Department of Molecular Oncology

Department head: Professor Ragnhild A. Lothe
Deputy department head: Professor Rolf I. Skotheim
Laboratory manager: Professor Guro E. Lind
Department administrative consultant: Ikram Mahnin

As a research department within the OUH Comprehensive Cancer Centre, it is our responsibility and goal to accomplish high quality and interdisciplinary biomedical research for improved precision medicine and management of cancer patients.

Research groups

Genetics Genome Biology Epigenetics
Ragnhild A. Lothe
Rolf I. Skotheim
Guro E. Lind

Project groups

Computational Oncology  Cancer Informatics Statistical Epigenomics
Anita Sveen
Bjarne Johannessen
Marine Jeanmougin
Cell Signalling    
Edward Leithe
   

2021 – 15th Anniversary of Dept. Molecular Oncology
The year 2020
Scientific achievements in 2019

About

Our main research programs are devoted to colorectal cancer and prostate cancer, and we have a longstanding project portfolio also on other solid tumor types. Our expertise in biomedical research spans several disciplines from cell biology to translational research, including also active clinical research collaborations, and we have a broad range of advanced technologies established in-lab. The department scientists are inventors of several biomedical patents and active innovation projects.

Lothe lab – genetics, genomics, cell signaling, colorectal cancer, MPNST, tumor heterogeneity, pharmacogenomics, biomarkers

Skotheim lab – genome biology, transcript variation, tumor heterogeneity, prostate cancer, testicular cancer, bioinformatics

Lind lab – epigenetics, genetics, GI-cancers, bladder cancer, early detection, monitoring

Affiliations

All three group leaders are adjunct professors at the University of Oslo and are affiliated with the Institute for Clinical Medicine, the Institute for Biosciences and the Institute for Informatics. We aim to complete at least 3 academic degrees annually, and since the inauguration of the Department in 2006, 75 MSc/PhD degrees have successfully been defended.

The research groups are partners of the Oslo University Hospital strategic research area - Precision colorectal cancer therapy, colorectal cancer COST – actions, The Global Testicular Cancer Consortium, The European network for study on Cholangiocarcinoma, a European multicenter study on MPNST (malignant peripheral nerve sheath tumor), The Norwegian Esophageal Cancer Consortium

Latest News

Pharmacogenomics to improve transplantation oncology of metastatic colorectal cancer

Anita Sveen and Pål-Dag Line
Anita Sveen and Pål-Dag Line

Molecular biologist Anita Sveen and surgeon Pål-Dag Line join forces in a new project to improve the patient benefit from liver transplantation of metastatic colorectal cancer. This is a collaborative effort between Dept Molecular Oncology (KRE) and Dept Transplantation Medicine (KIT)

The project is a translational substudy of ongoing clinical studies and will generate the first large-scale molecular and pharmacological data of transplantable metastatic colorectal cancers. This project was recently supported by a research grant from the Norwegian Cancer Society.

Anita Sveen invited speaker at AACR special conference on colorectal cancer

Anita Sveen
Anita Sveen

Anita Sveen, project group leader and member of the Lothe lab at the Department of Molecular Oncology at the Institute for Cancer research, was invited speaker at the AACR special conference colorectal cancer, held October 1-4th in Portland, Oregon, USA.
In her well received speech Dr. Sveen presented the multidisciplinary work from the TEAM-ACT (Tumor Evolution in Advanced Models to Accelerate precision Cancer Therapy) - a strategic research area of OUS. 

Christian Holst Bergsland defended his doctoral thesis

On the 21st of April, the 4x-great-grandchild of Frederik Holst - the first who defended a doctoral thesis in Norway, University of Christiania - Christian Holst Bergsland defended his thesis “Fluorescence-based multiplex immunohistochemistry in precision medicine of colorectal cancer” for the PhD degree at the Faculty of Medicine, University of Oslo.
He received excellent assessment from the committee, both in the written report and during the defense. The first and second opponents were Professors Manuel Salto-Tellez, Institute for Cancer Research, London and Lars Akslen, University of Bergen. Professor Anne Hansen Ree was the chair of the evaluation committee.

Dr Ragnar Mørk´s Prize for excellent cancer research 2021 to Anita Sveen

Anita Sveen, flanked by Harald Stenmark (left) and Carl Rieber-Mohn
Anita Sveen, flanked by Harald Stenmark (left) and Carl Rieber-Mohn

Anita Sveen from the Department of Molecular Oncolocy is this year's winner of the prestigious Dr. Ragnar Mørk's Prize for cancer research. Anita received the prize of NOK 200.000 for her excellent work on colorectal cancer during an award ceremony in the Auditorium of the Research building on Friday 19th November. After receiving the prize, Anita gave a 30-minutes presentation of her work, and this was be followed by cakes and drinks in the canteen area.

Kristina Totland Carm defended her thesis

The dissertation was held over zoom, and also broadcasted to an auditorium (Photo: Anne Cathrine Bakken)
The dissertation was held over zoom, and also broadcasted to an auditorium (Photo: Anne Cathrine Bakken)

On October 15th 2021, Kristina Totland Carm successfully defended her thesis “Genomic aberrations and molecular subtypes in multifocal prostate cancer” for the PhD degree at the Medical Faculty, University of Oslo. She also gave a trial lecture on the given topic: “Multiparametric MRI-guided biopsies in prostate cancer diagnostics – challenges on the road towards radiogenomics”.

The adjudication committee included first opponent, Professor Ian Mills, University of Oxford, UK; second opponent, Professor Karl-Henning Kalland, University of Bergen, and chair of the evaluation committee was Associate Professor Stig Müller, University of Oslo. Chair of the defence was Associate Professor June Helen Myklebust, University of Oslo.

Principal Supervisor was Rolf I. Skotheim, and co-supervisors were Marthe Løvf, Andreas Hoff and Ragnhild A. Lothe. 

Improved detection of cholangiocarcinoma in high risk patients by biomarker analyses of small amounts of bile

From left: HM Vedeld, MM Grimsrud, T Folseraas, GE Lind
From left: HM Vedeld, MM Grimsrud, T Folseraas, GE Lind

Primary sclerosing cholangitis (PSC) is a progressive chronic liver disease associated with increased risk of cholangiocarcinoma; a highly deadly malignancy that arises in the bile ducts. Due to nonspecific presenting features and overlapping findings in malignant and benign disease progression in PSC, the diagnostic accuracy for cholangiocarcinoma in PSC is low. Consequently, cholangiocarcinoma is commonly detected at advanced stage where most patients have a poor chance of surviving, making cholangiocarcinoma the most common cause of death among patients with PSC.