Publications 2024

Helland Å, Steinskog ESS, Blix ES, Flobak Å, Brabrand S, Puco K, Niehusmann P, Meltzer S, Oppedal IA, Haug Å, Torkildsen CF, Randen U, Gilje B, Lønning PE, Gjertsen BT, Hovland R, Russnes HG, Fagereng GL, Smeland S, Tasken K (2024)
[Not Available]
Tidsskr Nor Laegeforen, 144 (1)
DOI 10.4045/tidsskr.23.0740, PubMed 38258713

Skaga E, Trewin-Nybråten CB, Niehusmann P, Johannesen TB, Marienhagen K, Oltedal L, Schipman S, Skjulsvik AJ, Solheim O, Solheim TS, Sundstrøm T, Vik-Mo EO, Petter Brandal, Ingebrigtsen T (2024)
Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study
Acta Oncol, 63, 83-94
DOI 10.2340/1651-226X.2024.24970, PubMed 38501768

Tauziède-Espariat A, Nicaise Y, Sievers P, Sahm F, von Deimling A, Guillemot D, Pierron G, Duchesne M, Edjlali M, Dangouloff-Ros V, Boddaert N, Roux A, Dezamis E, Hasty L, Lhermitte B, Hirsch E, Hirsch MPV, Ardellier FD, Karnoub MA, Csanyi M, Maurage CA, Mokhtari K, Bielle F, Rigau V, Roujeau T et al. (2024)
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas
Acta Neuropathol Commun, 12 (1), 55
DOI 10.1186/s40478-023-01695-7, PubMed 38581034

Publications 2023

Blakstad H, Mendoza Mireles EE, Heggebø LC, Magelssen H, Sprauten M, Johannesen TB, Vik-Mo EO, Leske H, Niehusmann P, Skogen K, Helseth E, Emblem KE, Brandal P (2023)
Incidence and outcome of pseudoprogression after radiation therapy in glioblastoma patients: A cohort study
Neurooncol Pract, 11 (1), 36-45
DOI 10.1093/nop/npad063, PubMed 38222046

Leske H, Blakstad H, Lund-Iversen M, Skovholt EK, Niehusmann P, Ramm-Pettersen JT, Skogen K, Kongelf G, Sprauten M, Magelssen H, Brandal P (2023)
Astrocytoma (CNS WHO grade 4), IDH-mutant with co-occurrence of BRAF p.V600E mutation, and homozygous loss of CDKN2A
Neuropathology, 43 (5), 385-390
DOI 10.1111/neup.12895, PubMed 36754566

Publications 2022

Gielen GH, Baugh JN, van Vuurden DG, Veldhuijzen van Zanten SEM, Hargrave D, Massimino M, Biassoni V, Morales la Madrid A, Karremann M, Wiese M, Thomale U, Janssens GO, von Bueren AO, Perwein T, Nussbaumer G, Hoving EW, Niehusmann P, Gessi M, Kwiecien R, Bailey S, Pietsch T, Andreiuolo F, Kramm CM (2022)
Pediatric high-grade gliomas and the WHO CNS Tumor Classification-Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates
Neurooncol Adv, 4 (1), vdac077
DOI 10.1093/noajnl/vdac077, PubMed 35733513

Hassel B, Niehusmann P, Halvorsen B, Dahlberg D (2022)
Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma
Front Oncol, 12, 846674
DOI 10.3389/fonc.2022.846674, PubMed 35965529

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045

Niehusmann P, Stensvold E, Leske H, Pietsch T, Goschzik T, Gielen GH, Due-Tønnessen B, Frič R, Nilssen Y, Brandal P (2022)
Molecular pathological insights reveal a high number of unfavorable risk patients among children treated for medulloblastoma and CNS-PNET in Oslo 2005-2017
Pediatr Blood Cancer, 69 (9), e29736
DOI 10.1002/pbc.29736, PubMed 35570402

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R et al. (2022)
Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types
Neuropathol Appl Neurobiol, 48 (7), e12847
DOI 10.1111/nan.12847, PubMed 35977725

Publications 2021

Blümcke I, Coras R, Busch RM, Morita-Sherman M, Lal D, Prayson R, Cendes F, Lopes-Cendes I, Rogerio F, Almeida VS, Rocha CS, Sim NS, Lee JH, Kim SH, Baulac S, Baldassari S, Adle-Biassette H, Walsh CA, Bizzotto S, Doan RN, Morillo KS, Aronica E, Mühlebner A, Becker A, Cienfuegos J et al. (2021)
Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial
Epilepsia, 62 (6), 1416-1428
DOI 10.1111/epi.16899, PubMed 33949696

Djirackor L, Halldorsson S, Niehusmann P, Leske H, Capper D, Kuschel LP, Pahnke J, Due-Tønnessen BJ, Langmoen IA, Sandberg CJ, Euskirchen P, Vik-Mo EO (2021)
Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy
Neurooncol Adv, 3 (1), vdab149
DOI 10.1093/noajnl/vdab149, PubMed 34729487

Reimers A, Hummel CA, Eis-Hübinger AM, Surges R, Niehusmann P, Schoch S, Becker AJ, Pitsch J (2021)
Analysis of autoantibody spectrum and human herpesvirus 6 in adult patients with 'early' versus 'late' diagnosis of 'possible limbic encephalitis'
Epilepsy Res, 176, 106698
DOI 10.1016/j.eplepsyres.2021.106698, PubMed 34246119

Switlyk MD, Niehusmann P, Sprauten M, Magelssen H, Aarhus M, Rasmussen FØ, Knutstad K, Brandal P (2021)
Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge
Acta Radiol Open, 10 (7), 20584601211036550
DOI 10.1177/20584601211036550, PubMed 34377543

Publications 2020

Kolnes AJ, Øystese KA, Dahlberg D, Berg-Johnsen J, Niehusmann P, Pahnke J, Bollerslev J, Jørgensen AP (2020)
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien), 162 (4), 845-852
DOI 10.1007/s00701-019-04068-z, PubMed 31907611

Kubach J, Muhlebner-Fahrngruber A, Soylemezoglu F, Miyata H, Niehusmann P, Honavar M, Rogerio F, Kim SH, Aronica E, Garbelli R, Vilz S, Popp A, Walcher S, Neuner C, Scholz M, Kuerten S, Schropp V, Roeder S, Eichhorn P, Eckstein M, Brehmer A, Kobow K, Coras R, Blumcke I, Jabari S (2020)
Same same but different: A Web-based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations
Epilepsia, 61 (3), 421-432
DOI 10.1111/epi.16447, PubMed 32080846

Publications 2019

Schäfer N, Gielen GH, Rauschenbach L, Kebir S, Till A, Reinartz R, Simon M, Niehusmann P, Kleinschnitz C, Herrlinger U, Pietsch T, Scheffler B, Glas M (2019)
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
J Transl Med, 17 (1), 96
DOI 10.1186/s12967-019-1846-y, PubMed 30894200

Publications 2018

Engdahl E, Niehusmann P, Fogdell-Hahn A (2018)
The effect of human herpesvirus 6B infection on the MAPK pathway
Virus Res, 256, 134-141
DOI 10.1016/j.virusres.2018.08.014, PubMed 30130603

Leske H, Rushing E, Budka H, Niehusmann P, Pahnke J, Panagopoulos I (2018)
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution
Acta Neuropathol, 136 (1), 175-176
DOI 10.1007/s00401-018-1867-2, PubMed 29766298

Panagopoulos I, Gorunova L, Leske H, Niehusmann P, Johannessen LE, Staurseth J, Øino N, Meling TR, Heim S, Micci F, Brandal P (2018)
Pyrosequencing Analysis of MGMT Promoter Methylation in Meningioma
Cancer Genomics Proteomics, 15 (5), 379-385
DOI 10.21873/cgp.20096, PubMed 30194078

Publications 2017

Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker AJ, Ekström TJ, Almgren M, Fogdell-Hahn A (2017)
Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration
J Virol, 91 (11)
DOI 10.1128/JVI.02105-16, PubMed 28298607

Greschus S, Niehusmann P, Pauleit DO, Sommer B, Pietsch T, Gessi M (2017)
Frontal cystic lesion with a contrast-enhancing mural nodule: Question
J. Clin. Neurosci., 37, 40
DOI 10.1016/j.jocn.2016.10.026

Greschus S, Niehusmann P, Pauleit DO, Sommer B, Pietsch T, Gessi M (2017)
Frontal cystic lesion with a contrast-enhancing mural nodule: Answer
J. Clin. Neurosci., 37, 104
DOI 10.1016/j.jocn.2016.10.037

Leske H, Brandal P, Rushing EJ, Niehusmann P (2017)
IDH-mutant giant cell glioblastoma: A neglected tumor variant?
Clin Neuropathol, 36 (6), 293-295
DOI 10.5414/NP301054, PubMed 29035191

Niehusmann P, Becker AJ (2017)
Epilepsy-associated tumors in the context of the current 2016 WHO classification for tumors of the central nervous system
Z. Epileptol., 30 (3), 192-199
DOI 10.1007/s10309-017-0118-1

Poulheim F, Esposito L, Elger CE, Eis-Hübinger AM, Becker AJ, Niehusmann P (2017)
Large-scale analysis of herpesviridae in epilepsy-patients with signs of autoimmune encephalitis
Seizure, 53, 100-102
DOI 10.1016/j.seizure.2017.11.012, PubMed 29156319

Publications 2016

Danis B, van Rikxoort M, Kretschmann A, Zhang J, Godard P, Andonovic L, Siegel F, Niehusmann P, Hanon E, Delev D, von Lehe M, Kaminski RM, Pfeifer A, Foerch P (2016)
Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis - Influence on microglial function
Sci Rep, 6, 33943
DOI 10.1038/srep33943, PubMed 27666871

Elkommos S, Weber B, Niehusmann P, Volmering E, Richardson MP, Goh YY, Marson AG, Elger C, Keller SS (2016)
Hippocampal internal architecture and postoperative seizure outcome in temporal lobe epilepsy due to hippocampal sclerosis
Seizure, 35, 65-71
DOI 10.1016/j.seizure.2016.01.007, PubMed 26803053

Kebir S, Kimmich O, Niehusmann P, Gaertner FC, Essler M, Landsberg J, Klockgether T, Simon M, Herrlinger U, Glas M (2016)
¹⁸F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor
Oncol Lett, 12 (6), 4705-4707
DOI 10.3892/ol.2016.5234, PubMed 28105177

Niehusmann P, Widman G, Eis-Hübinger AM, Greschus S, Robens BK, Grote A, Becker AJ (2016)
Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence?
Neuropathology, 36 (4), 376-80
DOI 10.1111/neup.12283, PubMed 27431532

Volmering E, Niehusmann P, Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS (2016)
Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy
Acta Neuropathol, 132 (2), 277-288
DOI 10.1007/s00401-016-1561-1, PubMed 26993140

Publications 2015

Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ et al. (2015)
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus
Nat Commun, 6, 6031
DOI 10.1038/ncomms7031, PubMed 25615886

Malter MP, Bahrenberg C, Niehusmann P, Elger CE, Surges R (2015)
Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery
Clin Neurophysiol, 127 (2), 1081-1087
DOI 10.1016/j.clinph.2015.06.035, PubMed 26321666

Publications 2014

Esposito L, Drexler JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten C, Eis-Hübinger AM, Schoch S, Elger CE, Becker AJ, Niehusmann P (2014)
Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies
Epilepsia, 56 (2), 234-43
DOI 10.1111/epi.12890, PubMed 25530314

Gousias K, Niehusmann P, Gielen G, Simon M, Boström J (2014)
KPNA2 predicts long term survival in patients with anaplastic oligoastrocytomas
J Clin Neurosci, 21 (10), 1719-24
DOI 10.1016/j.jocn.2014.01.011, PubMed 24929863

Gousias K, Niehusmann P, Gielen GH, Simon M (2014)
Karyopherin a2 and chromosome region maintenance protein 1 expression in meningiomas: novel biomarkers for recurrence and malignant progression
J Neurooncol, 118 (2), 289-296
DOI 10.1007/s11060-014-1423-4, PubMed 24664371

Schoene-Bake JC, Keller SS, Niehusmann P, Volmering E, Elger C, Deppe M, Weber B (2014)
In vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology
Hum Brain Mapp, 35 (9), 4718-28
DOI 10.1002/hbm.22506, PubMed 24638919

von der Brelie C, von Lehe M, Raabe A, Niehusmann P, Urbach H, Mayer C, Elger CE, Malter MP (2014)
Surgical resection can be successful in a large fraction of patients with drug-resistant epilepsy associated with multiple cerebral cavernous malformations
Neurosurgery, 74 (2), 147-53; discussion 153
DOI 10.1227/NEU.0000000000000210, PubMed 24435138

Publications 2013

Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, von Lehe M, Hoffmann P, Cichon S, Schoch S, Becker AJ (2013)
Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi
Neurobiol Dis, 60, 115-25
DOI 10.1016/j.nbd.2013.08.015, PubMed 24018139

Niehusmann P, Becker AJ, Malter MP, Raabe A, Boström A, von der Brelie C (2013)
Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas
Epilepsy Res, 107 (1-2), 190-4
DOI 10.1016/j.eplepsyres.2013.07.006, PubMed 23968818

Schäfer N, Scheffler B, Stuplich M, Schaub C, Kebir S, Rehkämper C, Mack F, Niehusmann P, Simon M, Greschus S, Kuchelmeister K, Herrlinger U, Glas M (2013)
Vemurafenib for leptomeningeal melanomatosis
J Clin Oncol, 31 (11), e173-4
DOI 10.1200/JCO.2012.46.5773, PubMed 23460716

von der Brelie C, Malter MP, Niehusmann P, Elger CE, von Lehe M, Schramm J (2013)
Surgical management and long-term seizure outcome after epilepsy surgery for different types of epilepsy associated with cerebral cavernous malformations
Epilepsia, 54 (9), 1699-706
DOI 10.1111/epi.12327, PubMed 23944932

Publications 2012

Kebir S, Kuchelmeister K, Niehusmann P, Nelles M, Kim Y, Thanendrarajan S, Schäfer N, Stuplich M, Mack F, Scheffler B, Urbach H, Glas M, Herrlinger U (2012)
Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
Exp Hematol Oncol, 1 (1), 37
DOI 10.1186/2162-3619-1-37, PubMed 23217063

Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P (2012)
Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions
Epilepsia, 53 (3), 539-48
DOI 10.1111/j.1528-1167.2012.03405.x, PubMed 22372630

Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P (2012)
Albumin storage in neoplastic astroglial elements of gangliogliomas
Seizure, 22 (2), 144-50
DOI 10.1016/j.seizure.2012.10.014, PubMed 23182422

Publications 2011

Pernhorst K, Raabe A, Niehusmann P, van Loo KM, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ (2011)
Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi
J Neuropathol Exp Neurol, 70 (12), 1080-8
DOI 10.1097/NEN.0b013e318238b9af, PubMed 22082659

Schönberger A, Gembe E, Grote A, Witt JA, Elger CE, Bien CG, Urbach H, Becker AJ, Niehusmann P (2011)
Genetic analysis of tuberous-sclerosis genes 1 and 2 in nonlesional focal epilepsy
Epilepsy Behav, 21 (3), 233-7
DOI 10.1016/j.yebeh.2011.03.034, PubMed 21555252

Wagner J, Urbach H, Niehusmann P, von Lehe M, Elger CE, Wellmer J (2011)
Focal cortical dysplasia type IIb: completeness of cortical, not subcortical, resection is necessary for seizure freedom
Epilepsia, 52 (8), 1418-24
DOI 10.1111/j.1528-1167.2011.03158.x, PubMed 21740420

Publications 2010

Gousias K, Boström J, Kovacs A, Niehusmann P, Wagner I, Kristof R (2010)
Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case
Radiat Oncol, 5, 114
DOI 10.1186/1748-717X-5-114, PubMed 21106096

Niehusmann P, Mittelstaedt T, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ (2010)
Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis
Epilepsia, 51 (12), 2478-83
DOI 10.1111/j.1528-1167.2010.02741.x, PubMed 21204811

Niehusmann P, Seifert G, Clark K, Atas HC, Herpfer I, Fiebich B, Bischofberger J, Normann C (2010)
Coincidence detection and stress modulation of spike time-dependent long-term depression in the hippocampus
J Neurosci, 30 (18), 6225-35
DOI 10.1523/JNEUROSCI.6411-09.2010, PubMed 20445048

Niehusmann P, Surges R, von Wrede RD, Elger CE, Wellmer J, Reimann J, Urbach H, Vielhaber S, Bien CG, Kunz WS (2010)
Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery
Epilepsy Behav, 20 (1), 38-43
DOI 10.1016/j.yebeh.2010.11.008, PubMed 21145289

Publications 2009

Campos AR, Clusmann H, von Lehe M, Niehusmann P, Becker AJ, Schramm J, Urbach H (2009)
Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology
Neuroradiology, 51 (7), 433-43
DOI 10.1007/s00234-009-0511-1, PubMed 19242688

Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S, Becker A (2009)
Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro
J Neuropathol Exp Neurol, 68 (10), 1136-46
DOI 10.1097/NEN.0b013e3181b9a699, PubMed 19918125

Niehusmann P, Dalmau J, Rudlowski C, Vincent A, Elger CE, Rossi JE, Bien CG (2009)
Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy
Arch Neurol, 66 (4), 458-64
DOI 10.1001/archneurol.2009.5, PubMed 19364930

Schönberger A, Niehusmann P, Urbach H, Majores M, Grote A, Holthausen H, Blümcke I, Deckert M, Becker AJ (2009)
Increased frequency of distinct TSC2 allelic variants in focal cortical dysplasias with balloon cells and mineralization
Neuropathology, 29 (5), 559-65
DOI 10.1111/j.1440-1789.2009.01018.x, PubMed 19422538

Publications 2008

Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S, Becker AJ (2008)
Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors
Brain, 131 (Pt 11), 3034-50
DOI 10.1093/brain/awn233, PubMed 18819986