
Lene Støkken Høydahl
Publications 2022
Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
Protein Eng Des Sel, 35
DOI 10.1093/protein/gzac005, PubMed 35871543
Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life
Commun Biol, 5 (1), 832
DOI 10.1038/s42003-022-03787-x, PubMed 35982144
Focused B cell response to recurring gluten motif with implications for epitope spreading in celiac disease
Cell Rep, 41 (4), 111541
DOI 10.1016/j.celrep.2022.111541, PubMed 36288703
Publications 2021
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
Sci Immunol, 6 (62)
DOI 10.1126/sciimmunol.abg4925, PubMed 34417258
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses
Vaccine, 39 (11), 1583-1592
DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340
Publications 2020
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243
Publications 2019
A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease
Eur J Immunol, 50 (1), 142-145
DOI 10.1002/eji.201948235, PubMed 31580480
Targeting the MHC Ligandome by Use of TCR-Like Antibodies
Antibodies (Basel), 8 (2)
DOI 10.3390/antib8020032, PubMed 31544838
Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease
Proc Natl Acad Sci U S A, 116 (30), 15134-15139
DOI 10.1073/pnas.1901561116, PubMed 31285344
Publications 2018
Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture
Sci Rep, 8 (1), 10836
DOI 10.1038/s41598-018-28918-5, PubMed 30022069
Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system
PLoS One, 13 (4), e0195868
DOI 10.1371/journal.pone.0195868, PubMed 29649333
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798
Publications 2017
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121
Publications 2016
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230
Multivalent pIX phage display selects for distinct and improved antibody properties
Sci Rep, 6, 39066
DOI 10.1038/srep39066, PubMed 27966617
Publications 2013
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486
Publications 2012
CD40/APC-specific antibodies with three T-cell epitopes loaded in the constant domains induce CD4+ T-cell responses
Protein Eng Des Sel, 25 (3), 89-96
DOI 10.1093/protein/gzr063, PubMed 22233931