Our main research program involves translational studies of primary and metastatic colorectal cancers (CRC), using genomics, drug screening, digital pathology and functional analyses. We are also the core lab of a European multicenter research study on MPNST (malignant peripheral nerve sheath tumor), an orphan disease. To gain knowledge of the complex dynamics of cancer development we combine large-scale and detailed biology research using in vitro models and patient samples. The main goal is to translate biological discoveries into improved patient stratification and treatment.
The group includes two project groups in Cell signaling, led by Dr. Edward Leithe, and Computational oncology, led by Assoc. prof. Anita Sveen.
- Prognostic and predictive biomarkers
- Modeling tumor heterogeneity and clonal evolution
- Pharmacogenomics of solid tumors using patient-derived organoids (PDO)
- E3 ubiquitin ligases in intercellular communication and carcinogenesis
Research Centres and networks
|Strategic research area
|Cancer Stem Cells