Our main research program involves translational studies of primary and metastatic colorectal cancers (CRC), using genomics, drug screening, digital pathology and functional analyses. We are also the core lab of a European multicenter research study on MPNST (malignant peripheral nerve sheath tumor), an orphan disease. To gain knowledge of the complex dynamics of cancer development we combine large-scale and detailed biology research using in vitro models and patient samples. The main goal is to translate biological discoveries into improved patient stratification and treatment.

The group includes two project groups in Cell signaling, led by Dr. Edward Leithe, and Computational oncology, led by Assoc. prof. Anita Sveen.

Diseases

• Colorectal cancer
• MPNST
• Other solid tumours: prostate, ovarian, testis

Projects

• Prognostic and predictive biomarkers
• Modeling tumor heterogeneity and clonal evolution
• Pharmacogenomics of solid tumors using patient-derived organoids (PDO)
• E3 ubiquitin ligases in intercellular communication and carcinogenesis

Research Centres and networks

Strategic research area TEAM-ACT 2019-24	“Toppforsk” Tumor heterogeneity 2017-22	Colorectal cancer research centre 2014-20	Priority area SMART-CRC 2014-18	2012-19	Cancer Biomedicine 2007-17	Cancer Stem Cells 2007-14

Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745
E-mail: ragnhild.a.lothe@rr-research.no