Publications by Tom Eirik Mollnes
627 publications found
Publications 2024
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Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor
Int J Mol Sci, 25 (2)
DOI 10.3390/ijms25021091, PubMed 38256162 -
Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients
J Intern Med, 296 (1), 80-92
DOI 10.1111/joim.13783, PubMed 38539241 -
Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury After Mild Traumatic Brain Injury
J Neurotrauma, 41 (7-8), 862-878
DOI 10.1089/neu.2023.0419, PubMed 38117157 -
Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition
Transpl Int, 37, 13348
DOI 10.3389/ti.2024.13348, PubMed 39606689 -
The function of the complement system remains fully intact throughout the course of allogeneic stem cell transplantation
Front Immunol, 15, 1422370
DOI 10.3389/fimmu.2024.1422370, PubMed 38938578 -
The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model
J Innate Immun, 16 (1), 324-336
DOI 10.1159/000539368, PubMed 38768576 -
A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli
J Leukoc Biol, 115 (4), 647-663
DOI 10.1093/jleuko/qiad151, PubMed 38057165 -
The detrimental effects of intestinal injury mediated by inflammation are limited in cardiac arrest patients: A prospective cohort study
Resusc Plus, 18, 100639
DOI 10.1016/j.resplu.2024.100639, PubMed 38666252 -
Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation
ACS Omega, 9 (39), 40468-40476
DOI 10.1021/acsomega.4c03189, PubMed 39372034 -
Retraction Note: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 14 (1), 3704
DOI 10.1038/s41598-024-54117-6, PubMed 38355714 -
Femoral Nailing in a Porcine Model Causes Bone Marrow Emboli in the Lungs and Systemic Emboli in the Heart and Brain
JB JS Open Access, 9 (1)
DOI 10.2106/JBJS.OA.23.00128, PubMed 38419616 -
Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs
Front Immunol, 15, 1396800
DOI 10.3389/fimmu.2024.1396800, PubMed 39100680 -
Corrigendum: Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies
Front Immunol, 15, 1378003
DOI 10.3389/fimmu.2024.1378003, PubMed 38380313 -
Damage Control Orthopaedics Induced Less Trauma-Induced Coagulopathy than Early Total Care in a Porcine Polytrauma Model
Eur Surg Res, 65 (1), 115-122
DOI 10.1159/000541399, PubMed 39348804 -
Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy
Acta Neuropsychiatr, 1-7 (in press)
DOI 10.1017/neu.2023.56, PubMed 38173235 -
Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes
Cell Death Dis, 15 (4), 285
DOI 10.1038/s41419-024-06676-9, PubMed 38653969 -
No Short-Term Effect of Low-Dose Nicotine on Inflammation after Global Hypoxia in Newborn Piglets
Neonatology, 1-10 (in press)
DOI 10.1159/000541217, PubMed 39317175 -
Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery - A Porcine Model
Transpl Int, 37, 13569
DOI 10.3389/ti.2024.13569, PubMed 39544322 -
Pulmonary miRNA expression after polytrauma depends on the surgical invasiveness and displays an anti-inflammatory pattern by the combined inhibition of C5 and CD14
Front Immunol, 15, 1402571
DOI 10.3389/fimmu.2024.1402571, PubMed 39267761
Publications 2023
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Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia
Proc Natl Acad Sci U S A, 120 (30), e2301538120
DOI 10.1073/pnas.2301538120, PubMed 37459522 -
The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
Commun Biol, 6 (1), 42
DOI 10.1038/s42003-023-04431-y, PubMed 36639734 -
Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
Pediatr Res, 94 (2), 512-519
DOI 10.1038/s41390-023-02489-2, PubMed 36725909 -
Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo
Mol Immunol, 157, 70-77
DOI 10.1016/j.molimm.2023.03.006, PubMed 37001293 -
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
J Innate Immun, 15 (1), 836-849
DOI 10.1159/000535084, PubMed 37952515 -
Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro
Int Immunopharmacol, 124 (Pt B), 111021
DOI 10.1016/j.intimp.2023.111021, PubMed 37816262 -
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
Front Immunol, 14, 1101387
DOI 10.3389/fimmu.2023.1101387, PubMed 37081885 -
Increased thromboinflammatory load in hereditary angioedema
Clin Exp Immunol, 214 (2), 170-181
DOI 10.1093/cei/uxad091, PubMed 37561062 -
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
J Thromb Haemost, 21 (7), 1849-1860
DOI 10.1016/j.jtha.2023.03.024, PubMed 37003465 -
Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study
Front Immunol, 14, 1253991
DOI 10.3389/fimmu.2023.1253991, PubMed 37849758 -
Editorial: Organ cross talk and its impact on the clinical course in multiple trauma and critical illness
Front Immunol, 14, 1195371
DOI 10.3389/fimmu.2023.1195371, PubMed 37090701 -
Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies
Front Immunol, 14, 1230049
DOI 10.3389/fimmu.2023.1230049, PubMed 37795086 -
H2S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model
Antioxidants (Basel), 12 (3)
DOI 10.3390/antiox12030749, PubMed 36978997 -
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
Transplant Direct, 10 (1), e1567
DOI 10.1097/TXD.0000000000001567, PubMed 38094132 -
Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
Front Immunol, 14, 1044444
DOI 10.3389/fimmu.2023.1044444, PubMed 37063904 -
Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study
Stroke, 54 (5), 1303-1311
DOI 10.1161/STROKEAHA.122.041965, PubMed 37026459 -
Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults
JAMA Netw Open, 6 (3), e235763
DOI 10.1001/jamanetworkopen.2023.5763, PubMed 36995712 -
A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis
Front Med (Lausanne), 10, 1236495
DOI 10.3389/fmed.2023.1236495, PubMed 37621463 -
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
Clin Immunol, 249, 109278
DOI 10.1016/j.clim.2023.109278, PubMed 36894046 -
Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
Clin Psychopharmacol Neurosci, 22 (2), 285-294
DOI 10.9758/cpn.23.1091, PubMed 38627075 -
Inflammatory markers and pulmonary function in adolescents and young adults 6 months after mild COVID-19
Front Immunol, 13, 1081718
DOI 10.3389/fimmu.2022.1081718, PubMed 36685555 -
Effect of Intraperitoneal 224Radium-Labelled Microparticles on Compartmentalized Inflammation After Cytoreductive Surgery and Hypertherm Intraperitoneal Chemotherapy
Technol Cancer Res Treat, 22, 15330338231192902
DOI 10.1177/15330338231192902, PubMed 37574949 -
Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma
Front Immunol, 14, 1279496
DOI 10.3389/fimmu.2023.1279496, PubMed 38035093
Publications 2022
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C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study
Brain Behav Immun Health, 27, 100571
DOI 10.1016/j.bbih.2022.100571, PubMed 36583067 -
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Arterioscler Thromb Vasc Biol, 42 (9), 1186-1197
DOI 10.1161/ATVBAHA.122.317746, PubMed 35861070 -
Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release
J Immunol, 209 (9), 1760-1767
DOI 10.4049/jimmunol.2101191, PubMed 36104112 -
Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene
Noncoding RNA, 8 (2)
DOI 10.3390/ncrna8020024, PubMed 35447887 -
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
Front Immunol, 13, 901876
DOI 10.3389/fimmu.2022.901876, PubMed 35935964 -
Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
J Pain Symptom Manage, 64 (4), 330-339
DOI 10.1016/j.jpainsymman.2022.06.018, PubMed 35803553 -
Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality
Am J Transplant, 22 (8), 2016-2027
DOI 10.1111/ajt.17047, PubMed 35352462 -
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
Front Immunol, 13, 831371
DOI 10.3389/fimmu.2022.831371, PubMed 35911712 -
Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
J Immunol, 208 (12), 2771-2778
DOI 10.4049/jimmunol.2101033, PubMed 35675954 -
Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Front Immunol, 13, 1020712
DOI 10.3389/fimmu.2022.1020712, PubMed 36591264 -
Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults
Front Immunol, 13, 837288
DOI 10.3389/fimmu.2022.837288, PubMed 35222429 -
Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma
Front Immunol, 13, 952267
DOI 10.3389/fimmu.2022.952267, PubMed 36059503 -
Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood
Shock, 57 (1), 72-80
DOI 10.1097/SHK.0000000000001834, PubMed 34265830 -
Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research - 20 years of experience and future perspectives
Semin Immunol, 59, 101604
DOI 10.1016/j.smim.2022.101604, PubMed 35570131 -
Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis
PLoS One, 17 (2), e0264628
DOI 10.1371/journal.pone.0264628, PubMed 35213675 -
A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment
Front Immunol, 13, 852119
DOI 10.3389/fimmu.2022.852119, PubMed 35432333 -
Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner
Front Immunol, 13, 865386
DOI 10.3389/fimmu.2022.865386, PubMed 35444648 -
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
BMC Psychiatry, 22 (1), 84
DOI 10.1186/s12888-022-03744-2, PubMed 35114967 -
Dental and Periodontal Health in Acute Intermittent Porphyria
Life (Basel), 12 (8)
DOI 10.3390/life12081270, PubMed 36013449 -
Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs
Front Immunol, 13, 839632
DOI 10.3389/fimmu.2022.839632, PubMed 35371063 -
Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
Front Immunol, 13, 870811
DOI 10.3389/fimmu.2022.870811, PubMed 35432387
Publications 2021
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Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
BMC Neurol, 21 (1), 318
DOI 10.1186/s12883-021-02343-0, PubMed 34399717 -
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke
BMC Neurol, 21 (1), 476
DOI 10.1186/s12883-021-02498-w, PubMed 34879833 -
The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection
Nat Commun, 12 (1), 1230
DOI 10.1038/s41467-021-21473-0, PubMed 33623002 -
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
Resuscitation, 166, 129-136
DOI 10.1016/j.resuscitation.2021.05.038, PubMed 34126135 -
Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury
Mediators Inflamm, 2021, 6654318
DOI 10.1155/2021/6654318, PubMed 33574730 -
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front Immunol, 12, 715102
DOI 10.3389/fimmu.2021.715102, PubMed 34987499 -
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
Pharmacol Rev, 73 (2), 792-827
DOI 10.1124/pharmrev.120.000072, PubMed 33687995 -
Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
Thromb Haemost, 122 (4), 540-551
DOI 10.1055/s-0041-1733906, PubMed 34428832 -
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
Front Immunol, 12, 800978
DOI 10.3389/fimmu.2021.800978, PubMed 35003128 -
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
Acta Biomater, 127, 169-179
DOI 10.1016/j.actbio.2021.03.047, PubMed 33785451 -
The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
Resuscitation, 170, 115-125
DOI 10.1016/j.resuscitation.2021.11.026, PubMed 34838662 -
The allosteric modulation of complement C5 by knob domain peptides
Elife, 10
DOI 10.7554/eLife.63586, PubMed 33570492 -
A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity
J Immunol, 207 (6), 1641-1651
DOI 10.4049/jimmunol.2001471, PubMed 34380648 -
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay
Methods Mol Biol, 2227, 51-59
DOI 10.1007/978-1-0716-1016-9_5, PubMed 33847930 -
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
Sci Immunol, 6 (66), eabf2489
DOI 10.1126/sciimmunol.abf2489, PubMed 34932384 -
A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood
Ren Fail, 43 (1), 1609-1620
DOI 10.1080/0886022X.2021.2007127, PubMed 34882053 -
Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
Mol Med, 27 (1), 35
DOI 10.1186/s10020-021-00286-3, PubMed 33832430 -
Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects
Macromol Biosci, 21 (4), e2000379
DOI 10.1002/mabi.202000379, PubMed 33624923 -
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Bioact Mater, 6 (11), 3947-3961
DOI 10.1016/j.bioactmat.2021.03.042, PubMed 33937594 -
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Blood, 138 (21), 2129-2137
DOI 10.1182/blood.2021010822, PubMed 34339498 -
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration
Front Pharmacol, 12, 679741
DOI 10.3389/fphar.2021.679741, PubMed 34054553 -
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
J Immunol, 207 (11), 2828-2840
DOI 10.4049/jimmunol.2100308, PubMed 34732467 -
Open chest and pericardium facilitate transpulmonary passage of venous air emboli
Acta Anaesthesiol Scand, 65 (5), 648-655
DOI 10.1111/aas.13796, PubMed 33595102 -
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol Med, 27 (1), 29
DOI 10.1186/s10020-021-00288-1, PubMed 33771098 -
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
Mol Immunol, 141, 273-279
DOI 10.1016/j.molimm.2021.11.016, PubMed 34906905 -
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185 -
Morten Harboe (1929-2021), one of the founders of Scandinavian Journal of Immunology OBITUARY
Scand. J. Immunol., 94 (1), e13054
DOI 10.1111/sji.13054 -
Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
Front Immunol, 12, 738927
DOI 10.3389/fimmu.2021.738927, PubMed 34759922 -
Memories of Bob Sim-Genius Complementologist and Cheerful Travel Companion
Viruses, 13 (6)
DOI 10.3390/v13061068, PubMed 34199701 -
Innate Immune Invisible Ultrasmall Gold Nanoparticles-Framework for Synthesis and Evaluation
ACS Appl Mater Interfaces, 13 (20), 23410-23422
DOI 10.1021/acsami.1c02834, PubMed 33978409
Publications 2020
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Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome
Scand J Gastroenterol, 55 (5), 537-542
DOI 10.1080/00365521.2020.1754455, PubMed 32329383 -
Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
J Neurotrauma, 37 (19), 2120-2130
DOI 10.1089/neu.2019.6963, PubMed 32326805 -
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
J Leukoc Biol, 107 (4), 673-683
DOI 10.1002/JLB.3A0120-114R, PubMed 32083344 -
Complement Activation in 22q11.2 Deletion Syndrome
J Clin Immunol, 40 (3), 515-523
DOI 10.1007/s10875-020-00766-x, PubMed 32152940 -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538 -
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J, 54 (5), 274-279
DOI 10.1080/14017431.2020.1775878, PubMed 32500743 -
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843 -
CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
J Thromb Haemost, 19 (2), 429-443
DOI 10.1111/jth.15162, PubMed 33174372 -
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
MAbs, 12 (1), 1686319
DOI 10.1080/19420862.2019.1686319, PubMed 31671278 -
Endotoxin Removal in Septic Shock with the Alteco LPS Adsorber Was Safe But Showed no Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial-the Asset Study
Shock, 54 (2), 224-231
DOI 10.1097/SHK.0000000000001503, PubMed 31880758 -
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155 -
Complement in sepsis-when science meets clinics
FEBS Lett, 594 (16), 2621-2632
DOI 10.1002/1873-3468.13881, PubMed 32621378 -
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275 -
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
J Immunol, 205 (8), 2287-2300
DOI 10.4049/jimmunol.2000752, PubMed 32938727 -
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888 -
Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility
Transl Vis Sci Technol, 9 (13), 41
DOI 10.1167/tvst.9.13.41, PubMed 33442495 -
Analysis of cytokines
Tidsskr. Nor. Laegeforen., 140 (1), 71 -
Analysis of cytokines
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.18.0961, PubMed 31948201 -
Avoiding ambient air in test tubes during incubations of human whole-blood minimizes complement background activation
J Immunol Methods, 487, 112876
DOI 10.1016/j.jim.2020.112876, PubMed 33031792 -
Choice of immunoassay to evaluate porcine cytokine levels
Vet Immunol Immunopathol, 230, 110129
DOI 10.1016/j.vetimm.2020.110129, PubMed 33059181 -
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109 -
The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment
Cell Mol Immunol, 17 (6), 653-655
DOI 10.1038/s41423-020-0406-y, PubMed 32210393 -
Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
Elife, 9
DOI 10.7554/eLife.60908, PubMed 32909942 -
Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease
J Crohns Colitis, 14 (7), 920-934
DOI 10.1093/ecco-jcc/jjaa022, PubMed 32020185
Publications 2019
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Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood
Mol Immunol, 114, 139-148
DOI 10.1016/j.molimm.2019.07.014, PubMed 31352230 -
Corrigendum to "Changes in cytokines during treatment of elderly, hospitalized psychiatric patients-A naturalistic study" [Psychoneuroendocrinology, 108C (2019), 135-139]
Psychoneuroendocrinology, 109, 104427
DOI 10.1016/j.psyneuen.2019.104427, PubMed 31537376 -
Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study
Psychoneuroendocrinology, 108, 135-139
DOI 10.1016/j.psyneuen.2019.06.014, PubMed 31276906 -
Editorial: The Role of Complement in Health and Disease
Front Immunol, 10, 1869
DOI 10.3389/fimmu.2019.01869, PubMed 31440250 -
Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis
Thromb Haemost, 119 (9), 1481-1488
DOI 10.1055/s-0039-1692426, PubMed 31254974 -
The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
APMIS, 127 (6), 475-483
DOI 10.1111/apm.12946, PubMed 30916807 -
Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
J Immunol, 203 (4), 853-863
DOI 10.4049/jimmunol.1900503, PubMed 31270150 -
Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs
Endocrinology, 160 (12), 2892-2902
DOI 10.1210/en.2019-00374, PubMed 31589305 -
Comparison of cytokine changes in three different lipoprotein apheresis systems in an ex vivo whole blood model
J Clin Apher, 35 (2), 104-116
DOI 10.1002/jca.21765, PubMed 31782556 -
Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
PLoS One, 14 (7), e0220079
DOI 10.1371/journal.pone.0220079, PubMed 31335881 -
Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
Open Heart, 6 (2), e001098
DOI 10.1136/openhrt-2019-001098, PubMed 31798913 -
Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism
J Thromb Haemost, 17 (6), 934-943
DOI 10.1111/jth.14438, PubMed 30920726 -
Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts
Acta Biomater, 96, 330-344
DOI 10.1016/j.actbio.2019.07.002, PubMed 31284096 -
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568 -
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions
ACS Nano, 13 (8), 9315-9324
DOI 10.1021/acsnano.9b03942, PubMed 31348638 -
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
J Thromb Haemost, 17 (10), 1661-1669
DOI 10.1111/jth.14539, PubMed 31220397 -
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9 (1), 9427
DOI 10.1038/s41598-019-45861-1, PubMed 31263122 -
'Stealth' corporate innovation: an emerging threat for therapeutic drug development
Nat Immunol, 20 (11), 1409-1413
DOI 10.1038/s41590-019-0503-1, PubMed 31562490 -
Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development
Nat Immunol, 20 (11), 1556
DOI 10.1038/s41590-019-0531-x, PubMed 31605100 -
Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome
Crit Care Med, 47 (8), e614-e622
DOI 10.1097/CCM.0000000000003800, PubMed 31162203 -
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
PLoS One, 14 (6), e0218624
DOI 10.1371/journal.pone.0218624, PubMed 31247004 -
Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis
J Immunol, 203 (7), 1973-1980
DOI 10.4049/jimmunol.1801244, PubMed 31492744 -
Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
ERJ Open Res, 5 (1)
DOI 10.1183/23120541.00014-2019, PubMed 30863773 -
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14
Mol Immunol, 112, 131-139
DOI 10.1016/j.molimm.2019.03.014, PubMed 31102985 -
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood
J Immunol, 203 (6), 1571-1578
DOI 10.4049/jimmunol.1900047, PubMed 31413105 -
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508, PubMed 30653682
Publications 2018
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Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
Front Microbiol, 9, 262
DOI 10.3389/fmicb.2018.00262, PubMed 29515544 -
Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome
Case Rep Nephrol, 2018, 3810249
DOI 10.1155/2018/3810249, PubMed 30662780 -
Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients
BMC Psychiatry, 18 (1), 315
DOI 10.1186/s12888-018-1900-y, PubMed 30261848 -
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
Front Immunol, 9, 2664
DOI 10.3389/fimmu.2018.02664, PubMed 30515158 -
Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
BMC Geriatr, 18 (1), 149
DOI 10.1186/s12877-018-0836-x, PubMed 29940870 -
The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain
BMC Palliat Care, 17 (1), 110
DOI 10.1186/s12904-018-0362-9, PubMed 30266081 -
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) - an ex vivo study with blood from a C5-deficient individual
APMIS, 126 (4), 342-352
DOI 10.1111/apm.12821, PubMed 29575196 -
Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism
Thromb Res, 169, 50-56
DOI 10.1016/j.thromres.2018.06.019, PubMed 30015228 -
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Int J Cardiol, 271, 1-7
DOI 10.1016/j.ijcard.2018.04.136, PubMed 29961572 -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
Clin Exp Immunol, 196 (1), 97-110
DOI 10.1111/cei.13240, PubMed 30444525 -
Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study
JMIR Res Protoc, 7 (1), e17
DOI 10.2196/resprot.8558, PubMed 29351897 -
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
ESC Heart Fail, 5 (3), 292-301
DOI 10.1002/ehf2.12266, PubMed 29424484 -
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front Immunol, 9, 2035
DOI 10.3389/fimmu.2018.02035, PubMed 30258440 -
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Int J Cardiol, 268, 187-192
DOI 10.1016/j.ijcard.2018.05.032, PubMed 29853279 -
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
J Neuroinflammation, 15 (1), 327
DOI 10.1186/s12974-018-1366-3, PubMed 30470234 -
Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
Open Forum Infect Dis, 5 (2), ofy002
DOI 10.1093/ofid/ofy002, PubMed 29410975 -
Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation
J Thromb Haemost, 16 (5), 905-918
DOI 10.1111/jth.13979, PubMed 29437288 -
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Int J Mol Sci, 19 (10)
DOI 10.3390/ijms19103257, PubMed 30347808 -
Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation
J Ren Nutr, 28 (5), 333-339
DOI 10.1053/j.jrn.2018.02.008, PubMed 29703632 -
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
Neonatology, 113 (4), 322-330
DOI 10.1159/000486542, PubMed 29486477 -
Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
Vox Sang, 113 (7), 657-668
DOI 10.1111/vox.12703, PubMed 30159896 -
Iron oxide nanoparticles enhance Toll-like receptor-induced cytokines in a particle size- and actin-dependent manner in human blood
Nanomedicine (Lond), 13 (14), 1773-1785
DOI 10.2217/nnm-2017-0362, PubMed 30084726
Publications 2017
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Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
J Immunol, 199 (8), 2910-2920
DOI 10.4049/jimmunol.1700302, PubMed 28855312 -
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
Scand Cardiovasc J, 52 (1), 43-50
DOI 10.1080/14017431.2017.1416157, PubMed 29233022 -
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
Acta Biomater, 58, 158-167
DOI 10.1016/j.actbio.2017.05.052, PubMed 28576714 -
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
Medicine (Baltimore), 96 (11), e6338
DOI 10.1097/MD.0000000000006338, PubMed 28296762 -
Properdin binding to complement activating surfaces depends on initial C3b deposition
Proc Natl Acad Sci U S A, 114 (4), E534-E539
DOI 10.1073/pnas.1612385114, PubMed 28069958 -
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
J Intensive Care, 5, 21
DOI 10.1186/s40560-017-0217-0, PubMed 28261486 -
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans
Cytokine, 97, 86-95
DOI 10.1016/j.cyto.2017.05.014, PubMed 28595117 -
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Proc Natl Acad Sci U S A, 114 (31), E6390-E6399
DOI 10.1073/pnas.1706818114, PubMed 28720697 -
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
Mol Immunol, 89, 111-114
DOI 10.1016/j.molimm.2017.05.021, PubMed 28610663 -
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
Clin Proteomics, 14, 30
DOI 10.1186/s12014-017-9165-x, PubMed 28814945 -
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Basic Res Cardiol, 112 (3), 20
DOI 10.1007/s00395-017-0610-9, PubMed 28258298 -
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
Mol Immunol, 89, 10-21
DOI 10.1016/j.molimm.2017.05.013, PubMed 28576323 -
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532, PubMed 28195242 -
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
PLoS One, 12 (3), e0174577
DOI 10.1371/journal.pone.0174577, PubMed 28362874 -
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
Eur J Clin Invest, 48 (1)
DOI 10.1111/eci.12865, PubMed 29171871 -
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
Nat Nanotechnol, 12 (6), 589-594
DOI 10.1038/nnano.2017.47, PubMed 28396605 -
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model
Int J Nanomedicine, 12, 3927-3940
DOI 10.2147/IJN.S136453, PubMed 28579778 -
Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
J Transl Med, 15 (1), 245
DOI 10.1186/s12967-017-1350-1, PubMed 29202780
Publications 2016
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Increased Levels of Interferon-Inducible Protein 10 (IP-10) in 22q11.2 Deletion Syndrome
Scand J Immunol, 83 (3), 188-94
DOI 10.1111/sji.12406, PubMed 26708691 -
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
Rheumatology (Oxford), 55 (7), 1337-9
DOI 10.1093/rheumatology/kew040, PubMed 27105662 -
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
J Leukoc Biol, 101 (1), 193-204
DOI 10.1189/jlb.3VMR0316-132R, PubMed 27581539 -
Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients
J Ren Nutr, 27 (3), 161-168
DOI 10.1053/j.jrn.2016.09.008, PubMed 27838193 -
Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus
Scand J Immunol, 84 (2), 95-9
DOI 10.1111/sji.12445, PubMed 27135178 -
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex
J Infect Dis, 214 (1), 140-50
DOI 10.1093/infdis/jiw100, PubMed 26977050 -
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Neuropsychiatr Dis Treat, 12, 817-22
DOI 10.2147/NDT.S101925, PubMed 27110115 -
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597 -
C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry
Thromb Res, 143, 63-70
DOI 10.1016/j.thromres.2016.04.024, PubMed 27197075 -
LDL apheresis activates the complement system and the cytokine network, whereas PCSK9 inhibition with evolocumab induces no inflammatory response
J Clin Lipidol, 10 (6), 1481-1487
DOI 10.1016/j.jacl.2016.09.001, PubMed 27919366 -
Complement activation by cholesterol crystals triggers a subsequent cytokine response
Mol Immunol, 84, 43-50
DOI 10.1016/j.molimm.2016.09.019, PubMed 27692470 -
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
J Immunol, 196 (5), 2293-9
DOI 10.4049/jimmunol.1502220, PubMed 26800874 -
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202 -
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Clin Microbiol Infect, 22 (8), 734.e1-6
DOI 10.1016/j.cmi.2016.05.010, PubMed 27217049 -
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
J Immunol, 196 (12), 5064-74
DOI 10.4049/jimmunol.1502595, PubMed 27183610 -
Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome
J Infect, 73 (4), 383-6
DOI 10.1016/j.jinf.2016.07.011, PubMed 27452197 -
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
BMC Nephrol, 17 (1), 148
DOI 10.1186/s12882-016-0373-9, PubMed 27760523 -
Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation
Am J Transplant, 17 (1), 265-271
DOI 10.1111/ajt.13933, PubMed 27341702 -
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144 -
Systemic inflammation in acute intermittent porphyria: a case-control study
Clin Exp Immunol, 187 (3), 466-479
DOI 10.1111/cei.12899, PubMed 27859020 -
Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis
Scand J Clin Lab Invest, 76 (2), 118-27
DOI 10.3109/00365513.2015.1110856, PubMed 26878875 -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
J Control Release, 229, 58-69
DOI 10.1016/j.jconrel.2016.03.021, PubMed 26993426
Publications 2015
-
Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome
Acta Paediatr, 104 (5), 498-503
DOI 10.1111/apa.12950, PubMed 25640602 -
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
J Infect Dis, 212 (11), 1835-40
DOI 10.1093/infdis/jiv283, PubMed 25980034 -
TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway
J Immunol, 195 (3), 1100-11
DOI 10.4049/jimmunol.1403176, PubMed 26085680 -
Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation
Mol Immunol, 66 (2), 164-70
DOI 10.1016/j.molimm.2015.02.029, PubMed 25795308 -
The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load
Clin Exp Immunol, 181 (3), 457-67
DOI 10.1111/cei.12645, PubMed 25907631 -
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
Immunobiology, 220 (8), 999-1005
DOI 10.1016/j.imbio.2015.04.002, PubMed 25956456 -
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial
Medicine (Baltimore), 94 (42), e1786
DOI 10.1097/MD.0000000000001786, PubMed 26496309 -
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo
Clin Exp Immunol, 179 (2), 294-9
DOI 10.1111/cei.12446, PubMed 25174443 -
Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock
Shock, 44 (5), 458-69
DOI 10.1097/SHK.0000000000000441, PubMed 26473439 -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
Atherosclerosis, 241 (2), 480-94
DOI 10.1016/j.atherosclerosis.2015.05.038, PubMed 26086357 -
Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
Biomaterials, 77, 111-9
DOI 10.1016/j.biomaterials.2015.10.067, PubMed 26584351 -
Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies
Neonatology, 107 (3), 225-230
DOI 10.1159/000369373, PubMed 25721501 -
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
Scand J Immunol, 82 (5), 467-75
DOI 10.1111/sji.12332, PubMed 26099791 -
The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood
Clin Exp Immunol, 182 (1), 81-9
DOI 10.1111/cei.12663, PubMed 26241501 -
Therapeutic complement inhibition – from experimental to clinical medicine
Tidsskr Nor Laegeforen, 135 (19), 1745-9
DOI 10.4045/tidsskr.15.0049, PubMed 26486669 -
Effect of Cardiac Resynchronization Therapy on Inflammation in Congestive Heart Failure: A Review
Scand J Immunol, 82 (3), 191-8
DOI 10.1111/sji.12328, PubMed 26099323 -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641 -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252 -
Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery
Blood, 127 (3), 365-7
DOI 10.1182/blood-2015-09-672139, PubMed 26644452 -
Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders
Alcohol, 49 (5), 471-8
DOI 10.1016/j.alcohol.2015.01.012, PubMed 25873205 -
Preface. 15th European Meeting on Complement in Human Disease 2015, Uppsala, Sweden
Mol Immunol, 67 (1), 1-2
DOI 10.1016/j.molimm.2015.04.006, PubMed 25934434 -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
J Immunol, 195 (1), 257-64
DOI 10.4049/jimmunol.1403044, PubMed 26026058 -
High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection
J Acquir Immune Defic Syndr, 69 (4), 395-402
DOI 10.1097/QAI.0000000000000617, PubMed 26115437 -
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
Crit Care, 19, 415
DOI 10.1186/s13054-015-1129-9, PubMed 26612199 -
High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients
Transplantation, 99 (4), 791-6
DOI 10.1097/TP.0000000000000422, PubMed 25222012 -
Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo
Blood, 126 (2), 278-9
DOI 10.1182/blood-2015-03-637645, PubMed 26160188 -
Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome
Clin Immunol, 160 (2), 237-43
DOI 10.1016/j.clim.2015.05.018, PubMed 26111482 -
Complement activation patterns in atypical haemolytic uraemic syndrome during acute phase and in remission
Clin Exp Immunol, 181 (2), 306-13
DOI 10.1111/cei.12426, PubMed 25079699 -
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
J Infect, 70 (4), 381-91
DOI 10.1016/j.jinf.2014.12.019, PubMed 25597826 -
Chronic fatigue syndrome/myalgic encephalo-myelitis--pathophysiology, diagnosis and treatment
Tidsskr Nor Laegeforen, 135 (23-24), 2172-5
DOI 10.4045/tidsskr.15.1180, PubMed 26674040 -
European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha
Mol Immunol, 68 (1), 63-6
DOI 10.1016/j.molimm.2015.05.003, PubMed 26006049
Publications 2014
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Cytokine network in adults with falciparum Malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
PLoS One, 9 (12), e114480
DOI 10.1371/journal.pone.0114480, PubMed 25503583 -
An international serum standard for application in assays to detect human complement activation products (vol 56, pg 232, 2013)
Mol. Immunol., 60 (2), 115
DOI 10.1016/j.molimm.2014.04.008 -
Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study
Crit Care, 18 (5), 546
DOI 10.1186/s13054-014-0546-5, PubMed 25304549 -
A novel method for direct measurement of complement convertases activity in human serum
Clin Exp Immunol, 178 (1), 142-53
DOI 10.1111/cei.12388, PubMed 24853370 -
Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma
Biomaterials, 36, 55-65
DOI 10.1016/j.biomaterials.2014.09.011, PubMed 25292422 -
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
Immunobiology, 220 (4), 452-9
DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724 -
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
J Immunol, 192 (11), 5324-31
DOI 10.4049/jimmunol.1400341, PubMed 24790148 -
A vital role for complement in heart disease
Mol Immunol, 61 (2), 126-34
DOI 10.1016/j.molimm.2014.06.036, PubMed 25037633 -
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers
PLoS One, 9 (1), e85604
DOI 10.1371/journal.pone.0085604, PubMed 24416431 -
High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders
CNS Neurosci Ther, 20 (10), 898-904
DOI 10.1111/cns.12303, PubMed 24995667 -
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
Immunobiology, 219 (10), 786-92
DOI 10.1016/j.imbio.2014.06.006, PubMed 25053140 -
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
Inflamm Bowel Dis, 20 (6), 995-1003
DOI 10.1097/MIB.0000000000000035, PubMed 24739633 -
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases
Mol Immunol, 64 (1), 170-6
DOI 10.1016/j.molimm.2014.11.010, PubMed 25534848 -
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
J Immunol, 192 (6), 2837-45
DOI 10.4049/jimmunol.1302484, PubMed 24554772 -
Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model
J Immunol, 192 (6), 2857-64
DOI 10.4049/jimmunol.1300755, PubMed 24516199 -
Plasma cytokine expression in adolescent chronic fatigue syndrome
Brain Behav Immun, 46, 80-6
DOI 10.1016/j.bbi.2014.12.025, PubMed 25555530
Publications 2013
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Multiorgan procurement increases systemic inflammation in brain dead donors
Clin Transplant, 27 (4), 613-8
DOI 10.1111/ctr.12175, PubMed 23803161 -
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
J Immunol, 191 (2), 819-27
DOI 10.4049/jimmunol.1201909, PubMed 23761634 -
An international serum standard for application in assays to detect human complement activation products
Mol Immunol, 56 (3), 232-9
DOI 10.1016/j.molimm.2013.05.221, PubMed 23787367 -
The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood
Adv Exp Med Biol, 735, 123-36
DOI 10.1007/978-1-4614-4118-2_8, PubMed 23402023 -
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
Innate Immun, 20 (1), 68-77
DOI 10.1177/1753425913482993, PubMed 23669326 -
Complement C3 and C5 deficiency affects fracture healing
PLoS One, 8 (11), e81341
DOI 10.1371/journal.pone.0081341, PubMed 24260573 -
Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis
PLoS One, 8 (8), e72769
DOI 10.1371/journal.pone.0072769, PubMed 24023645 -
Serum cytokines and chronic fatigue in adults surviving after childhood leukemia and lymphoma
Brain Behav Immun, 30, 80-7
DOI 10.1016/j.bbi.2013.01.006, PubMed 23333795 -
COMP-C3b complexes in rheumatoid arthritis with severe extraarticular manifestations
J Rheumatol, 40 (12), 2001-5
DOI 10.3899/jrheum.130613, PubMed 24187101 -
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transpl, 19 (3), 305-14
DOI 10.1002/lt.23578, PubMed 23193034 -
C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood
Clin Exp Immunol, 173 (2), 217-29
DOI 10.1111/cei.12098, PubMed 23607270 -
Atrial fibrillation: inflammation in disguise?
Scand J Immunol, 78 (2), 112-9
DOI 10.1111/sji.12061, PubMed 23672430 -
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486 -
Letter to editor
J Clin Biochem Nutr, 52 (3), 253-4
DOI 10.3164/jcbn.52-3_LtoE, PubMed 23704816 -
Association of ficolin-3 with severity and outcome of chronic heart failure
PLoS One, 8 (4), e60976
DOI 10.1371/journal.pone.0060976, PubMed 23596511 -
Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome
Neonatology, 105 (2), 128-35
DOI 10.1159/000356065, PubMed 24356240 -
Primary complement C5 deficiencies - molecular characterization and clinical review of two families
Immunobiology, 218 (10), 1304-10
DOI 10.1016/j.imbio.2013.04.021, PubMed 23743184 -
Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis
Infect Immun, 81 (9), 3173-81
DOI 10.1128/IAI.00390-13, PubMed 23774598 -
Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard
J Immunol Methods, 402 (1-2), 50-6
DOI 10.1016/j.jim.2013.11.010, PubMed 24287422 -
Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis-exposed whole blood
Innate Immun, 20 (5), 552-60
DOI 10.1177/1753425913502099, PubMed 24051102
Publications 2012
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Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons
Brain Res, 1458, 12-7
DOI 10.1016/j.brainres.2012.04.007, PubMed 22546346 -
Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation
Immunobiology, 217 (11), 1047-56
DOI 10.1016/j.imbio.2012.07.019, PubMed 22964230 -
Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs
Immunobiology, 218 (5), 683-9
DOI 10.1016/j.imbio.2012.08.268, PubMed 22947599 -
Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance
Crit Care Med, 40 (4), 1136-42
DOI 10.1097/CCM.0b013e3182377050, PubMed 22020246 -
Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood
Adv Exp Med Biol, 946, 237-51
DOI 10.1007/978-1-4614-0106-3_14, PubMed 21948372 -
Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults
Pediatr Res, 73 (3), 294-300
DOI 10.1038/pr.2012.193, PubMed 23232670 -
The role of properdin in zymosan- and Escherichia coli-induced complement activation
J Immunol, 189 (5), 2606-13
DOI 10.4049/jimmunol.1200269, PubMed 22851705 -
Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
Liver Transpl, 18 (12), 1421-9
DOI 10.1002/lt.23503, PubMed 22767413 -
Complement profile and activation mechanisms by different LDL apheresis systems
Acta Biomater, 8 (6), 2288-96
DOI 10.1016/j.actbio.2012.02.017, PubMed 22373816 -
LDL apheresis and inflammation--implications for atherosclerosis
Scand J Immunol, 76 (3), 229-36
DOI 10.1111/j.1365-3083.2012.02734.x, PubMed 22670805 -
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878 -
Alternative pathway activation of complement in laparoscopic and open rectal surgery
Scand J Immunol, 76 (1), 49-53
DOI 10.1111/j.1365-3083.2012.02702.x, PubMed 22486843 -
The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
Biomaterials, 34 (3), 621-30
DOI 10.1016/j.biomaterials.2012.10.012, PubMed 23103159 -
Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis
BMC Infect Dis, 12, 144
DOI 10.1186/1471-2334-12-144, PubMed 22731696 -
Inflammatory response induced by candidate biomaterials of an implantable microfabricated sensor
J Biomed Mater Res A, 100 (5), 1142-50
DOI 10.1002/jbm.a.34054, PubMed 22337626 -
Activation of coagulation and platelets by candidate membranes of implantable devices in a whole blood model without soluble anticoagulant
J Biomed Mater Res A, 101 (2), 575-81
DOI 10.1002/jbm.a.34348, PubMed 22949225 -
Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention
J Intern Med, 272 (3), 267-76
DOI 10.1111/j.1365-2796.2012.02517.x, PubMed 22243053
Publications 2011
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The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis
Shock, 36 (5), 517-23
DOI 10.1097/SHK.0b013e3182336a34, PubMed 21921836 -
Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans
J Immunol, 187 (9), 4913-9
DOI 10.4049/jimmunol.1101000, PubMed 21964028 -
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
J Infect, 63 (4), 308-16
DOI 10.1016/j.jinf.2011.07.004, PubMed 21781987 -
Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person
Ann Thorac Surg, 91 (2), 527-33
DOI 10.1016/j.athoracsur.2010.10.084, PubMed 21256307 -
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood
Mol Immunol, 48 (15-16), 2159-69
DOI 10.1016/j.molimm.2011.07.011, PubMed 21839519 -
Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics
J Med Chem, 54 (13), 4659-69
DOI 10.1021/jm2003365, PubMed 21591694 -
Staphylococcus epidermidis polysaccharide intercellular adhesin activates complement
FEMS Immunol Med Microbiol, 63 (2), 269-80
DOI 10.1111/j.1574-695X.2011.00854.x, PubMed 22077230 -
Recurrent meningococcal sepsis in a presumptive immunocompetent host shown to be complement C5 deficient-a case report
APMIS, 119 (7), 479-84
DOI 10.1111/j.1600-0463.2011.02740.x, PubMed 21635555 -
Advances in assay of complement function and activation
Adv Drug Deliv Rev, 63 (12), 976-87
DOI 10.1016/j.addr.2011.05.010, PubMed 21664392 -
Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles
Transfus Apher Sci, 46 (1), 73-6
DOI 10.1016/j.transci.2011.11.016, PubMed 22206792 -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
Acta Biomater, 7 (6), 2566-78
DOI 10.1016/j.actbio.2011.03.011, PubMed 21402181 -
Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor
J Diabetes Sci Technol, 5 (6), 1490-8
DOI 10.1177/193229681100500625, PubMed 22226271 -
Complement activation by candidate biomaterials of an implantable microfabricated medical device
J Biomed Mater Res B Appl Biomater, 98 (2), 323-9
DOI 10.1002/jbm.b.31855, PubMed 21648060 -
Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis
Br J Dermatol, 164 (2), 344-55
DOI 10.1111/j.1365-2133.2010.10149.x, PubMed 21271993 -
The mild inflammatory response in febrile neutropenic lymphoma patients with low risk of complications is more pronounced in patients receiving tobramycin once daily compared with three times daily
Scand J Immunol, 74 (6), 632-9
DOI 10.1111/j.1365-3083.2011.02618.x, PubMed 21883353 -
Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment
J Clin Lipidol, 5 (4), 273-80
DOI 10.1016/j.jacl.2011.05.003, PubMed 21784372
Publications 2010
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Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood
Mol Immunol, 47 (9), 1774-82
DOI 10.1016/j.molimm.2010.02.026, PubMed 20334922 -
Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
J Perinat Med, 38 (5), 545-56
DOI 10.1515/JPM.2010.081, PubMed 20629493 -
Systemic mannose-binding lectin is not associated with Chronic Obstructive Pulmonary Disease
Respir Med, 104 (2), 283-90
DOI 10.1016/j.rmed.2009.09.015, PubMed 19836222 -
Body composition and plasma levels of inflammatory biomarkers in COPD
Eur Respir J, 36 (5), 1027-33
DOI 10.1183/09031936.00194209, PubMed 20413541 -
Neutrophil gelatinase-associated lipocalin: a biomarker in COPD
Chest, 138 (4), 888-95
DOI 10.1378/chest.09-2718, PubMed 20495108 -
Arginine catabolic mobile element is associated with low antibiotic resistance and low pathogenicity in Staphylococcus epidermidis from neonates
Pediatr Res, 68 (3), 237-41
DOI 10.1203/PDR.0b013e3181eb01e0, PubMed 20703143 -
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
DOI 10.1097/CCM.0b013e3181de8c94, PubMed 20400898 -
The complement system is activated in a biphasic pattern after coronary artery bypass grafting
Ann Thorac Surg, 89 (3), 710-6
DOI 10.1016/j.athoracsur.2009.11.049, PubMed 20172115 -
Patient tolerance regarding different low-density lipoprotein apheresis columns: frequent minor side effects and high patient satisfaction
J Clin Lipidol, 5 (1), 45-9
DOI 10.1016/j.jacl.2010.11.003, PubMed 21262506 -
Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia
JOP, 11 (5), 467-9
PubMed 20818118 -
Hematologic and hemostatic changes induced by different columns during LDL apheresis
J Clin Apher, 25 (5), 294-300
DOI 10.1002/jca.20256, PubMed 20806414 -
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Immunity, 33 (4), 583-96
DOI 10.1016/j.immuni.2010.09.010, PubMed 20933442 -
Toward an injectable continuous osmotic glucose sensor
J Diabetes Sci Technol, 4 (4), 882-92
DOI 10.1177/193229681000400417, PubMed 20663452 -
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis
Blood, 116 (4), 631-9
DOI 10.1182/blood-2010-01-264051, PubMed 20424189 -
Meconium-induced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner
Mol Immunol, 47 (6), 1226-34
DOI 10.1016/j.molimm.2009.12.015, PubMed 20092898 -
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
Blood, 116 (6), 1002-10
DOI 10.1182/blood-2010-02-269746, PubMed 20466856 -
Comparable biocompatibility of Phisio- and Bioline-coated cardiopulmonary bypass circuits indicated by the inflammatory response
Perfusion, 25 (1), 9-16
DOI 10.1177/0267659110362822, PubMed 20172900 -
Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgery
Perfusion, 26 (2), 107-14
DOI 10.1177/0267659110392438, PubMed 21177724 -
Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis
Clin Physiol Funct Imaging, 31 (2), 151-8
DOI 10.1111/j.1475-097X.2010.00994.x, PubMed 21087397
Publications 2009
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Hirudin versus heparin for use in whole blood in vitro biocompatibility models
J Biomed Mater Res A, 89 (4), 951-9
DOI 10.1002/jbm.a.32034, PubMed 18470919 -
Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
Scand J Immunol, 69 (6), 479-91
DOI 10.1111/j.1365-3083.2009.02255.x, PubMed 19439008 -
The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis
Rheumatology (Oxford), 48 (3), 293-8
DOI 10.1093/rheumatology/ken495, PubMed 19168833 -
Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study
Eur Respir J, 35 (3), 540-8
DOI 10.1183/09031936.00088209, PubMed 19643942 -
Perfusion temperature, thyroid hormones and inflammation during pediatric cardiac surgery
Interact Cardiovasc Thorac Surg, 10 (1), 76-80
DOI 10.1510/icvts.2009.213876, PubMed 19822605 -
The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification
Mol Immunol, 47 (2-3), 373-80
DOI 10.1016/j.molimm.2009.09.005, PubMed 19800125 -
Critical roles of complement and antibodies in host defense mechanisms against Neisseria meningitidis as revealed by human complement genetic deficiencies
Infect Immun, 78 (2), 802-9
DOI 10.1128/IAI.01044-09, PubMed 19933829 -
In vitro evaluation of PHISIO-coated sets for pediatric cardiac surgery
Scand Cardiovasc J, 43 (2), 129-35
DOI 10.1080/14017430802302316, PubMed 19294579 -
Different inflammatory responses induced by three LDL-lowering apheresis columns
J Clin Apher, 24 (6), 247-53
DOI 10.1002/jca.20223, PubMed 19927364 -
A helicopter flight does not induce significant changes in systemic biomarker profiles
Scand J Clin Lab Invest, 69 (4), 462-74
DOI 10.1080/00365510902745360, PubMed 19333819 -
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature
Proc Natl Acad Sci U S A, 106 (37), 15861-6
DOI 10.1073/pnas.0903613106, PubMed 19717455 -
Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system
Mol Immunol, 46 (16), 3388-98
DOI 10.1016/j.molimm.2009.07.011, PubMed 19674792 -
Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients
J Vasc Surg, 50 (1), 100-6
DOI 10.1016/j.jvs.2008.12.033, PubMed 19563958 -
Professor emeritus Morten Harboe, one of the founders of Scandinavian Journal of Immunology, turns 80
Scand. J. Immunol., 69 (6), 469-470
DOI 10.1111/j.1365-3083.2009.02259.x -
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
DOI 10.1097/SHK.0b013e31819c37be, PubMed 19174740 -
The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction
Am J Cardiol, 104 (9), 1179-83
DOI 10.1016/j.amjcard.2009.06.028, PubMed 19840558 -
In situ deposition of complement in human acute brain ischaemia
Scand J Immunol, 69 (6), 555-62
DOI 10.1111/j.1365-3083.2009.02253.x, PubMed 19439017 -
Pathway-specific complement activity in pigs evaluated with a human functional complement assay
Mol Immunol, 46 (8-9), 1620-5
DOI 10.1016/j.molimm.2009.02.028, PubMed 19328551 -
Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
Clin Exp Immunol, 157 (1), 98-103
DOI 10.1111/j.1365-2249.2009.03959.x, PubMed 19659775 -
Occupational exposure to bacterial single cell protein induces inflammation in lung and blood
Inhal Toxicol, 21 (8), 674-81
DOI 10.1080/08958370802491425, PubMed 19558225 -
Mannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock
Clin Infect Dis, 49 (9), 1380-6
DOI 10.1086/606054, PubMed 19793001 -
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
FASEB J, 24 (3), 712-22
DOI 10.1096/fj.09-140798, PubMed 19841036 -
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity
Innate Immun, 16 (4), 254-64
DOI 10.1177/1753425909340420, PubMed 19710096 -
The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome
Metab Syndr Relat Disord, 7 (6), 579-84
DOI 10.1089/met.2009.0003, PubMed 19900154 -
C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction
Eur Heart J, 30 (10), 1180-6
DOI 10.1093/eurheartj/ehp070, PubMed 19299430
Publications 2008
-
Complement activation by neutrophil granulocytes
Scand J Immunol, 67 (4), 354-61
DOI 10.1111/j.1365-3083.2008.02077.x, PubMed 18248527 -
Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood
Mol Immunol, 45 (14), 3804-13
DOI 10.1016/j.molimm.2008.05.017, PubMed 18606453 -
Biomarker profile in off-pump and on-pump coronary artery bypass grafting surgery in low-risk patients
Ann Thorac Surg, 85 (6), 1994-2002
DOI 10.1016/j.athoracsur.2008.03.012, PubMed 18498809 -
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand J Immunol, 68 (1), 75-84
DOI 10.1111/j.1365-3083.2008.02122.x, PubMed 18466195 -
Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
Brain Res, 1259, 80-9
DOI 10.1016/j.brainres.2008.12.055, PubMed 19146835 -
Effect of perfusion temperature on the inflammatory response during pediatric cardiac surgery
Ann Thorac Surg, 85 (2), 611-7
DOI 10.1016/j.athoracsur.2007.10.062, PubMed 18222275 -
The alternative complement pathway revisited
J Cell Mol Med, 12 (4), 1074-84
DOI 10.1111/j.1582-4934.2008.00350.x, PubMed 18419792 -
Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation
Infect Immun, 76 (9), 4183-9
DOI 10.1128/IAI.00195-08, PubMed 18591229 -
The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent
J Biomed Mater Res A, 87 (1), 129-35
DOI 10.1002/jbm.a.31750, PubMed 18085644 -
High mobility group box-1 protein--one step closer to the clinic?
Crit Care, 12 (4), 168
DOI 10.1186/cc6944, PubMed 18671827 -
The role of complement in meconium aspiration syndrome
J Perinatol, 28 Suppl 3, S116-9
DOI 10.1038/jp.2008.148, PubMed 19057601 -
Hypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response
Adv Exp Med Biol, 632, 253-63
DOI 10.1007/978-0-387-78952-1_18, PubMed 19025127 -
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model
J Immunol, 180 (9), 6346-53
DOI 10.4049/jimmunol.180.9.6346, PubMed 18424758 -
Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation
Nephrol Dial Transplant, 23 (12), 4054-60
DOI 10.1093/ndt/gfn355, PubMed 18577532 -
Role of complement and CD14 in meconium-induced cytokine formation
Pediatrics, 121 (3), e496-505
DOI 10.1542/peds.2007-0878, PubMed 18299306 -
Albumin lavage does not improve the outcome of meconium aspiration syndrome
J Matern Fetal Neonatal Med, 21 (10), 719-25
DOI 10.1080/14767050802255561, PubMed 19012188 -
Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood
Mol Immunol, 46 (4), 688-94
DOI 10.1016/j.molimm.2008.09.001, PubMed 18950866 -
Cyanobacterial LPS antagonist (CyP)-a novel and efficient inhibitor of Escherichia coli LPS-induced cytokine response in the pig
Mol Immunol, 45 (13), 3553-7
DOI 10.1016/j.molimm.2008.05.005, PubMed 18571239 -
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood
Infect Immun, 77 (2), 725-32
DOI 10.1128/IAI.01305-08, PubMed 19047409 -
Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation
Transplantation, 86 (8), 1096-103
DOI 10.1097/TP.0b013e31818775ca, PubMed 18946348
Publications 2007
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The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood
J Leukoc Biol, 81 (6), 1404-13
DOI 10.1189/jlb.0806538, PubMed 17389579 -
Off-pump cardiac surgery abolishes complement activation
Perfusion, 22 (4), 251-6
DOI 10.1177/0267659107084142, PubMed 18181513 -
Complement and coagulation: strangers or partners in crime?
Trends Immunol, 28 (4), 184-92
DOI 10.1016/j.it.2007.02.006, PubMed 17336159 -
Complement analysis in the 21st century
Mol Immunol, 44 (16), 3838-49
DOI 10.1016/j.molimm.2007.06.150, PubMed 17768101 -
CD59 efficiently protects human NT2-N neurons against complement-mediated damage
Scand J Immunol, 66 (2-3), 345-51
DOI 10.1111/j.1365-3083.2007.01959.x, PubMed 17635812 -
Complement activation in experimental human malaria infection
Trans R Soc Trop Med Hyg, 101 (7), 643-9
DOI 10.1016/j.trstmh.2007.02.023, PubMed 17481680 -
Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells
Transplantation, 84 (2), 244-50
DOI 10.1097/01.tp.0000268815.90675.d5, PubMed 17667817 -
Complement activation and cytokine response by BioProtein, a bacterial single cell protein
Clin Exp Immunol, 148 (1), 146-52
DOI 10.1111/j.1365-2249.2007.03339.x, PubMed 17302729 -
The inflammatory response to stent grafting of the thoracic aorta
Int Angiol, 26 (3), 219-27
PubMed 17622202
Publications 2006
-
Comparison of in vitro and in vivo complement activation by metal and bioabsorbable screws used in anterior cruciate ligament reconstruction
Arthroscopy, 22 (5), 489-96
DOI 10.1016/j.arthro.2006.03.011, PubMed 16651157 -
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250 -
Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions
Clin Exp Immunol, 144 (3), 512-20
DOI 10.1111/j.1365-2249.2006.03072.x, PubMed 16734621 -
Strategies of therapeutic complement inhibition
Mol Immunol, 43 (1-2), 107-21
DOI 10.1016/j.molimm.2005.06.014, PubMed 16011851 -
Complement analysis in clinic and research
Adv Exp Med Biol, 586, 361-80
DOI 10.1007/0-387-34134-X_24, PubMed 16893084 -
Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement
Mol Immunol, 44 (8), 1819-26
DOI 10.1016/j.molimm.2006.10.003, PubMed 17101176 -
The role of complement in biomaterial-induced inflammation
Mol Immunol, 44 (1-3), 82-94
DOI 10.1016/j.molimm.2006.06.020, PubMed 16905192 -
Expression of complement regulators and receptors on human NT2-N neurons--effect of hypoxia and reoxygenation
Mol Immunol, 44 (9), 2459-68
DOI 10.1016/j.molimm.2006.10.022, PubMed 17116331 -
Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation
Xenotransplantation, 13 (3), 215-23
DOI 10.1111/j.1399-3089.2006.00289.x, PubMed 16756564 -
Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
Blood, 107 (12), 4865-70
DOI 10.1182/blood-2005-07-2820, PubMed 16527897 -
Candidate inhibitors of porcine complement
Mol Immunol, 44 (8), 1827-34
DOI 10.1016/j.molimm.2006.10.004, PubMed 17109963 -
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
J Card Fail, 12 (8), 659-63
DOI 10.1016/j.cardfail.2006.07.002, PubMed 17045187 -
Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions
Scand J Immunol, 64 (3), 345-52
DOI 10.1111/j.1365-3083.2006.01826.x, PubMed 16918704
Publications 2005
-
Meconium aspiration syndrome induces complement-associated systemic inflammatory response in newborn piglets
Scand J Immunol, 61 (3), 217-25
DOI 10.1111/j.1365-3083.2005.01532.x, PubMed 15787738 -
Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
Clin Exp Immunol, 142 (3), 576-84
DOI 10.1111/j.1365-2249.2005.02951.x, PubMed 16297171 -
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
DOI 10.1093/eurheartj/ehi198, PubMed 15821010 -
Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection
Eur J Clin Invest, 35 (12), 765-70
DOI 10.1111/j.1365-2362.2005.01579.x, PubMed 16313253 -
Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosis
J Heart Lung Transplant, 24 (8), 1026-32
DOI 10.1016/j.healun.2004.07.018, PubMed 16102437 -
Role of granulocytes and monocytes in the polyvinyl chloride-induced synthesis of interleukin 8, monocyte chemoattractant protein 1, and leukotriene B4
J Biomed Mater Res A, 74 (2), 230-6
DOI 10.1002/jbm.a.30372, PubMed 15962266 -
Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production
Ann Thorac Surg, 79 (3), 917-23
DOI 10.1016/j.athoracsur.2004.08.015, PubMed 15734405 -
[A programme for boosting medical research in North Norway, 1992-2001]
Tidsskr Nor Laegeforen, 125 (4), 449-50
PubMed 15742020 -
Changes in serum levels of E-selectin correlate to improved glycaemic control and reduced obesity in subjects with the metabolic syndrome
Scand J Clin Lab Invest, 65 (4), 283-90
DOI 10.1080/00365510510013811, PubMed 16076683
Publications 2004
-
Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex
J Immunol, 173 (11), 6921-7
DOI 10.4049/jimmunol.173.11.6921, PubMed 15557188 -
Complement C5a is a key mediator of meconium-induced neutrophil activation
Pediatr Res, 57 (2), 242-7
DOI 10.1203/01.PDR.0000150725.78971.30, PubMed 15585680 -
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
Clin Exp Immunol, 138 (3), 439-46
DOI 10.1111/j.1365-2249.2004.02627.x, PubMed 15544620 -
Soluble toll-like receptor 2 in HIV infection: association with disease progression
AIDS, 18 (18), 2437-9
PubMed 15622324 -
Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery
Perfusion, 19 (3), 177-84
DOI 10.1191/0267659104pf737oa, PubMed 15298426 -
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation
Ann Thorac Surg, 77 (3), 932-41
DOI 10.1016/S0003-4975(03)01519-4, PubMed 14992902 -
Artificial surface-induced cytokine synthesis: effect of heparin coating and complement inhibition
Ann Thorac Surg, 78 (1), 38-44; discussion 44-5
DOI 10.1016/j.athoracsur.2004.02.005, PubMed 15223398 -
Statin drugs do not affect serum complement activation in vitro
Scand J Immunol, 60 (1-2), 178-83
DOI 10.1111/j.0300-9475.2004.01439.x, PubMed 15238087 -
Complement activation reflects severity of meconium aspiration syndrome in newborn pigs
Pediatr Res, 56 (5), 810-7
DOI 10.1203/01.PDR.0000141983.32466.2A, PubMed 15347770 -
Systemic complement activation following human acute ischaemic stroke
Clin Exp Immunol, 137 (1), 117-22
DOI 10.1111/j.1365-2249.2004.02489.x, PubMed 15196251 -
Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
J Immunol Methods, 296 (1-2), 187-98
DOI 10.1016/j.jim.2004.11.016, PubMed 15680163 -
Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide
Infect Immun, 72 (6), 3344-9
DOI 10.1128/IAI.72.6.3344-3349.2004, PubMed 15155639 -
Glomerular monocyte/macrophage influx correlates strongly with complement activation in 1-week protocol kidney allograft biopsies
Clin Nephrol, 62 (2), 121-30
DOI 10.5414/cnp62121, PubMed 15356969 -
Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
Eur Heart J, 25 (4), 349-55
DOI 10.1016/j.ehj.2003.12.006, PubMed 14984925
Publications 2003
-
Meconium is a potent activator of complement in human serum and in piglets
Pediatr Res, 55 (2), 310-8
DOI 10.1203/01.PDR.0000100902.76021.8E, PubMed 14605246 -
Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair
Circulation, 108 (7), 849-56
DOI 10.1161/01.CIR.0000084550.16565.01, PubMed 12900342 -
Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage
Clin Exp Immunol, 133 (2), 160-9
DOI 10.1046/j.1365-2249.2003.02213.x, PubMed 12869020 -
Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy
J Acquir Immune Defic Syndr, 32 (4), 354-61
DOI 10.1097/00126334-200304010-00002, PubMed 12640191 -
Modern complement analysis
Clin Diagn Lab Immunol, 10 (6), 982-9
DOI 10.1128/cdli.10.6.982-989.2003, PubMed 14607856 -
Measurement of complement activation
Methods Mol Biol, 225, 69-75
DOI 10.1385/1-59259-374-7:69, PubMed 12769475 -
Perspectives on complement in xenotransplantation
Mol Immunol, 40 (2-4), 135-43
DOI 10.1016/s0161-5890(03)00106-8, PubMed 12914819 -
Complement activation and cytokine and chemokines release during mediastinitis
Ann Thorac Surg, 75 (3), 981-5
DOI 10.1016/s0003-4975(02)04556-3, PubMed 12645727 -
Changes in the cytokine network and complement parameters during open heart surgery
Interact Cardiovasc Thorac Surg, 2 (1), 19-24
DOI 10.1016/S1569-9293(02)00088-9, PubMed 17669979 -
Improved preservation of coagulation factors after pre-storage leukocyte depletion of whole blood
Transfus Apher Sci, 29 (2), 133-9
DOI 10.1016/S1473-0502(03)00117-4, PubMed 12941351 -
Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis
Blood, 102 (10), 3702-10
DOI 10.1182/blood-2003-03-0703, PubMed 12881318 -
Complement activation in early protocol kidney graft biopsies after living-donor transplantation
Transplantation, 75 (8), 1204-13
DOI 10.1097/01.TP.0000062835.30165.2C, PubMed 12717204 -
Universal fresh frozen plasma (Uniplas): a safe product in open-heart surgery
Intensive Care Med, 29 (10), 1736-43
DOI 10.1007/s00134-003-1952-3, PubMed 12955185
Publications 2002
-
Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant
J Infect Dis, 185 (2), 220-8
DOI 10.1086/338269, PubMed 11807696 -
Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep
Eur Respir J, 20 (4), 957-64
DOI 10.1183/09031936.02.00932001, PubMed 12412689 -
[Ethical aspects of xenotransplantation]
Tidsskr Nor Laegeforen, 122 (4), 397-400
PubMed 11915670 -
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation
Blood, 100 (5), 1869-77
PubMed 12176911 -
Role of complement in xenotransplantation
Allergy, 57 Suppl 72, 75-8
DOI 10.1034/j.1398-9995.57.s72.10.x, PubMed 12144560 -
Complement in inflammatory tissue damage and disease
Trends Immunol, 23 (2), 61-4
DOI 10.1016/s1471-4906(01)02129-9, PubMed 11929126 -
C1-inhibitor reduces the ischaemia-reperfusion injury of skeletal muscles in mice after aortic cross-clamping
Scand J Immunol, 56 (6), 588-92
DOI 10.1046/j.1365-3083.2002.01173.x, PubMed 12472670 -
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies
Xenotransplantation, 9 (5), 350-8
DOI 10.1034/j.1399-3089.2002.01094.x, PubMed 12199866 -
The significance of heparin-coated veno-venous bypass circuits in liver transplantation
Perfusion, 17 (1), 45-50
DOI 10.1191/0267659102pf523oa, PubMed 11817529
Publications 2001
-
Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
Circulation, 104 (13), 1494-500
DOI 10.1161/hc3801.096353, PubMed 11571242 -
C1-inhibitor: an anti-inflammatory reagent with therapeutic potential
Expert Opin Pharmacother, 2 (7), 1073-83
DOI 10.1517/14656566.2.7.1073, PubMed 11583058 -
Expression of active human C1 inhibitor serpin domain in Escherichia coli
Protein Expr Purif, 22 (2), 349-58
DOI 10.1006/prep.2001.1445, PubMed 11437612 -
Increased systemic activation of neutrophils but not complement in preeclampsia
Obstet Gynecol, 97 (3), 371-4
DOI 10.1016/s0029-7844(00)01179-0, PubMed 11239639 -
Veno-venous bypass in liver transplantation: heparin-coated perfusion circuits reduce the activation of humoral defense systems in an in vitro model
Perfusion, 16 (4), 285-92
DOI 10.1177/026765910101600404, PubMed 11486847 -
C1-inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells
Transplant Proc, 33 (1-2), 789-90
DOI 10.1016/s0041-1345(00)02256-9, PubMed 11267073 -
Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated
Transplantation, 72 (12), 1967-73
DOI 10.1097/00007890-200112270-00017, PubMed 11773897 -
Acute phase haemolysis in chronic cold agglutinin disease
Scand J Immunol, 54 (1-2), 239-42
DOI 10.1046/j.1365-3083.2001.00960.x, PubMed 11439172
Publications 2000
-
A novel enzyme immunoassay for plasma thrombospondin. Comparison with beta-thromboglobulin as platelet activation marker in vitro and in vivo
Thromb Res, 99 (1), 41-50
DOI 10.1016/s0049-3848(00)00226-7, PubMed 10904102 -
Pig endogenous retrovirus--a threat to clinical xenotransplantation?
APMIS, 108 (4), 241-50
DOI 10.1034/j.1600-0463.2000.d01-51.x, PubMed 10843410 -
Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model
Transplant Proc, 32 (5), 899-900
DOI 10.1016/s0041-1345(00)01028-9, PubMed 10936264 -
Interferon-alpha2a effects on complement activation and regulation in MS patients
Acta Neurol Scand, 101 (1), 30-5
DOI 10.1034/j.1600-0404.2000.00013.x, PubMed 10660149 -
The inflammatory response following treatment of abdominal aortic aneurysms: a comparison between open surgery and endovascular repair
Eur J Vasc Endovasc Surg, 19 (5), 536-44
DOI 10.1053/ejvs.1999.1092, PubMed 10828237 -
On the blood compatibility of end-point immobilized heparin
J Biomater Sci Polym Ed, 11 (11), 1261-73
DOI 10.1163/156856200744192, PubMed 11263812
Publications 1999
-
Leucocyte filtration during cardiopulmonary reperfusion in coronary artery bypass surgery
Perfusion, 14 (2), 107-17
DOI 10.1177/026765919901400204, PubMed 10338322 -
In vitro evaluation of new surface coatings for extracorporeal circulation
Perfusion, 14 (1), 11-9
DOI 10.1177/026765919901400103, PubMed 10074642 -
Comparison of three oxygenator-coated and one total-circuit-coated extracorporeal devices
Perfusion, 14 (2), 119-27
DOI 10.1177/026765919901400205, PubMed 10338323 -
[Transplantation from animal to man]
Tidsskr Nor Laegeforen, 119 (28), 4213-8
PubMed 10668386 -
Prolongation of ex vivo-perfused pig xenograft survival by the complement inhibitor Compstatin
Transplant Proc, 31 (1-2), 934-5
DOI 10.1016/s0041-1345(98)01844-2, PubMed 10083413 -
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts
Xenotransplantation, 6 (1), 52-65
DOI 10.1034/j.1399-3089.1999.00007.x, PubMed 10355733 -
C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model
Immunopharmacology, 42 (1-3), 231-43
DOI 10.1016/s0162-3109(99)00008-9, PubMed 10408384 -
Inhibition of platelet aggregation by the GPIIb/IIIa antagonist reopro does not significantly prolong xenograft survival in an ex vivo model
Transpl Int, 12 (5), 323-33
DOI 10.1007/s001470050235, PubMed 10551997 -
Complement activation and increased systemic and pulmonary vascular resistance indices during infusion of postoperatively drained untreated blood
Br J Anaesth, 82 (1), 47-51
DOI 10.1093/bja/82.1.47, PubMed 10325835 -
Xenotransplantation: how to overcome the complement obstacle?
Mol Immunol, 36 (4-5), 269-76
DOI 10.1016/s0161-5890(99)00050-4, PubMed 10403480 -
Complement activation in patients with systemic lupus erythematosus without nephritis
Rheumatology (Oxford), 38 (10), 933-40
DOI 10.1093/rheumatology/38.10.933, PubMed 10534542 -
Platelet compatibility of an artificial surface modified with functionally active heparin
Thromb Haemost, 82 (3), 1132-6
PubMed 10494777 -
Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H
Infect Immun, 67 (9), 4517-24
DOI 10.1128/IAI.67.9.4517-4524.1999, PubMed 10456894 -
Heparin-coated cardiopulmonary bypass equipment. II. Mechanisms for reduced complement activation in vivo
J Thorac Cardiovasc Surg, 117 (4), 803-9
DOI 10.1016/S0022-5223(99)70302-8, PubMed 10096977 -
Heparin-coated cardiopulmonary bypass equipment. I. Biocompatibility markers and development of complications in a high-risk population
J Thorac Cardiovasc Surg, 117 (4), 794-802
DOI 10.1016/s0022-5223(99)70301-6, PubMed 10096976
Publications 1998
-
Removal of activated complement from shed blood: comparison of high- and low-dilutional haemofiltration
Acta Anaesthesiol Scand, 42 (7), 811-5
DOI 10.1111/j.1399-6576.1998.tb05327.x, PubMed 9698958 -
Leucocyte filtration during cardiopulmonary bypass hardly changed leucocyte counts and did not influence myeloperoxidase, complement, cytokines or platelets
Perfusion, 13 (6), 429-36
DOI 10.1177/026765919801300606, PubMed 9881390 -
Anti-TNF treatment of baboons with sepsis reduces TNF-alpha, IL-6 and IL-8, but not the degree of complement activation
Scand J Immunol, 48 (5), 509-14
DOI 10.1046/j.1365-3083.1998.00433.x, PubMed 9822260 -
An ex vivo perfusion model to evaluate hyperacute rejection in a discordant pig-to-human combination
Eur Surg Res, 30 (5), 341-51
DOI 10.1159/000008597, PubMed 9731103 -
Immunoglobulin prolongs survival of pig kidneys perfused ex vivo with human blood
Scand J Immunol, 47 (6), 568-74
DOI 10.1046/j.1365-3083.1998.00341.x, PubMed 9652825 -
Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma
Injury, 29 (7), 509-14
DOI 10.1016/s0020-1383(98)00113-2, PubMed 10193492 -
Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4
Transfusion, 38 (1), 16-23
DOI 10.1046/j.1537-2995.1998.38198141493.x, PubMed 9482389 -
Characterization of soluble terminal complement complex assembled in C8beta-deficient plasma and serum
Scand J Immunol, 48 (3), 261-8
DOI 10.1046/j.1365-3083.1998.00390.x, PubMed 9743210 -
Complement activation and release of interleukin-6 and tumour necrosis factor-alpha in drained and systemic blood after major orthopaedic surgery
Eur J Surg, 164 (2), 103-8
DOI 10.1080/110241598750004742, PubMed 9537716 -
Complement and biocompatibility
Vox Sang, 74 Suppl 2, 303-7
DOI 10.1111/j.1423-0410.1998.tb05435.x, PubMed 9704460 -
High-dose intravenous immunoglobulin treatment activates complement in vivo
Scand J Immunol, 48 (3), 312-7
DOI 10.1046/j.1365-3083.1998.00386.x, PubMed 9743219 -
Identification of a C-->T mutation in the reactive-site coding region of the C1-inhibitor gene and its detection by an improved mutation-specific polymerase chain reaction method
Scand J Immunol, 47 (3), 273-6
DOI 10.1046/j.1365-3083.1998.00290.x, PubMed 9519866 -
Complement activation in sudden deafness
Arch Otolaryngol Head Neck Surg, 124 (6), 633-6
DOI 10.1001/archotol.124.6.633, PubMed 9639471 -
Improved blood preservation with 0.5CPD erythro-sol. Coagulation factor VIII activity and erythrocyte quality after delayed separation of blood
Vox Sang, 74 (3), 168-75
DOI 10.1046/j.1423-0410.1998.7430168.x, PubMed 9595644
Publications 1997
-
Effects on complement, granulocytes and platelets of a leukocyte-depletion filter during in vitro extracorporeal circulation
Scand Cardiovasc J, 31 (2), 73-7
DOI 10.3109/14017439709058072, PubMed 9211593 -
Duraflo II coating of cardiopulmonary bypass circuits reduces complement activation, but does not affect the release of granulocyte enzymes : a European multicentre study
Eur J Cardiothorac Surg, 11 (2), 320-7
DOI 10.1016/s1010-7940(96)01062-7, PubMed 9080162 -
A neoepitope-based enzyme immunoassay for quantification of C1-inhibitor in complex with C1r and C1s
Scand J Immunol, 46 (6), 553-7
DOI 10.1046/j.1365-3083.1997.d01-168.x, PubMed 9420617 -
Immobilized heparin inhibits the increase in leukocyte surface expression of adhesion molecules
Artif Organs, 21 (4), 293-9
DOI 10.1111/j.1525-1594.1997.tb00364.x, PubMed 9096801 -
Both plasma- and leukocyte-associated C5a are essential for assessment of C5a generation in vivo
Ann Thorac Surg, 63 (4), 1076-80
DOI 10.1016/s0003-4975(96)01255-6, PubMed 9124908 -
Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality
Gut, 40 (4), 544-9
DOI 10.1136/gut.40.4.544, PubMed 9176087 -
Attenuation of changes in leukocyte surface markers and complement activation with heparin-coated cardiopulmonary bypass
Ann Thorac Surg, 63 (1), 105-11
DOI 10.1016/s0003-4975(96)00743-6, PubMed 8993250 -
Biocompatibility: complement as mediator of tissue damage and as indicator of incompatibility
Exp Clin Immunogenet, 14 (1), 24-9
PubMed 9187920 -
Effect of whole and fractionated intravenous immunoglobulin on complement in vitro
Mol Immunol, 34 (10), 719-29
DOI 10.1016/s0161-5890(97)00091-6, PubMed 9430199 -
Extracorporeal membrane oxygenation using a centrifugal pump and a servo regulator to prevent negative inlet pressure
Ann Thorac Surg, 63 (5), 1333-9
DOI 10.1016/s0003-4975(97)00098-2, PubMed 9146324 -
Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique
Plast Reconstr Surg, 99 (6), 1591-4; discussion 1595-6
DOI 10.1097/00006534-199705000-00017, PubMed 9145127
Publications 1996
-
Effects on complement activation and cytokine (TNF-alpha and IL-8) release of infusion of anti-TNF-antibodies or a xanthine derivative (HWA 138) in septic baboons
Acta Anaesthesiol Scand, 40 (2), 244-9
DOI 10.1111/j.1399-6576.1996.tb04427.x, PubMed 8848926 -
The excessive complement activation in fulminant meningococcal septicemia is predominantly caused by alternative pathway activation
J Infect Dis, 173 (3), 647-55
DOI 10.1093/infdis/173.3.647, PubMed 8627028 -
[Reduced blood utilization in hip arthroplasty. Introduction of a blood preservation program]
Tidsskr Nor Laegeforen, 116 (1), 30-3
PubMed 8553331 -
Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model
J Clin Immunol, 16 (4), 222-9
DOI 10.1007/BF01541228, PubMed 8840224 -
Serum clusterin and vitronectin in alcoholic cirrhosis
Liver, 16 (2), 140-6
DOI 10.1111/j.1600-0676.1996.tb00719.x, PubMed 8740849 -
Adhesion molecule expression and complement activation in vessel walls in synovial tissue from patients with chronic inflammatory joint disease
Clin Rheumatol, 15 (5), 441-7
DOI 10.1007/BF02229640, PubMed 8894356 -
Differences in blood activation related to roller/centrifugal pumps and heparin-coated/uncoated surfaces in a cardiopulmonary bypass model circuit
Perfusion, 11 (2), 113-23
DOI 10.1177/026765919601100205, PubMed 8740352 -
Centrifugal pump and heparin coating improves cardiopulmonary bypass biocompatibility
Ann Thorac Surg, 62 (4), 1134-40
DOI 10.1016/0003-4975(96)00492-4, PubMed 8823102 -
Clinical immunology
BMJ, 312 (7044), 1465-9
DOI 10.1136/bmj.312.7044.1465, PubMed 8664630 -
Hereditary angio-oedema: new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses
J Intern Med, 239 (2), 119-30
DOI 10.1046/j.1365-2796.1996.418764000.x, PubMed 8568479 -
Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema
Scand J Immunol, 44 (2), 185-92
DOI 10.1046/j.1365-3083.1996.d01-298.x, PubMed 8711433 -
Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema
Immunopharmacology, 33 (1-3), 359-60
DOI 10.1016/0162-3109(96)00085-9, PubMed 8856186 -
Complete heparin-coated cardiopulmonary bypass and low heparin dose reduce complement and granulocyte activation
Eur J Cardiothorac Surg, 10 (1), 54-60
DOI 10.1016/s1010-7940(96)80266-1, PubMed 8776186 -
Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic
Clin Immunol Immunopathol, 79 (3), 217-23
DOI 10.1006/clin.1996.0071, PubMed 8635278 -
Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement
Perfusion, 11 (4), 326-32
DOI 10.1177/026765919601100405, PubMed 8884861 -
Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement
Cardiovasc Res, 31 (4), 596-602
PubMed 8689651 -
Release of interleukin 6 and activation of complement during and after paediatric cardiopulmonary bypass. Effect of autotransfusion of shed mediastinal blood and ultrafiltration
Cytokine, 8 (5), 417-20
DOI 10.1006/cyto.1996.0057, PubMed 8726671
Publications 1995
-
Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis
Biol Neonate, 68 (2), 153-6
DOI 10.1159/000244231, PubMed 8534775 -
Ex vivo model for xenotransplantation
Transplant Proc, 27 (6), 3560-1
PubMed 8540102 -
Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency
J Clin Invest, 95 (3), 1054-61
DOI 10.1172/JCI117751, PubMed 7883953 -
Terminal complement pathway activation and low lysis inhibitors in rheumatoid arthritis synovial fluid
J Rheumatol, 22 (1), 24-8
PubMed 7535360 -
Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet
Scand J Rheumatol, 24 (2), 85-93
DOI 10.3109/03009749509099290, PubMed 7747149 -
Complement activation by angiographic catheters in vitro
J Vasc Interv Radiol, 6 (5), 819-26
DOI 10.1016/s1051-0443(95)71193-9, PubMed 8541691 -
Disparity in blood activation by two different heparin-coated cardiopulmonary bypass systems
Ann Thorac Surg, 60 (5), 1317-23
DOI 10.1016/0003-4975(95)00777-i, PubMed 8526620 -
Inhibition of complement-mediated red cell lysis by immunoglobulins is dependent on the IG isotype and its C1 binding properties
Scand J Immunol, 41 (5), 449-56
DOI 10.1111/j.1365-3083.1995.tb03591.x, PubMed 7725063 -
A new model for evaluation of biocompatibility: combined determination of neoepitopes in blood and on artificial surfaces demonstrates reduced complement activation by immobilization of heparin
Artif Organs, 19 (9), 909-17
DOI 10.1111/j.1525-1594.1995.tb02450.x, PubMed 8687297 -
C3 is activated in hereditary angioedema, and C1/C1-inhibitor complexes rise during physical stress in untreated patients
Scand J Immunol, 42 (6), 679-85
DOI 10.1111/j.1365-3083.1995.tb03711.x, PubMed 8552992 -
Complement and granulocyte activation in two different types of heparinized extracorporeal circuits
J Thorac Cardiovasc Surg, 110 (6), 1623-32
DOI 10.1016/s0022-5223(95)70023-4, PubMed 8523872 -
High and low heparin dose with heparin-coated cardiopulmonary bypass: activation of complement and granulocytes
Ann Thorac Surg, 60 (6), 1755-61
DOI 10.1016/0003-4975(95)00763-6, PubMed 8787476 -
Surface modification with functionally active heparin
Med Device Technol, 6 (2), 24-31
PubMed 10155375 -
The Fluid-phase SC5b-9 Terminal Complement Complex Binds to the GPIIb/IIIa Complex of Thrombin-stimulated Human Blood Platelets Inhibiting Platelet Aggregation
Platelets, 6 (3), 160-8
DOI 10.3109/09537109509013269, PubMed 21043620 -
Effect of syringe-assisted liposuction on activation of cascade systems and circulating cells when using the superwet or tumescent technique
Ann Plast Surg, 35 (3), 242-8
DOI 10.1097/00000637-199509000-00004, PubMed 7503516 -
Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass in children
Scand J Clin Lab Invest, 55 (1), 79-86
DOI 10.3109/00365519509075381, PubMed 7624740
Publications 1994
-
The effects of plasma and albumin infusion on organ function and sepsis markers in experimental gram-negative sepsis
Shock, 2 (6), 402-7
DOI 10.1097/00024382-199412000-00003, PubMed 7743369 -
Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass
Ann Thorac Surg, 58 (2), 472-7
DOI 10.1016/0003-4975(94)92231-4, PubMed 8067851 -
Low levels of vitronectin and clusterin in acute meningococcal disease are closely associated with formation of the terminal-complement complex and the vitronectin-thrombin-antithrombin complex
Infect Immun, 62 (11), 4874-80
DOI 10.1128/iai.62.11.4874-4880.1994, PubMed 7523299 -
IgG subclass distribution and complement activation ability of autoantibodies to neutrophil cytoplasmic antigens (ANCA)
Clin Immunol Immunopathol, 70 (1), 32-9
DOI 10.1006/clin.1994.1007, PubMed 8261667 -
Roller and centrifugal pumps compared in vitro with regard to haemolysis, granulocyte and complement activation
Perfusion, 9 (2), 109-17
DOI 10.1177/026765919400900205, PubMed 7919596 -
The complement system in trauma-related and ischemic tissue damage: a brief review
Shock, 2 (4), 301-10
DOI 10.1097/00024382-199410000-00012, PubMed 7757525 -
C1 inhibitor and diagnosis of hereditary angioedema in newborns
Pediatr Res, 35 (2), 184-7
DOI 10.1203/00006450-199402000-00012, PubMed 8165053 -
Effect of time, temperature and additives on a functional assay of C1 inhibitor
J Immunol Methods, 173 (2), 245-51
DOI 10.1016/0022-1759(94)90303-4, PubMed 8046257 -
[Angioedema associated with ACE inhibitors]
Tidsskr Nor Laegeforen, 114 (7), 804-6
PubMed 8009499 -
The Membrane Glycoprotein IIb/IIIa Complex Mediates Deposition of Thrombin-stimulated Blood Platelets on Polystyrene Plastic Under Static Conditions
Platelets, 5 (2), 96-104
DOI 10.3109/09537109409005519, PubMed 21043610 -
Differences in complement activation between complement-resistant and complement-sensitive Moraxella (Branhamella) catarrhalis strains occur at the level of membrane attack complex formation
Infect Immun, 62 (2), 589-95
DOI 10.1128/iai.62.2.589-595.1994, PubMed 8300216 -
Human complement activation by polygeline and dextran 70
Scand J Immunol, 39 (3), 314-20
DOI 10.1111/j.1365-3083.1994.tb03377.x, PubMed 7510416
Publications 1993
-
Complement and leukocyte activation in septic baboons
Circ Shock, 39 (2), 83-8
PubMed 8490996 -
Calprotectin and complement activation during major operations with or without cardiopulmonary bypass
Ann Thorac Surg, 55 (3), 694-9
DOI 10.1016/0003-4975(93)90277-o, PubMed 8452432 -
Deposition of C3, the terminal complement complex and vitronectin in primary biliary cirrhosis and primary sclerosing cholangitis
Liver, 13 (6), 305-10
DOI 10.1111/j.1600-0676.1993.tb00650.x, PubMed 7507546 -
The B chain, but not the A chain, of Ricinus communis activates human complement
Cancer Lett, 75 (1), 59-63
DOI 10.1016/0304-3835(93)90208-q, PubMed 8287382 -
Quantitation of vitronectin and clusterin. Pitfalls and solutions in enzyme immunoassays for adhesive proteins
J Immunol Methods, 160 (1), 107-15
DOI 10.1016/0022-1759(93)90014-x, PubMed 7680696 -
Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease)
Am J Pathol, 143 (5), 1356-65
PubMed 8238252 -
Complement activation by Pseudomonas aeruginosa biofilms
Microb Pathog, 15 (5), 377-88
DOI 10.1006/mpat.1993.1087, PubMed 8015418 -
[Complement analysis tests]
Tidsskr Nor Laegeforen, 113 (2), 211-3
PubMed 8430403 -
Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC)
Clin Exp Immunol, 91 (2), 295-300
DOI 10.1111/j.1365-2249.1993.tb05898.x, PubMed 7679061 -
Effects of high dose E. coli lipopolysaccharide on rabbit lung function, and of subsequent addition of chemotactic granulocyte activators to their isolated, blood-perfused lungs
Acta Anaesthesiol Scand, 37 (4), 334-42
DOI 10.1111/j.1399-6576.1993.tb03725.x, PubMed 8322560 -
Vitronectin inhibits blood platelet aggregation
Platelets, 4 (4), 225-9
DOI 10.3109/09537109309013222, PubMed 21043846 -
Complement activation during extracorporeal circulation. In vitro comparison of Duraflo II heparin-coated and uncoated oxygenator circuits
J Thorac Cardiovasc Surg, 106 (3), 466-72
PubMed 8361189
Publications 1992
-
Surface epithelium related activation of complement differs in Crohn's disease and ulcerative colitis
Gut, 33 (7), 902-8
DOI 10.1136/gut.33.7.902, PubMed 1379568 -
Biocompatibility of white cell filters as evaluated by complement activation
Transfusion, 32 (6), 557-61
DOI 10.1046/j.1537-2995.1992.32692367201.x, PubMed 1502709 -
Heparin-binding properties of vitronectin are linked to complex formation as illustrated by in vitro polymerization and binding to the terminal complement complex
J Biol Chem, 267 (32), 23076-82
PubMed 1385412 -
Platelets and vitronectin: immunocytochemical localization and platelet interaction with exogenously added vitronectin
Nouv Rev Fr Hematol (1978), 34 (1), 47-54
PubMed 1381819 -
Time for new concepts about measurement of complement activation by cardiopulmonary bypass?
Ann Thorac Surg, 54 (4), 725-31
DOI 10.1016/0003-4975(92)91018-5, PubMed 1417231 -
Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations
J Thorac Cardiovasc Surg, 103 (4), 806-13
PubMed 1548925
Publications 1991
-
Severe human septic shock involves more than tumor necrosis factor
Prog Clin Biol Res, 367, 25-42
PubMed 1924430 -
The use of flow cytometry to detect the biosynthesis of complement components
J Immunol Methods, 140 (2), 167-71
DOI 10.1016/0022-1759(91)90367-o, PubMed 2066563 -
Activation of complement during apheresis
Clin Exp Immunol, 84 (3), 535-8
PubMed 1904328 -
Immunopathology of subcutaneous rheumatoid nodules
Ann Rheum Dis, 50 (12), 909-12
DOI 10.1136/ard.50.12.909, PubMed 1768157 -
Formation of C5a during cardiopulmonary bypass: inhibition by precoating with heparin
Ann Thorac Surg, 52 (1), 92-7
DOI 10.1016/0003-4975(91)91426-v, PubMed 2069469 -
Complement activation and bioincompatibility. The terminal complement complex for evaluation and surface modification with heparin for improvement of biomaterials
Clin Exp Immunol, 86 Suppl 1 (Suppl 1), 21-6
PubMed 1934602 -
C3 activation products, C3 containing immune complexes, the terminal complement complex and native C9 in patients with rheumatoid arthritis
Scand J Rheumatol, 20 (3), 183-9
DOI 10.3109/03009749109103019, PubMed 2068540 -
Activation of complement, kallikrein-kinin, fibrinolysis and coagulation systems by urinary catheters. Effect of time and temperature in biocompatibility studies
Br J Urol, 67 (1), 83-7
DOI 10.1111/j.1464-410x.1991.tb15075.x, PubMed 1993281 -
Biocompatibility of extracorporeal circulation. In vitro comparison of heparin-coated and uncoated oxygenator circuits
J Thorac Cardiovasc Surg, 101 (4), 654-60
PubMed 2008104
Publications 1990
-
Synthesis of C3, C5, C6, C7, C8, and C9 by human fibroblasts
Scand J Immunol, 32 (5), 555-60
DOI 10.1111/j.1365-3083.1990.tb03196.x, PubMed 2270435 -
C3, C4, and the terminal complement complex differ from C1q by binding predominantly to the antigenic part of solid phase immune complexes
J Immunol, 144 (1), 198-203
PubMed 2295791 -
Increased amounts of C4-containing immune complexes and inefficient activation of C3 and the terminal complement pathway in a patient with homozygous C2 deficiency and systemic lupus erythematosus
Scand J Immunol, 31 (1), 59-64
DOI 10.1111/j.1365-3083.1990.tb02743.x, PubMed 2300790 -
Latex gloves as a cause of inflammation and eczema
Lancet, 335 (8703), 1469
DOI 10.1016/0140-6736(90)91502-2, PubMed 1972244 -
Epithelial deposition of immunoglobulin G1 and activated complement (C3b and terminal complement complex) in ulcerative colitis
Gastroenterology, 98 (5 Pt 1), 1264-71
DOI 10.1016/0016-5085(90)90343-y, PubMed 1691118 -
S protein binds to serum-treated agarose beads independently of complement activation and the formation of the terminal complement complex on the beads
Clin Exp Immunol, 79 (3), 459-62
DOI 10.1111/j.1365-2249.1990.tb08112.x, PubMed 1690618 -
IgG and IgA subclass distribution of total immunoglobulin and rheumatoid factors in rheumatoid tissue plasma cells
Scand J Rheumatol, 19 (5), 333-40
DOI 10.3109/03009749009096788, PubMed 2218430 -
Complement-mediated demyelination in patients with IgM monoclonal gammopathy and polyneuropathy
N Engl J Med, 322 (10), 649-52
DOI 10.1056/NEJM199003083221002, PubMed 1689461 -
Quantification of non-activated (native) complement component C9 synthesized by alveolar macrophages from patients with sarcoidosis
Scand J Immunol, 31 (5), 657-63
DOI 10.1111/j.1365-3083.1990.tb02816.x, PubMed 2189215 -
Synthesis of complement by alveolar macrophages from patients with sarcoidosis
Scand J Immunol, 31 (1), 15-23
DOI 10.1111/j.1365-3083.1990.tb02738.x, PubMed 1689072 -
Methylprednisolone in high doses gives different effects on the early and the late part of complement
Eur Surg Res, 22 (1), 41-9
DOI 10.1159/000129081, PubMed 2199200 -
Immunohistochemical detection of terminal complement complex and S protein in normal and pre-eclamptic placentae
Clin Exp Immunol, 80 (2), 236-40
DOI 10.1111/j.1365-2249.1990.tb05240.x, PubMed 2357851 -
Complement activation with bubble and membrane oxygenators in aortocoronary bypass grafting
Ann Thorac Surg, 50 (3), 387-91
DOI 10.1016/0003-4975(90)90480-t, PubMed 2205161 -
Elutable factors from latex-containing materials activate complement and inhibit cell proliferation. An in vitro biocompatibility study of medical devices
Complement Inflamm, 7 (2), 63-70
DOI 10.1159/000463130, PubMed 2225794
Publications 1989
-
Complement activation and endotoxin levels in systemic meningococcal disease
J Infect Dis, 160 (1), 58-65
DOI 10.1093/infdis/160.1.58, PubMed 2471750 -
Activation-dependent antigenic changes of human C3
Complement Inflamm, 6 (3), 205-18
DOI 10.1159/000463094, PubMed 2472922 -
Enzyme immunoassay detection of circulating immune complexes by monoclonal antibodies to C3 neoepitopes with special reference to IgG concentration and to interfering anti-immunoglobulin antibodies
J Immunol Methods, 117 (1), 59-66
DOI 10.1016/0022-1759(89)90119-1, PubMed 2464039 -
Biocompatibility of urinary catheters. Effect on complement activation
Br J Urol, 63 (4), 367-71
DOI 10.1111/j.1464-410x.1989.tb05219.x, PubMed 2713618 -
Persistent complement activation in submucosal blood vessels of active inflammatory bowel disease: immunohistochemical evidence
Gastroenterology, 97 (1), 10-9
DOI 10.1016/0016-5085(89)91409-1, PubMed 2498144 -
Deposits of terminal complement complex (TCC) in muscularis mucosae and submucosal vessels in ulcerative colitis and Crohn's disease of the colon
Gut, 30 (3), 361-6
DOI 10.1136/gut.30.3.361, PubMed 2707635 -
S-protein is synthesized by human monocytes and macrophages in vitro
Scand J Immunol, 29 (1), 15-21
DOI 10.1111/j.1365-3083.1989.tb01094.x, PubMed 2466326 -
High doses of corticosteroids in total hip replacement. Effects on components of coagulation, fibrinolytic, plasma kallikrein-kinin and complement systems
Acta Chir Scand, 155 (4-5), 247-50
PubMed 2678856 -
Different activation patterns in the plasma kallikrein-kinin and complement systems during coronary bypass surgery
Acta Anaesthesiol Scand, 33 (5), 343-7
DOI 10.1111/j.1399-6576.1989.tb02921.x, PubMed 2800971 -
Antigenic changes of complement components: relevance for the analysis of complement activation
Complement Inflamm, 6 (3), 134-41
DOI 10.1159/000463090, PubMed 2472919 -
[The complement system--a fascinating biological cascade. 1--physiologic aspects]
Tidsskr Nor Laegeforen, 109 (27), 2782-8
PubMed 2815011 -
[The complement system--a fascinating biological cascade. 2--clinical aspects]
Tidsskr Nor Laegeforen, 109 (28), 2891-6
PubMed 2815029 -
Alterations in the terminal complement pathway in leukopenic children with malignant diseases during episodes with evidence of infection
Complement Inflamm, 6 (6), 460-9
DOI 10.1159/000463115, PubMed 2598645 -
Activation-dependent epitopes in the terminal complement pathway
Complement Inflamm, 6 (3), 223-35
DOI 10.1159/000463096, PubMed 2472924 -
Studies on the dose dependence of endotoxin-induced in vitro activation of the complement system
Eur Surg Res, 21 (1), 34-41
DOI 10.1159/000129001, PubMed 2714308 -
Different oxygenators for cardiopulmonary bypass lead to varying degrees of human complement activation in vitro
J Thorac Cardiovasc Surg, 97 (5), 764-70
PubMed 2709867
Publications 1988
-
Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes
Clin Exp Immunol, 74 (3), 459-64
PubMed 2466593 -
Systemic meningococcal disease: a model infection to study acute endotoxinemia in man
Prog Clin Biol Res, 272, 263-71
PubMed 3393567 -
Quantification in enzyme-linked immunosorbent assay of a C3 neoepitope expressed on activated human complement factor C3
Scand J Immunol, 27 (3), 329-35
DOI 10.1111/j.1365-3083.1988.tb02354.x, PubMed 2451274 -
Characterization of a monoclonal antibody MoAb bH6 reacting with a neoepitope of human C3 expressed on C3b, iC3b, and C3c
Scand J Immunol, 27 (3), 319-27
DOI 10.1111/j.1365-3083.1988.tb02353.x, PubMed 2451273 -
Terminal complement complex (TCC) and S-protein (vitronectin) on follicular dendritic cells in human lymphoid tissues
Immunology, 65 (2), 193-7
PubMed 2461343 -
Deposits of terminal complement complex and S-protein on follicular dendritic cells in human lymphoid tissue
Adv Exp Med Biol, 237, 185-9
DOI 10.1007/978-1-4684-5535-9_27, PubMed 2978199 -
Terminal complement complexes and anaphylatoxins in septic and ischemic patients
Arch Surg, 123 (2), 188-92
DOI 10.1001/archsurg.1988.01400260068008, PubMed 3277584 -
Complement in chronic cutaneous lupus erythematosus
Br J Dermatol, 118 (1), 131-3
DOI 10.1111/j.1365-2133.1988.tb01762.x, PubMed 3257702 -
Complement activation during cardiopulmonary bypass: comparison between the use of large volumes of plasma and dextran 70
Eur Surg Res, 20 (2), 101-9
DOI 10.1159/000128748, PubMed 2455645 -
Effect of time, temperature and anticoagulants on in vitro complement activation: consequences for collection and preservation of samples to be examined for complement activation
Clin Exp Immunol, 73 (3), 484-8
PubMed 2463123 -
Identification of a human C5 beta-chain epitope exposed in the native complement component but concealed in the SC5b-9 complex
Scand J Immunol, 28 (3), 307-12
DOI 10.1111/j.1365-3083.1988.tb01453.x, PubMed 2461581 -
Regulation of complement
Scand J Immunol, 27 (2), 127-42
DOI 10.1111/j.1365-3083.1988.tb02331.x, PubMed 3277261 -
Acute phase reactants and complement activation in patients with acute myocardial infarction
Complement, 5 (1), 33-9
DOI 10.1159/000463029, PubMed 2448082 -
Synthesis of soluble C3 and C9 neoepitopes by human alveolar macrophages in vitro
Scand J Immunol, 28 (4), 431-4
DOI 10.1111/j.1365-3083.1988.tb01472.x, PubMed 2461585 -
Demonstration of C3d and the terminal complement complex on thymic large granular lymphocytes and common thymocytes after incubation with naturally thymocytotoxic serum
Int Arch Allergy Appl Immunol, 87 (3), 239-46
DOI 10.1159/000234679, PubMed 3264545 -
Plasma exchange in myasthenia gravis: changes in serum complement and immunoglobulins
Acta Neurol Scand, 78 (3), 221-7
DOI 10.1111/j.1600-0404.1988.tb03650.x, PubMed 3227807 -
Complement activation by extracorporeal circulation: effects of precoating a membrane oxygenator circuit with human whole blood
Scand J Thorac Cardiovasc Surg, 22 (3), 251-6
DOI 10.3109/14017438809106071, PubMed 3227328
Publications 1987
-
Complement activation during major operations with or without cardiopulmonary bypass
J Thorac Cardiovasc Surg, 93 (6), 860-6
PubMed 3494886 -
Effects of methylprednisolone on complement activation and leukocyte counts during cardiopulmonary bypass
Scand J Thorac Cardiovasc Surg, 21 (3), 255-61
DOI 10.3109/14017438709106035, PubMed 2964081 -
Complement activation following multiple injuries
Acta Chir Scand, 153 (5-6), 325-30
PubMed 3499041 -
Immunohistochemical detection of the membrane and fluid-phase terminal complement complexes C5b-9(m) and SC5b-9. Consequences for interpretation and terminology
Scand J Immunol, 26 (4), 381-6
DOI 10.1111/j.1365-3083.1987.tb02270.x, PubMed 3685888 -
Activation of the third component of complement (C3) detected by a monoclonal anti-C3'g' neoantigen antibody in a one-step enzyme immunoassay
J Immunol Methods, 101 (2), 201-7
DOI 10.1016/0022-1759(87)90151-7, PubMed 2440954 -
A unique epitope exposed in native complement component C9 and hidden in the terminal SC5b-9 complex enables selective detection and quantification of non-activated C9
J Immunol Methods, 100 (1-2), 215-21
DOI 10.1016/0022-1759(87)90192-x, PubMed 2439601 -
Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex
J Neurol Sci, 78 (1), 17-28
DOI 10.1016/0022-510x(87)90074-8, PubMed 3572448
Publications 1986
-
Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex
Arthritis Rheum, 29 (6), 715-21
DOI 10.1002/art.1780290603, PubMed 3718564 -
The terminal complement complex in sera deficient in the eighth component of complement (C8)
Scand J Immunol, 24 (3), 307-12
DOI 10.1111/j.1365-3083.1986.tb02098.x, PubMed 3749815 -
Effect of nephritic factor on C3 and on the terminal pathway of complement in vivo and in vitro
Clin Exp Immunol, 65 (1), 73-9
PubMed 3641694 -
Complement activation in synovial fluid and tissue from patients with juvenile rheumatoid arthritis
Arthritis Rheum, 29 (11), 1359-64
DOI 10.1002/art.1780291108, PubMed 3778542 -
Antigenic crossreactivity of the alpha subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor
Proc Natl Acad Sci U S A, 83 (12), 4223-7
DOI 10.1073/pnas.83.12.4223, PubMed 2424021
Publications 1985
-
Early- and late-phase activation of complement evaluated by plasma levels of C3d,g and the terminal complement complex
Complement, 2 (2-3), 156-64
DOI 10.1159/000467856, PubMed 3878764 -
Quantification of the C3d split products of human complement by a sensitive enzyme-linked immunosorbent assay
Scand J Immunol, 21 (6), 607-13
DOI 10.1111/j.1365-3083.1985.tb01851.x, PubMed 3895396 -
Increased plasma levels of the terminal complement complex in patients with evidence of complement activation
Complement, 2 (2-3), 175-84
DOI 10.1159/000467858, PubMed 3878765 -
Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex
Scand J Immunol, 22 (2), 197-202
DOI 10.1111/j.1365-3083.1985.tb01871.x, PubMed 2412280 -
Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma
Scand J Immunol, 22 (2), 183-95
DOI 10.1111/j.1365-3083.1985.tb01870.x, PubMed 4035298
Publications 1984
-
Detection and quantification of the terminal C5b-9 complex of human complement by a sensitive enzyme-linked immunosorbent assay
Scand J Immunol, 20 (2), 157-66
DOI 10.1111/j.1365-3083.1984.tb00989.x, PubMed 6474098