Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
From major journals, first or last author from the Institute for Cancer Research
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(2025) Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database Br J Surg, 112(4) DOI 10.1093/bjs/znaf061, PubMed 40231433
Tsuruda KM, Hektoen HH, Aamelfot C, Andreassen BK(2025) Let's talk about sex: Survival among females and males in a real-world cohort treated with pembrolizumab for non-small cell lung cancer Int J Cancer(in press) DOI 10.1002/ijc.35445, PubMed 40298324
Dillard C, Teles-Reis J, Jain A, Antunes MG, Ruiz-Duran P, Qi Y, Le Borgne R, Jasper H, Rusten TE(2025) NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model PLoS Biol, 23(4), e3002663 DOI 10.1371/journal.pbio.3002663, PubMed 40294135
Dominguez-Valentin M(2025) Comment on Building a hereditary cancer program in Colombia: analysis of germline pathogenic and likely pathogenic variants spectrum in a high-risk cohort Eur J Hum Genet(in press) DOI 10.1038/s41431-025-01853-6, PubMed 40295843