Welcome to Kjetil Taskén's research group:Cell Signaling and Immune Regulation

Kjetil Taskén
Group leader

Signal transduction in health and disease: the role of cAMP signalling pathways.

The group's work addresses major health problems such as cancer, cardiovascular disease and obesity, as well as AIDS and other infectious diseases. Currently, the group is focused on understanding intracellular signalling pathways and in particular, how cAMP signalling networks cross-talk with and integrate into the complex web of signalling pathways. In order to perform their research, the group also establishes new tools and technology platforms for in-depth study of these pathways and to promote the development of highly specific pharmaceuticals with minimal side-effects. Furthermore, several translational research projects are running, including the discovery of and intervention with mechanisms of suppression of anti-tumor immunity, development of immunostimulating therapies in HIV and perturbation of damaging signal pathways in heart failure.

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Aims:

  • To understand how signalling networks mediate hormonally regulated physiological and pathophysiological processes (e.g. PGE2-stimulation)
  • To investigate the role of anchoring proteins in signalling networks and to engineer specific anchoring disruptors to perturb signalling in defined localizations
  • To understand the role of the cAMP second messenger system in the regulation of T cell function and immunomodulation, and the significance in immune diseases and inflammation
  • To better characterise regulatory T cell subsets and investigate their intercellular communication and functions
  • To develop mouse transgenic models and disease models for testing of small-molecule disrupters in 'Proof-of -Principle' experiments