. Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
    Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
    Int J Cancer, 144 (4), 841-847
    DOI 10.1002/ijc.31809, PubMed 30121958
  4. Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA (2018)
    Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53
    Mod Pathol, 31 (11), 1694-1707
    DOI 10.1038/s41379-018-0074-y, PubMed 29946184
  5. Lønning PE, Berge EO, Bjørnslett M, Minsaas L, Chrisanthar R, Høberg-Vetti H, Dulary C, Busato F, Bjørneklett S, Eriksen C, Kopperud R, Axcrona U, Davidson B, Bjørge L, Evans G, Howell A, Salvesen HB, Janszky I, Hveem K, Romundstad PR, Vatten LJ, Tost J, Dørum A, Knappskog S (2018)
    White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk
    Ann Intern Med, 168 (5), 326-334
    DOI 10.7326/M17-0101, PubMed 29335712
  6. Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
    Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
    Eur Urol, 75 (3), 498-505
    DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
  7. Mezheyeuski A, Bergsland CH, Backman M, Djureinovic D, Sjöblom T, Bruun J, Micke P (2018)
    Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
    J Pathol, 244 (4), 421-431
    DOI 10.1002/path.5026, PubMed 29282718
  8. Oltedal S, Kørner H, Aasprong OG, Hussain I, Tjensvoll K, Smaaland R, Søreide JA, Søreide K, Lothe RA, Heikkilä R, Gilje B, Nordgård O (2018)
    The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer
    Transl Oncol, 11 (2), 436-443
    DOI 10.1016/j.tranon.2018.01.015, PubMed 29475140
  9. Pharo HD, Andresen K, Berg KCG, Lothe RA, Jeanmougin M, Lind GE (2018)
    A robust internal control for high-precision DNA methylation analyses by droplet digital PCR
    Clin Epigenetics, 10, 24
    DOI 10.1186/s13148-018-0456-5, PubMed 29484034
  10. Pinto D, Pinto C, Guerra J, Pinheiro M, Santos R, Vedeld HM, Yohannes Z, Peixoto A, Santos C, Pinto P, Lopes P, Lothe R, Lind GE, Henrique R, Teixeira MR (2018)
    Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation
    Cancer Med, 7 (2), 433-444
    DOI 10.1002/cam4.1285, PubMed 29341452
  11. Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA (2018)
    CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
    Ann Oncol, 29 (5), 1227-1234
    DOI 10.1093/annonc/mdy085, PubMed 29518181
  12. Vedeld HM, Nesbakken A, Lothe RA, Lind GE (2018)
    Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
    Clin Epigenetics, 10, 70
    DOI 10.1186/s13148-018-0503-2, PubMed 29854011

Publications 2017

  1. Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
    Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
    Mol Cancer, 16 (1), 116
    DOI 10.1186/s12943-017-0691-y, PubMed 28683746
  2. Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J (2017)
    Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study
    Ann Oncol, 28 (5), 1023-1031
    DOI 10.1093/annonc/mdx052, PubMed 28453697
  3. Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
    A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
    Cell Signal, 32, 1-11
    DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322
  4. Eide PW, Bruun J, Lothe RA, Sveen A (2017)
    CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
    Sci Rep, 7 (1), 16618
    DOI 10.1038/s41598-017-16747-x, PubMed 29192179
  5. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S (2017)
    MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
    BMC Cancer, 17 (1), 97
    DOI 10.1186/s12885-017-3094-y, PubMed 28158999
  6. Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA (2017)
    Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
    Mol Oncol, 11 (9), 1156-1171
    DOI 10.1002/1878-0261.12086, PubMed 28556483
  7. Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
    C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
    PLoS One, 12 (7), e0182030
    DOI 10.1371/journal.pone.0182030, PubMed 28759630
  8. Leithe E, Mesnil M, Aasen T (2017)
    The connexin 43 C-terminus: A tail of many tales
    Biochim Biophys Acta Biomembr, 1860 (1), 48-64
    DOI 10.1016/j.bbamem.2017.05.008, PubMed 28526583
  9. Lind GE, Guriby M, Ahlquist T, Hussain I, Jeanmougin M, Søreide K, Kørner H, Lothe RA, Nordgård O (2017)
    Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
    Clin Epigenetics, 9, 97
    DOI 10.1186/s13148-017-0397-4, PubMed 28878843
  10. Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2017)
    An update on minding the gap in cancer
    Biochim Biophys Acta Biomembr, 1860 (1), 237-243
    DOI 10.1016/j.bbamem.2017.06.015, PubMed 28655619
  11. Solheim O, Førsund M, Tropé CG, Kraggerud SM, Nesland JM, Davidson B (2017)
    Epithelial-mesenchymal transition markers in malignant ovarian germ cell tumors
    APMIS, 125 (9), 781-786
    DOI 10.1111/apm.12715, PubMed 28585395
  12. Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
    Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
    Clin Cancer Res, 24 (4), 794-806
    DOI 10.1158/1078-0432.CCR-17-1234, PubMed 29242316
  13. Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
    Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
    Genome Med, 9 (1), 46
    DOI 10.1186/s13073-017-0434-0, PubMed 28539123
  14. Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
    The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
    J Cell Sci, 130 (17), 2867-2882
    DOI 10.1242/jcs.202408, PubMed 28733455
  15. Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
    CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
    Int J Cancer, 141 (5), 967-976
    DOI 10.1002/ijc.30796, PubMed 28542846

Publications 2016

  1. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
    MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
    Oncotarget, 7 (6), 6476-505
    DOI 10.18632/oncotarget.6390, PubMed 26623728
  2. Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, Epicolon consortium, de Bruyn M, Nijman HW et al. (2016)
    Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
    Lancet Gastroenterol Hepatol, 1 (3), 207-216
    DOI 10.1016/S2468-1253(16)30014-0, PubMed 28404093
  3. Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
    Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
    Cell Cycle, 15 (21), 2943-2957
    DOI 10.1080/15384101.2016.1231280, PubMed 27625181
  4. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Dørum A, Birkeland E, Hveem K, Romundstad P, Vatten L, Lønning PE, Knappskog S (2016)
    The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer
    Tumour Biol, 37 (8), 10697-702
    DOI 10.1007/s13277-016-4940-2, PubMed 26867771
  5. Leithe E (2016)
    Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
    Biochim Biophys Acta, 1865 (2), 133-46
    DOI 10.1016/j.bbcan.2016.02.001, PubMed 26855059
  6. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
    Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
    Oncotarget, 7 (5), 5273-88
    DOI 10.18632/oncotarget.6567, PubMed 26672768
  7. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
    Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
    Urol Oncol, 35 (3), 111.e1-111.e8
    DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
  8. Ramalho-Carvalho J, Martins JB, Cekaite L, Sveen A, Torres-Ferreira J, Graça I, Costa-Pinheiro P, Eilertsen IA, Antunes L, Oliveira J, Lothe RA, Henrique R, Jerónimo C (2016)
    Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1
    Cancer Lett, 385, 150-159
    DOI 10.1016/j.canlet.2016.10.028, PubMed 27984115
  9. Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
    Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
    PLoS Genet, 12 (7), e1006225
    DOI 10.1371/journal.pgen.1006225, PubMed 27472274

Publications 2015

  1. Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
    Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
    Hepatology, 61 (5), 1651-9
    DOI 10.1002/hep.27707, PubMed 25644509
  2. Bjørnslett M, Dahl AA, Sørebø Ø, Dørum A (2015)
    Psychological distress related to BRCA testing in ovarian cancer patients
    Fam Cancer, 14 (4), 495-504
    DOI 10.1007/s10689-015-9811-2, PubMed 25980896
  3. Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
    Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
    Neoplasia, 17 (2), 167-74
    DOI 10.1016/j.neo.2014.12.005, PubMed 25748235
  4. Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
    Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
    Clin Cancer Res, 21 (16), 3759-70
    DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
  5. Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
    Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
    Cancer Res, 76 (1), 108-16
    DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575
  6. Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
    Novel RNA variants in colorectal cancers
    Oncotarget, 6 (34), 36587-602
    DOI 10.18632/oncotarget.5500, PubMed 26474385
  7. Johannessen B, Sveen A, Skotheim RI (2015)
    TIN: An R Package for Transcriptome Instability Analysis
    Cancer Inform, 14, 109-12
    DOI 10.4137/CIN.S31363, PubMed 26448683
  8. Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
    Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
    Mol Oncol, 9 (6), 1129-39
    DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
  9. Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
    Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
    Oncotarget, 6 (7), 5217-36
    DOI 10.18632/oncotarget.2847, PubMed 25595908
  10. Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
    Macroautophagic cargo sequestration assays
    Methods, 75, 25-36
    DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638
  11. Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
    Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
    Oncogene, 35 (19), 2413-27
    DOI 10.1038/onc.2015.318, PubMed 26300000

Publications 2014

  1. Almeida M, Costa VL, Costa NR, Ramalho-Carvalho J, Baptista T, Ribeiro FR, Paulo P, Teixeira MR, Oliveira J, Lothe RA, Lind GE, Henrique R, Jerónimo C (2014)
    Epigenetic regulation of EFEMP1 in prostate cancer: biological relevance and clinical potential
    J Cell Mol Med, 18 (11), 2287-97
    DOI 10.1111/jcmm.12394, PubMed 25211630
  2. Bruun J, Kolberg M, Nesland JM, Svindland A, Nesbakken A, Lothe RA (2014)
    Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
    Front Oncol, 4, 118
    DOI 10.3389/fonc.2014.00118, PubMed 24904831
  3. Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2014)
    Portrait of the PI3K/AKT pathway in colorectal cancer
    Biochim Biophys Acta, 1855 (1), 104-21
    DOI 10.1016/j.bbcan.2014.09.008, PubMed 25450577
  4. Hveem TS, Merok MA, Pretorius ME, Novelli M, Bævre MS, Sjo OH, Clinch N, Liestøl K, Svindland A, Lothe RA, Nesbakken A, Danielsen HE (2014)
    Prognostic impact of genomic instability in colorectal cancer
    Br J Cancer, 110 (8), 2159-64
    DOI 10.1038/bjc.2014.133, PubMed 24642618
  5. Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2014)
    A novel transcript, VNN1-AB, as a biomarker for colorectal cancer
    Int J Cancer, 135 (9), 2077-84
    DOI 10.1002/ijc.28855, PubMed 24687856
  6. Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E (2014)
    Connexins in colorectal cancer pathogenesis
    Int J Cancer, 137 (1), 1-11
    DOI 10.1002/ijc.28911, PubMed 24752574
  7. Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
    Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
    Genes Chromosomes Cancer, 53 (7), 558-67
    DOI 10.1002/gcc.22166, PubMed 24634323
  8. Sveen A, Johannessen B, Teixeira MR, Lothe RA, Skotheim RI (2014)
    Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
    BMC Genomics, 15, 672
    DOI 10.1186/1471-2164-15-672, PubMed 25109687
  9. Sørlie T, Johnsen H, Vu P, Lind GE, Lothe R, Børresen-Dale AL (2014)
    Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE)
    Methods Mol Biol, 1105, 315-24
    DOI 10.1007/978-1-62703-739-6_25, PubMed 24623239
  10. Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE (2014)
    The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
    Int J Cancer, 136 (4), 844-53
    DOI 10.1002/ijc.29039, PubMed 24948044
  11. Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
    The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
    Epigenetics, 9 (3), 346-50
    DOI 10.4161/epi.27582, PubMed 24384857

Publications 2013

  1. Ahmed D, Eide PW, Eilertsen IA, Danielsen SA, Eknæs M, Hektoen M, Lind GE, Lothe RA (2013)
    Epigenetic and genetic features of 24 colon cancer cell lines
    Oncogenesis, 2, e71
    DOI 10.1038/oncsis.2013.35, PubMed 24042735
  2. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
    Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
    Stem Cells Dev, 22 (7), 1136-46
    DOI 10.1089/scd.2012.0369, PubMed 23137282
  3. Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P, Andrews PW, Knowles BB (2013)
    BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures
    Stem Cell Reports, 1 (5), 379-86
    DOI 10.1016/j.stemcr.2013.10.005, PubMed 24286026
  4. Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, Teixeira MR (2013)
    Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
    Neoplasia, 15 (7), 720-6
    DOI 10.1593/neo.13232, PubMed 23814484
  5. Berg M, Guriby M, Nordgård O, Nedrebø BS, Ahlquist TC, Smaaland R, Oltedal S, Søreide JA, Kørner H, Lothe RA, Søreide K (2013)
    Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers
    Mol Med, 19, 286-93
    DOI 10.2119/molmed.2013.00049, PubMed 23979710
  6. Bethge N, Honne H, Hilden V, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
    Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma
    PLoS One, 8 (11), e79602
    DOI 10.1371/journal.pone.0079602, PubMed 24260260
  7. Bethge N, Lothe RA, Honne H, Andresen K, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
    Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
    Epigenetics, 9 (3), 428-36
    DOI 10.4161/epi.27554, PubMed 24362313
  8. Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR et al. (2013)
    Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Nat Genet, 45 (6), 680-5
    DOI 10.1038/ng.2634, PubMed 23666239
  9. Håvik AB, Lind GE, Honne H, Meling TR, Scheie D, Hall KS, van den Berg E, Mertens F, Picci P, Lothe RA, Heim S, Brandal P (2013)
    Sequencing IDH1/2 glioma mutation hotspots in gliomas and malignant peripheral nerve sheath tumors
    Neuro Oncol, 16 (2), 320-2
    DOI 10.1093/neuonc/not230, PubMed 24311631
  10. Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
    Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
    Endocr Rev, 34 (3), 339-76
    DOI 10.1210/er.2012-1045, PubMed 23575763
  11. Løvf M, Thomassen GO, Mertens F, Cerveira N, Teixeira MR, Lothe RA, Skotheim RI (2013)
    Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray
    PLoS One, 8 (8), e70649
    DOI 10.1371/journal.pone.0070649, PubMed 23967081
  12. Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (2013)
    Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes
    Breast Cancer Res Treat, 138 (1), 37-45
    DOI 10.1007/s10549-013-2408-2, PubMed 23329352
  13. Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
    Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
    Transl Oncol, 6 (5), 546-53
    DOI 10.1593/tlo.13457, PubMed 24151535
  14. Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM et al. (2013)
    Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23
    Hum Mol Genet, 22 (13), 2748-53
    DOI 10.1093/hmg/ddt109, PubMed 23462292

Publications 2012

  1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
    ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
    Gut, 61 (11), 1560-7
    DOI 10.1136/gutjnl-2011-301179, PubMed 22213796
  2. Ahmed D, Danielsen SA, Aagesen TH, Bretthauer M, Thiis-Evensen E, Hoff G, Rognum TO, Nesbakken A, Lothe RA, Lind GE (2012)
    A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors
    Clin Transl Gastroenterol, 3, e27
    DOI 10.1038/ctg.2012.21, PubMed 23324654
  3. Andresen K, Boberg KM, Vedeld HM, Honne H, Hektoen M, Wadsworth CA, Clausen OP, Karlsen TH, Foss A, Mathisen O, Schrumpf E, Lothe RA, Lind GE (2012)
    Novel target genes and a valid biomarker panel identified for cholangiocarcinoma
    Epigenetics, 7 (11), 1249-57
    DOI 10.4161/epi.22191, PubMed 22983262
  4. Camões MJ, Paulo P, Ribeiro FR, Barros-Silva JD, Almeida M, Costa VL, Cerveira N, Skotheim RI, Lothe RA, Henrique R, Jerónimo C, Teixeira MR (2012)
    Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
    PLoS One, 7 (11), e49819
    DOI 10.1371/journal.pone.0049819, PubMed 23185447
  5. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
    MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
    Neoplasia, 14 (9), 868-79
    DOI 10.1593/neo.121094, PubMed 23019418
  6. Celestino R, Sigstad E, Løvf M, Thomassen GO, Grøholt KK, Jørgensen LH, Berner A, Castro P, Lothe RA, Bjøro T, Sobrinho-Simões M, Soares P, Skotheim RI (2012)
    Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes
    Genes Chromosomes Cancer, 51 (12), 1154-64
    DOI 10.1002/gcc.22003, PubMed 22961909
  7. Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E (2012)
    NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
    Cell Signal, 25 (1), 12-8
    DOI 10.1016/j.cellsig.2012.08.012, PubMed 22974840
  8. Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
    Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
    J Cell Sci, 125 (Pt 17), 3966-76
    DOI 10.1242/jcs.093500, PubMed 22623726
  9. Håvik AB, Brandal P, Honne H, Dahlback HS, Scheie D, Hektoen M, Meling TR, Helseth E, Heim S, Lothe RA, Lind GE (2012)
    MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR
    J Transl Med, 10, 36
    DOI 10.1186/1479-5876-10-36, PubMed 22390413
  10. Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E (2012)
    The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
    J Biol Chem, 287 (19), 15851-61
    DOI 10.1074/jbc.M111.281832, PubMed 22411987
  11. Kolberg M, Høland M, Agesen TH, Brekke HR, Liestøl K, Hall KS, Mertens F, Picci P, Smeland S, Lothe RA (2012)
    Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
    Neuro Oncol, 15 (2), 135-47
    DOI 10.1093/neuonc/nos287, PubMed 23161774
  12. Lind GE, Ahmed D, Lothe RA (2012)
    Vimentin in upper gastrointestinal pathologies--letter
    Cancer Epidemiol Biomarkers Prev, 21 (10), 1889; author reply 1890
    DOI 10.1158/1055-9965.EPI-12-0894, PubMed 22929079
  13. Lobert VH, Bruun J, Abrahamsen H, Lothe RA, Stenmark H, Kolberg M, Campsteijn C (2012)
    Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
    EMBO Rep, 14 (1), 10-1
    DOI 10.1038/embor.2012.188, PubMed 23229585
  14. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R (2012)
    Oncogenicity of the developmental transcription factor Sox9
    Cancer Res, 72 (5), 1301-15
    DOI 10.1158/0008-5472.CAN-11-3660, PubMed 22246670
  15. Merok MA, Ahlquist T, Røyrvik EC, Tufteland KF, Hektoen M, Sjo OH, Mala T, Svindland A, Lothe RA, Nesbakken A (2012)
    Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series
    Ann Oncol, 24 (5), 1274-82
    DOI 10.1093/annonc/mds614, PubMed 23235802
  16. Nordgård O, Oltedal S, Aasprong OG, Søreide JA, Søreide K, Tjensvoll K, Gilje B, Heikkilä R, Guriby M, Lothe RA, Smaaland R, Kørner H (2012)
    Prognostic relevance of occult metastases detected by cytokeratin 20 and mucin 2 mRNA levels in sentinel lymph nodes from colon cancer patients
    Ann Surg Oncol, 19 (12), 3719-26
    DOI 10.1245/s10434-012-2454-8, PubMed 22752373
  17. Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012)
    Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    PLoS One, 7 (11), e49705
    DOI 10.1371/journal.pone.0049705, PubMed 23185413
  18. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
    Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    Neoplasia, 14 (7), 600-11
    DOI 10.1593/neo.12600, PubMed 22904677
  19. Sjo OH, Merok MA, Svindland A, Nesbakken A (2012)
    Prognostic impact of lymph node harvest and lymph node ratio in patients with colon cancer
    Dis Colon Rectum, 55 (3), 307-15
    DOI 10.1097/DCR.0b013e3182423f62, PubMed 22469798
  20. Sveen A, Bakken AC, Ågesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI (2012)
    The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
    Int J Cancer, 131 (6), 1479-85
    DOI 10.1002/ijc.27399, PubMed 22173985
  21. Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
    ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
    Clin Cancer Res, 18 (21), 6001-10
    DOI 10.1158/1078-0432.CCR-11-3302, PubMed 22991413

Publications 2011

  1. Ahmed D, Lothe RA, Rivedal E, Lind GE (2011)
    Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors
    Endocr Relat Cancer, 18 (6), C31-4
    DOI 10.1530/ERC-11-0204, PubMed 21868474
  2. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
    The testicular germ cell tumour transcriptome
    Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
    DOI 10.1111/j.1365-2605.2011.01169.x, PubMed 21651573
  3. Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, Oliveira J, Lothe RA, Teixeira MR, Lind GE, Jerónimo C (2011)
    TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers
    Epigenetics, 6 (9), 1120-30
    DOI 10.4161/epi.6.9.16376, PubMed 21847011
  4. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
    Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
    PLoS One, 6 (9), e24419
    DOI 10.1371/journal.pone.0024419, PubMed 21909432
  5. Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E (2011)
    Endocytosis and post-endocytic sorting of connexins
    Biochim Biophys Acta, 1818 (8), 1870-9
    DOI 10.1016/j.bbamem.2011.09.029, PubMed 21996040
  6. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
    Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
    Mol Cancer, 10, 85
    DOI 10.1186/1476-4598-10-85, PubMed 21777459
  7. Lind GE, Raiborg C, Danielsen SA, Rognum TO, Thiis-Evensen E, Hoff G, Nesbakken A, Stenmark H, Lothe RA (2011)
    SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
    Oncogene, 30 (37), 3967-78
    DOI 10.1038/onc.2011.109, PubMed 21499309
  8. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
    Fusion gene microarray reveals cancer type-specificity among fusion genes
    Genes Chromosomes Cancer, 50 (5), 348-57
    DOI 10.1002/gcc.20860, PubMed 21305644
  9. Ohnstad HO, Paulsen EB, Noordhuis P, Berg M, Lothe RA, Vassilev LT, Myklebost O (2011)
    MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
    BMC Cancer, 11, 211:1-11
    DOI 10.1186/1471-2407-11-211, PubMed 21624110
  10. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Genes Chromosomes Cancer, 51 (3), 240-9
    DOI 10.1002/gcc.20948, PubMed 22081504
  11. Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
    PLoS One, 6 (7), e22317
    DOI 10.1371/journal.pone.0022317, PubMed 21814574
  12. Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
    Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
    Int J Cancer, 131 (3), 570-81
    DOI 10.1002/ijc.26392, PubMed 21866551
  13. Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE (2011)
    DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
    Epigenetics, 6 (5), 602-9
    DOI 10.4161/epi.6.5.15237, PubMed 21406965
  14. Sjo OH, Berg M, Merok MA, Kolberg M, Svindland A, Lothe RA, Nesbakken A (2011)
    Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors
    J Surg Oncol, 104 (7), 792-7
    DOI 10.1002/jso.21959, PubMed 21547915
  15. Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
    Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
    Genome Med, 3 (5), 32
    DOI 10.1186/gm248, PubMed 21619627
  16. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
    CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
    Genes Immun, 12 (8), 653-62
    DOI 10.1038/gene.2011.43, PubMed 21716316

Publications 2010

  1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
    Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Mol Cancer, 9, 100
    DOI 10.1186/1476-4598-9-100, PubMed 20459617
  2. Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA (2010)
    DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset
    PLoS One, 5 (11), e13978
    DOI 10.1371/journal.pone.0013978, PubMed 21103049
  3. Berge G, Costea DE, Berg M, Rasmussen H, Grotterød I, Lothe RA, Mælandsmo GM, Flatmark K (2010)
    Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma
    Amino Acids, 41 (4), 875-84
    DOI 10.1007/s00726-010-0514-6, PubMed 20191297
  4. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
    Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    J Clin Oncol, 28 (9), 1573-82
    DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
  5. Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
    Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
    J Carcinog, 9, 1
    DOI 10.4103/1477-3163.60358, PubMed 20411023
  6. Cekaite L, Clancy T, Sioud M (2010)
    Increased miR-21 expression during human monocyte differentiation into DCs
    Front Biosci (Elite Ed), 2, 818-28
    DOI 10.2741/e143, PubMed 20515755
  7. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
    Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
    Clin Cancer Res, 16 (23), 5842-51
    DOI 10.1158/1078-0432.CCR-10-1312, PubMed 20975101
  8. Kjenseth A, Fykerud T, Rivedal E, Leithe E (2010)
    Regulation of gap junction intercellular communication by the ubiquitin system
    Cell Signal, 22 (9), 1267-73
    DOI 10.1016/j.cellsig.2010.03.005, PubMed 20206687
  9. Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, Simonsen A (2010)
    UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
    Autophagy, 6 (7), 863-70
    DOI 10.4161/auto.6.7.13033, PubMed 20724836
  10. Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E (2010)
    Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil
    Toxicol Appl Pharmacol, 247 (1), 10-7
    DOI 10.1016/j.taap.2010.05.006, PubMed 20510257
  11. Micci F, Haugom L, Ahlquist T, Andersen HK, Abeler VM, Davidson B, Trope CG, Lothe RA, Heim S (2010)
    Genomic aberrations in borderline ovarian tumors
    J Transl Med, 8, 21
    DOI 10.1186/1479-5876-8-21, PubMed 20184781
  12. Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
    Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
    Genes Chromosomes Cancer, 49 (11), 1046-53
    DOI 10.1002/gcc.20813, PubMed 20725991
  13. Pinheiro M, Ahlquist T, Danielsen SA, Lind GE, Veiga I, Pinto C, Costa V, Afonso L, Sousa O, Fragoso M, Santos L, Henrique R, Lopes P, Lopes C, Lothe RA, Teixeira MR (2010)
    Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin
    BMC Cancer, 10, 587
    DOI 10.1186/1471-2407-10-587, PubMed 20979647
  14. Sioud M, Cekaite L (2010)
    Profiling of miRNA expression and prediction of target genes
    Methods Mol Biol, 629, 257-71
    DOI 10.1007/978-1-60761-657-3_16, PubMed 20387154
  15. Zwierzina H, Bardelli A, Ciardiello F, Gariboldi M, Håkansson L, Lambrechts D, Lind GE, Loeffler-Ragg J, Schmoll H, Siena S, Tabernero J, Van Cutsem E (2010)
    Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials
    Curr Opin Mol Ther, 12 (6), 703-11
    PubMed 21154162

Publications 2009

  1. Bottillo I, Ahlquist T, Brekke H, Danielsen SA, van den Berg E, Mertens F, Lothe RA, Dallapiccola B (2009)
    Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
    J Pathol, 217 (5), 693-701
    DOI 10.1002/path.2494, PubMed 19142971
  2. Brech A, Ahlquist T, Lothe RA, Stenmark H (2009)
    Autophagy in tumour suppression and promotion
    Mol Oncol, 3 (4), 366-75
    DOI 10.1016/j.molonc.2009.05.007, PubMed 19559660
  3. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
    Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    Neuro Oncol, 11 (5), 514-28
    DOI 10.1215/15228517-2008-127, PubMed 19182148
  4. Danielsen SA, Lind GE, Biornslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2009)
    Novel Mutations of the Suppressor Gene PTEN in Colorectal Carcinomas Stratified by Microsatellite Instability- and TP53 Mutation- Status (vol 29, pg E252, 2008)
    Hum. Mutat., 30 (6), 1023
  5. Kraggerud SM, Oldenburg J, Alnaes GI, Berg M, Kristensen VN, Fossa SD, Lothe RA (2009)
    Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
    Pharmacogenet Genomics, 19 (10), 751-9
    DOI 10.1097/FPC.0b013e3283304253, PubMed 19741569
  6. Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
    Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
    J Cell Sci, 122 (Pt 21), 3883-93
    DOI 10.1242/jcs.053801, PubMed 19808888
  7. Micci F, Haugom L, Ahlquist T, Abeler VM, Trope CG, Lothe RA, Heim S (2009)
    Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution
    J Oncol, 2010, 646340
    DOI 10.1155/2010/646340, PubMed 19759843
  8. Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
    Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
    Genes Chromosomes Cancer, 48 (2), 184-93
    DOI 10.1002/gcc.20628, PubMed 18973136
  9. Pretorius ME, Waehre H, Abeler VM, Davidson B, Vlatkovic L, Lothe RA, Giercksky KE, Danielsen HE (2009)
    Large scale genomic instability as an additive prognostic marker in early prostate cancer
    Cell Oncol, 31 (4), 251-9
    DOI 10.3233/CLO-2009-0463, PubMed 19633362
  10. Rivedal E, Witz G, Leithe E (2009)
    Gap junction intercellular communication and benzene toxicity
    Chem Biol Interact, 184 (1-2), 229-32
    DOI 10.1016/j.cbi.2009.11.013, PubMed 19932693
  11. Sirnes S, Kjenseth A, Leithe E, Rivedal E (2009)
    Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication
    Biochem Biophys Res Commun, 382 (1), 41-5
    DOI 10.1016/j.bbrc.2009.02.141, PubMed 19258009
  12. Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
    A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
    Mol Cancer, 8, 5
    DOI 10.1186/1476-4598-8-5, PubMed 19152679
  13. Vrålstad T, Knutsen AK, Tengs T, Holst-Jensen A (2009)
    A quantitative TaqMan MGB real-time polymerase chain reaction based assay for detection of the causative agent of crayfish plague Aphanomyces astaci
    Vet Microbiol, 137 (1-2), 146-55
    DOI 10.1016/j.vetmic.2008.12.022, PubMed 19201113

Publications 2008

  1. Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA (2008)
    RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A
    Neoplasia, 10 (7), 680-6, 2 p following 686
    DOI 10.1593/neo.08312, PubMed 18592002
  2. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
    Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    Mol Cancer, 7, 94
    DOI 10.1186/1476-4598-7-94, PubMed 19117505
  3. Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008)
    TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
    Mol Cell Endocrinol, 306 (1-2), 75-80
    DOI 10.1016/j.mce.2008.10.043, PubMed 19041365
  4. Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2008)
    Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status
    Hum Mutat, 29 (11), E252-62
    DOI 10.1002/humu.20860, PubMed 18781614
  5. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
    Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    J Transl Med, 6, 13
    DOI 10.1186/1479-5876-6-13, PubMed 18346269
  6. Rivedal E, Leithe E (2008)
    The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43
    Toxicol Appl Pharmacol, 232 (3), 463-8
    DOI 10.1016/j.taap.2008.07.022, PubMed 18723040
  7. Sioud M, Cekaite L (2008)
    Expression profiling of microRNAs in cancer cells: technical considerations
    Methods Mol Biol, 439, 179-90
    DOI 10.1007/978-1-59745-188-8_12, PubMed 18370103
  8. Sirnes S, Leithe E, Rivedal E (2008)
    The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis
    Biochem Biophys Res Commun, 373 (4), 597-601
    DOI 10.1016/j.bbrc.2008.06.095, PubMed 18601906

Publications 2007

  1. Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
    Improved gene expression signature of testicular carcinoma in situ
    Int J Androl, 30 (4), 292-302; discussion 303
    DOI 10.1111/j.1365-2605.2007.00758.x, PubMed 17488342
  2. Hoei-Hansen CE, Kraggerud SM, Abeler VM, Kaern J, Rajpert-De Meyts E, Lothe RA (2007)
    Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
    Mol Cancer, 6, 12
    DOI 10.1186/1476-4598-6-12, PubMed 17274819
  3. Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
    Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
    Mol Cancer, 6, 2
    DOI 10.1186/1476-4598-6-2, PubMed 17201907
  4. Leithe E, Rivedal E (2007)
    Ubiquitination of gap junction proteins
    J Membr Biol, 217 (1-3), 43-51
    DOI 10.1007/s00232-007-9050-z, PubMed 17657522
  5. Lind GE, Ahlquist T, Lothe RA (2007)
    DNA hypermethylation of MAL: a promising diagnostic biomarker for colorectal tumors
    Gastroenterology, 132 (4), 1631-2; author reply 1632
    DOI 10.1053/j.gastro.2007.03.003, PubMed 17408629
  6. Lind GE, Skotheim RI, Lothe RA (2007)
    The epigenome of testicular germ cell tumors
    APMIS, 115 (10), 1147-60
    DOI 10.1111/j.1600-0463.2007.apm_660.xml.x, PubMed 18042148
  7. Logares R, Rengefors K, Kremp A, Shalchian-Tabrizi K, Boltovskoy A, Tengs T, Shurtleff A, Klaveness D (2007)
    Phenotypically different microalgal morphospecies with identical ribosomal DNA: a case of rapid adaptive evolution?
    Microb Ecol, 53 (4), 549-61
    DOI 10.1007/s00248-006-9088-y, PubMed 17410396
  8. Mikalsen J, Olsen AB, Tengs T, Colquhoun DJ (2007)
    Francisella philomiragia subsp. noatunensis subsp. nov., isolated from farmed Atlantic cod (Gadus morhua L.)
    Int J Syst Evol Microbiol, 57 (Pt 9), 1960-5
    DOI 10.1099/ijs.0.64765-0, PubMed 17766855
  9. Oldenburg J, Kraggerud SM, Brydøy M, Cvancarova M, Lothe RA, Fossa SD (2007)
    Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study
    J Transl Med, 5, 70
    DOI 10.1186/1479-5876-5-70, PubMed 18162130
  10. Oldenburg J, Kraggerud SM, Cvancarova M, Lothe RA, Fossa SD (2007)
    Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors
    J Clin Oncol, 25 (6), 708-14
    DOI 10.1200/JCO.2006.08.9599, PubMed 17228018
  11. Røyrvik EC, Ahlquist T, Rognes T, Lothe RA (2007)
    Slip slidin' away: a duodecennial review of targeted genes in mismatch repair deficient colorectal cancer
    Crit Rev Oncog, 13 (3), 229-57
    DOI 10.1615/critrevoncog.v13.i3.20, PubMed 18298386
  12. Sioud M, Furset G, Cekaite L (2007)
    Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs
    Biochem Biophys Res Commun, 361 (1), 122-6
    DOI 10.1016/j.bbrc.2007.06.177, PubMed 17658482
  13. Wu Q, Lind GE, Aasheim HC, Micci F, Silins I, Tropé CG, Nesland JM, Lothe RA, Suo Z (2007)
    The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
    Epigenetics, 2 (4), 237-43
    DOI 10.4161/epi.2.4.5406, PubMed 18281782
  14. Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE (2007)
    DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
    Mol Cancer, 6, 45
    DOI 10.1186/1476-4598-6-45, PubMed 17623056

Publications 2006

  1. Andersen CB, Holst-Jensen A, Berdal KG, Thorstensen T, Tengs T (2006)
    Equal performance of TaqMan, MGB, molecular beacon, and SYBR green-based detection assays in detection and quantification of roundup ready soybean
    J Agric Food Chem, 54 (26), 9658-63
    DOI 10.1021/jf061987c, PubMed 17177484
  2. Bowers HA, Tomas C, Tengs T, Kempton JW, Lewitus AJ, Oldach DW (2006)
    J Phycol, 42 (6), 1333-1348
    DOI 10.1111/j.1529-8817.2006.00285.x, PubMed 20411032
  3. Diep CB, Kleivi K, Ribeiro FR, Teixeira MR, Lindgjaerde OC, Lothe RA (2006)
    The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes
    Genes Chromosomes Cancer, 45 (1), 31-41
    DOI 10.1002/gcc.20261, PubMed 16145679
  4. Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung CS, Ko JM, Yuen S, Ho J, Leung SY, Crapez E, Duffour J, Ychou M, Leahy DT, O'Donoghue DP, Agnese V, Cascio S et al. (2006)
    Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study
    Ann Oncol, 17 (5), 842-7
    DOI 10.1093/annonc/mdl035, PubMed 16524972
  5. Johnson MD, Tengs T, Oldach D, Stoecker DK (2006)
    Sequestration, performance, and functional control of cryptophyte plastids in the ciliate Myrionecta rubra (Ciliophora)
    J. Phycol., 42 (6), 1235-1246
  6. Leithe E, Brech A, Rivedal E (2006)
    Endocytic processing of connexin43 gap junctions: a morphological study
    Biochem J, 393 (Pt 1), 59-67
    DOI 10.1042/BJ20050674, PubMed 16162097
  7. Leithe E, Sirnes S, Omori Y, Rivedal E (2006)
    Downregulation of gap junctions in cancer cells
    Crit Rev Oncog, 12 (3-4), 225-56
    DOI 10.1615/critrevoncog.v12.i3-4.30, PubMed 17425504
  8. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell Oncol, 28 (5-6), 259-72
    DOI 10.1155/2006/949506, PubMed 17167179
  9. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell. Oncol., 28 (5-6), 259-272
  10. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
    Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
    J Pathol, 210 (4), 441-9
    DOI 10.1002/path.2064, PubMed 17029216
  11. Lothe RA, Skotheim RI, Kallioniemi O, Esteller M (2006)
    To the Readers and Future Authors of Critical Reviews in Oncogenesis
    Critical Reviews in Oncogenesis, 12 (1-2), 1-2
    PublikaID 27
  12. Prasmickaite L, Cekaite L, Hellum M, Hovig E, Høgset A, Berg K (2006)
    Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
    FEBS Lett, 580 (24), 5739-46
    DOI 10.1016/j.febslet.2006.09.028, PubMed 17007842
  13. Ribeiro FR, Diep CB, Jerónimo C, Henrique R, Lopes C, Eknaes M, Lingjaerde OC, Lothe RA, Teixeira MR (2006)
    Statistical dissection of genetic pathways involved in prostate carcinogenesis
    Genes Chromosomes Cancer, 45 (2), 154-63
    DOI 10.1002/gcc.20279, PubMed 16235241
  14. Ribeiro FR, Henrique R, Hektoen M, Berg M, Jerónimo C, Teixeira MR, Lothe RA (2006)
    Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
    Mol Cancer, 5, 33
    DOI 10.1186/1476-4598-5-33, PubMed 16952311
  15. Ribeiro FR, Jerónimo C, Henrique R, Fonseca D, Oliveira J, Lothe RA, Teixeira MR (2006)
    8q gain is an independent predictor of poor survival in diagnostic needle biopsies from prostate cancer suspects
    Clin Cancer Res, 12 (13), 3961-70
    DOI 10.1158/1078-0432.CCR-05-1977, PubMed 16818693
  16. Shalchian-Tabrizi K, Skånseng M, Ronquist F, Klaveness D, Bachvaroff TR, Delwiche CF, Botnen A, Tengs T, Jakobsen KS (2006)
    Heterotachy processes in rhodophyte-derived secondhand plastid genes: Implications for addressing the origin and evolution of dinoflagellate plastids
    Mol Biol Evol, 23 (8), 1504-15
    DOI 10.1093/molbev/msl011, PubMed 16699169
  17. Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA (2006)
    Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
    Cell Oncol, 28 (5-6), 315-26
    DOI 10.1155/2006/219786, PubMed 17167184
  18. Storlazzi CT, Brekke HR, Mandahl N, Brosjö O, Smeland S, Lothe RA, Mertens F (2006)
    Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
    J Pathol, 209 (4), 492-500
    DOI 10.1002/path.1998, PubMed 16721726
  19. Thomas RK, Nickerson E, Simons JF, Jänne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P et al. (2006)
    Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
    Nat Med, 12 (7), 852-5
    DOI 10.1038/nm1437, PubMed 16799556

Publications 2005

  1. Agesen TH, Flørenes VA, Molenaar WM, Lind GE, Berner JM, Plaat BE, Komdeur R, Myklebost O, van den Berg E, Lothe RA (2005)
    Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
    J Neuropathol Exp Neurol, 64 (1), 74-81
    DOI 10.1093/jnen/64.1.74, PubMed 15715087
  2. Castro P, Eknaes M, Teixeira MR, Danielsen HE, Soares P, Lothe RA, Sobrinho-Simões M (2005)
    Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes
    J Pathol, 206 (3), 305-11
    DOI 10.1002/path.1772, PubMed 15852498
  3. Hofer MD, Browne TJ, He L, Skotheim RI, Lothe RA, Rubin MA (2005)
    Identification of two molecular groups of seminomas by using expression and tissue microarrays
    Clin Cancer Res, 11 (16), 5722-9
    DOI 10.1158/1078-0432.CCR-05-0533, PubMed 16115909
  4. Kleivi K, Diep CB, Pandis N, Heim S, Teixeira MR, Lothe RA (2005)
    TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
    J Pathol, 207 (1), 14-9
    DOI 10.1002/path.1812, PubMed 16007576
  5. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Henrique R, Saatcioglu F, Esteller M, Teixeira MR, Lothe RA (2005)
    The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
    Mol Cancer, 4 (1), 8
    DOI 10.1186/1476-4598-4-8, PubMed 15691383
  6. Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fosså SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW, Lothe RA (2005)
    Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
    Cancer Res, 65 (13), 5588-98
    DOI 10.1158/0008-5472.CAN-05-0153, PubMed 15994931
  7. Sørlie T, Johnsen H, Vu P, Lind GE, Lothe R, Børresen-Dale AL (2005)
    Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
    Methods Mol Biol, 291, 207-16
    DOI 10.1385/1-59259-840-4:207, PubMed 15502225
  8. Thomas RK, Greulich H, Yuza Y, Lee JC, Tengs T, Feng W, Chen TH, Nickerson E, Simons J, Egholm M, Rothberg JM, Sellers WR, Meyerson ML (2005)
    Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors
    Cold Spring Harb Symp Quant Biol, 70, 73-81
    DOI 10.1101/sqb.2005.70.056, PubMed 16869740
  9. Thorstensen L, Lind GE, Løvig T, Diep CB, Meling GI, Rognum TO, Lothe RA (2005)
    Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability
    Neoplasia, 7 (2), 99-108
    DOI 10.1593/neo.04448, PubMed 15802015

Publications 2004

  1. Cekaite L, Hovig E, Hauge HH (2004)
    Double-sided silicon strip detectors: new applications within genomics and proteomics
    Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip., 527 (1-2), 68-72
  2. Johnson MD, Tengs T, Oldach DW, Delwiche CF, Stoecker DK (2004)
    Highly divergent SSU rRNA genes found in the marine ciliates Myrionecta rubra and Mesodinium pulex
    Protist, 155 (3), 347-59
    DOI 10.1078/1434461041844222, PubMed 15552061
  3. Kildal W, Kaern J, Kraggerud SM, Abeler VM, Sudbø J, Tropè CG, Lothe RA, Danielsen HE (2004)
    Evaluation of genomic changes in a large series of malignant ovarian germ cell tumors--relation to clinicopathologic variables
    Cancer Genet Cytogenet, 155 (1), 25-32
    DOI 10.1016/j.cancergencyto.2004.02.010, PubMed 15527899
  4. Kleivi K, Teixeira MR, Eknaes M, Diep CB, Jakobsen KS, Hamelin R, Lothe RA (2004)
    Genome signatures of colon carcinoma cell lines
    Cancer Genet Cytogenet, 155 (2), 119-31
    DOI 10.1016/j.cancergencyto.2004.03.014, PubMed 15571797
  5. LaFramboise TL, Hayes DN, Tengs T (2004)
    Statistical analysis of genomic tag data
    Stat Appl Genet Mol Biol, 3, Article34
    DOI 10.2202/1544-6115.1099, PubMed 16646814
  6. Richard SM, Bianchi NO, Bianchi MS, Peltomäki P, Lothe RA, Pavicic W (2004)
    Ethnic variation in the prevalence of AZF deletions in testicular cancer
    Mutat Res, 554 (1-2), 45-51
    DOI 10.1016/j.mrfmmm.2004.03.001, PubMed 15450403
  7. Teixeira MR, Ribeiro FR, Eknaes M, Waehre H, Stenwig AE, Giercksky KE, Heim S, Lothe RA (2004)
    Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making
    Cancer, 101 (8), 1786-93
    DOI 10.1002/cncr.20527, PubMed 15386312
  8. Teixeira MR, Ribeiro FR, Torres L, Pandis N, Andersen JA, Lothe RA, Heim S (2004)
    Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis
    Br J Cancer, 91 (4), 775-82
    DOI 10.1038/sj.bjc.6602021, PubMed 15266323

Publications 2003

  1. Brandal P, Micci F, Bjerkehagen B, Eknaes M, Larramendy M, Lothe RA, Knuutila S, Heim S (2003)
    Molecular cytogenetic characterization of desmoid tumors
    Cancer Genet Cytogenet, 146 (1), 1-7
    DOI 10.1016/s0165-4608(03)00122-5, PubMed 14499689
  2. Diep CB, Parada LA, Teixeira MR, Eknaes M, Nesland JM, Johansson B, Lothe RA (2003)
    Genetic profiling of colorectal cancer liver metastases by combined comparative genomic hybridization and G-banding analysis
    Genes Chromosomes Cancer, 36 (2), 189-97
    DOI 10.1002/gcc.10162, PubMed 12508247
  3. Diep CB, Thorstensen L, Meling GI, Skovlund E, Rognum TO, Lothe RA (2003)
    Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients
    J Clin Oncol, 21 (5), 820-9
    DOI 10.1200/JCO.2003.05.190, PubMed 12610180
  4. Henriksen J, Aagesen TH, Maelandsmo GM, Lothe RA, Myklebost O, Forus A (2003)
    Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
    Oncogene, 22 (34), 5358-61
    DOI 10.1038/sj.onc.1206671, PubMed 12917637
  5. Kildal W, Kraggerud SM, Abeler VM, Heim S, Tropé CG, Kristensen GB, Risberg B, Lothe RA, Danielsen HE (2003)
    Genome profiles of bilateral dysgerminomas, a unilateral gonadoblastoma, and a metastasis from a 46, XY phenotypic female
    Hum Pathol, 34 (9), 946-9
    DOI 10.1016/s0046-8177(03)00345-9, PubMed 14562293
  6. Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA (2003)
    Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
    Cancer Genet Cytogenet, 147 (1), 1-8
    DOI 10.1016/s0165-4608(03)00160-2, PubMed 14580764
  7. Løvig T, Thorstensen L, Hofstad B, Andersen SN, Clausen OP, Vatn M, Lothe RA, Rognum TO (2003)
    Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas
    Scand J Gastroenterol, 38 (3), 298-306
    DOI 10.1080/00365520310000618, PubMed 12737446
  8. Skotheim RI, Abeler VM, Nesland JM, Fosså SD, Holm R, Wagner U, Flørenes VA, Aass N, Kallioniemi OP, Lothe RA (2003)
    Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
    Neoplasia, 5 (5), 397-404
    DOI 10.1016/s1476-5586(03)80042-8, PubMed 14670177
  9. Skotheim RI, Kallioniemi A, Bjerkhagen B, Mertens F, Brekke HR, Monni O, Mousses S, Mandahl N, Soeter G, Nesland JM, Smeland S, Kallioniemi OP, Lothe RA (2003)
    Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
    J Clin Oncol, 21 (24), 4586-91
    DOI 10.1200/JCO.2003.07.067, PubMed 14673046
  10. Skotheim RI, Korkmaz KS, Klokk TI, Abeler VM, Korkmaz CG, Nesland JM, Fosså SD, Lothe RA, Saatcioglu F (2003)
    NKX3.1 expression is lost in testicular germ cell tumors
    Am J Pathol, 163 (6), 2149-54
    DOI 10.1016/S0002-9440(10)63571-7, PubMed 14633588
  11. Skotheim RI, Lothe RA (2003)
    The testicular germ cell tumour genome
    APMIS, 111 (1), 136-50; discussion 50-1
    DOI 10.1034/j.1600-0463.2003.11101181.x, PubMed 12752254
  12. Thorstensen L, Holm R, Lothe RA, Tropé C, Carvalho B, Sobrinho-Simoes M, Seruca R (2003)
    WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas
    Gastroenterology, 124 (1), 270-1
    DOI 10.1053/gast.2003.50034, PubMed 12512062

Publications 2002

  1. Jakobsen KS, Tengs T, Vatne A, Bowers HA, Oldach DW, Burkholder JM, Glasgow HB, Rublee PA, Klaveness D (2002)
    Discovery of the toxic dinoflagellate Pfiesteria in northern European waters
    Proc Biol Sci, 269 (1487), 211-4
    DOI 10.1098/rspb.2001.1852, PubMed 11798438
  2. Kleivi K, Lothe RA, Heim S, Tsarouha H, Kraggerud SM, Pandis N, Papadopoulou A, Andersen J, Jakobsen KS, Teixeira MR (2002)
    Genome profiling of breast cancer cells selected against in vitro shows copy number changes
    Genes Chromosomes Cancer, 33 (3), 304-9
    DOI 10.1002/gcc.10032, PubMed 11807988
  3. Kraggerud SM, Aman P, Holm R, Stenwig AE, Fosså SD, Nesland JM, Lothe RA (2002)
    Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis
    Cancer Res, 62 (2), 512-7
    PubMed 11809703
  4. Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fosså SD, Stenwig AE, Peltomäki P, Lothe RA (2002)
    Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
    Genes Chromosomes Cancer, 34 (2), 168-74
    DOI 10.1002/gcc.10058, PubMed 11979550
  5. Langerød A, Bukholm IR, Bregård A, Lønning PE, Andersen TI, Rognum TO, Meling GI, Lothe RA, Børresen-Dale AL (2002)
    The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
    Cancer Epidemiol Biomarkers Prev, 11 (12), 1684-8
    PubMed 12496062
  6. Løvig T, Andersen SN, Thorstensen L, Diep CB, Meling GI, Lothe RA, Rognum TO (2002)
    Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis
    Br J Cancer, 87 (7), 756-62
    DOI 10.1038/sj.bjc.6600507, PubMed 12232760
  7. Løvig T, Meling GI, Diep CB, Thorstensen L, Norheim Andersen S, Lothe RA, Rognum TO (2002)
    APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status
    Scand J Gastroenterol, 37 (10), 1184-93
    DOI 10.1080/003655202760373407, PubMed 12408524
  8. Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A (2002)
    New insights into testicular germ cell tumorigenesis from gene expression profiling
    Cancer Res, 62 (8), 2359-64
    PubMed 11956097
  9. Smiraglia DJ, Szymanska J, Kraggerud SM, Lothe RA, Peltomäki P, Plass C (2002)
    Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors
    Oncogene, 21 (24), 3909-16
    DOI 10.1038/sj.onc.1205488, PubMed 12032829
  10. Smith-Sørensen B, Lind GE, Skotheim RI, Fosså SD, Fodstad Ø, Stenwig AE, Jakobsen KS, Lothe RA (2002)
    Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
    Oncogene, 21 (57), 8878-84
    DOI 10.1038/sj.onc.1205978, PubMed 12483540

Publications 2001

  1. Bomme L, Lothe RA, Bardi G, Fenger C, Kronborg O, Heim S (2001)
    Assessments of clonal composition of colorectal adenomas by FISH analysis of chromosomes 1, 7, 13 and 20
    Int J Cancer, 92 (6), 816-23
    DOI 10.1002/ijc.1275, PubMed 11351301
  2. Duval A, Iacopetta B, Thorstensen L, Meling GI, Lothe RA, Thuille B, Suraweera N, Thomas G, Hamelin R (2001)
    Gender difference for mismatch repair deficiency in human colorectal cancer
    Gastroenterology, 121 (4), 1026-7
    DOI 10.1053/gast.2001.28585, PubMed 11665694
  3. Gjertsen MK, Buanes T, Rosseland AR, Bakka A, Gladhaug I, Søreide O, Eriksen JA, Møller M, Baksaas I, Lothe RA, Saeterdal I, Gaudernack G (2001)
    Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
    Int J Cancer, 92 (3), 441-50
    DOI 10.1002/ijc.1205, PubMed 11291084
  4. Lothe RA, Smith-Sørensen B, Hektoen M, Stenwig AE, Mandahl N, Saeter G, Mertens F (2001)
    Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors
    Genes Chromosomes Cancer, 30 (2), 202-6
    DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1079>3.3.CO;2-X, PubMed 11135438
  5. Rublee PA, Kempton JW, Schaefer EF, Allen C, Harris J, Oldach DW, Bowers H, Tengs T, Burkholder JM, Glasgow HB (2001)
    Use of molecular probes to assess geographic distribution of Pfiesteria species
    Environ Health Perspect, 109 Suppl 5, 765-7
    DOI 10.1289/ehp.01109s5765, PubMed 11677186
  6. Salahshor S, Hou H, Diep CB, Loukola A, Zhang H, Liu T, Chen J, Iselius L, Rubio C, Lothe RA, Aaltonen L, Sun XF, Lindmark G, Lindblom A (2001)
    A germline E-cadherin mutation in a family with gastric and colon cancer
    Int J Mol Med, 8 (4), 439-43
    DOI 10.3892/ijmm.8.4.439, PubMed 11562785
  7. Skotheim RI, Diep CB, Kraggerud SM, Jakobsen KS, Lothe RA (2001)
    Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA
    Cancer Genet Cytogenet, 127 (1), 64-70
    DOI 10.1016/s0165-4608(00)00433-7, PubMed 11408068
  8. Skotheim RI, Kraggerud SM, Fosså SD, Stenwig AE, Gedde-Dahl T, Danielsen HE, Jakobsen KS, Lothe RA (2001)
    Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence
    Neoplasia, 3 (3), 196-203
    DOI 10.1038/sj.neo.7900153, PubMed 11494113
  9. Steidinger K, Landsberg J, Richardson RW, Truby E, Blakesley B, Scott P, Tester P, Tengs T, Mason P, Morton S, Seaborn D, Litaker W, Reece K, Oldach D, Haas L, Vasta G (2001)
    Classification and identification of Pfiesteria and Pfiesteria-like species
    Environ Health Perspect, 109 Suppl 5, 661-5
    DOI 10.1289/ehp.01109s5661, PubMed 11677173
  10. Teixeira MR, Tsarouha H, Kraggerud SM, Pandis N, Dimitriadis E, Andersen JA, Lothe RA, Heim S (2001)
    Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridization analysis
    Neoplasia, 3 (3), 204-14
    DOI 10.1038/sj.neo.7900152, PubMed 11494114
  11. Thorstensen L, Diep CB, Meling GI, Aagesen TH, Ahrens CH, Rognum TO, Lothe RA (2001)
    WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability
    Gastroenterology, 121 (6), 1275-80
    DOI 10.1053/gast.2001.29570, PubMed 11729105
  12. Thorstensen L, Qvist H, Nesland JM, Giercksky KE, Lothe RA (2001)
    Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas
    Scand J Gastroenterol, 36 (12), 1327-31
    DOI 10.1080/003655201317097209, PubMed 11761025

Publications 2000

  1. Bowers HA, Tengs T, Glasgow HB, Burkholder JM, Rublee PA, Oldach DW (2000)
    Development of real-time PCR assays for rapid detection of Pfiesteria piscicida and related dinoflagellates
    Appl Environ Microbiol, 66 (11), 4641-8
    DOI 10.1128/aem.66.11.4641-4648.2000, PubMed 11055905
  2. Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG (2000)
    Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
    Oncogene, 19 (1), 164-8
    DOI 10.1038/sj.onc.1203227, PubMed 10644993
  3. Helland A, Kraggerud SM, Kristensen GB, Holm R, Abeler VM, Huebner K, Borresen-Dale AL, Lothe RA (2000)
    Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival
    Int J Cancer, 88 (2), 217-22
    DOI 10.1002/1097-0215(20001015)88:2<217::aid-ijc11>;2-i, PubMed 11004671
  4. Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S, Teixeira MR, Tropé CG, Peltomäki P, Lothe RA (2000)
    DNA copy number changes in malignant ovarian germ cell tumors
    Cancer Res, 60 (11), 3025-30
    PubMed 10850452
  5. Oldach DW, Delwiche CF, Jakobsen KS, Tengs T, Brown EG, Kempton JW, Schaefer EF, Bowers HA, Glasgow HB, Burkholder JM, Steidinger KA, Rublee PA (2000)
    Heteroduplex mobility assay-guided sequence discovery: elucidation of the small subunit (18S) rDNA sequences of Pfiesteria piscicida and related dinoflagellates from complex algal culture and environmental sample DNA pools
    Proc Natl Acad Sci U S A, 97 (8), 4303-8
    DOI 10.1073/pnas.97.8.4303, PubMed 10760297
  6. Teixeira MR, Waehre H, Lothe RA, Stenwig AE, Pandis N, Giercksky KE, Heim S (2000)
    High frequency of clonal chromosome abnormalities in prostatic neoplasms sampled by prostatectomy or ultrasound-guided needle biopsy
    Genes Chromosomes Cancer, 28 (2), 211-9
    DOI 10.1002/(SICI)1098-2264(200006)28:2<211::AID-GCC10>3.0.CO;2-Y, PubMed 10825006
  7. Thorstensen L, Qvist H, Heim S, Liefers GJ, Nesland JM, Giercksky KE, Lothe RA (2000)
    Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients
    Neoplasia, 2 (6), 514-22
    DOI 10.1038/sj.neo.7900111, PubMed 11228544

Publications 1999

  1. Berner JM, Sørlie T, Mertens F, Henriksen J, Saeter G, Mandahl N, Brøgger A, Myklebost O, Lothe RA (1999)
    Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway
    Genes Chromosomes Cancer, 26 (2), 151-60
    DOI 10.1002/(SICI)1098-2264(199910)26:2<151::AID-GCC7>3.0.CO;2-A, PubMed 10469453
  2. Duval A, Iacopetta B, Ranzani GN, Lothe RA, Thomas G, Hamelin R (1999)
    Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability
    Oncogene, 18 (48), 6806-9
    DOI 10.1038/sj.onc.1203287, PubMed 10597289

Publications 1998

  1. Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fosså SD, Salovaara R, Aaltonen LA (1998)
    Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors
    Cancer Res, 58 (10), 2087-90
    PubMed 9605748
  2. Bomme L, Heim S, Bardi G, Fenger C, Kronborg O, Brøgger A, Lothe RA (1998)
    Allelic imbalance and cytogenetic deletion of 1p in colorectal adenomas: a target region identified between DIS199 and DIS234
    Genes Chromosomes Cancer, 21 (3), 185-94
    DOI 10.1002/(sici)1098-2264(199803)21:3<185::aid-gcc2>;2-w, PubMed 9523193
  3. Børresen-Dale AL, Lothe RA, Meling GI, Hainaut P, Rognum TO, Skovlund E (1998)
    TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival
    Clin Cancer Res, 4 (1), 203-10
    PubMed 9516972
  4. Børresen-Dale AL, Lothe RA, Nesland JM (1998)
    [Molecular biology. Basis for increased understanding of diseases and improved diagnostics]
    Tidsskr Nor Laegeforen, 118 (11), 1681
    PubMed 9621751
  5. Clausen OP, Lothe RA, Børresen-Dale AL, De Angelis P, Chen Y, Rognum TO, Meling GI (1998)
    Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas
    Diagn Mol Pathol, 7 (4), 215-23
    DOI 10.1097/00019606-199808000-00006, PubMed 9917132
  6. De Angelis PM, Stokke T, Thorstensen L, Lothe RA, Clausen OP (1998)
    Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
    Mol Pathol, 51 (5), 254-61
    DOI 10.1136/mp.51.5.254, PubMed 10193519
  7. Lothe RA, Hektoen M, Johnsen H, Meling GI, Andersen TI, Rognum TO, Lindblom A, Børresen-Dale AL (1998)
    The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer
    Cancer Res, 58 (14), 2923-4
    PubMed 9679946
  8. Zhou XP, Hoang JM, Li YJ, Seruca R, Carneiro F, Sobrinho-Simoes M, Lothe RA, Gleeson CM, Russell SE, Muzeau F, Fléjou JF, Hoang-Xuan K, Lidereau R, Thomas G, Hamelin R (1998)
    Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
    Genes Chromosomes Cancer, 21 (2), 101-7
    DOI 10.1002/(sici)1098-2264(199802)21:2<101::aid-gcc4>;2-4, PubMed 9491320

Publications 1997

  1. Breivik J, Lothe RA, Meling GI, Rognum TO, Børresen-Dale AL, Gaudernack G (1997)
    Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
    Int J Cancer, 74 (6), 664-9
    DOI 10.1002/(sici)1097-0215(19971219)74:6<664::aid-ijc18>;2-5, PubMed 9421366
  2. Fosså SD, De Angelis P, Kraggerud SM, Evenson D, Theodorsen L, Clausen OP (1997)
    Prediction of posttreatment spermatogenesis in patients with testicular cancer by flow cytometric sperm chromatin structure assay
    Cytometry, 30 (4), 192-6
    PubMed 9298838
  3. Giercksky HE, Thorstensen L, Qvist H, Nesland JM, Lothe RA (1997)
    Comparison of genetic changes in frozen biopsies and microdissected archival material from the same colorectal liver metastases
    Diagn Mol Pathol, 6 (6), 318-25
    DOI 10.1097/00019606-199712000-00003, PubMed 9559291
  4. Helland A, Børresen-Dale AL, Peltomäki P, Hektoen M, Kristensen GB, Nesland JM, de la Chapelle A, Lothe RA (1997)
    Microsatellite instability in cervical and endometrial carcinomas
    Int J Cancer, 70 (5), 499-501
    DOI 10.1002/(sici)1097-0215(19970304)70:5<499::aid-ijc1>;2-t, PubMed 9052745
  5. Soares P, dos Santos NR, Seruca R, Lothe RA, Sobrinho-Simões M (1997)
    Benign and malignant thyroid lesions show instability at microsatellite loci
    Eur J Cancer, 33 (2), 293-6
    DOI 10.1016/s0959-8049(96)00457-1, PubMed 9135503

Publications 1996

  1. Thorstensen L, Qvist H, Nesland JM, Giercksky KE, Lothe RA (1996)
    Allelotype profiles of local recurrences and distant metastases from colorectal-cancer patients
    Int J Cancer, 69 (6), 452-6
    DOI 10.1002/(SICI)1097-0215(19961220)69:6<452::AID-IJC6>3.0.CO;2-3, PubMed 8980246

Publications 1995

  1. Børresen AL, Lothe RA, Meling GI, Lystad S, Morrison P, Lipford J, Kane MF, Rognum TO, Kolodner RD (1995)
    Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
    Hum Mol Genet, 4 (11), 2065-72
    DOI 10.1093/hmg/4.11.2065, PubMed 8589682
  2. De Angelis P, Stokke T, Smedshammer L, Lothe RA, Lehne G, Chen Y, Clausen OP (1995)
    P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo
    Br J Cancer, 72 (2), 307-11
    DOI 10.1038/bjc.1995.329, PubMed 7640210
  3. Kraggerud SM, Sandvik JA, Pettersen EO (1995)
    Regulation of protein synthesis in human cells exposed to extreme hypoxia
    Anticancer Res, 15 (3), 683-6
    PubMed 7645943
  4. Seruca R, Santos NR, David L, Constância M, Barroca H, Carneiro F, Seixas M, Peltomäki P, Lothe R, Sobrinho-Simões M (1995)
    Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile
    Int J Cancer, 64 (1), 32-6
    DOI 10.1002/ijc.2910640108, PubMed 7665246

Publications 1994

  1. Heimdal KR, Lothe RA, Fosså SD, Børresen AL (1994)
    Association studies of a polymorphism in the Wilms' tumor 1 locus in Norwegian patients with testicular cancer
    Int J Cancer, 58 (4), 523-6
    DOI 10.1002/ijc.2910580412, PubMed 8056449

Publications 1993

  1. Deangelis P, Stokke T, Smedshammer L, Lothe R, Meling G, Rofstad M, Chen Y, Clausen O (1993)
    P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas
    Int J Oncol, 3 (2), 305-12
    DOI 10.3892/ijo.3.2.305, PubMed 21573365
  2. Heimdal K, Lothe RA, Lystad S, Holm R, Fosså SD, Børresen AL (1993)
    No germline TP53 mutations detected in familial and bilateral testicular cancer
    Genes Chromosomes Cancer, 6 (2), 92-7
    DOI 10.1002/gcc.2870060205, PubMed 7680893
  3. Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO (1993)
    The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables
    Br J Cancer, 67 (1), 93-8
    DOI 10.1038/bjc.1993.15, PubMed 8427784
  4. Meling GI, Lothe RA, Børresen AL, Graue C, Hauge S, Clausen OP, Rognum TO (1993)
    The TP53 tumour suppressor gene in colorectal carcinomas. I. Genetic alterations on chromosome 17
    Br J Cancer, 67 (1), 88-92
    DOI 10.1038/bjc.1993.14, PubMed 8094008
  5. Peltomäki P, Lothe RA, Aaltonen LA, Pylkkänen L, Nyström-Lahti M, Seruca R, David L, Holm R, Ryberg D, Haugen A (1993)
    Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
    Cancer Res, 53 (24), 5853-5
    PubMed 8261393
  6. Ridanpää M, Lothe RA, Onfelt A, Fosså S, Børresen AL, Husgafvel-Pursiainen K (1993)
    K-ras oncogene codon 12 point mutations in testicular cancer
    Environ Health Perspect, 101 Suppl 3, 185-7
    DOI 10.1289/ehp.101-1521158, PubMed 8143614

Publications 1992

  1. Hovig E, Smith-Sørensen B, Gebhardt MC, Ryberg D, Lothe R, Børresen AL (1992)
    No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung
    Genes Chromosomes Cancer, 5 (2), 97-103
    DOI 10.1002/gcc.2870050202, PubMed 1381957
  2. Peltomäki P, Lothe RA, Børresen AL, Fosså SD, Brøgger A, de la Chapelle A (1992)
    Chromosome 12 in human testicular cancer: dosage changes and their parental origin
    Cancer Genet Cytogenet, 64 (1), 21-6
    DOI 10.1016/0165-4608(92)90316-z, PubMed 1458445
  3. Tommerup N, Lothe R (1992)
    Constitutional ring chromosomes and tumour suppressor genes
    J Med Genet, 29 (12), 879-82
    DOI 10.1136/jmg.29.12.879, PubMed 1336057

Publications 1991

  1. Hovig E, Lothe R, Farrants G, Brøgger A, Fodstad O, Børresen AL (1991)
    Chromosome 13 alterations in osteosarcoma cell lines derived from a patient with previous retinoblastoma
    Cancer Genet Cytogenet, 57 (1), 31-40
    DOI 10.1016/0165-4608(91)90186-x, PubMed 1684533
  2. Meling GI, Lothe RA, Børresen AL, Hauge S, Graue C, Clausen OP, Rognum TO (1991)
    Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis
    Br J Cancer, 64 (3), 475-80
    DOI 10.1038/bjc.1991.334, PubMed 1911187
  3. Peltomäki P, Lothe R, Børresen AL, Fosså SD, Brøgger A, de la Chapelle A (1991)
    Altered dosage of the sex chromosomes in human testicular cancer: a molecular genetic study
    Int J Cancer, 47 (4), 518-22
    DOI 10.1002/ijc.2910470408, PubMed 1995482

Publications 1990

  1. Boudi FH, Lothe RA, Taggart RT (1990)
    Human pepsinogen A (PGA): an informative gene complex located at 11q13
    Hum Genet, 84 (3), 293-5
    DOI 10.1007/BF00200579, PubMed 1968039
  2. Fosså SD, Langmark F, Aass N, Andersen A, Lothe R, Børresen AL (1990)
    Second non-germ cell malignancies after radiotherapy of testicular cancer with or without chemotherapy
    Br J Cancer, 61 (4), 639-43
    DOI 10.1038/bjc.1990.142, PubMed 2109999

Publications 1989

  1. Gedde-Dahl T, Heim S, Lothe R, Bye R, Geitvik GA, Kyrkjebø HT, Hognestad J, Nygaard K, Bergan A, Olaisen B (1989)
    [The polyposis project]
    Nord Med, 104 (1), 12-5
    PubMed 2536147

Publications 1988

  1. Gedde-Dahl T, Heim S, Lothe R, Bye R, Brevik K, Geitvik GA, Kyrkjebø HT, Hognestad J, Nygaard K, Bergan A (1988)
    [The polyposis project]
    Tidsskr Nor Laegeforen, 108 (29), 2465-8
    PubMed 2905084

Publications 1987

  1. Geitvik GA, Høyheim B, Gedde-Dahl T, Grzeschik KH, Lothe R, Tomter H, Olaisen B (1987)
    The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP
    Hum Genet, 77 (3), 205-9
    DOI 10.1007/BF00284470, PubMed 2890568
  2. Lothe RA, Gedde-Dahl T, Lier ME, Aamdahl S, Bergan A, Stenwig AE, Broegger A (1987)
    Loss of one chromosome #13 during development of a polyposis tumor
    Cancer Genet Cytogenet, 28 (2), 335-42
    DOI 10.1016/0165-4608(87)90220-2, PubMed 2887278

Publications 1985

  1. Lothe RA, Frøholm LO, Westre G, Kjennerud U (1985)
    Stainer and Scholte's pertussis medium with an alternative buffer
    J Biol Stand, 13 (2), 129-34
    DOI 10.1016/s0092-1157(85)80018-4, PubMed 2860114
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