Publications by Lasse Pihlstrøm

101 publications found

Publications 2026

  1. Dalbro SE, Pihlstrøm L, Kerty E, Toft M (2026)
    Pupil-light reflex in early-stage Parkinson's disease
    J Parkinsons Dis, 16 (4), 803-805
    DOI 10.1177/1877718X261436290, PubMed 41949462
  2. Geithus S, Flønes IH, Alves G, Tysnes OB, van de Berg WDJ, Pihlstrøm L, Nido GS, Tzoulis C (2026)
    Comparative transcriptomics reveal molecular convergence and divergence in parkinsonian disorders
    Brain (in press)
    DOI 10.1093/brain/awag153, PubMed 42052893
  3. Kaddoura A, Dalbro SEJ, van Walsem MR, Pihlstrøm L (2026)
    Assessing the prognostic value of early oculomotor abnormalities in Huntington's disease
    Front Neurol, 17, 1844433
    DOI 10.3389/fneur.2026.1844433, PubMed 42376453
  4. Landoulsi Z, Sreelatha AAK, Kuznetsov N, Schulte C, Bobbili DR, Montanucci L, Leu C, Niestroj LM, Hassanin E, Domenighetti C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Portugal B, Edsall C, Krüger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC et al. (2026)
    Genome-wide association study of copy number variations in Parkinson's disease
    NPJ Parkinsons Dis, 12 (1)
    DOI 10.1038/s41531-025-01245-z, PubMed 42009659
  5. Vincze K, Szwajda A, Ploner A, Karlsson R, Kang X, Tang B, Qin C, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC et al. (2026)
    Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset
    NPJ Parkinsons Dis, 12 (1)
    DOI 10.1038/s41531-026-01398-5, PubMed 42209523

Publications 2025

  1. Lie IH, Maurtveten EH, Andersen MS, Dalbro SEJ, Tunold JA, Pihlstrøm L (2025)
    The Menstrual Cycle and Pregnancy Commonly Impact Symptoms of Women with Early-Onset Parkinson's Disease
    Mov Disord Clin Pract, 13 (5), 1236-1244
    DOI 10.1002/mdc3.70438, PubMed 41235605
  2. Lie IH, Tan MMX, Andersen MS, Toft M, Pihlstrøm L (2025)
    Epigenome-wide association study, meta-analysis, and multiscore profiling of whole blood in Parkinson's disease
    Ann Clin Transl Neurol, 12 (4), 701-713
    DOI 10.1002/acn3.52292, PubMed 39907161
  3. Sosero YL, Heilbron K, Fontanillas P, Norcliffe-Kaufmann L, Yu E, Rudakou U, Ruskey JA, Freeman K, Asayesh F, Brolin KA, Swanberg M, Morris HR, Wu L, Real R, Pihlstrøm L, Tan M, Gasser T, Brockmann K, Liu H, Hu MTM, Grosset DG, Lewis SJG, Kwok JB, Pastor P, Alvarez I, Skorvanek M, Lackova A, Ostrozovicova M, Rizig M, 23andMe Research Team et al. (2025)
    Genome-wide association study of REM sleep behavior disorder in Parkinson's disease
    NPJ Parkinsons Dis, 11 (1), 272
    DOI 10.1038/s41531-025-01078-w, PubMed 40998812
  4. Udayar V, Gilormini PA, Bryois J, Gehrlein A, Chen X, Sonea S, Zhu S, Deen MC, Anastasi N, Murphy AE, Skene N, Tan MMX, Tunold JA, Roudnicky F, van de Berg WDJ, Pihlstrøm L, Vocadlo DJ, Jagasia R (2025)
    Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease
    ACS Cent Sci, 11 (10), 1933-1945
    DOI 10.1021/acscentsci.5c00240, PubMed 41142333
  5. van Wetering J, Geut H, Bol JJ, Galis Y, Timmermans E, Twisk JWR, Hepp DH, Morella ML, Pihlstrom L, Lemstra AW, Rozemuller AJM, Jonkman LE, van de Berg WDJ (2025)
    Correction: Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies
    Acta Neuropathol Commun, 13 (1), 250
    DOI 10.1186/s40478-025-02169-8, PubMed 41366818

Publications 2024

  1. Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Portugal B, Lee PC, May P, Bobbili D, Radivojkov Blagojevic M, Lichtner P, Singleton AB, Hernandez D, Edsall C, Mellick GD, Zimprich AA, Pirker W, Rogaeva EA, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Hadjigeorgiou GM, Dardiotis E et al. (2024)
    Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study
    Neurology, 103 (3), e209620
    DOI 10.1212/WNL.0000000000209620, PubMed 38986057
  2. Faouzi J, Tan M, Casse F, Lesage S, Tesson C, Brice A, Mangone G, Mariani LL, Iwaki H, Colliot O, Pihlstrøm L, Corvol JC (2024)
    Proxy-analysis of the genetics of cognitive decline in Parkinson's disease through polygenic scores
    NPJ Parkinsons Dis, 10 (1), 8
    DOI 10.1038/s41531-023-00619-5, PubMed 38177146
  3. Murthy M, Fodder K, Miki Y, Rambarack N, De Pablo Fernandez E, Pihlstrøm L, Mill J, Warner TT, Lashley T, Bettencourt C (2024)
    DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson's disease, and progressive supranuclear palsy: a cross-comparative investigation
    Acta Neuropathol, 148 (1), 4
    DOI 10.1007/s00401-024-02764-4, PubMed 38995454
  4. Nordengen K, Cappelletti C, Bahrami S, Frei O, Pihlstrøm L, Henriksen SP, Geut H, Rozemuller AJM, van de Berg WDJ, Andreassen OA, Toft M (2024)
    Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease
    Brain, 147 (3), 858-870
    DOI 10.1093/brain/awad297, PubMed 37671566
  5. Tan MMX, Lawton MA, Pollard MI, Brown E, Real R, Carrasco AM, Bekadar S, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, Kanavou S, Hubbard L, Malek N, Grosset KA, Bajaj N, Barker RA, Burn DJ, Bresner C, Foltynie T, Wood NW, Williams-Gray CH, Andreassen OA, Toft M, Elbaz A, Artaud F, Brice A, Corvol JC, Aasly J, Farrer MJ et al. (2024)
    Genome-wide determinants of mortality and motor progression in Parkinson's disease
    NPJ Parkinsons Dis, 10 (1), 113
    DOI 10.1038/s41531-024-00729-8, PubMed 38849413
  6. van Wetering J, Geut H, Bol JJ, Galis Y, Timmermans E, Twisk JWR, Hepp DH, Morella ML, Pihlstrom L, Lemstra AW, Rozemuller AJM, Jonkman LE, van de Berg WDJ (2024)
    Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies
    Acta Neuropathol Commun, 12 (1), 73
    DOI 10.1186/s40478-024-01786-z, PubMed 38715119

Publications 2023

  1. Andersen MS, Leikfoss IS, Brorson IS, Cappelletti C, Bettencourt C, Toft M, Pihlstrøm L (2023)
    Epigenome-wide association study of peripheral immune cell populations in Parkinson's disease
    NPJ Parkinsons Dis, 9 (1), 149
    DOI 10.1038/s41531-023-00594-x, PubMed 37903812
  2. Cappelletti C, Henriksen SP, Geut H, Rozemuller AJM, van de Berg WDJ, Pihlstrøm L, Toft M (2023)
    Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes
    Acta Neuropathol, 146 (2), 227-244
    DOI 10.1007/s00401-023-02597-7, PubMed 37347276
  3. Sugier PE, Lucotte EA, Domenighetti C, Law MH, Iles MM, Brown K, Amos C, McKay JD, Hung RJ, Karimi M, Bacq-Daian D, Boland-Augé A, Olaso R, Deleuze JF, Lesueur F, Ostroumova E, Kesminiene A, de Vathaire F, Guénel P, EPITHYR consortium, Sreelatha AAK, Schulte C, Grover S, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C et al. (2023)
    Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers
    Mov Disord, 38 (4), 604-615
    DOI 10.1002/mds.29337, PubMed 36788297
  4. Tunold JA, Tan MMX, Koga S, Geut H, Rozemuller AJM, Valentino R, Sekiya H, Martin NB, Heckman MG, Bras J, Guerreiro R, Dickson DW, Toft M, van de Berg WDJ, Ross OA, Pihlstrøm L (2023)
    Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease
    Brain, 146 (10), 4077-4087
    DOI 10.1093/brain/awad183, PubMed 37247383
  5. Tunold JA, Tan MMX, Toft M, Ross O, van de Berg WDJ, Pihlstrøm L (2023)
    Lysosomal Polygenic Burden Drives Cognitive Decline in Parkinson's Disease with Low Alzheimer Risk
    Mov Disord, 39 (3), 596-601
    DOI 10.1002/mds.29698, PubMed 38124396

Publications 2022

  1. Domenighetti C, Douillard V, Sugier PE, Sreelatha AAK, Schulte C, Grover S, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Gourraud PA, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E et al. (2022)
    The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited
    Mov Disord, 37 (9), 1929-1937
    DOI 10.1002/mds.29133, PubMed 35810454
  2. Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E et al. (2022)
    Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
    Mov Disord, 37 (4), 857-864
    DOI 10.1002/mds.28902, PubMed 34997937
  3. Domenighetti C, Sugier PE, Sreelatha AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E et al. (2022)
    Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease
    J Parkinsons Dis, 12 (1), 267-282
    DOI 10.3233/JPD-212851, PubMed 34633332
  4. Grover S, Kumar Sreelatha AA, Pihlstrom L, Domenighetti C, Schulte C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Mohamed O, Portugal B, Landoulsi Z, May P, Bobbili D, Edsall C, Bartusch F, Hanussek M, Krüger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC et al. (2022)
    Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium
    Neurology, 99 (7), e698-e710
    DOI 10.1212/WNL.0000000000200699, PubMed 35970579
  5. Krohn L, Heilbron K, Blauwendraat C, Reynolds RH, Yu E, Senkevich K, Rudakou U, Estiar MA, Gustavsson EK, Brolin K, Ruskey JA, Freeman K, Asayesh F, Chia R, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Högl B, Stefani A, Ibrahim A, Šonka K, Kemlink D, Oertel W et al. (2022)
    Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
    Nat Commun, 13 (1), 7496
    DOI 10.1038/s41467-022-34732-5, PubMed 36470867
  6. Motazedi E, Cheng W, Thomassen JQ, Frei O, Rongve A, Athanasiu L, Bahrami S, Shadrin A, Ulstein I, Stordal E, Brækhus A, Saltvedt I, Sando SB, O'Connell KS, Hindley G, van der Meer D, Bergh S, Nordestgaard BG, Tybjærg-Hansen A, Bråthen G, Pihlstrøm L, Djurovic S, Frikke-Schmidt R, Fladby T, Aarsland D, Selbæk G, Seibert TM, Dale AM, Fan CC, Andreassen OA (2022)
    Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations
    J Alzheimers Dis, 88 (4), 1533-1544
    DOI 10.3233/JAD-220174, PubMed 35848024
  7. Pihlstrøm L (2022)
    [Kavli Prize awarded to four pioneers in neurogenetics]
    Tidsskr Nor Laegeforen, 142 (14)
    DOI 10.4045/tidsskr.22.0604, PubMed 36226419
  8. Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemuller AJM, Tunold JA, Hannon E, Francis P, Thomas AJ, Love S, Mill J, van de Berg WDJ, Toft M (2022)
    Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
    Nat Commun, 13 (1), 4932
    DOI 10.1038/s41467-022-32619-z, PubMed 35995800
  9. Stolp Andersen M, Tan M, Holtman IR, Hardy J, International Parkinson's Disease Genomics Consortium, Pihlstrøm L (2022)
    Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease
    Ann Clin Transl Neurol, 9 (8), 1289-1295
    DOI 10.1002/acn3.51606, PubMed 35684951
  10. van Walsem MR, Frich JC, Gómez Castañeda M, Howe EI, Pihlstrøm L, Andelic N, Aas E (2022)
    Health related quality of life, service utilization and costs for patients with Huntington's disease in Norway
    BMC Health Serv Res, 22 (1), 1527
    DOI 10.1186/s12913-022-08881-8, PubMed 36517848

Publications 2021

  1. Alfradique-Dunham I, Al-Ouran R, von Coelln R, Blauwendraat C, Hill E, Luo L, Stillwell A, Young E, Kaw A, Tan M, Liao C, Hernandez D, Pihlstrom L, Grosset D, Shulman LM, Liu Z, Rouleau GA, Nalls M, Singleton AB, Morris H, Jankovic J, Shulman JM (2021)
    Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes
    Neurol Genet, 7 (2), e557
    DOI 10.1212/NXG.0000000000000557, PubMed 33987465
  2. Andersen MS, Bandres-Ciga S, Reynolds RH, Hardy J, Ryten M, Krohn L, Gan-Or Z, Holtman IR, Pihlstrøm L, International Parkinson's Disease Genomics Consortium (2021)
    Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis
    Ann Neurol, 89 (5), 942-951
    DOI 10.1002/ana.26032, PubMed 33502028
  3. Bandres-Ciga S, Saez-Atienzar S, Kim JJ, Makarious MB, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs JR, Ding J, Gan-Or Z, Noyce A, Pihlstrom L, Torkamani A, Soltis AR, Dalgard CL, American Genome Center, Scholz SW, Traynor BJ, Ehrlich D, Scherzer CR, Bookman M, Cookson M, Blauwendraat C, Nalls MA, Singleton AB, International Parkinson Disease Genomics Consortium (2021)
    Correction to: Large‑scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
    Acta Neuropathol, 142 (1), 223-224
    DOI 10.1007/s00401-021-02309-z, PubMed 33944973
  4. Berge-Seidl V, Pihlstrøm L, Toft M (2021)
    Integrative analysis identifies bHLH transcription factors as contributors to Parkinson's disease risk mechanisms
    Sci Rep, 11 (1), 3502
    DOI 10.1038/s41598-021-83087-2, PubMed 33568722
  5. Blauwendraat C, Iwaki H, Makarious MB, Bandres-Ciga S, Leonard HL, Grenn FP, Lake J, Krohn L, Tan M, Kim JJ, Gibbs JR, Hernandez DG, Ruskey JA, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Grosset DG, Lesage S, Corvol JC, Brice A, Wood N, Hardy J et al. (2021)
    Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease
    Ann Neurol, 90 (1), 35-42
    DOI 10.1002/ana.26090, PubMed 33901317
  6. Brolin K, Bandres-Ciga S, Leonard H, Makarious MB, Blauwendraat C, Mata IF, Foo JN, Pihlstrøm L, Swanberg M, Gan-Or Z, Tan MM, International Parkinson's Disease Genomics Consortium (2021)
    RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts
    Neurobiol Aging, 109, 264-268
    DOI 10.1016/j.neurobiolaging.2021.08.009, PubMed 34538707
  7. Langmyhr M, Henriksen SP, Cappelletti C, van de Berg WDJ, Pihlstrøm L, Toft M (2021)
    Allele-specific expression of Parkinson's disease susceptibility genes in human brain
    Sci Rep, 11 (1), 504
    DOI 10.1038/s41598-020-79990-9, PubMed 33436766
  8. Pihlstrøm L, Fan CC, Frei O, Tan M, Karunamuni RA, Blauwendraat C, Bandres-Ciga S, Gan-Or Z, Grosset DG, International Parkinson's Disease Genomics Consortium (IPDGC), Dale AM, Seibert TM, Andreassen OA (2021)
    Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score
    Mov Disord, 37 (1), 62-69
    DOI 10.1002/mds.28808, PubMed 34612543
  9. Tunold JA, Geut H, Rozemuller JMA, Henriksen SP, Toft M, van de Berg WDJ, Pihlstrøm L (2021)
    APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease
    Front Neurol, 12, 631145
    DOI 10.3389/fneur.2021.631145, PubMed 33613437
  10. Yu E, Ambati A, Andersen MS, Krohn L, Estiar MA, Saini P, Senkevich K, Sosero YL, Sreelatha AAK, Ruskey JA, Asayesh F, Spiegelman D, Toft M, Viken MK, Sharma M, Blauwendraat C, Pihlstrøm L, Mignot E, Gan-Or Z (2021)
    Fine mapping of the HLA locus in Parkinson's disease in Europeans
    NPJ Parkinsons Dis, 7 (1), 84
    DOI 10.1038/s41531-021-00231-5, PubMed 34548497

Publications 2020

  1. Bandres-Ciga S, Saez-Atienzar S, Kim JJ, Makarious MB, Faghri F, Diez-Fairen M, Iwaki H, Leonard H, Botia J, Ryten M, Hernandez D, Gibbs JR, Ding J, Gan-Or Z, Noyce A, Pihlstrom L, Torkamani A, Soltis AR, Dalgard CL, American Genome Center, Scholz SW, Traynor BJ, Ehrlich D, Scherzer CR, Bookman M, Cookson M, Blauwendraat C, Nalls MA, Singleton AB, International Parkinson Disease Genomics Consortium (2020)
    Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
    Acta Neuropathol, 140 (3), 341-358
    DOI 10.1007/s00401-020-02181-3, PubMed 32601912
  2. Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K et al. (2020)
    Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia
    Brain, 143 (1), 234-248
    DOI 10.1093/brain/awz350, PubMed 31755958
  3. Iwaki H, Blauwendraat C, Leonard HL, Makarious MB, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Smolensky L, Amondikar N, Hutten SJ, Frasier M, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs RJ, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR et al. (2020)
    Differences in the Presentation and Progression of Parkinson's Disease by Sex
    Mov Disord, 36 (1), 106-117
    DOI 10.1002/mds.28312, PubMed 33002231
  4. Krohn L, Wu RYJ, Heilbron K, Ruskey JA, Laurent SB, Blauwendraat C, Alam A, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Toft M, Bjørnarå KA, Stefani A, Holzknecht E, Monaca CC, Abril B, Plazzi G, Antelmi E, Ferini-Strambi L, Young P, Heidbreder A, Cochen De Cock V, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Sonka K, Kemlink D, Figorilli M, Puligheddu M et al. (2020)
    Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies
    Ann Neurol, 87 (4), 584-598
    DOI 10.1002/ana.25687, PubMed 31976583
  5. Smeland OB, Shadrin A, Bahrami S, Broce I, Tesli M, Frei O, Wirgenes KV, O'Connell KS, Krull F, Bettella F, Steen NE, Sugrue L, Wang Y, Svenningsson P, Sharma M, Pihlstrøm L, Toft M, O'Donovan M, Djurovic S, Desikan R, Dale AM, Andreassen OA (2020)
    Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
    Biol Psychiatry, 89 (3), 227-235
    DOI 10.1016/j.biopsych.2020.01.026, PubMed 32201043

Publications 2019

  1. Bandres-Ciga S, Saez-Atienzar S, Bonet-Ponce L, Billingsley K, Vitale D, Blauwendraat C, Gibbs JR, Pihlstrøm L, Gan-Or Z, International Parkinson's Disease Genomics Consortium (IPDGC), Cookson MR, Nalls MA, Singleton AB (2019)
    The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
    Mov Disord, 34 (4), 460-468
    DOI 10.1002/mds.27614, PubMed 30675927
  2. Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J, 23andMe Research Team, Eerola-Rautio J, Tienari P, Majamaa K, Toft M et al. (2019)
    Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
    Mov Disord, 34 (6), 866-875
    DOI 10.1002/mds.27659, PubMed 30957308
  3. Fernandez-Santiago R, Martin-Flores N, Antonelli F, Cerquera C, Moreno V, Bandres-Ciga S, Manduchi E, Tolosa E, Singleton AB, Moore JH, Noyce AJ, Kaiyrzhanov R, Middlehurst B, Kia DA, Tan M, Houlden H, Morris HR, Plun-Favreau H, Holmans P, Hardy J, Trabzuni D, Bras J, Quinn J, Mok KY, Kinghorn KJ, Billingsley K, Wood NW, Lewis P, Schreglmann S, Guerreiro R et al. (2019)
    SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease
    Mov. Disord., 34 (9), 1333-1344
    DOI 10.1002/mds.27770
  4. Iqbal Z, Koht J, Pihlstrøm L, Henriksen SP, Cappelletti C, Russel MB, Norberto de Souza O, Skogseid IM, Toft M (2019)
    Missense mutations in DYT-TOR1A dystonia
    Neurol Genet, 5 (4), e343
    DOI 10.1212/NXG.0000000000000343, PubMed 31321303
  5. Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs JR, International Parkinson's Disease Genomics Consortium, Chitrala KN, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K et al. (2019)
    Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts
    Mov Disord, 34 (12), 1839-1850
    DOI 10.1002/mds.27845, PubMed 31505070
  6. Iwaki H, Blauwendraat C, Leonard HL, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Ravina B et al. (2019)
    Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts
    Neurol Genet, 5 (4), e348
    DOI 10.1212/NXG.0000000000000348, PubMed 31404238
  7. Ligaard J, Sannæs J, Pihlstrøm L (2019)
    Deep brain stimulation and genetic variability in Parkinson's disease: a review of the literature
    NPJ Parkinsons Dis, 5, 18
    DOI 10.1038/s41531-019-0091-7, PubMed 31508488
  8. Maeland JG, Pihlstrom L, Skagen KM, Kvale G (2019)
    Doctors demand climate action now!
    Tidsskr. Nor. Laegeforen., 139 (17), 1636
  9. Makarious MB, Diez-Fairen M, Krohn L, Blauwendraat C, Bandres-Ciga S, Ding J, Pihlstrøm L, Houlden H, Scholz SW, Gan-Or Z (2019)
    ARSA variants in α-synucleinopathies
    Brain, 142 (12), e70
    DOI 10.1093/brain/awz340, PubMed 31670782
  10. Mæland JG, Pihlstrøm L, Skagen KM, Kvåle G (2019)
    [Doctors demand climate action now!]
    Tidsskr Nor Laegeforen, 139 (17)
    DOI 10.4045/tidsskr.19.0657, PubMed 31746170
  11. Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Pihlstrøm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J et al. (2019)
    Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
    Lancet Neurol, 18 (12), 1091-1102
    DOI 10.1016/S1474-4422(19)30320-5, PubMed 31701892
  12. Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I, Ulstein ID, Bettella F, Desikan RS, Idland AV, Toft M et al. (2019)
    GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
    Sci Rep, 9 (1), 7013
    DOI 10.1038/s41598-019-43458-2, PubMed 31065058
  13. Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I, Ulstein ID, Bettella F, Desikan RS, Idland AV, Toft M et al. (2019)
    Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
    Sci Rep, 9 (1), 15168
    DOI 10.1038/s41598-019-51827-0, PubMed 31619746
  14. Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, Dawson TM, Rosenthal LS, Houlden H, Pletnikova O, Troncoso J, Scholz SW (2019)
    Assessment of APOE in atypical parkinsonism syndromes
    Neurobiol Dis, 127, 142-146
    DOI 10.1016/j.nbd.2019.02.016, PubMed 30798004

Publications 2018

  1. Berge-Seidl V, Pihlstrøm L, Wszolek ZK, Ross OA, Toft M (2018)
    No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease
    Neurobiol Aging, 74, 236.e1-236.e5
    DOI 10.1016/j.neurobiolaging.2018.09.022, PubMed 30340792
  2. Bjørnarå KA, Pihlstrøm L, Dietrichs E, Toft M (2018)
    Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study
    BMC Neurol, 18 (1), 20
    DOI 10.1186/s12883-018-1023-6, PubMed 29466944
  3. Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Gibbs JR, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Hernandez DG, Chung SJ, Goldwurm S, Toft M, Schulte C, Bras J, Wood NW, Brice A, Morris HR, Scholz SW, Nalls MA, Singleton AB, Cookson MR, COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease) Consortium, the French Parkinson’s Disease Consortium, and the International Parkinson’s Disease Genomics Consortium (IPDGC) (2018)
    Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
    JAMA Neurol, 75 (11), 1416-1422
    DOI 10.1001/jamaneurol.2018.1885, PubMed 30039155
  4. Kishore A, Ashok Kumar Sreelatha A, Sturm M, von-Zweydorf F, Pihlstrøm L, Raimondi F, Russell R, Lichtner P, Banerjee M, Krishnan S, Rajan R, Puthenveedu DK, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD), Bauer P, Riess O, Gloeckner CJ, Kruger R, Gasser T, Sharma M (2018)
    Understanding the role of genetic variability in LRRK2 in Indian population
    Mov Disord, 34 (4), 496-505
    DOI 10.1002/mds.27558, PubMed 30485545
  5. Kristiansen M, Maple-Grødem J, Alves G, Arepalli S, Hernandez DG, Iwaki H, Nalls MA, Singleton A, Tysnes OB, Toft M, Pihlstrøm L (2018)
    A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease
    Mov Disord, 34 (2), 298-299
    DOI 10.1002/mds.27555, PubMed 30484896
  6. Pihlstrøm L, Blauwendraat C, Cappelletti C, Berge-Seidl V, Langmyhr M, Henriksen SP, van de Berg WDJ, Gibbs JR, Cookson MR, International Parkinson Disease Genomics Consortium, North American Brain Expression Consortium, Singleton AB, Nalls MA, Toft M (2018)
    A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease
    Ann Neurol, 84 (1), 117-129
    DOI 10.1002/ana.25274, PubMed 30146727
  7. Pihlstrøm L, Schottlaender L, Chelban V, Houlden H, MSA Exome Consortium (2018)
    LRP10 in α-synucleinopathies
    Lancet Neurol, 17 (12), 1033-1034
    DOI 10.1016/S1474-4422(18)30407-1, PubMed 30507385
  8. Pihlstrøm L, Schottlaender L, Chelban V, MSA Exome Consortium, Meissner WG, Federoff M, Singleton A, Houlden H (2018)
    Lysosomal storage disorder gene variants in multiple system atrophy
    Brain, 141 (7), e53
    DOI 10.1093/brain/awy124, PubMed 29741613

Publications 2017

  1. Berge-Seidl V, Pihlstrøm L, Maple-Grødem J, Forsgren L, Linder J, Larsen JP, Tysnes OB, Toft M (2017)
    The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal
    Neurosci Lett, 658, 48-52
    DOI 10.1016/j.neulet.2017.08.040, PubMed 28830825
  2. Blauwendraat C, Faghri F, Pihlstrom L, Geiger JT, Elbaz A, Lesage S, Corvol JC, May P, Nicolas A, Abramzon Y, Murphy NA, Gibbs JR, Ryten M, Ferrari R, Bras J, Guerreiro R, Williams J, Sims R, Lubbe S, Hernandez DG, Mok KY, Robak L, Campbell RH, Rogaeva E, Traynor BJ, Chia R, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hardy JA, Brice A et al. (2017)
    NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
    Neurobiol Aging, 57, 247.e9-247.e13
    DOI 10.1016/j.neurobiolaging.2017.05.009, PubMed 28602509
  3. Blauwendraat C, Kia DA, Pihlstrøm L, Gan-Or Z, Lesage S, Gibbs JR, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Chung SJ, Goldwurm S, Toft M, Schulte C, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hernandez D, Singleton AB, Nalls MA, Brice A, Scholz SW, Wood NW (2017)
    Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease
    Neurobiol Aging, 64, 159.e5-159.e8
    DOI 10.1016/j.neurobiolaging.2017.12.012, PubMed 29398121
  4. Ezat B, Pihlstrøm L, Aasly J, Tysnes OB, Egge A, Dietrichs E (2017)
    Use of advanced therapies for Parkinson's disease in Norway
    Tidsskr Nor Laegeforen, 137 (9), 619-623
    DOI 10.4045/tidsskr.16.0711, PubMed 28468476
  5. Fagan ES, Pihlstrøm L (2017)
    Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature
    Eur J Neurol, 24 (4), 561-e20
    DOI 10.1111/ene.13258, PubMed 28220571
  6. Faiz KW, Pihlstrøm L (2017)
    [Parkinson's disease and parkinsonism]
    Tidsskr Nor Laegeforen, 137 (4), 298
    DOI 10.4045/tidsskr.16.0915, PubMed 28225240
  7. Iqbal Z, Rydning SL, Wedding IM, Koht J, Pihlstrøm L, Rengmark AH, Henriksen SP, Tallaksen CM, Toft M (2017)
    Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia
    PLoS One, 12 (3), e0174667
    DOI 10.1371/journal.pone.0174667, PubMed 28362824
  8. Iqbal Z, Rydning SL, Wedding IM, Koht J, Pihlstrøm L, Rengmark AH, Henriksen SP, Tallaksen CME, Toft M (2017)
    Correction: Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia
    PLoS One, 12 (10), e0186571
    DOI 10.1371/journal.pone.0186571, PubMed 29023604
  9. Pihlstrøm L (2017)
    Dr. Watson og vi
    Tidsskr Nor Laegeforen, 137 (5), 388
    DOI 10.4045/tidsskr.17.0070, PubMed 28272576
  10. Pihlstrøm L, Wiethoff S, Houlden H (2017)
    Genetics of neurodegenerative diseases: an overview
    Handb Clin Neurol, 145, 309-323
    DOI 10.1016/B978-0-12-802395-2.00022-5, PubMed 28987179

Publications 2016

  1. Chelban V, Manole A, Pihlstrøm L, Schottlaender L, Efthymiou S, OConnor E, Meissner WG, Holton JL, Houlden H (2016)
    Analysis of the prion protein gene in multiple system atrophy
    Neurobiol Aging, 49, 216.e15-216.e18
    DOI 10.1016/j.neurobiolaging.2016.09.021, PubMed 27793473
  2. Iqbal Z, Pihlstrøm L, Rengmark A, Henriksen SP, Linder J, Forsgren L, Toft M (2016)
    Rare variants in dementia genes and Parkinson's disease
    Eur J Hum Genet, 24 (12), 1661-1662
    DOI 10.1038/ejhg.2016.79, PubMed 27329738
  3. Pihlstrøm L (2016)
    Den kulturelle legekofferten
    Tidsskr Nor Laegeforen, 136 (10), 944
    DOI 10.4045/tidsskr.16.0422, PubMed 27272377
  4. Pihlstrøm L (2016)
    Når leger vet for mye
    Tidsskr Nor Laegeforen, 136 (18), 1570
    DOI 10.4045/tidsskr.16.0796, PubMed 27731607
  5. Pihlstrøm L, Morset KR, Grimstad E, Vitelli V, Toft M (2016)
    A cumulative genetic risk score predicts progression in Parkinson's disease
    Mov Disord, 31 (4), 487-90
    DOI 10.1002/mds.26505, PubMed 26853697
  6. Rengmark A, Pihlstrøm L, Linder J, Forsgren L, Toft M (2016)
    Low frequency of GCH1 and TH mutations in Parkinson's disease
    Parkinsonism Relat Disord, 29, 109-11
    DOI 10.1016/j.parkreldis.2016.05.010, PubMed 27185167

Publications 2015

  1. Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE et al. (2015)
    The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
    Alzheimers Dement, 11 (12), 1407-1416
    DOI 10.1016/j.jalz.2014.12.009, PubMed 25936935
  2. Pihlstrom L (2015)
    The old man and his coat
    Tidsskr. Nor. Laegeforen., 135 (2), 162
    DOI 10.4045/tidsskr.14.1517
  3. Pihlstrom L (2015)
    With beard in your inbox
    Tidsskr. Nor. Laegeforen., 135 (7), 676
    DOI 10.4045/tidsskr.15.0283
  4. Pihlstrøm L (2015)
    [The wonders of practical teaching]
    Tidsskr Nor Laegeforen, 135 (20), 1878
    DOI 10.4045/tidsskr.15.1014, PubMed 26534820
  5. Pihlstrøm L, Rengmark A, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Dietrichs E, Toft M (2015)
    Fine mapping and resequencing of the PARK16 locus in Parkinson's disease
    J Hum Genet, 60 (7), 357-62
    DOI 10.1038/jhg.2015.34, PubMed 25855069
  6. Pihlstrøm L, Toft M (2015)
    Cumulative genetic risk and age at onset in Parkinson's disease
    Mov Disord, 30 (12), 1712-3
    DOI 10.1002/mds.26366, PubMed 26234887
  7. Wang L, Aasly JO, Annesi G, Bardien S, Bozi M, Brice A, Carr J, Chung SJ, Clarke C, Crosiers D, Deutschländer A, Eckstein G, Farrer MJ, Goldwurm S, Garraux G, Hadjigeorgiou GM, Hicks AA, Hattori N, Klein C, Jeon B, Kim YJ, Lesage S, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE et al. (2015)
    Large-scale assessment of polyglutamine repeat expansions in Parkinson disease
    Neurology, 85 (15), 1283-92
    DOI 10.1212/WNL.0000000000002016, PubMed 26354989

Publications 2014

  1. Pihlstrøm L (2014)
    [Re: Affection for affection]
    Tidsskr Nor Laegeforen, 134 (20), 1920
    DOI 10.4045/tidsskr.14.1211, PubMed 25350431
  2. Pihlstrøm L, Berge V, Rengmark A, Toft M (2014)
    Parkinson's disease correlates with promoter methylation in the α-synuclein gene
    Mov Disord, 30 (4), 577-80
    DOI 10.1002/mds.26073, PubMed 25545759
  3. Pihlstrøm L, Nedregaard B, Krossnes B, Aamodt AH (2014)
    [Septic embolus]
    Tidsskr Nor Laegeforen, 134 (9), 945
    DOI 10.4045/tidsskr.13.1656, PubMed 24828721
  4. Pihlstrøm L, Rengmark A, Bjørnarå KA, Toft M (2014)
    Effective variant detection by targeted deep sequencing of DNA pools: an example from Parkinson's disease
    Ann Hum Genet, 78 (3), 243-52
    DOI 10.1111/ahg.12060, PubMed 24660942

Publications 2012

  1. Pihlstrøm L, Axelsson G, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Ohman E, Dietrichs E, Toft M (2012)
    Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
    Neurobiol Aging, 34 (6), 1708.e7-13
    DOI 10.1016/j.neurobiolaging.2012.10.019, PubMed 23153929

Publications 2011

  1. Kvåle G, Fadnes LT, Tryland M, Pihlstrøm L (2011)
    Climate change--the biggest health threat of our time
    Tidsskr Nor Laegeforen, 131 (17), 1670-2
    DOI 10.4045/tidsskr.11.0607, PubMed 21901045
  2. Pihlstrøm L (2011)
    [The sardonic smile]
    Tidsskr Nor Laegeforen, 131 (24), 2500-3
    DOI 10.4045/tidsskr.11.0256, PubMed 22170142
  3. Pihlstrøm L, Alfstad KÅ, Solyga V, Ringstad GA, Kerty E (2011)
    [A 55-year old man with recurrent brain infarction]
    Tidsskr Nor Laegeforen, 131 (11), 1089-91
    DOI 10.4045/tidsskr.10.0162, PubMed 21681238
  4. Pihlstrøm L, Toft M (2011)
    Genetic variability in SNCA and Parkinson's disease
    Neurogenetics, 12 (4), 283-93
    DOI 10.1007/s10048-011-0292-7, PubMed 21800132
  5. Pihlstrøm L, Toft M (2011)
    Parkinson's disease: What remains of the "missing heritability"?
    Mov Disord, 26 (11), 1971-3
    DOI 10.1002/mds.23898, PubMed 21812035

 
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