Tom Eirik Mollnes

  • Group leader, professor; MD, PhD
  • +47 90 63 00 15

Publications 2022

Emblem Å, Knutsen E, Jørgensen TE, Fure H, Johansen SD, Brekke OL, Mollnes TE, Karlsen BO (2022)
Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene
Noncoding RNA, 8 (2)
DOI 10.3390/ncrna8020024, PubMed 35447887

Habberstad R, Aass N, Mollnes TE, Damås JK, Brunelli C, Rossi R, Garcia-Alonso E, Kaasa S, Klepstad P (2022)
Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
J Pain Symptom Manage (in press)
DOI 10.1016/j.jpainsymman.2022.06.018, PubMed 35803553

Heldal TF, Åsberg A, Ueland T, Reisaeter AV, Pischke SE, Mollnes TE, Aukrust P, Hartmann A, Heldal K, Jenssen T (2022)
Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality
Am J Transplant, 22 (8), 2016-2027
DOI 10.1111/ajt.17047, PubMed 35352462

Jager NM, Venema LH, Arykbaeva AS, Meter-Arkema AH, Ottens PJ, van Kooten C, Mollnes TE, Alwayn IPJ, Leuvenink HGD, Pischke SE, PROPER study consortium (2022)
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
Front Immunol, 13, 831371
DOI 10.3389/fimmu.2022.831371, PubMed 35911712

Johnson C, Quach HQ, Lau C, Ekholt K, Espevik T, Woodruff TM, Pischke SE, Mollnes TE, Nilsson PH (2022)
Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
J Immunol, 208 (12), 2771-2778
DOI 10.4049/jimmunol.2101033, PubMed 35675954

Lund Berven L, Selvakumar J, Havdal L, Stiansen-Sonerud T, Einvik G, Leegaard TM, Tjade T, Michelsen AE, Mollnes TE, Wyller VBB (2022)
Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults
Front Immunol, 13, 837288
DOI 10.3389/fimmu.2022.837288, PubMed 35222429

Medeiros PMC, Schjalm C, Christiansen D, Sokolova M, Pischke SE, Würzner R, Mollnes TE, Barratt-Due A (2022)
Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood
Shock, 57 (1), 72-80
DOI 10.1097/SHK.0000000000001834, PubMed 34265830

Mollnes TE, Storm BS, Brekke OL, Nilsson PH, Lambris JD (2022)
Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research - 20 years of experience and future perspectives
Semin Immunol, 101604 (in press)
DOI 10.1016/j.smim.2022.101604, PubMed 35570131

Nguyen THP, Hokstad I, Fagerland MW, Mollnes TE, Hollan I, Feinberg MW, Hjeltnes G, Eilertsen GØ, Mikkelsen K, Agewall S (2022)
Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis
PLoS One, 17 (2), e0264628
DOI 10.1371/journal.pone.0264628, PubMed 35213675

Nielsen EW, Miller Y, Brekke OL, Grond J, Duong AH, Fure H, Ludviksen JK, Pettersen K, Reubsaet L, Solberg R, Johansen HT, Mollnes TE (2022)
A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment
Front Immunol, 13, 852119
DOI 10.3389/fimmu.2022.852119, PubMed 35432333

Quach HQ, Johnson C, Ekholt K, Islam R, Mollnes TE, Nilsson PH (2022)
Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner
Front Immunol, 13, 865386
DOI 10.3389/fimmu.2022.865386, PubMed 35444648

Soloey-Nilsen H, Nygaard-Odeh K, Kristiansen MG, Brekke OL, Mollnes TE, Reitan SK, Oiesvold T (2022)
Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients
BMC Psychiatry, 22 (1), 84
DOI 10.1186/s12888-022-03744-2, PubMed 35114967

Storm BS, Ludviksen JK, Christiansen D, Fure H, Pettersen K, Landsem A, Nilsen BA, Dybwik K, Braaten T, Nielsen EW, Mollnes TE (2022)
Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs
Front Immunol, 13, 839632
DOI 10.3389/fimmu.2022.839632, PubMed 35371063

Torp MK, Ranheim T, Schjalm C, Hjorth M, Heiestad CM, Dalen KT, Nilsson PH, Mollnes TE, Pischke SE, Lien E, Vaage J, Yndestad A, Stensløkken KO (2022)
Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
Front Immunol, 13, 870811
DOI 10.3389/fimmu.2022.870811, PubMed 35432387

Publications 2021

Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB (2021)
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
BMC Neurol, 21 (1), 318
DOI 10.1186/s12883-021-02343-0, PubMed 34399717

Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Næss H, Saltvedt I, Ueland PM, Knapskog AB (2021)
Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke
BMC Neurol, 21 (1), 476
DOI 10.1186/s12883-021-02498-w, PubMed 34879833

Askarian F, Uchiyama S, Masson H, Sørensen HV, Golten O, Bunæs AC, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Arntzen MØ, Schmidt B, Zurich RH, van Sorge NM, Eijsink VGH, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G (2021)
The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection
Nat Commun, 12 (1), 1230
DOI 10.1038/s41467-021-21473-0, PubMed 33623002

Chaban V, Nakstad ER, Stær-Jensen H, Schjalm C, Seljeflot I, Vaage J, Lundqvist C, Benth JŠ, Sunde K, Mollnes TE, Andersen GØ, Pischke SE (2021)
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
Resuscitation, 166, 129-136
DOI 10.1016/j.resuscitation.2021.05.038, PubMed 34126135

Debler L, Palmer A, Braumüller S, Klohs B, Mollnes TE, Holzmann K, Huber-Lang M, Halbgebauer R (2021)
Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury
Mediators Inflamm, 2021, 6654318
DOI 10.1155/2021/6654318, PubMed 33574730

Fevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K (2021)
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front Immunol, 12, 715102
DOI 10.3389/fimmu.2021.715102, PubMed 34987499

Garred P, Tenner AJ, Mollnes TE (2021)
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
Pharmacol Rev, 73 (2), 792-827
DOI 10.1124/pharmrev.120.000072, PubMed 33687995

Grimnes G, Bhoelan S, Hindberg K, Davids M, Nieuwdorp M, Mollnes TE, Michelsen AE, Ueland T, Brækkan SK, Hansen JB, Tichelaar V (2021)
Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial
Thromb Haemost, 122 (4), 540-551
DOI 10.1055/s-0041-1733906, PubMed 34428832

Holt MF, Michelsen AE, Shahini N, Bjørkelund E, Bendz CH, Massey RJ, Schjalm C, Halvorsen B, Broch K, Ueland T, Gullestad L, Nilsson PH, Aukrust P, Mollnes TE, Louwe MC (2021)
The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure
Front Immunol, 12, 800978
DOI 10.3389/fimmu.2021.800978, PubMed 35003128

Islam R, Islam MM, Nilsson PH, Mohlin C, Hagen KT, Paschalis EI, Woods RL, Bhowmick SC, Dohlman CH, Espevik T, Chodosh J, Gonzalez-Andrades M, Mollnes TE (2021)
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
Acta Biomater, 127, 169-179
DOI 10.1016/j.actbio.2021.03.047, PubMed 33785451

Langeland H, Damås JK, Mollnes TE, Ludviksen JK, Ueland T, Michelsen AE, Løberg M, Bergum D, Nordseth T, Skjærvold NK, Klepstad P (2021)
The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
Resuscitation, 170, 115-125
DOI 10.1016/j.resuscitation.2021.11.026, PubMed 34838662

Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM (2021)
The allosteric modulation of complement C5 by knob domain peptides
Elife, 10
DOI 10.7554/eLife.63586, PubMed 33570492

Nilsson PH, Johnson C, Quach QH, Macpherson A, Durrant O, Pischke SE, Fure H, Landsem A, Bergseth G, Schjalm C, Haugaard-Kedström LM, Huber-Lang M, van den Elsen J, Brekke OL, Mollnes TE (2021)
A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity
J Immunol, 207 (6), 1641-1651
DOI 10.4049/jimmunol.2001471, PubMed 34380648

Nilsson PH, Pettersen K, Oppermann M, Skjeflo EW, Fure H, Christiansen D, Mollnes TE (2021)
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay
Methods Mol Biol, 2227, 51-59
DOI 10.1007/978-1-0716-1016-9_5, PubMed 33847930

Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM et al. (2021)
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
Sci Immunol, 6 (66), eabf2489
DOI 10.1126/sciimmunol.abf2489, PubMed 34932384

Pethő Á, Piecha D, Mészáros T, Urbanics R, Moore C, Canaud B, Rosivall L, Mollnes TE, Steppan S, Szénási G, Szebeni J, Dézsi L (2021)
A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood
Ren Fail, 43 (1), 1609-1620
DOI 10.1080/0886022X.2021.2007127, PubMed 34882053

Rognes IN, Pischke SE, Ottestad W, Røislien J, Berg JP, Johnson C, Eken T, Mollnes TE (2021)
Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
Mol Med, 27 (1), 35
DOI 10.1186/s10020-021-00286-3, PubMed 33832430

Sharifi S, Islam MM, Sharifi H, Islam R, Huq TN, Nilsson PH, Mollnes TE, Tran KD, Patzer C, Dohlman CH, Patra HK, Paschalis EI, Gonzalez-Andrades M, Chodosh J (2021)
Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects
Macromol Biosci, 21 (4), e2000379
DOI 10.1002/mabi.202000379, PubMed 33624923

Sharifi S, Islam MM, Sharifi H, Islam R, Koza D, Reyes-Ortega F, Alba-Molina D, Nilsson PH, Dohlman CH, Mollnes TE, Chodosh J, Gonzalez-Andrades M (2021)
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Bioact Mater, 6 (11), 3947-3961
DOI 10.1016/j.bioactmat.2021.03.042, PubMed 33937594

Skjeflo EW, Brækkan SK, Ludviksen JK, Snir O, Hindberg K, Mollnes TE, Hansen JB (2021)
Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism
Blood, 138 (21), 2129-2137
DOI 10.1182/blood.2021010822, PubMed 34339498

Skovdahl HK, Gopalakrishnan S, Svendsen TD, Granlund AVB, Bakke I, Ginbot ZG, Thorsvik S, Flatberg A, Sporsheim B, Ostrop J, Mollnes TE, Sandvik AK, Bruland T (2021)
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration
Front Pharmacol, 12, 679741
DOI 10.3389/fphar.2021.679741, PubMed 34054553

Storm BS, Christiansen D, Fure H, Ludviksen JK, Lau C, Lambris JD, Woodruff TM, Brekke OL, Braaten T, Nielsen EW, Mollnes TE (2021)
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
J Immunol, 207 (11), 2828-2840
DOI 10.4049/jimmunol.2100308, PubMed 34732467

Storm BS, Halvorsen PS, Skulstad H, Dybwik K, Schjalm C, Christiansen D, Wisløff-Aase K, Fosse E, Braaten T, Nielsen EW, Mollnes TE (2021)
Open chest and pericardium facilitate transpulmonary passage of venous air emboli
Acta Anaesthesiol Scand, 65 (5), 648-655
DOI 10.1111/aas.13796, PubMed 33595102

Sundnes O, Ottestad W, Schjalm C, Lundbäck P, la Cour Poulsen L, Mollnes TE, Haraldsen G, Eken T (2021)
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol Med, 27 (1), 29
DOI 10.1186/s10020-021-00288-1, PubMed 33771098

Thomas AM, Chaban V, Pischke SE, Orrem HL, Bosnes V, Sunde K, Seljeflot I, Lundqvist C, Nakstad ER, Andersen GØ, Schjalm C, Mollnes TE, Barratt-Due A (2021)
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
Mol Immunol, 141, 273-279
DOI 10.1016/j.molimm.2021.11.016, PubMed 34906905

Thorgersen EB, Asvall J, Frøysnes IS, Schjalm C, Larsen SG, Dueland S, Andersson Y, Fodstad Ø, Mollnes TE, Flatmark K (2021)
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann Surg Oncol, 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0, PubMed 34019185

Wiker HG, Mollnes TE, Garred P, Bjune G, Bjorvatn B (2021)
Morten Harboe (1929-2021), one of the founders of Scandinavian Journal of Immunology OBITUARY
Scand. J. Immunol., 94 (1), e13054
DOI 10.1111/sji.13054

Witczak BJ, Pischke SE, Reisæter AV, Midtvedt K, Ludviksen JK, Heldal K, Jenssen T, Hartmann A, Åsberg A, Mollnes TE (2021)
Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
Front Immunol, 12, 738927
DOI 10.3389/fimmu.2021.738927, PubMed 34759922

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Daha MR (2021)
Memories of Bob Sim-Genius Complementologist and Cheerful Travel Companion
Viruses, 13 (6)
DOI 10.3390/v13061068, PubMed 34199701

Zhu GH, Azharuddin M, Islam R, Rahmoune H, Deb S, Kanji U, Das J, Osterrieth J, Aulakh P, Ibrahim-Hashi H, Manchanda R, Nilsson PH, Mollnes TE, Bhattacharyya M, Islam MM, Hinkula J, Slater NKH, Patra HK (2021)
Innate Immune Invisible Ultrasmall Gold Nanoparticles-Framework for Synthesis and Evaluation
ACS Appl Mater Interfaces, 13 (20), 23410-23422
DOI 10.1021/acsami.1c02834, PubMed 33978409

Publications 2020

Berg LK, Goll R, Fagerli E, Ludviksen JK, Fure H, Moen OS, Sørbye SW, Mollnes TE, Florholmen J (2020)
Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome
Scand J Gastroenterol, 55 (5), 537-542
DOI 10.1080/00365521.2020.1754455, PubMed 32329383

Chaban V, Clarke GJB, Skandsen T, Islam R, Einarsen CE, Vik A, Damås JK, Mollnes TE, Håberg AK, Pischke SE (2020)
Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
J Neurotrauma, 37 (19), 2120-2130
DOI 10.1089/neu.2019.6963, PubMed 32326805

Ehrnström B, Kojen JF, Giambelluca M, Ryan L, Moen SH, Hu Z, Yin H, Mollnes TE, Damås JK, Espevik T, Stenvik J (2020)
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
J Leukoc Biol, 107 (4), 673-683
DOI 10.1002/JLB.3A0120-114R, PubMed 32083344

Grinde D, Øverland T, Lima K, Schjalm C, Mollnes TE, Abrahamsen TG (2020)
Complement Activation in 22q11.2 Deletion Syndrome
J Clin Immunol, 40 (3), 515-523
DOI 10.1007/s10875-020-00766-x, PubMed 32152940

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Hovland A, Retterstøl K, Mollnes TE, Halvorsen B, Aukrust P, Lappegård KT (2020)
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J, 54 (5), 274-279
DOI 10.1080/14017431.2020.1775878, PubMed 32500743

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Keshari RS, Silasi R, Popescu NI, Regmi G, Chaaban H, Lambris JD, Lupu C, Mollnes TE, Lupu F (2020)
CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
J Thromb Haemost, 19 (2), 429-443
DOI 10.1111/jth.15162, PubMed 33174372

Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE (2020)
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
MAbs, 12 (1), 1686319
DOI 10.1080/19420862.2019.1686319, PubMed 31671278

Lipcsey M, Tenhunen J, Pischke SE, Kuitunen A, Flaatten H, De Geer L, Sjölin J, Frithiof R, Chew MS, Bendel S, Kawati R, Larsson A, Mollnes TE, Tønnessen TI, Rubertsson S (2020)
Endotoxin Removal in Septic Shock with the Alteco LPS Adsorber Was Safe But Showed no Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial-the Asset Study
Shock, 54 (2), 224-231
DOI 10.1097/SHK.0000000000001503, PubMed 31880758

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Trøseid M, Halvorsen B, Aukrust P, Fevang B, Jørgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155

Mollnes TE, Huber-Lang M (2020)
Complement in sepsis-when science meets clinics
FEBS Lett, 594 (16), 2621-2632
DOI 10.1002/1873-3468.13881, PubMed 32621378

Niyonzima N, Bakke SS, Gregersen I, Holm S, Sandanger Ø, Orrem HL, Sporsheim B, Ryan L, Kong XY, Dahl TB, Skjelland M, Sørensen KK, Rokstad AM, Yndestad A, Latz E, Gullestad L, Andersen GØ, Damås JK, Aukrust P, Mollnes TE, Halvorsen B, Espevik T (2020)
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275

Pedersen H, Jensen RK, Jensen JMB, Fox R, Pedersen DV, Olesen HG, Hansen AG, Christiansen D, Mazarakis SMM, Lojek N, Hansen P, Gadeberg TAF, Zarantonello A, Laursen NS, Mollnes TE, Johnson MB, Stevens B, Thiel S, Andersen GR (2020)
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
J Immunol, 205 (8), 2287-2300
DOI 10.4049/jimmunol.2000752, PubMed 32938727

Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC (2020)
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888

Sharifi S, Islam MM, Sharifi H, Islam R, Nilsson PH, Dohlman CH, Mollnes TE, Paschalis EI, Chodosh J (2020)
Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility
Transl Vis Sci Technol, 9 (13), 41
DOI 10.1167/tvst.9.13.41, PubMed 33442495

Storjord E, Henno LT, Mollnes TE, Brekke OL (2020)
Analysis of cytokines
Tidsskr. Nor. Laegeforen., 140 (1), 71

Storjord E, Hennø LT, Mollnes TE, Brekke OL (2020)
Analysis of cytokines
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.18.0961, PubMed 31948201

Storm BS, Christiansen D, Mollnes TE, Nielsen EW (2020)
Avoiding ambient air in test tubes during incubations of human whole-blood minimizes complement background activation
J Immunol Methods, 487, 112876
DOI 10.1016/j.jim.2020.112876, PubMed 33031792

Ueland NL, Ludvigsen JK, Hellerud BC, Mollnes TE, Skjeflo EW (2020)
Choice of immunoassay to evaluate porcine cytokine levels
Vet Immunol Immunopathol, 230, 110129
DOI 10.1016/j.vetimm.2020.110129, PubMed 33059181

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

van den Heuvel LP, van de Kar NCAJ, Duineveld C, Sarlea A, van der Velden TJAM, Liebrand WTB, van Kraaij S, Schjalm C, Bouwmeester R, Wetzels JFM, Mollnes TE, Volokhina EB (2020)
The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment
Cell Mol Immunol, 17 (6), 653-655
DOI 10.1038/s41423-020-0406-y, PubMed 32210393

Zhang J, Song L, Pedersen DV, Li A, Lambris JD, Andersen GR, Mollnes TE, Ma YJ, Garred P (2020)
Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement
Elife, 9
DOI 10.7554/eLife.60908, PubMed 32909942

Østvik AE, Svendsen TD, Granlund AVB, Doseth B, Skovdahl HK, Bakke I, Thorsvik S, Afroz W, Walaas GA, Mollnes TE, Gustafsson BI, Sandvik AK, Bruland T (2020)
Intestinal Epithelial Cells Express Immunomodulatory ISG15 During Active Ulcerative Colitis and Crohn's Disease
J Crohns Colitis, 14 (7), 920-934
DOI 10.1093/ecco-jcc/jjaa022, PubMed 32020185

Publications 2019

Brekke OL, Christiansen D, Kisserli A, Fure H, Dahl JA, Donvito B, Reveil B, Ludviksen JK, Tabary T, Mollnes TE, Cohen JHM (2019)
Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood
Mol Immunol, 114, 139-148
DOI 10.1016/j.molimm.2019.07.014, PubMed 31352230

Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Gronli OK (2019)
Corrigendum to "Changes in cytokines during treatment of elderly, hospitalized psychiatric patients-A naturalistic study" [Psychoneuroendocrinology, 108C (2019), 135-139]
Psychoneuroendocrinology, 109, 104427
DOI 10.1016/j.psyneuen.2019.104427, PubMed 31537376

Bugge E, Wynn R, Mollnes TE, Reitan SK, Lapid MI, Grønli OK (2019)
Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study
Psychoneuroendocrinology, 108, 135-139
DOI 10.1016/j.psyneuen.2019.06.014, PubMed 31276906

Cedzyński M, Thielens NM, Mollnes TE, Vorup-Jensen T (2019)
Editorial: The Role of Complement in Health and Disease
Front Immunol, 10, 1869
DOI 10.3389/fimmu.2019.01869, PubMed 31440250

Dahm AEA, Jacobsen EM, Wik HS, Jacobsen AF, Mollnes TE, Kanse SM, Sandset PM (2019)
Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis
Thromb Haemost, 119 (9), 1481-1488
DOI 10.1055/s-0039-1692426, PubMed 31254974

Granslo HN, Aarag Fredheim EG, Esaiassen E, Christophersen L, Jensen PØ, Mollnes TE, Moser C, Flaegstad T, Klingenberg C, Cavanagh JP (2019)
The synthetic antimicrobial peptide LTX21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
APMIS, 127 (6), 475-483
DOI 10.1111/apm.12946, PubMed 30916807

Gravastrand CS, Steinkjer B, Halvorsen B, Landsem A, Skjelland M, Jacobsen EA, Woodruff TM, Lambris JD, Mollnes TE, Brekke OL, Espevik T, Rokstad AMA (2019)
Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
J Immunol, 203 (4), 853-863
DOI 10.4049/jimmunol.1900503, PubMed 31270150

Hagve M, Gjessing PF, Hole MJ, Jansen KM, Fuskevåg OM, Mollnes TE, Larsen TS, Irtun Ø (2019)
Perioperative Infusion of Glucagon-Like Peptide-1 Prevents Insulin Resistance After Surgical Trauma in Female Pigs
Endocrinology, 160 (12), 2892-2902
DOI 10.1210/en.2019-00374, PubMed 31589305

Hardersen R, Enebakk T, Christiansen D, Ludviksen JK, Mollnes TE, Lappegård KT, Hovland A (2019)
Comparison of cytokine changes in three different lipoprotein apheresis systems in an ex vivo whole blood model
J Clin Apher, 35 (2), 104-116
DOI 10.1002/jca.21765, PubMed 31782556

Hokstad I, Deyab G, Wang Fagerland M, Lyberg T, Hjeltnes G, Førre Ø, Agewall S, Mollnes TE, Hollan I (2019)
Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
PLoS One, 14 (7), e0220079
DOI 10.1371/journal.pone.0220079, PubMed 31335881

Holt M, Seim BE, Øgaard J, Olsen MB, Woldbæk PR, Kvitting JP, Aukrust P, Yndestad A, Mollnes TE, Nilsson PH, Louwe MC, Ranheim T (2019)
Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
Open Heart, 6 (2), e001098
DOI 10.1136/openhrt-2019-001098, PubMed 31798913

Høiland II, Liang RA, Braekkan SK, Pettersen K, Ludviksen JK, Latysheva N, Snir O, Ueland T, Hindberg K, Mollnes TE, Hansen JB (2019)
Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism
J Thromb Haemost, 17 (6), 934-943
DOI 10.1111/jth.14438, PubMed 30920726

Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M (2019)
Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts
Acta Biomater, 96, 330-344
DOI 10.1016/j.actbio.2019.07.002, PubMed 31284096

Jørgensen SF, Macpherson ME, Bjørnetrø T, Holm K, Kummen M, Rashidi A, Michelsen AE, Lekva T, Halvorsen B, Trøseid M, Mollnes TE, Berge RK, Yndestad A, Ueland T, Karlsen TH, Aukrust P, Hov JR, Fevang B (2019)
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167
DOI 10.1038/s41598-018-35367-7, PubMed 30655568

Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J (2019)
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions
ACS Nano, 13 (8), 9315-9324
DOI 10.1021/acsnano.9b03942, PubMed 31348638

Liang RA, Høiland II, Ueland T, Aukrust P, Snir O, Hindberg K, Braekkan SK, Garred P, Mollnes TE, Hansen JB (2019)
Plasma levels of mannose-binding lectin and future risk of venous thromboembolism
J Thromb Haemost, 17 (10), 1661-1669
DOI 10.1111/jth.14539, PubMed 31220397

Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jørgensen SF (2019)
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9 (1), 9427
DOI 10.1038/s41598-019-45861-1, PubMed 31263122

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD (2019)
'Stealth' corporate innovation: an emerging threat for therapeutic drug development
Nat Immunol, 20 (11), 1409-1413
DOI 10.1038/s41590-019-0503-1, PubMed 31562490

Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD (2019)
Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development
Nat Immunol, 20 (11), 1556
DOI 10.1038/s41590-019-0531-x, PubMed 31605100

Ottestad W, Rognes IN, Pischke SE, Mollnes TE, Andersson U, Eken T (2019)
Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome
Crit Care Med, 47 (8), e614-e622
DOI 10.1097/CCM.0000000000003800, PubMed 31162203

Pischke SE, Hestenes S, Johansen HT, Fure H, Bugge JF, Espinoza A, Skulstad H, Edvardsen T, Fosse E, Mollnes TE, Halvorsen PS, Nielsen EW (2019)
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
PLoS One, 14 (6), e0218624
DOI 10.1371/journal.pone.0218624, PubMed 31247004

Shahini N, Ueland T, Auensen A, Michelsen AE, Ludviksen JK, Hussain AI, Pettersen KI, Aakhus S, Espeland T, Lunde IG, Kirschfink M, Nilsson PH, Mollnes TE, Gullestad L, Aukrust P, Yndestad A, Louwe MC (2019)
Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis
J Immunol, 203 (7), 1973-1980
DOI 10.4049/jimmunol.1801244, PubMed 31492744

Siljan WW, Holter JC, Michelsen AE, Nymo SH, Lauritzen T, Oppen K, Husebye E, Ueland T, Mollnes TE, Aukrust P, Heggelund L (2019)
Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
ERJ Open Res, 5 (1)
DOI 10.1183/23120541.00014-2019, PubMed 30863773

Skjeflo EW, Christiansen D, Landsem A, Stenvik J, Woodruff TM, Espevik T, Nielsen EW, Mollnes TE (2019)
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14
Mol Immunol, 112, 131-139
DOI 10.1016/j.molimm.2019.03.014, PubMed 31102985

Thomas AM, Gerogianni A, McAdam MB, Fløisand Y, Lau C, Espevik T, Nilsson PH, Mollnes TE, Barratt-Due A (2019)
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood
J Immunol, 203 (6), 1571-1578
DOI 10.4049/jimmunol.1900047, PubMed 31413105

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508, PubMed 30653682

Publications 2018

Askarian F, Lapek JD, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M (2018)
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
Front Microbiol, 9, 262
DOI 10.3389/fmicb.2018.00262, PubMed 29515544

Bjerre A, Bergseth G, Ludviksen JK, Stokke A, Bosnes V, Karpman D, Mollnes TE (2018)
Clinical and Complement Long-Term Follow-Up of a Pediatric Patient with C3 Mutation-Related Atypical Hemolytic Uremic Syndrome
Case Rep Nephrol, 2018, 3810249
DOI 10.1155/2018/3810249, PubMed 30662780

Bugge E, Wynn R, Mollnes TE, Reitan SK, Grønli OK (2018)
Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients
BMC Psychiatry, 18 (1), 315
DOI 10.1186/s12888-018-1900-y, PubMed 30261848

Gaya da Costa M, Poppelaars F, van Kooten C, Mollnes TE, Tedesco F, Würzner R, Trouw LA, Truedsson L, Daha MR, Roos A, Seelen MA (2018)
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
Front Immunol, 9, 2664
DOI 10.3389/fimmu.2018.02664, PubMed 30515158

Gaarden TL, Engedal K, Benth JŠ, Larsen M, Lorentzen B, Mollnes TE, Bjølseth TM, Castellheim A (2018)
Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
BMC Geriatr, 18 (1), 149
DOI 10.1186/s12877-018-0836-x, PubMed 29940870

Habberstad R, Frøseth TCS, Aass N, Abramova T, Baas T, Mørkeset ST, Caraceni A, Laird B, Boland JW, Rossi R, Garcia-Alonso E, Stensheim H, Loge JH, Hjermstad MJ, Bjerkeset E, Bye A, Lund JÅ, Solheim TS, Vagnildhaug OM, Brunelli C, Damås JK, Mollnes TE, Kaasa S, Klepstad P (2018)
The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain
BMC Palliat Care, 17 (1), 110
DOI 10.1186/s12904-018-0362-9, PubMed 30266081

Hardersen R, Enebakk T, Christiansen D, Bergseth G, Brekke OL, Mollnes TE, Lappegård KT, Hovland A (2018)
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) - an ex vivo study with blood from a C5-deficient individual
APMIS, 126 (4), 342-352
DOI 10.1111/apm.12821, PubMed 29575196

Høiland II, Liang RA, Hindberg K, Latysheva N, Brekke OL, Mollnes TE, Hansen JB (2018)
Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism
Thromb Res, 169, 50-56
DOI 10.1016/j.thromres.2018.06.019, PubMed 30015228

Kleveland O, Ueland T, Kunszt G, Bratlie M, Yndestad A, Broch K, Holte E, Ryan L, Amundsen BH, Bendz B, Aakhus S, Espevik T, Halvorsen B, Mollnes TE, Wiseth R, Gullestad L, Aukrust P, Damås JK (2018)
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Int J Cardiol, 271, 1-7
DOI 10.1016/j.ijcard.2018.04.136, PubMed 29961572

Landsem A, Fure H, Krey Ludviksen J, Christiansen D, Lau C, Mathisen M, Bergseth G, Nymo S, Lappegård KT, Woodruff TM, Espevik T, Mollnes TE, Brekke OL (2018)
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
Clin Exp Immunol, 196 (1), 97-110
DOI 10.1111/cei.13240, PubMed 30444525

Langeland H, Bergum D, Løberg M, Bjørnstad K, Damås JK, Mollnes TE, Skjærvold NK, Klepstad P (2018)
Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study
JMIR Res Protoc, 7 (1), e17
DOI 10.2196/resprot.8558, PubMed 29351897

Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE (2018)
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
ESC Heart Fail, 5 (3), 292-301
DOI 10.1002/ehf2.12266, PubMed 29424484

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE (2018)
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front Immunol, 9, 2035
DOI 10.3389/fimmu.2018.02035, PubMed 30258440

Orrem HL, Shetelig C, Ueland T, Limalanathan S, Nilsson PH, Husebye T, Aukrust P, Seljeflot I, Hoffmann P, Eritsland J, Mollnes TE, Andersen GØ, Yndestad A (2018)
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Int J Cardiol, 268, 187-192
DOI 10.1016/j.ijcard.2018.05.032, PubMed 29853279

Quist-Paulsen E, Aukrust P, Kran AB, Dunlop O, Ormaasen V, Stiksrud B, Midttun Ø, Ueland T, Ueland PM, Mollnes TE, Dyrhol-Riise AM (2018)
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
J Neuroinflammation, 15 (1), 327
DOI 10.1186/s12974-018-1366-3, PubMed 30470234

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Skattum L, Bosnes V, Garred P, Frøland SS, Mollnes TE, Aukrust P, Heggelund L (2018)
Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
Open Forum Infect Dis, 5 (2), ofy002
DOI 10.1093/ofid/ofy002, PubMed 29410975

Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE (2018)
Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation
J Thromb Haemost, 16 (5), 905-918
DOI 10.1111/jth.13979, PubMed 29437288

Skovdahl HK, Damås JK, Granlund AVB, Østvik AE, Doseth B, Bruland T, Mollnes TE, Sandvik AK (2018)
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Int J Mol Sci, 19 (10)
DOI 10.3390/ijms19103257, PubMed 30347808

Skaare H, Svensson M, Jenssen T, Åsberg A, Schmidt EB, Chandra A, Ueland T, Mollnes TE, Hartmann A, Eide IA (2018)
Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation
J Ren Nutr, 28 (5), 333-339
DOI 10.1053/j.jrn.2018.02.008, PubMed 29703632

Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A (2018)
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
Neonatology, 113 (4), 322-330
DOI 10.1159/000486542, PubMed 29486477

Wendelbo Ø, Opheim EN, Hervig T, Felli Lunde TH, Bruserud Ø, Mollnes TE, Reikvam H (2018)
Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
Vox Sang, 113 (7), 657-668
DOI 10.1111/vox.12703, PubMed 30159896

Wolf-Grosse S, Mollnes TE, Ali S, Stenvik J, Nilsen AM (2018)
Iron oxide nanoparticles enhance Toll-like receptor-induced cytokines in a particle size- and actin-dependent manner in human blood
Nanomedicine (Lond), 13 (14), 1773-1785
DOI 10.2217/nnm-2017-0362, PubMed 30084726

Publications 2017

Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T (2017)
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
J Immunol, 199 (8), 2910-2920
DOI 10.4049/jimmunol.1700302, PubMed 28855312

Fiane KKH, Dahle G, Bendz B, Halvorsen PS, Abdelnoor M, Mollnes TE, Fosse E (2017)
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
Scand Cardiovasc J, 52 (1), 43-50
DOI 10.1080/14017431.2017.1416157, PubMed 29233022

Gravastrand C, Hamad S, Fure H, Steinkjer B, Ryan L, Oberholzer J, Lambris JD, Lacík I, Mollnes TE, Espevik T, Brekke OL, Rokstad AM (2017)
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
Acta Biomater, 58, 158-167
DOI 10.1016/j.actbio.2017.05.052, PubMed 28576714

Gustavsen A, Skattum L, Bergseth G, Lorentzen B, Floisand Y, Bosnes V, Mollnes TE, Barratt-Due A (2017)
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
Medicine (Baltimore), 96 (11), e6338
DOI 10.1097/MD.0000000000006338, PubMed 28296762

Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH (2017)
Properdin binding to complement activating surfaces depends on initial C3b deposition
Proc Natl Acad Sci U S A, 114 (4), E534-E539
DOI 10.1073/pnas.1612385114, PubMed 28069958

Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE (2017)
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
J Intensive Care, 5, 21
DOI 10.1186/s40560-017-0217-0, PubMed 28261486

Hennø LT, Storjord E, Christiansen D, Bergseth G, Ludviksen JK, Fure H, Barene S, Nielsen EW, Mollnes TE, Brekke OL (2017)
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans
Cytokine, 97, 86-95
DOI 10.1016/j.cyto.2017.05.014, PubMed 28595117

Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F (2017)
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Proc Natl Acad Sci U S A, 114 (31), E6390-E6399
DOI 10.1073/pnas.1706818114, PubMed 28720697

Nilsson PH, Thomas AM, Bergseth G, Gustavsen A, Volokhina EB, van den Heuvel LP, Barratt-Due A, Mollnes TE (2017)
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
Mol Immunol, 89, 111-114
DOI 10.1016/j.molimm.2017.05.021, PubMed 28610663

Paunas TIF, Finne K, Leh S, Marti HP, Mollnes TE, Berven F, Vikse BE (2017)
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
Clin Proteomics, 14, 30
DOI 10.1186/s12014-017-9165-x, PubMed 28814945

Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE (2017)
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Basic Res Cardiol, 112 (3), 20
DOI 10.1007/s00395-017-0610-9, PubMed 28258298

Ricklin D, Barratt-Due A, Mollnes TE (2017)
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
Mol Immunol, 89, 10-21
DOI 10.1016/j.molimm.2017.05.013, PubMed 28576323

Shahini N, Michelsen AE, Nilsson PH, Ekholt K, Gullestad L, Broch K, Dahl CP, Aukrust P, Ueland T, Mollnes TE, Yndestad A, Louwe MC (2017)
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532, PubMed 28195242

Shields KJ, Mollnes TE, Eidet JR, Mikkelsen K, Almdahl SM, Bottazzi B, Lyberg T, Manzi S, Ahearn JM, Hollan I (2017)
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
PLoS One, 12 (3), e0174577
DOI 10.1371/journal.pone.0174577, PubMed 28362874

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L (2017)
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
Eur J Clin Invest, 48 (1)
DOI 10.1111/eci.12865, PubMed 29171871

Wibroe PP, Anselmo AC, Nilsson PH, Sarode A, Gupta V, Urbanics R, Szebeni J, Hunter AC, Mitragotri S, Mollnes TE, Moghimi SM (2017)
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
Nat Nanotechnol, 12 (6), 589-594
DOI 10.1038/nnano.2017.47, PubMed 28396605

Wolf-Grosse S, Rokstad AM, Ali S, Lambris JD, Mollnes TE, Nilsen AM, Stenvik J (2017)
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model
Int J Nanomedicine, 12, 3927-3940
DOI 10.2147/IJN.S136453, PubMed 28579778

Wyller VB, Nguyen CB, Ludviksen JA, Mollnes TE (2017)
Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
J Transl Med, 15 (1), 245
DOI 10.1186/s12967-017-1350-1, PubMed 29202780

Publications 2016

Aresvik DM, Lima K, Øverland T, Mollnes TE, Abrahamsen TG (2016)
Increased Levels of Interferon-Inducible Protein 10 (IP-10) in 22q11.2 Deletion Syndrome
Scand J Immunol, 83 (3), 188-94
DOI 10.1111/sji.12406, PubMed 26708691

Barratt-Due A, Fløisand Y, Orrem HL, Kvam AK, Holme PA, Bergseth G, Tjønnfjord GE, Mollnes TE (2016)
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
Rheumatology (Oxford), 55 (7), 1337-9
DOI 10.1093/rheumatology/kew040, PubMed 27105662

Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE (2016)
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
J Leukoc Biol, 101 (1), 193-204
DOI 10.1189/jlb.3VMR0316-132R, PubMed 27581539

Eide IA, Åsberg A, Svensson M, Ueland T, Mollnes TE, Hartmann A, Bjerve KS, Michelsen A, Aukrust P, Christensen JH, Schmidt EB, Jenssen T (2016)
Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients
J Ren Nutr, 27 (3), 161-168
DOI 10.1053/j.jrn.2016.09.008, PubMed 27838193

Garabet L, Gilboe IM, Mowinckel MC, Jacobsen AF, Mollnes TE, Sandset PM, Jacobsen EM (2016)
Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus
Scand J Immunol, 84 (2), 95-9
DOI 10.1111/sji.12445, PubMed 27135178

Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE (2016)
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex
J Infect Dis, 214 (1), 140-50
DOI 10.1093/infdis/jiw100, PubMed 26977050

Hestad KA, Engedal K, Whist JE, Aukrust P, Farup PG, Mollnes TE, Ueland T (2016)
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Neuropsychiatr Dis Treat, 12, 817-22
DOI 10.2147/NDT.S101925, PubMed 27110115

Jørgensen SF, Trøseid M, Kummen M, Anmarkrud JA, Michelsen AE, Osnes LT, Holm K, Høivik ML, Rashidi A, Dahl CP, Vesterhus M, Halvorsen B, Mollnes TE, Berge RK, Moum B, Lundin KE, Fevang B, Ueland T, Karlsen TH, Aukrust P, Hov JR (2016)
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597

Landsem A, Fure H, Mollnes TE, Nielsen EW, Brekke OL (2016)
C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry
Thromb Res, 143, 63-70
DOI 10.1016/j.thromres.2016.04.024, PubMed 27197075

Lappegård KT, Enebakk T, Thunhaug H, Ludviksen JK, Mollnes TE, Hovland A (2016)
LDL apheresis activates the complement system and the cytokine network, whereas PCSK9 inhibition with evolocumab induces no inflammatory response
J Clin Lipidol, 10 (6), 1481-1487
DOI 10.1016/j.jacl.2016.09.001, PubMed 27919366

Niyonzima N, Halvorsen B, Sporsheim B, Garred P, Aukrust P, Mollnes TE, Espevik T (2016)
Complement activation by cholesterol crystals triggers a subsequent cytokine response
Mol Immunol, 84, 43-50
DOI 10.1016/j.molimm.2016.09.019, PubMed 27692470

Nymo S, Gustavsen A, Nilsson PH, Lau C, Espevik T, Mollnes TE (2016)
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
J Immunol, 196 (5), 2293-9
DOI 10.4049/jimmunol.1502220, PubMed 26800874

Otterdal K, Portillo A, Astrup E, Ludviksen J, Davì G, Holm S, Santilli F, Vitale G, Raoult D, Olano JP, Schjalm C, Halvorsen B, Oteo JA, Mollnes TE, Aukrust P, Nilsson PH (2016)
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202

Otterdal K, Portillo A, Astrup E, Ludviksen JK, Schjalm C, Raoult D, Olano JP, Halvorsen B, Oteo JA, Aukrust P, Mollnes TE, Nilsson PH (2016)
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Clin Microbiol Infect, 22 (8), 734.e1-6
DOI 10.1016/j.cmi.2016.05.010, PubMed 27217049

Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P (2016)
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
J Immunol, 196 (12), 5064-74
DOI 10.4049/jimmunol.1502595, PubMed 27183610

Siljan WW, Holter JC, Nymo SH, Schjalm C, Müller F, Jenum PA, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L (2016)
Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome
J Infect, 73 (4), 383-6
DOI 10.1016/j.jinf.2016.07.011, PubMed 27452197

Smedbråten J, Mjøen G, Hartmann A, Åsberg A, Rollag H, Mollnes TE, Sandvik L, Fagerland MW, Thiel S, Sagedal S (2016)
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
BMC Nephrol, 17 (1), 148
DOI 10.1186/s12882-016-0373-9, PubMed 27760523

Smedbråten J, Sagedal S, Åsberg A, Hartmann A, Rollag H, Mjøen G, Fagerland MW, Hansen SW, Mollnes TE, Thiel S (2016)
Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation
Am J Transplant, 17 (1), 265-271
DOI 10.1111/ajt.13933, PubMed 27341702

Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trøseid M, Taskén K, Dyrhol-Riise AM (2016)
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144

Storjord E, Dahl JA, Landsem A, Fure H, Ludviksen JK, Goldbeck-Wood S, Karlsen BO, Berg KS, Mollnes TE, W Nielsen E, Brekke OL (2016)
Systemic inflammation in acute intermittent porphyria: a case-control study
Clin Exp Immunol, 187 (3), 466-479
DOI 10.1111/cei.12899, PubMed 27859020

Stylianou E, Ueland T, Borchsenius F, Michelsen AE, Øvstebø R, Mollnes TE, Skjønsberg OH, Aukrust P (2016)
Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis
Scand J Clin Lab Invest, 76 (2), 118-27
DOI 10.3109/00365513.2015.1110856, PubMed 26878875

Ørning P, Hoem KS, Coron AE, Skjåk-Bræk G, Mollnes TE, Brekke OL, Espevik T, Rokstad AM (2016)
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
J Control Release, 229, 58-69
DOI 10.1016/j.jconrel.2016.03.021, PubMed 26993426

Publications 2015

Asprusten TT, Fagermoen E, Sulheim D, Skovlund E, Sørensen Ø, Mollnes TE, Wyller VB (2015)
Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome
Acta Paediatr, 104 (5), 498-503
DOI 10.1111/apa.12950, PubMed 25640602

Berg A, Otterdal K, Patel S, Gonca M, David C, Dalen I, Nymo S, Nilsson M, Nordling S, Magnusson PU, Ueland T, Prato M, Giribaldi G, Mollnes TE, Aukrust P, Langeland N, Nilsson PH (2015)
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
J Infect Dis, 212 (11), 1835-40
DOI 10.1093/infdis/jiv283, PubMed 25980034

Bergstrøm B, Aune MH, Awuh JA, Kojen JF, Blix KJ, Ryan L, Flo TH, Mollnes TE, Espevik T, Stenvik J (2015)
TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway
J Immunol, 195 (3), 1100-11
DOI 10.4049/jimmunol.1403176, PubMed 26085680

Blom AM, Österborg A, Mollnes TE, Okroj M (2015)
Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation
Mol Immunol, 66 (2), 164-70
DOI 10.1016/j.molimm.2015.02.029, PubMed 25795308

Egge KH, Barratt-Due A, Nymo S, Lindstad JK, Pharo A, Lau C, Espevik T, Thorgersen EB, Mollnes TE (2015)
The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load
Clin Exp Immunol, 181 (3), 457-67
DOI 10.1111/cei.12645, PubMed 25907631

Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE (2015)
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
Immunobiology, 220 (8), 999-1005
DOI 10.1016/j.imbio.2015.04.002, PubMed 25956456

Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B (2015)
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial
Medicine (Baltimore), 94 (42), e1786
DOI 10.1097/MD.0000000000001786, PubMed 26496309

Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P (2015)
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo
Clin Exp Immunol, 179 (2), 294-9
DOI 10.1111/cei.12446, PubMed 25174443

Hellerud BC, Olstad OK, Nielsen EW, Trøseid AM, Skadberg Ø, Thorgersen EB, Vege Å, Mollnes TE, Brandtzæg P (2015)
Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock
Shock, 44 (5), 458-69
DOI 10.1097/SHK.0000000000000441, PubMed 26473439

Hovland A, Jonasson L, Garred P, Yndestad A, Aukrust P, Lappegård KT, Espevik T, Mollnes TE (2015)
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
Atherosclerosis, 241 (2), 480-94
DOI 10.1016/j.atherosclerosis.2015.05.038, PubMed 26086357

Huang S, Engberg AE, Jonsson N, Sandholm K, Nicholls IA, Mollnes TE, Fromell K, Nilsson B, Ekdahl KN (2015)
Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood
Biomaterials, 77, 111-9
DOI 10.1016/j.biomaterials.2015.10.067, PubMed 26584351

Haakonsen Lindenskov PH, Castellheim A, Saugstad OD, Mollnes TE (2015)
Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies
Neonatology, 107 (3), 225-230
DOI 10.1159/000369373, PubMed 25721501

Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE (2015)
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
Scand J Immunol, 82 (5), 467-75
DOI 10.1111/sji.12332, PubMed 26099791

Landsem A, Fure H, Christiansen D, Nielsen EW, Østerud B, Mollnes TE, Brekke OL (2015)
The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood
Clin Exp Immunol, 182 (1), 81-9
DOI 10.1111/cei.12663, PubMed 26241501

Lappegård KT, Bjerre A, Tjønnfjord GE, Mollnes TE (2015)
Therapeutic complement inhibition – from experimental to clinical medicine
Tidsskr Nor Laegeforen, 135 (19), 1745-9
DOI 10.4045/tidsskr.15.0049, PubMed 26486669

Lappegård KT, Bjørnstad H, Mollnes TE, Hovland A (2015)
Effect of Cardiac Resynchronization Therapy on Inflammation in Congestive Heart Failure: A Review
Scand J Immunol, 82 (3), 191-8
DOI 10.1111/sji.12328, PubMed 26099323

Lau C, Nygård S, Fure H, Olstad OK, Holden M, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641

Lau C, Olstad OK, Holden M, Nygård S, Fure H, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE (2015)
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252

Meroni PL, Macor P, Durigutto P, De Maso L, Gerosa M, Ferraresso M, Borghi MO, Mollnes TE, Tedesco F (2015)
Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery
Blood, 127 (3), 365-7
DOI 10.1182/blood-2015-09-672139, PubMed 26644452

Neupane SP, Lien L, Ueland T, Mollnes TE, Aukrust P, Bramness JG (2015)
Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders
Alcohol, 49 (5), 471-8
DOI 10.1016/j.alcohol.2015.01.012, PubMed 25873205

Nilsson B, Ekdahl KN, Kemper C, Mollnes TE (2015)
Preface. 15th European Meeting on Complement in Human Disease 2015, Uppsala, Sweden
Mol Immunol, 67 (1), 1-2
DOI 10.1016/j.molimm.2015.04.006, PubMed 25934434

Niyonzima N, Samstad EO, Aune MH, Ryan L, Bakke SS, Rokstad AM, Wright SD, Damås JK, Mollnes TE, Latz E, Espevik T (2015)
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
J Immunol, 195 (1), 257-64
DOI 10.4049/jimmunol.1403044, PubMed 26026058

Prebensen C, Ueland T, Michelsen AE, Lind A, Pettersen FO, Mollnes TE, Aukrust P, Dyrhol-Riise AM, Kvale D (2015)
High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection
J Acquir Immune Defic Syndr, 69 (4), 395-402
DOI 10.1097/QAI.0000000000000617, PubMed 26115437

Skjeflo EW, Sagatun C, Dybwik K, Aam S, Urving SH, Nunn MA, Fure H, Lau C, Brekke OL, Huber-Lang M, Espevik T, Barratt-Due A, Nielsen EW, Mollnes TE (2015)
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
Crit Care, 19, 415
DOI 10.1186/s13054-015-1129-9, PubMed 26612199

Smedbråten YV, Sagedal S, Mjøen G, Hartmann A, Fagerland MW, Rollag H, Mollnes TE, Thiel S (2015)
High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients
Transplantation, 99 (4), 791-6
DOI 10.1097/TP.0000000000000422, PubMed 25222012

Volokhina EB, Bergseth G, van de Kar NC, van den Heuvel LP, Mollnes TE (2015)
Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo
Blood, 126 (2), 278-9
DOI 10.1182/blood-2015-03-637645, PubMed 26160188

Volokhina EB, van de Kar NC, Bergseth G, van der Velden TJ, Westra D, Wetzels JF, van den Heuvel LP, Mollnes TE (2015)
Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome
Clin Immunol, 160 (2), 237-43
DOI 10.1016/j.clim.2015.05.018, PubMed 26111482

Volokhina EB, Westra D, van der Velden TJ, van de Kar NC, Mollnes TE, van den Heuvel LP (2015)
Complement activation patterns in atypical haemolytic uraemic syndrome during acute phase and in remission
Clin Exp Immunol, 181 (2), 306-13
DOI 10.1111/cei.12426, PubMed 25079699

Wergeland I, Pullar N, Assmus J, Ueland T, Tonby K, Feruglio S, Kvale D, Damås JK, Aukrust P, Mollnes TE, Dyrhol-Riise AM (2015)
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
J Infect, 70 (4), 381-91
DOI 10.1016/j.jinf.2014.12.019, PubMed 25597826

Wyller VB, Reme SE, Mollnes TE (2015)
Chronic fatigue syndrome/myalgic encephalo-myelitis--pathophysiology, diagnosis and treatment
Tidsskr Nor Laegeforen, 135 (23-24), 2172-5
DOI 10.4045/tidsskr.15.1180, PubMed 26674040

Würzner R, Tedesco F, Garred P, Mollnes TE, Truedsson L, Turner MW, Sommarin Y, Wieslander J, Sim RB (2015)
European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha
Mol Immunol, 68 (1), 63-6
DOI 10.1016/j.molimm.2015.05.003, PubMed 26006049

Publications 2014

Berg A, Patel S, Gonca M, David C, Otterdal K, Ueland T, Dalen I, Kvaløy JT, Mollnes TE, Aukrust P, Langeland N (2014)
Cytokine network in adults with falciparum Malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
PLoS One, 9 (12), e114480
DOI 10.1371/journal.pone.0114480, PubMed 25503583

Bergseth G, Ludviksen JK, Kirschfink M, Giclas PC, Nilsson B, Mollnes TE (2014)
An international serum standard for application in assays to detect human complement activation products (vol 56, pg 232, 2013)
Mol. Immunol., 60 (2), 115
DOI 10.1016/j.molimm.2014.04.008

Bisschops LL, van der Hoeven JG, Mollnes TE, Hoedemaekers CW (2014)
Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study
Crit Care, 18 (5), 546
DOI 10.1186/s13054-014-0546-5, PubMed 25304549

Blom AM, Volokhina EB, Fransson V, Strömberg P, Berghard L, Viktorelius M, Mollnes TE, López-Trascasa M, van den Heuvel LP, Goodship TH, Marchbank KJ, Okroj M (2014)
A novel method for direct measurement of complement convertases activity in human serum
Clin Exp Immunol, 178 (1), 142-53
DOI 10.1111/cei.12388, PubMed 24853370

Engberg AE, Nilsson PH, Huang S, Fromell K, Hamad OA, Mollnes TE, Rosengren-Holmberg JP, Sandholm K, Teramura Y, Nicholls IA, Nilsson B, Ekdahl KN (2014)
Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma
Biomaterials, 36, 55-65
DOI 10.1016/j.biomaterials.2014.09.011, PubMed 25292422

Hallstensen RF, Bergseth G, Foss S, Jæger S, Gedde-Dahl T, Holt J, Christiansen D, Lau C, Brekke OL, Armstrong E, Stefanovic V, Andersen JT, Sandlie I, Mollnes TE (2014)
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
Immunobiology, 220 (4), 452-9
DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724

Huber-Lang M, Barratt-Due A, Pischke SE, Sandanger Ø, Nilsson PH, Nunn MA, Denk S, Gaus W, Espevik T, Mollnes TE (2014)
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
J Immunol, 192 (11), 5324-31
DOI 10.4049/jimmunol.1400341, PubMed 24790148

Lappegård KT, Garred P, Jonasson L, Espevik T, Aukrust P, Yndestad A, Mollnes TE, Hovland A (2014)
A vital role for complement in heart disease
Mol Immunol, 61 (2), 126-34
DOI 10.1016/j.molimm.2014.06.036, PubMed 25037633

Lind A, Brekke K, Pettersen FO, Mollnes TE, Trøseid M, Kvale D (2014)
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers
PLoS One, 9 (1), e85604
DOI 10.1371/journal.pone.0085604, PubMed 24416431

Neupane SP, Lien L, Martinez P, Aukrust P, Ueland T, Mollnes TE, Hestad K, Bramness JG (2014)
High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders
CNS Neurosci Ther, 20 (10), 898-904
DOI 10.1111/cns.12303, PubMed 24995667

Nymo S, Niyonzima N, Espevik T, Mollnes TE (2014)
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
Immunobiology, 219 (10), 786-92
DOI 10.1016/j.imbio.2014.06.006, PubMed 25053140

Ostvik AE, Granlund Av, Gustafsson BI, Torp SH, Espevik T, Mollnes TE, Damås JK, Sandvik AK (2014)
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
Inflamm Bowel Dis, 20 (6), 995-1003
DOI 10.1097/MIB.0000000000000035, PubMed 24739633

Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A (2014)
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases
Mol Immunol, 64 (1), 170-6
DOI 10.1016/j.molimm.2014.11.010, PubMed 25534848

Samstad EO, Niyonzima N, Nymo S, Aune MH, Ryan L, Bakke SS, Lappegård KT, Brekke OL, Lambris JD, Damås JK, Latz E, Mollnes TE, Espevik T (2014)
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
J Immunol, 192 (6), 2837-45
DOI 10.4049/jimmunol.1302484, PubMed 24554772

Skjeflo EW, Christiansen D, Espevik T, Nielsen EW, Mollnes TE (2014)
Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model
J Immunol, 192 (6), 2857-64
DOI 10.4049/jimmunol.1300755, PubMed 24516199

Wyller VB, Sørensen Ø, Sulheim D, Fagermoen E, Ueland T, Mollnes TE (2014)
Plasma cytokine expression in adolescent chronic fatigue syndrome
Brain Behav Immun, 46, 80-6
DOI 10.1016/j.bbi.2014.12.025, PubMed 25555530

Publications 2013

Auråen H, Mollnes TE, Bjørtuft Ø, Bakkan PA, Geiran O, Kongerud J, Fiane A, Holm AM (2013)
Multiorgan procurement increases systemic inflammation in brain dead donors
Clin Transplant, 27 (4), 613-8
DOI 10.1111/ctr.12175, PubMed 23803161

Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE (2013)
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
J Immunol, 191 (2), 819-27
DOI 10.4049/jimmunol.1201909, PubMed 23761634

Bergseth G, Ludviksen JK, Kirschfink M, Giclas PC, Nilsson B, Mollnes TE (2013)
An international serum standard for application in assays to detect human complement activation products
Mol Immunol, 56 (3), 232-9
DOI 10.1016/j.molimm.2013.05.221, PubMed 23787367

Brekke OL, Waage C, Christiansen D, Fure H, Qu H, Lambris JD, Østerud B, Nielsen EW, Mollnes TE (2013)
The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood
Adv Exp Med Biol, 735, 123-36
DOI 10.1007/978-1-4614-4118-2_8, PubMed 23402023

Egge KH, Thorgersen EB, Lindstad JK, Pharo A, Lambris JD, Barratt-Due A, Mollnes TE (2013)
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
Innate Immun, 20 (1), 68-77
DOI 10.1177/1753425913482993, PubMed 23669326

Ehrnthaller C, Huber-Lang M, Nilsson P, Bindl R, Redeker S, Recknagel S, Rapp A, Mollnes T, Amling M, Gebhard F, Ignatius A (2013)
Complement C3 and C5 deficiency affects fracture healing
PLoS One, 8 (11), e81341
DOI 10.1371/journal.pone.0081341, PubMed 24260573

Gregersen I, Skjelland M, Holm S, Holven KB, Krogh-Sørensen K, Russell D, Askevold ET, Dahl CP, Ørn S, Gullestad L, Mollnes TE, Ueland T, Aukrust P, Halvorsen B (2013)
Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis
PLoS One, 8 (8), e72769
DOI 10.1371/journal.pone.0072769, PubMed 24023645

Hamre H, Zeller B, Kanellopoulos A, Ruud E, Fosså SD, Loge JH, Aukrust P, Halvorsen B, Mollnes TE, Kiserud CE (2013)
Serum cytokines and chronic fatigue in adults surviving after childhood leukemia and lymphoma
Brain Behav Immun, 30, 80-7
DOI 10.1016/j.bbi.2013.01.006, PubMed 23333795

Happonen KE, Saxne T, Jacobsson L, Sturfelt G, Rönnelid J, Mollnes TE, Heinegård D, Turesson C, Blom AM (2013)
COMP-C3b complexes in rheumatoid arthritis with severe extraarticular manifestations
J Rheumatol, 40 (12), 2001-5
DOI 10.3899/jrheum.130613, PubMed 24187101

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2013)
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transpl, 19 (3), 305-14
DOI 10.1002/lt.23578, PubMed 23193034

Landsem A, Nielsen EW, Fure H, Christiansen D, Ludviksen JK, Lambris JD, Østerud B, Mollnes TE, Brekke OL (2013)
C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood
Clin Exp Immunol, 173 (2), 217-29
DOI 10.1111/cei.12098, PubMed 23607270

Lappegård KT, Hovland A, Pop GA, Mollnes TE (2013)
Atrial fibrillation: inflammation in disguise?
Scand J Immunol, 78 (2), 112-9
DOI 10.1111/sji.12061, PubMed 23672430

Lau C, Gunnarsen KS, Høydahl LS, Andersen JT, Berntzen G, Pharo A, Lindstad JK, Ludviksen JK, Brekke OL, Barratt-Due A, Nielsen EW, Stokes CR, Espevik T, Sandlie I, Mollnes TE (2013)
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486

Mollnes TE, Nilsson PH (2013)
Letter to editor
J Clin Biochem Nutr, 52 (3), 253-4
DOI 10.3164/jcbn.52-3_LtoE, PubMed 23704816

Prohászka Z, Munthe-Fog L, Ueland T, Gombos T, Yndestad A, Förhécz Z, Skjoedt MO, Pozsonyi Z, Gustavsen A, Jánoskuti L, Karádi I, Gullestad L, Dahl CP, Askevold ET, Füst G, Aukrust P, Mollnes TE, Garred P (2013)
Association of ficolin-3 with severity and outcome of chronic heart failure
PLoS One, 8 (4), e60976
DOI 10.1371/journal.pone.0060976, PubMed 23596511

Salvesen B, Curstedt T, Mollnes TE, Saugstad OD (2013)
Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome
Neonatology, 105 (2), 128-35
DOI 10.1159/000356065, PubMed 24356240

Schejbel L, Fadnes D, Permin H, Lappegård KT, Garred P, Mollnes TE (2013)
Primary complement C5 deficiencies - molecular characterization and clinical review of two families
Immunobiology, 218 (10), 1304-10
DOI 10.1016/j.imbio.2013.04.021, PubMed 23743184

Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE (2013)
Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis
Infect Immun, 81 (9), 3173-81
DOI 10.1128/IAI.00390-13, PubMed 23774598

van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2013)
Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard
J Immunol Methods, 402 (1-2), 50-6
DOI 10.1016/j.jim.2013.11.010, PubMed 24287422

Øvstebø R, Hellum M, Aass HC, Trøseid AM, Brandtzaeg P, Mollnes TE, Henriksson CE (2013)
Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis-exposed whole blood
Innate Immun, 20 (5), 552-60
DOI 10.1177/1753425913502099, PubMed 24051102

Publications 2012

Almaas R, Hankø E, Mollnes TE, Rootwelt T (2012)
Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons
Brain Res, 1458, 12-7
DOI 10.1016/j.brainres.2012.04.007, PubMed 22546346

Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Huber-Lang M, Mollnes TE (2012)
Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation
Immunobiology, 217 (11), 1047-56
DOI 10.1016/j.imbio.2012.07.019, PubMed 22964230

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE (2012)
Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs
Immunobiology, 218 (5), 683-9
DOI 10.1016/j.imbio.2012.08.268, PubMed 22947599

Bisschops LL, Hoedemaekers CW, Mollnes TE, van der Hoeven JG (2012)
Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance
Crit Care Med, 40 (4), 1136-42
DOI 10.1097/CCM.0b013e3182377050, PubMed 22020246

Christiansen D, Brekke OL, Stenvik J, Lambris JD, Espevik T, Mollnes TE (2012)
Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood
Adv Exp Med Biol, 946, 237-51
DOI 10.1007/978-1-4614-0106-3_14, PubMed 21948372

Granslo HN, Klingenberg C, Fredheim EA, Acharya G, Mollnes TE, Flægstad T (2012)
Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults
Pediatr Res, 73 (3), 294-300
DOI 10.1038/pr.2012.193, PubMed 23232670

Harboe M, Garred P, Lindstad JK, Pharo A, Müller F, Stahl GL, Lambris JD, Mollnes TE (2012)
The role of properdin in zymosan- and Escherichia coli-induced complement activation
J Immunol, 189 (5), 2606-13
DOI 10.4049/jimmunol.1200269, PubMed 22851705

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Inge Tønnessen T (2012)
Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
Liver Transpl, 18 (12), 1421-9
DOI 10.1002/lt.23503, PubMed 22767413

Hovland A, Hardersen R, Nielsen EW, Enebakk T, Christiansen D, Ludviksen JK, Mollnes TE, Lappegård KT (2012)
Complement profile and activation mechanisms by different LDL apheresis systems
Acta Biomater, 8 (6), 2288-96
DOI 10.1016/j.actbio.2012.02.017, PubMed 22373816

Hovland A, Lappegård KT, Mollnes TE (2012)
LDL apheresis and inflammation--implications for atherosclerosis
Scand J Immunol, 76 (3), 229-36
DOI 10.1111/j.1365-3083.2012.02734.x, PubMed 22670805

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878

Kvarnström A, Sokolov A, Swartling T, Kurlberg G, Mollnes TE, Bengtsson A (2012)
Alternative pathway activation of complement in laparoscopic and open rectal surgery
Scand J Immunol, 76 (1), 49-53
DOI 10.1111/j.1365-3083.2012.02702.x, PubMed 22486843

Rokstad AM, Brekke OL, Steinkjer B, Ryan L, Kolláriková G, Strand BL, Skjåk-Bræk G, Lambris JD, Lacík I, Mollnes TE, Espevik T (2012)
The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
Biomaterials, 34 (3), 621-30
DOI 10.1016/j.biomaterials.2012.10.012, PubMed 23103159

Rødland EK, Ueland T, Bjørnsen S, Sagen EL, Dahl CP, Naalsund A, Mollnes TE, Brosstad FR, Müller F, Aukrust P, Frøland SS (2012)
Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis
BMC Infect Dis, 12, 144
DOI 10.1186/1471-2334-12-144, PubMed 22731696

Sokolov A, Hellerud BC, Johannessen EA, Mollnes TE (2012)
Inflammatory response induced by candidate biomaterials of an implantable microfabricated sensor
J Biomed Mater Res A, 100 (5), 1142-50
DOI 10.1002/jbm.a.34054, PubMed 22337626

Sokolov A, Hellerud BC, Tønnessen TI, Johannessen EA, Mollnes TE (2012)
Activation of coagulation and platelets by candidate membranes of implantable devices in a whole blood model without soluble anticoagulant
J Biomed Mater Res A, 101 (2), 575-81
DOI 10.1002/jbm.a.34348, PubMed 22949225

Ørn S, Ueland T, Manhenke C, Sandanger Ø, Godang K, Yndestad A, Mollnes TE, Dickstein K, Aukrust P (2012)
Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention
J Intern Med, 272 (3), 267-76
DOI 10.1111/j.1365-2796.2012.02517.x, PubMed 22243053

Publications 2011

Barratt-Due A, Johansen HT, Sokolov A, Thorgersen EB, Hellerud BC, Reubsaet JL, Seip KF, Tønnessen TI, Lindstad JK, Pharo A, Castellheim A, Mollnes TE, Nielsen EW (2011)
The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis
Shock, 36 (5), 517-23
DOI 10.1097/SHK.0b013e3182336a34, PubMed 21921836

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE (2011)
Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans
J Immunol, 187 (9), 4913-9
DOI 10.4049/jimmunol.1101000, PubMed 21964028

Berdal JE, Mollnes TE, Wæhre T, Olstad OK, Halvorsen B, Ueland T, Laake JH, Furuseth MT, Maagaard A, Kjekshus H, Aukrust P, Jonassen CM (2011)
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
J Infect, 63 (4), 308-16
DOI 10.1016/j.jinf.2011.07.004, PubMed 21781987

Bergseth G, Lambris JD, Mollnes TE, Lappegård KT (2011)
Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person
Ann Thorac Surg, 91 (2), 527-33
DOI 10.1016/j.athoracsur.2010.10.084, PubMed 21256307

Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE (2011)
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood
Mol Immunol, 48 (15-16), 2159-69
DOI 10.1016/j.molimm.2011.07.011, PubMed 21839519

Chavez SA, Martinko AJ, Lau C, Pham MN, Cheng K, Bevan DE, Mollnes TE, Yin H (2011)
Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics
J Med Chem, 54 (13), 4659-69
DOI 10.1021/jm2003365, PubMed 21591694

Fredheim EG, Granslo HN, Flægstad T, Figenschau Y, Rohde H, Sadovskaya I, Mollnes TE, Klingenberg C (2011)
Staphylococcus epidermidis polysaccharide intercellular adhesin activates complement
FEMS Immunol Med Microbiol, 63 (2), 269-80
DOI 10.1111/j.1574-695X.2011.00854.x, PubMed 22077230

Grimnes G, Beckman H, Lappegård KT, Mollnes TE, Skogen V (2011)
Recurrent meningococcal sepsis in a presumptive immunocompetent host shown to be complement C5 deficient-a case report
APMIS, 119 (7), 479-84
DOI 10.1111/j.1600-0463.2011.02740.x, PubMed 21635555

Harboe M, Thorgersen EB, Mollnes TE (2011)
Advances in assay of complement function and activation
Adv Drug Deliv Rev, 63 (12), 976-87
DOI 10.1016/j.addr.2011.05.010, PubMed 21664392

Hovland A, Marcovina S, Hardersen R, Enebakk T, Mollnes TE, Lappegård KT (2011)
Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles
Transfus Apher Sci, 46 (1), 73-6
DOI 10.1016/j.transci.2011.11.016, PubMed 22206792

Rokstad AM, Brekke OL, Steinkjer B, Ryan L, Kolláriková G, Strand BL, Skjåk-Bræk G, Lacík I, Espevik T, Mollnes TE (2011)
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
Acta Biomater, 7 (6), 2566-78
DOI 10.1016/j.actbio.2011.03.011, PubMed 21402181

Sokolov A, Hellerud BC, Lambris JD, Johannessen EA, Mollnes TE (2011)
Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor
J Diabetes Sci Technol, 5 (6), 1490-8
DOI 10.1177/193229681100500625, PubMed 22226271

Sokolov A, Hellerud BC, Pharo A, Johannessen EA, Mollnes TE (2011)
Complement activation by candidate biomaterials of an implantable microfabricated medical device
J Biomed Mater Res B Appl Biomater, 98 (2), 323-9
DOI 10.1002/jbm.b.31855, PubMed 21648060

Søyland E, Heier I, Rodríguez-Gallego C, Mollnes TE, Johansen FE, Holven KB, Halvorsen B, Aukrust P, Jahnsen FL, de la Rosa Carrillo D, Krogstad AL, Nenseter MS (2011)
Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis
Br J Dermatol, 164 (2), 344-55
DOI 10.1111/j.1365-2133.2010.10149.x, PubMed 21271993

Torfoss D, Sandstad B, Mollnes TE, Høiby EA, Holte H, Bjerner J, Bjøro T, Gaudernack G, Kvalheim G, Kvaløy S (2011)
The mild inflammatory response in febrile neutropenic lymphoma patients with low risk of complications is more pronounced in patients receiving tobramycin once daily compared with three times daily
Scand J Immunol, 74 (6), 632-9
DOI 10.1111/j.1365-3083.2011.02618.x, PubMed 21883353

van Kuilenburg J, Lappegård KT, Sexton J, Plesiewicz I, Lap P, Bouwels L, Sprong T, Mollnes TE, Verheugt F, van Heerde WL, Pop GA (2011)
Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment
J Clin Lipidol, 5 (4), 273-80
DOI 10.1016/j.jacl.2011.05.003, PubMed 21784372

Publications 2010

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE (2010)
Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood
Mol Immunol, 47 (9), 1774-82
DOI 10.1016/j.molimm.2010.02.026, PubMed 20334922

Dalen ML, Alme TN, Munkeby BH, Løberg EM, Pripp AH, Mollnes TE, Rootwelt T, Saugstad OD (2010)
Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
J Perinat Med, 38 (5), 545-56
DOI 10.1515/JPM.2010.081, PubMed 20629493

Eagan TM, Aukrust P, Bakke PS, Damås JK, Skorge TD, Hardie JA, Ueland T, Mollnes TE (2010)
Systemic mannose-binding lectin is not associated with Chronic Obstructive Pulmonary Disease
Respir Med, 104 (2), 283-90
DOI 10.1016/j.rmed.2009.09.015, PubMed 19836222

Eagan TM, Aukrust P, Ueland T, Hardie JA, Johannessen A, Mollnes TE, Damås JK, Bakke PS, Wagner PD (2010)
Body composition and plasma levels of inflammatory biomarkers in COPD
Eur Respir J, 36 (5), 1027-33
DOI 10.1183/09031936.00194209, PubMed 20413541

Eagan TM, Damås JK, Ueland T, Voll-Aanerud M, Mollnes TE, Hardie JA, Bakke PS, Aukrust P (2010)
Neutrophil gelatinase-associated lipocalin: a biomarker in COPD
Chest, 138 (4), 888-95
DOI 10.1378/chest.09-2718, PubMed 20495108

Granslo HN, Klingenberg C, Fredheim EG, Rønnestad A, Mollnes TE, Flaegstad T (2010)
Arginine catabolic mobile element is associated with low antibiotic resistance and low pathogenicity in Staphylococcus epidermidis from neonates
Pediatr Res, 68 (3), 237-41
DOI 10.1203/PDR.0b013e3181eb01e0, PubMed 20703143

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tønnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
DOI 10.1097/CCM.0b013e3181de8c94, PubMed 20400898

Hoedemaekers C, van Deuren M, Sprong T, Pickkers P, Mollnes TE, Klasen I, van der Hoeven J (2010)
The complement system is activated in a biphasic pattern after coronary artery bypass grafting
Ann Thorac Surg, 89 (3), 710-6
DOI 10.1016/j.athoracsur.2009.11.049, PubMed 20172115

Hovland A, Hardersen R, Enebakk T, Mollnes TE, Lappegård KT (2010)
Patient tolerance regarding different low-density lipoprotein apheresis columns: frequent minor side effects and high patient satisfaction
J Clin Lipidol, 5 (1), 45-9
DOI 10.1016/j.jacl.2010.11.003, PubMed 21262506

Hovland A, Hardersen R, Mollnes TE, Lappegård KT (2010)
Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia
JOP, 11 (5), 467-9
PubMed 20818118

Hovland A, Hardersen R, Nielsen EW, Mollnes TE, Lappegård KT (2010)
Hematologic and hemostatic changes induced by different columns during LDL apheresis
J Clin Apher, 25 (5), 294-300
DOI 10.1002/jca.20256, PubMed 20806414

Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T (2010)
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Immunity, 33 (4), 583-96
DOI 10.1016/j.immuni.2010.09.010, PubMed 20933442

Johannessen E, Krushinitskaya O, Sokolov A, Philipp H, Hoogerwerf A, Hinderling C, Kautio K, Lenkkeri J, Strömmer E, Kondratyev V, Tønnessen TI, Mollnes TE, Jakobsen H, Zimmer E, Akselsen B (2010)
Toward an injectable continuous osmotic glucose sensor
J Diabetes Sci Technol, 4 (4), 882-92
DOI 10.1177/193229681000400417, PubMed 20663452

Kourtzelis I, Markiewski MM, Doumas M, Rafail S, Kambas K, Mitroulis I, Panagoutsos S, Passadakis P, Vargemezis V, Magotti P, Qu H, Mollnes TE, Ritis K, Lambris JD (2010)
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis
Blood, 116 (4), 631-9
DOI 10.1182/blood-2010-01-264051, PubMed 20424189

Salvesen B, Stenvik J, Rossetti C, Saugstad OD, Espevik T, Mollnes TE (2010)
Meconium-induced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner
Mol Immunol, 47 (6), 1226-34
DOI 10.1016/j.molimm.2009.12.015, PubMed 20092898

Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD, Lupu F (2010)
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
Blood, 116 (6), 1002-10
DOI 10.1182/blood-2010-02-269746, PubMed 20466856

Thiara AS, Andersen VY, Videm V, Mollnes TE, Svennevig K, Hoel TN, Fiane AE (2010)
Comparable biocompatibility of Phisio- and Bioline-coated cardiopulmonary bypass circuits indicated by the inflammatory response
Perfusion, 25 (1), 9-16
DOI 10.1177/0267659110362822, PubMed 20172900

Thiara AS, Mollnes TE, Videm V, Andersen VY, Svennevig K, Kolset SO, Fiane AE (2010)
Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgery
Perfusion, 26 (2), 107-14
DOI 10.1177/0267659110392438, PubMed 21177724

Wester T, Häggblad E, Awan ZA, Barratt-Due A, Kvernebo M, Halvorsen PS, Mollnes TE, Kvernebo K (2010)
Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis
Clin Physiol Funct Imaging, 31 (2), 151-8
DOI 10.1111/j.1475-097X.2010.00994.x, PubMed 21087397

Publications 2009

Bexborn F, Engberg AE, Sandholm K, Mollnes TE, Hong J, Nilsson Ekdahl K (2009)
Hirudin versus heparin for use in whole blood in vitro biocompatibility models
J Biomed Mater Res A, 89 (4), 951-9
DOI 10.1002/jbm.a.32034, PubMed 18470919

Castellheim A, Brekke OL, Espevik T, Harboe M, Mollnes TE (2009)
Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
Scand J Immunol, 69 (6), 479-91
DOI 10.1111/j.1365-3083.2009.02255.x, PubMed 19439008

Corallini F, Bossi F, Gonelli A, Tripodo C, Castellino G, Mollnes TE, Tedesco F, Rizzi L, Trotta F, Zauli G, Secchiero P (2009)
The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis
Rheumatology (Oxford), 48 (3), 293-8
DOI 10.1093/rheumatology/ken495, PubMed 19168833

Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damås JK, Aukrust P, Bakke PS (2009)
Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study
Eur Respir J, 35 (3), 540-8
DOI 10.1183/09031936.00088209, PubMed 19643942

Eggum R, Ueland T, Mollnes TE, Videm V, Fiane AE, Aukrust P, Lindberg HL (2009)
Perfusion temperature, thyroid hormones and inflammation during pediatric cardiac surgery
Interact Cardiovasc Thorac Surg, 10 (1), 76-80
DOI 10.1510/icvts.2009.213876, PubMed 19822605

Harboe M, Garred P, Karlstrøm E, Lindstad JK, Stahl GL, Mollnes TE (2009)
The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification
Mol Immunol, 47 (2-3), 373-80
DOI 10.1016/j.molimm.2009.09.005, PubMed 19800125

Hellerud BC, Aase A, Herstad TK, Naess LM, Kristiansen LH, Trøseid AM, Harboe M, Lappegård KT, Brandtzaeg P, Høiby EA, Mollnes TE (2009)
Critical roles of complement and antibodies in host defense mechanisms against Neisseria meningitidis as revealed by human complement genetic deficiencies
Infect Immun, 78 (2), 802-9
DOI 10.1128/IAI.01044-09, PubMed 19933829

Hoel TN, Thiara AS, Videm V, Fiane AE, Mollnes TE, Castellheim A, Svennevig JL (2009)
In vitro evaluation of PHISIO-coated sets for pediatric cardiac surgery
Scand Cardiovasc J, 43 (2), 129-35
DOI 10.1080/14017430802302316, PubMed 19294579

Hovland A, Hardersen R, Sexton J, Mollnes TE, Lappegård KT (2009)
Different inflammatory responses induced by three LDL-lowering apheresis columns
J Clin Apher, 24 (6), 247-53
DOI 10.1002/jca.20223, PubMed 19927364

Kåsin JI, Kjekshus J, Aukrust P, Mollnes TE, Wagstaff A (2009)
A helicopter flight does not induce significant changes in systemic biomarker profiles
Scand J Clin Lab Invest, 69 (4), 462-74
DOI 10.1080/00365510902745360, PubMed 19333819

Lappegård KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abrahamsen TG, Høiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE (2009)
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature
Proc Natl Acad Sci U S A, 106 (37), 15861-6
DOI 10.1073/pnas.0903613106, PubMed 19717455

Manderson GA, Martin M, Onnerfjord P, Saxne T, Schmidtchen A, Mollnes TE, Heinegård D, Blom AM (2009)
Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system
Mol Immunol, 46 (16), 3388-98
DOI 10.1016/j.molimm.2009.07.011, PubMed 19674792

Martin M, Gottsäter A, Nilsson PM, Mollnes TE, Lindblad B, Blom AM (2009)
Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients
J Vasc Surg, 50 (1), 100-6
DOI 10.1016/j.jvs.2008.12.033, PubMed 19563958

Natvig JB, Mollnes TE (2009)
Professor emeritus Morten Harboe, one of the founders of Scandinavian Journal of Immunology, turns 80
Scand. J. Immunol., 69 (6), 469-470
DOI 10.1111/j.1365-3083.2009.02259.x

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tønnessen TI, Brandtzaeg P, Mollnes TE (2009)
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
DOI 10.1097/SHK.0b013e31819c37be, PubMed 19174740

Orn S, Breland UM, Mollnes TE, Manhenke C, Dickstein K, Aukrust P, Ueland T (2009)
The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction
Am J Cardiol, 104 (9), 1179-83
DOI 10.1016/j.amjcard.2009.06.028, PubMed 19840558

Pedersen ED, Løberg EM, Vege E, Daha MR, Maehlen J, Mollnes TE (2009)
In situ deposition of complement in human acute brain ischaemia
Scand J Immunol, 69 (6), 555-62
DOI 10.1111/j.1365-3083.2009.02253.x, PubMed 19439017

Salvesen B, Mollnes TE (2009)
Pathway-specific complement activity in pigs evaluated with a human functional complement assay
Mol Immunol, 46 (8-9), 1620-5
DOI 10.1016/j.molimm.2009.02.028, PubMed 19328551

Siezenga MA, Chandie Shaw PK, van der Geest RN, Mollnes TE, Daha MR, Rabelink TJ, Berger SP (2009)
Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
Clin Exp Immunol, 157 (1), 98-103
DOI 10.1111/j.1365-2249.2009.03959.x, PubMed 19659775

Sikkeland LI, Eduard W, Stangeland AM, Thorgersen EB, Haug T, Aukrust P, Halvorsen B, Mollnes TE, Kongerud J (2009)
Occupational exposure to bacterial single cell protein induces inflammation in lung and blood
Inhal Toxicol, 21 (8), 674-81
DOI 10.1080/08958370802491425, PubMed 19558225

Sprong T, Mollnes TE, Neeleman C, Swinkels D, Netea MG, van der Meer JW, van Deuren M (2009)
Mannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock
Clin Infect Dis, 49 (9), 1380-6
DOI 10.1086/606054, PubMed 19793001

Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE (2009)
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
FASEB J, 24 (3), 712-22
DOI 10.1096/fj.09-140798, PubMed 19841036

Thorgersen EB, Ludviksen JK, Lambris JD, Sfyroera G, Nielsen EW, Mollnes TE (2009)
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity
Innate Immun, 16 (4), 254-64
DOI 10.1177/1753425909340420, PubMed 19710096

Trøseid M, Lappegård KT, Mollnes TE, Arnesen H, Seljeflot I (2009)
The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome
Metab Syndr Relat Disord, 7 (6), 579-84
DOI 10.1089/met.2009.0003, PubMed 19900154

Ørn S, Manhenke C, Ueland T, Damås JK, Mollnes TE, Edvardsen T, Aukrust P, Dickstein K (2009)
C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction
Eur Heart J, 30 (10), 1180-6
DOI 10.1093/eurheartj/ehp070, PubMed 19299430

Publications 2008

Asberg AE, Mollnes TE, Videm V (2008)
Complement activation by neutrophil granulocytes
Scand J Immunol, 67 (4), 354-61
DOI 10.1111/j.1365-3083.2008.02077.x, PubMed 18248527

Brekke OL, Christiansen D, Fure H, Pharo A, Fung M, Riesenfeld J, Mollnes TE (2008)
Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood
Mol Immunol, 45 (14), 3804-13
DOI 10.1016/j.molimm.2008.05.017, PubMed 18606453

Castellheim A, Hoel TN, Videm V, Fosse E, Pharo A, Svennevig JL, Fiane AE, Mollnes TE (2008)
Biomarker profile in off-pump and on-pump coronary artery bypass grafting surgery in low-risk patients
Ann Thorac Surg, 85 (6), 1994-2002
DOI 10.1016/j.athoracsur.2008.03.012, PubMed 18498809

Castellheim A, Thorgersen EB, Hellerud BC, Pharo A, Johansen HT, Brosstad F, Gaustad P, Brun H, Fosse E, Tønnessen TI, Nielsen EW, Mollnes TE (2008)
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand J Immunol, 68 (1), 75-84
DOI 10.1111/j.1365-3083.2008.02122.x, PubMed 18466195

Dalen ML, Frøyland E, Saugstad OD, Mollnes TE, Rootwelt T (2008)
Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
Brain Res, 1259, 80-9
DOI 10.1016/j.brainres.2008.12.055, PubMed 19146835

Eggum R, Ueland T, Mollnes TE, Videm V, Aukrust P, Fiane AE, Lindberg HL (2008)
Effect of perfusion temperature on the inflammatory response during pediatric cardiac surgery
Ann Thorac Surg, 85 (2), 611-7
DOI 10.1016/j.athoracsur.2007.10.062, PubMed 18222275

Harboe M, Mollnes TE (2008)
The alternative complement pathway revisited
J Cell Mol Med, 12 (4), 1074-84
DOI 10.1111/j.1582-4934.2008.00350.x, PubMed 18419792

Hellerud BC, Stenvik J, Espevik T, Lambris JD, Mollnes TE, Brandtzaeg P (2008)
Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation
Infect Immun, 76 (9), 4183-9
DOI 10.1128/IAI.00195-08, PubMed 18591229

Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE (2008)
The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent
J Biomed Mater Res A, 87 (1), 129-35
DOI 10.1002/jbm.a.31750, PubMed 18085644

Mollnes TE (2008)
High mobility group box-1 protein--one step closer to the clinic?
Crit Care, 12 (4), 168
DOI 10.1186/cc6944, PubMed 18671827

Mollnes TE, Castellheim A, Lindenskov PH, Salvesen B, Saugstad OD (2008)
The role of complement in meconium aspiration syndrome
J Perinatol, 28 Suppl 3, S116-9
DOI 10.1038/jp.2008.148, PubMed 19057601

Mollnes TE, Christiansen D, Brekke OL, Espevik T (2008)
Hypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response
Adv Exp Med Biol, 632, 253-63
DOI 10.1007/978-0-387-78952-1_18, PubMed 19025127

Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE (2008)
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model
J Immunol, 180 (9), 6346-53
DOI 10.4049/jimmunol.180.9.6346, PubMed 18424758

Sagedal S, Thiel S, Hansen TK, Mollnes TE, Rollag H, Hartmann A (2008)
Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation
Nephrol Dial Transplant, 23 (12), 4054-60
DOI 10.1093/ndt/gfn355, PubMed 18577532

Salvesen B, Fung M, Saugstad OD, Mollnes TE (2008)
Role of complement and CD14 in meconium-induced cytokine formation
Pediatrics, 121 (3), e496-505
DOI 10.1542/peds.2007-0878, PubMed 18299306

Salvesen B, Mollnes TE, Saugstad OD (2008)
Albumin lavage does not improve the outcome of meconium aspiration syndrome
J Matern Fetal Neonatal Med, 21 (10), 719-25
DOI 10.1080/14767050802255561, PubMed 19012188

Salvesen B, Nielsen EW, Harboe M, Saugstad OD, Mollnes TE (2008)
Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood
Mol Immunol, 46 (4), 688-94
DOI 10.1016/j.molimm.2008.09.001, PubMed 18950866

Thorgersen EB, Macagno A, Rossetti C, Mollnes TE (2008)
Cyanobacterial LPS antagonist (CyP)-a novel and efficient inhibitor of Escherichia coli LPS-induced cytokine response in the pig
Mol Immunol, 45 (13), 3553-7
DOI 10.1016/j.molimm.2008.05.005, PubMed 18571239

Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE (2008)
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood
Infect Immun, 77 (2), 725-32
DOI 10.1128/IAI.01305-08, PubMed 19047409

Waelgaard L, Thorgersen EB, Line PD, Foss A, Mollnes TE, Tønnessen TI (2008)
Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation
Transplantation, 86 (8), 1096-103
DOI 10.1097/TP.0b013e31818775ca, PubMed 18946348

Publications 2007

Brekke OL, Christiansen D, Fure H, Fung M, Mollnes TE (2007)
The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood
J Leukoc Biol, 81 (6), 1404-13
DOI 10.1189/jlb.0806538, PubMed 17389579

Hoel TN, Videm V, Mollnes TE, Saatvedt K, Brosstad F, Fiane AE, Fosse E, Svennevig JL (2007)
Off-pump cardiac surgery abolishes complement activation
Perfusion, 22 (4), 251-6
DOI 10.1177/0267659107084142, PubMed 18181513

Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD (2007)
Complement and coagulation: strangers or partners in crime?
Trends Immunol, 28 (4), 184-92
DOI 10.1016/, PubMed 17336159

Mollnes TE, Jokiranta TS, Truedsson L, Nilsson B, Rodriguez de Cordoba S, Kirschfink M (2007)
Complement analysis in the 21st century
Mol Immunol, 44 (16), 3838-49
DOI 10.1016/j.molimm.2007.06.150, PubMed 17768101

Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE (2007)
CD59 efficiently protects human NT2-N neurons against complement-mediated damage
Scand J Immunol, 66 (2-3), 345-51
DOI 10.1111/j.1365-3083.2007.01959.x, PubMed 17635812

Roestenberg M, McCall M, Mollnes TE, van Deuren M, Sprong T, Klasen I, Hermsen CC, Sauerwein RW, van der Ven A (2007)
Complement activation in experimental human malaria infection
Trans R Soc Trop Med Hyg, 101 (7), 643-9
DOI 10.1016/j.trstmh.2007.02.023, PubMed 17481680

Saethre M, Baumann BC, Fung M, Seebach JD, Mollnes TE (2007)
Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells
Transplantation, 84 (2), 244-50
DOI 10.1097/, PubMed 17667817

Sikkeland LI, Thorgersen EB, Haug T, Mollnes TE (2007)
Complement activation and cytokine response by BioProtein, a bacterial single cell protein
Clin Exp Immunol, 148 (1), 146-52
DOI 10.1111/j.1365-2249.2007.03339.x, PubMed 17302729

Ødegård A, Aasland J, Myhre HO, Mollnes TE, Videm V (2007)
The inflammatory response to stent grafting of the thoracic aorta
Int Angiol, 26 (3), 219-27
PubMed 17622202

Publications 2006

Drogset JO, Grøntvedt T, Jessen V, Tegnander A, Mollnes TE, Bergh K (2006)
Comparison of in vitro and in vivo complement activation by metal and bioabsorbable screws used in anterior cruciate ligament reconstruction
Arthroscopy, 22 (5), 489-96
DOI 10.1016/j.arthro.2006.03.011, PubMed 16651157

Frøyland E, Pedersen ED, Kvissel AK, Almaas R, Pharo A, Skålhegg BS, Mollnes TE, Rootwelt T (2006)
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250

Harboe M, Garred P, Borgen MS, Stahl GL, Roos A, Mollnes TE (2006)
Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions
Clin Exp Immunol, 144 (3), 512-20
DOI 10.1111/j.1365-2249.2006.03072.x, PubMed 16734621

Mollnes TE, Kirschfink M (2006)
Strategies of therapeutic complement inhibition
Mol Immunol, 43 (1-2), 107-21
DOI 10.1016/j.molimm.2005.06.014, PubMed 16011851

Mollnes TE, Kirschfink M (2006)
Complement analysis in clinic and research
Adv Exp Med Biol, 586, 361-80
DOI 10.1007/0-387-34134-X_24, PubMed 16893084

Nielsen EW, Waage C, Fure H, Brekke OL, Sfyroera G, Lambris JD, Mollnes TE (2006)
Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement
Mol Immunol, 44 (8), 1819-26
DOI 10.1016/j.molimm.2006.10.003, PubMed 17101176

Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD (2006)
The role of complement in biomaterial-induced inflammation
Mol Immunol, 44 (1-3), 82-94
DOI 10.1016/j.molimm.2006.06.020, PubMed 16905192

Pedersen ED, Frøyland E, Kvissel AK, Pharo AM, Skålhegg BS, Rootwelt T, Mollnes TE (2006)
Expression of complement regulators and receptors on human NT2-N neurons--effect of hypoxia and reoxygenation
Mol Immunol, 44 (9), 2459-68
DOI 10.1016/j.molimm.2006.10.022, PubMed 17116331

Saethre M, Lea T, Borgen MS, Fiane AE, Michaelsen TE, Thorsby E, Haraldsen G, Mollnes TE (2006)
Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation
Xenotransplantation, 13 (3), 215-23
DOI 10.1111/j.1399-3089.2006.00289.x, PubMed 16756564

Sprong T, Roos D, Weemaes C, Neeleman C, Geesing CL, Mollnes TE, van Deuren M (2006)
Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
Blood, 107 (12), 4865-70
DOI 10.1182/blood-2005-07-2820, PubMed 16527897

Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE (2006)
Candidate inhibitors of porcine complement
Mol Immunol, 44 (8), 1827-34
DOI 10.1016/j.molimm.2006.10.004, PubMed 17109963

Ueland T, Espevik T, Kjekshus J, Gullestad L, Omland T, Squire IB, Frøland SS, Mollnes TE, Dickstein K, Aukrust P (2006)
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
J Card Fail, 12 (8), 659-63
DOI 10.1016/j.cardfail.2006.07.002, PubMed 17045187

Waelgaard L, Pharo A, Tønnessen TI, Mollnes TE (2006)
Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions
Scand J Immunol, 64 (3), 345-52
DOI 10.1111/j.1365-3083.2006.01826.x, PubMed 16918704

Publications 2005

Castellheim A, Lindenskov PH, Pharo A, Aamodt G, Saugstad OD, Mollnes TE (2005)
Meconium aspiration syndrome induces complement-associated systemic inflammatory response in newborn piglets
Scand J Immunol, 61 (3), 217-25
DOI 10.1111/j.1365-3083.2005.01532.x, PubMed 15787738

Fevang B, Mollnes TE, Holm AM, Ueland T, Heggelund L, Damås JK, Aukrust P, Frøland SS (2005)
Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
Clin Exp Immunol, 142 (3), 576-84
DOI 10.1111/j.1365-2249.2005.02951.x, PubMed 16297171

Fiane AE, Ueland T, Simonsen S, Scott H, Endresen K, Gullestad L, Geiran OR, Haraldsen G, Heggelund L, Andreassen AK, Wergeland R, Frøland S, Aukrust P, Mollnes TE (2005)
Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
Eur Heart J, 26 (16), 1660-5
DOI 10.1093/eurheartj/ehi198, PubMed 15821010

Heggelund L, Mollnes TE, Espevik T, Müller F, Kristiansen KI, Aukrust P, Frøland SS (2005)
Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection
Eur J Clin Invest, 35 (12), 765-70
DOI 10.1111/j.1365-2362.2005.01579.x, PubMed 16313253

Hognestad A, Endresen K, Wergeland R, Mellembakken JR, Mollnes TE, Omland T, Kjekshus JK, Aukrust P, Andreassen AK (2005)
Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosis
J Heart Lung Transplant, 24 (8), 1026-32
DOI 10.1016/j.healun.2004.07.018, PubMed 16102437

Lappegård KT, Bergseth G, Riesenfeld J, Sexton J, Mollnes TE (2005)
Role of granulocytes and monocytes in the polyvinyl chloride-induced synthesis of interleukin 8, monocyte chemoattractant protein 1, and leukotriene B4
J Biomed Mater Res A, 74 (2), 230-6
DOI 10.1002/jbm.a.30372, PubMed 15962266

Lappegård KT, Riesenfeld J, Brekke OL, Bergseth G, Lambris JD, Mollnes TE (2005)
Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production
Ann Thorac Surg, 79 (3), 917-23
DOI 10.1016/j.athoracsur.2004.08.015, PubMed 15734405

Sørlie D, Wisborg T, Wählby L, Wilskow A, Mollnes TE, Gamnes J, Arnesen E (2005)
[A programme for boosting medical research in North Norway, 1992-2001]
Tidsskr Nor Laegeforen, 125 (4), 449-50
PubMed 15742020

Trøseid M, Lappegård KT, Mollnes TE, Arnesen H, Seljeflot I (2005)
Changes in serum levels of E-selectin correlate to improved glycaemic control and reduced obesity in subjects with the metabolic syndrome
Scand J Clin Lab Invest, 65 (4), 283-90
DOI 10.1080/00365510510013811, PubMed 16076683

Publications 2004

Bossi F, Fischetti F, Pellis V, Bulla R, Ferrero E, Mollnes TE, Regoli D, Tedesco F (2004)
Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex
J Immunol, 173 (11), 6921-7
DOI 10.4049/jimmunol.173.11.6921, PubMed 15557188

Castellheim A, Pharo A, Fung M, Saugstad OD, Mollnes TE (2004)
Complement C5a is a key mediator of meconium-induced neutrophil activation
Pediatr Res, 57 (2), 242-7
DOI 10.1203/01.PDR.0000150725.78971.30, PubMed 15585680

Harboe M, Ulvund G, Vien L, Fung M, Mollnes TE (2004)
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
Clin Exp Immunol, 138 (3), 439-46
DOI 10.1111/j.1365-2249.2004.02627.x, PubMed 15544620

Heggelund L, Flo T, Berg K, Lien E, Mollnes TE, Ueland T, Aukrust P, Espevik T, Frøland SS (2004)
Soluble toll-like receptor 2 in HIV infection: association with disease progression
AIDS, 18 (18), 2437-9
PubMed 15622324

Hoel TN, Videm V, Baksaas ST, Mollnes TE, Brosstad F, Svennevig JL (2004)
Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery
Perfusion, 19 (3), 177-84
DOI 10.1191/0267659104pf737oa, PubMed 15298426

Lappegård KT, Fung M, Bergseth G, Riesenfeld J, Lambris JD, Videm V, Mollnes TE (2004)
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation
Ann Thorac Surg, 77 (3), 932-41
DOI 10.1016/S0003-4975(03)01519-4, PubMed 14992902

Lappegård KT, Fung M, Bergseth G, Riesenfeld J, Mollnes TE (2004)
Artificial surface-induced cytokine synthesis: effect of heparin coating and complement inhibition
Ann Thorac Surg, 78 (1), 38-44; discussion 44-5
DOI 10.1016/j.athoracsur.2004.02.005, PubMed 15223398

Lappegård KT, Hvassing T, Mollnes TE (2004)
Statin drugs do not affect serum complement activation in vitro
Scand J Immunol, 60 (1-2), 178-83
DOI 10.1111/j.0300-9475.2004.01439.x, PubMed 15238087

Lindenskov PH, Castellheim A, Aamodt G, Saugstad OD, Mollnes TE (2004)
Complement activation reflects severity of meconium aspiration syndrome in newborn pigs
Pediatr Res, 56 (5), 810-7
DOI 10.1203/01.PDR.0000141983.32466.2A, PubMed 15347770

Pedersen ED, Waje-Andreassen U, Vedeler CA, Aamodt G, Mollnes TE (2004)
Systemic complement activation following human acute ischaemic stroke
Clin Exp Immunol, 137 (1), 117-22
DOI 10.1111/j.1365-2249.2004.02489.x, PubMed 15196251

Seelen MA, Roos A, Wieslander J, Mollnes TE, Sjöholm AG, Wurzner R, Loos M, Tedesco F, Sim RB, Garred P, Alexopoulos E, Turner MW, Daha MR (2004)
Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
J Immunol Methods, 296 (1-2), 187-98
DOI 10.1016/j.jim.2004.11.016, PubMed 15680163

Sprong T, Møller AS, Bjerre A, Wedege E, Kierulf P, van der Meer JW, Brandtzaeg P, van Deuren M, Mollnes TE (2004)
Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide
Infect Immun, 72 (6), 3344-9
DOI 10.1128/IAI.72.6.3344-3349.2004, PubMed 15155639

Sund S, Reisaeter AV, Scott H, Mollnes TE, Hovig T (2004)
Glomerular monocyte/macrophage influx correlates strongly with complement activation in 1-week protocol kidney allograft biopsies
Clin Nephrol, 62 (2), 121-30
DOI 10.5414/cnp62121, PubMed 15356969

Trøseid M, Lappegård KT, Claudi T, Damås JK, Mørkrid L, Brendberg R, Mollnes TE (2004)
Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
Eur Heart J, 25 (4), 349-55
DOI 10.1016/j.ehj.2003.12.006, PubMed 14984925

Publications 2003

Castellheim A, Lindenskov PH, Pharo A, Fung M, Saugstad OD, Mollnes TE (2003)
Meconium is a potent activator of complement in human serum and in piglets
Pediatr Res, 55 (2), 310-8
DOI 10.1203/01.PDR.0000100902.76021.8E, PubMed 14605246

Fiane AE, Videm V, Lingaas PS, Heggelund L, Nielsen EW, Geiran OR, Fung M, Mollnes TE (2003)
Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair
Circulation, 108 (7), 849-56
DOI 10.1161/01.CIR.0000084550.16565.01, PubMed 12900342

Fung M, Lu M, Fure H, Sun W, Sun C, Shi NY, Dou Y, Su J, Swanson X, Mollnes TE (2003)
Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage
Clin Exp Immunol, 133 (2), 160-9
DOI 10.1046/j.1365-2249.2003.02213.x, PubMed 12869020

Heggelund L, Mollnes TE, Ueland T, Christophersen B, Aukrust P, Frøland SS (2003)
Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy
J Acquir Immune Defic Syndr, 32 (4), 354-61
DOI 10.1097/00126334-200304010-00002, PubMed 12640191

Kirschfink M, Mollnes TE (2003)
Modern complement analysis
Clin Diagn Lab Immunol, 10 (6), 982-9
DOI 10.1128/cdli.10.6.982-989.2003, PubMed 14607856

Mollnes TE (2003)
Measurement of complement activation
Methods Mol Biol, 225, 69-75
DOI 10.1385/1-59259-374-7:69, PubMed 12769475

Mollnes TE, Fiane AE (2003)
Perspectives on complement in xenotransplantation
Mol Immunol, 40 (2-4), 135-43
DOI 10.1016/s0161-5890(03)00106-8, PubMed 12914819

Risnes I, Ueland T, Aukrust P, Lundblad R, Baksaas ST, Mollnes TE, Svennevig JL (2003)
Complement activation and cytokine and chemokines release during mediastinitis
Ann Thorac Surg, 75 (3), 981-5
DOI 10.1016/s0003-4975(02)04556-3, PubMed 12645727

Risnes I, Ueland T, Lundblad R, Mollnes TE, Baksaas ST, Aukrust P, Svennevig JL (2003)
Changes in the cytokine network and complement parameters during open heart surgery
Interact Cardiovasc Thorac Surg, 2 (1), 19-24
DOI 10.1016/S1569-9293(02)00088-9, PubMed 17669979

Solheim BG, Flesland O, Brosstad F, Mollnes TE, Seghatchian J (2003)
Improved preservation of coagulation factors after pre-storage leukocyte depletion of whole blood
Transfus Apher Sci, 29 (2), 133-9
DOI 10.1016/S1473-0502(03)00117-4, PubMed 12941351

Sprong T, Brandtzaeg P, Fung M, Pharo AM, Høiby EA, Michaelsen TE, Aase A, van der Meer JW, van Deuren M, Mollnes TE (2003)
Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis
Blood, 102 (10), 3702-10
DOI 10.1182/blood-2003-03-0703, PubMed 12881318

Sund S, Hovig T, Reisaeter AV, Scott H, Bentdal Ø, Mollnes TE (2003)
Complement activation in early protocol kidney graft biopsies after living-donor transplantation
Transplantation, 75 (8), 1204-13
DOI 10.1097/01.TP.0000062835.30165.2C, PubMed 12717204

Tølløfsrud S, Noddeland H, Svennevig JL, Bentsen G, Mollnes TE, Solheim BG (2003)
Universal fresh frozen plasma (Uniplas): a safe product in open-heart surgery
Intensive Care Med, 29 (10), 1736-43
DOI 10.1007/s00134-003-1952-3, PubMed 12955185

Publications 2002

Bjerre A, Brusletto B, Mollnes TE, Fritzsønn E, Rosenqvist E, Wedege E, Namork E, Kierulf P, Brandtzaeg P (2002)
Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant
J Infect Dis, 185 (2), 220-8
DOI 10.1086/338269, PubMed 11807696

Evgenov OV, Evgenov NV, Mollnes TE, Bjertnaes LJ (2002)
Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep
Eur Respir J, 20 (4), 957-64
DOI 10.1183/09031936.02.00932001, PubMed 12412689

Fiane AE, Geiran OR, Mollnes TE (2002)
[Ethical aspects of xenotransplantation]
Tidsskr Nor Laegeforen, 122 (4), 397-400
PubMed 11915670

Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris JD (2002)
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation
Blood, 100 (5), 1869-77
PubMed 12176911

Mollnes TE, Fiane AE (2002)
Role of complement in xenotransplantation
Allergy, 57 Suppl 72, 75-8
DOI 10.1034/j.1398-9995.57.s72.10.x, PubMed 12144560

Mollnes TE, Song WC, Lambris JD (2002)
Complement in inflammatory tissue damage and disease
Trends Immunol, 23 (2), 61-4
DOI 10.1016/s1471-4906(01)02129-9, PubMed 11929126

Nielsen EW, Mollnes TE, Harlan JM, Winn RK (2002)
C1-inhibitor reduces the ischaemia-reperfusion injury of skeletal muscles in mice after aortic cross-clamping
Scand J Immunol, 56 (6), 588-92
DOI 10.1046/j.1365-3083.2002.01173.x, PubMed 12472670

Saethre M, Sølvik UØ, Haraldsen G, Fiane AE, Boretti E, Thorsby E, Platt JL, Mollnes TE (2002)
Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies
Xenotransplantation, 9 (5), 350-8
DOI 10.1034/j.1399-3089.2002.01094.x, PubMed 12199866

Scholz T, Solberg R, Okkenhaug C, Videm V, Gallimore MJ, Mathisen O, Mollnes TE, Bergan A, Søreide O, Klintmalm GB, Aasen AO (2002)
The significance of heparin-coated veno-venous bypass circuits in liver transplantation
Perfusion, 17 (1), 45-50
DOI 10.1191/0267659102pf523oa, PubMed 11817529

Publications 2001

Aukrust P, Gullestad L, Lappegård KT, Ueland T, Aass H, Wikeby L, Simonsen S, Frøland SS, Mollnes TE (2001)
Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
Circulation, 104 (13), 1494-500
DOI 10.1161/hc3801.096353, PubMed 11571242

Kirschfink M, Mollnes TE (2001)
C1-inhibitor: an anti-inflammatory reagent with therapeutic potential
Expert Opin Pharmacother, 2 (7), 1073-83
DOI 10.1517/14656566.2.7.1073, PubMed 11583058

Lamark T, Ingebrigtsen M, Bjørnstad C, Melkko T, Mollnes TE, Nielsen EW (2001)
Expression of active human C1 inhibitor serpin domain in Escherichia coli
Protein Expr Purif, 22 (2), 349-58
DOI 10.1006/prep.2001.1445, PubMed 11437612

Mellembakken JR, Høgåsen K, Mollnes TE, Hack CE, Abyholm T, Videm V (2001)
Increased systemic activation of neutrophils but not complement in preeclampsia
Obstet Gynecol, 97 (3), 371-4
DOI 10.1016/s0029-7844(00)01179-0, PubMed 11239639

Scholz T, Solberg R, Okkenhaug C, Videm V, Gallimore MJ, Mathisen O, Pedersen T, Mollnes TE, Bergan A, Søreide O, Klintmalm GB, Aasen AO (2001)
Veno-venous bypass in liver transplantation: heparin-coated perfusion circuits reduce the activation of humoral defense systems in an in vitro model
Perfusion, 16 (4), 285-92
DOI 10.1177/026765910101600404, PubMed 11486847

Sølvik UO, Haraldsen G, Fiane AE, Boretti E, Thorsby E, Mollnes TE (2001)
C1-inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells
Transplant Proc, 33 (1-2), 789-90
DOI 10.1016/s0041-1345(00)02256-9, PubMed 11267073

Sølvik UØ, Haraldsen G, Fiane AE, Boretti E, Lambris JD, Fung M, Thorsby E, Mollnes TE (2001)
Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated
Transplantation, 72 (12), 1967-73
DOI 10.1097/00007890-200112270-00017, PubMed 11773897

Ulvestad E, Berentsen S, Mollnes TE (2001)
Acute phase haemolysis in chronic cold agglutinin disease
Scand J Immunol, 54 (1-2), 239-42
DOI 10.1046/j.1365-3083.2001.00960.x, PubMed 11439172

Publications 2000

Bergseth G, Lappegård KT, Videm V, Mollnes TE (2000)
A novel enzyme immunoassay for plasma thrombospondin. Comparison with beta-thromboglobulin as platelet activation marker in vitro and in vivo
Thromb Res, 99 (1), 41-50
DOI 10.1016/s0049-3848(00)00226-7, PubMed 10904102

Fiane AE, Mollnes TE, Degré M (2000)
Pig endogenous retrovirus--a threat to clinical xenotransplantation?
APMIS, 108 (4), 241-50
DOI 10.1034/j.1600-0463.2000.d01-51.x, PubMed 10843410

Fiane AE, Videm V, Lambris JD, Geiran OR, Svennevig JL, Mollnes TE (2000)
Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model
Transplant Proc, 32 (5), 899-900
DOI 10.1016/s0041-1345(00)01028-9, PubMed 10936264

Myhr KM, Sadallah S, Mollnes TE, Meri S, Nyland HI, Schifferli J, Vedeler CA (2000)
Interferon-alpha2a effects on complement activation and regulation in MS patients
Acta Neurol Scand, 101 (1), 30-5
DOI 10.1034/j.1600-0404.2000.00013.x, PubMed 10660149

Odegård A, Lundbom J, Myhre HO, Hatlinghus S, Bergh K, Waage A, Bjerve KS, Mollnes TE, Aadahl P, Lie TA, Videm V (2000)
The inflammatory response following treatment of abdominal aortic aneurysms: a comparison between open surgery and endovascular repair
Eur J Vasc Endovasc Surg, 19 (5), 536-44
DOI 10.1053/ejvs.1999.1092, PubMed 10828237

Olsson P, Sanchez J, Mollnes TE, Riesenfeld J (2000)
On the blood compatibility of end-point immobilized heparin
J Biomater Sci Polym Ed, 11 (11), 1261-73
DOI 10.1163/156856200744192, PubMed 11263812

Ødegård A, Lundbom J, Myhre HO, Bergh K, Hatlinghus S, Waage A, Bjerve KS, Mollnes TE, Videm V, Videm V (2000)
The Inflammatory response following treatment of abdominal aortic aneurysms: a comparison between open surgery and endovascular repair
Harcourt Publishers, [London], S. [536]-544
BIBSYS 01055131x

Publications 1999

Baksaas ST, Flom-Halvorsen HI, Ovrum E, Videm V, Mollnes TE, Brosstad F, Svennevig JL (1999)
Leucocyte filtration during cardiopulmonary reperfusion in coronary artery bypass surgery
Perfusion, 14 (2), 107-17
DOI 10.1177/026765919901400204, PubMed 10338322

Baksaas ST, Videm V, Fosse E, Karlsen H, Pedersen T, Mollnes TE, Hagve TA, Svennevig JL (1999)
In vitro evaluation of new surface coatings for extracorporeal circulation
Perfusion, 14 (1), 11-9
DOI 10.1177/026765919901400103, PubMed 10074642

Baksaas ST, Videm V, Pedersen T, Karlsen H, Mollnes TE, Brosstad F, Svennevig JL (1999)
Comparison of three oxygenator-coated and one total-circuit-coated extracorporeal devices
Perfusion, 14 (2), 119-27
DOI 10.1177/026765919901400205, PubMed 10338323

Fiane AE, Mollnes TE (1999)
[Transplantation from animal to man]
Tidsskr Nor Laegeforen, 119 (28), 4213-8
PubMed 10668386

Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD (1999)
Prolongation of ex vivo-perfused pig xenograft survival by the complement inhibitor Compstatin
Transplant Proc, 31 (1-2), 934-5
DOI 10.1016/s0041-1345(98)01844-2, PubMed 10083413

Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD (1999)
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts
Xenotransplantation, 6 (1), 52-65
DOI 10.1034/j.1399-3089.1999.00007.x, PubMed 10355733

Fiane AE, Videm V, Johansen HT, Mellbye OJ, Nielsen EW, Mollnes TE (1999)
C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model
Immunopharmacology, 42 (1-3), 231-43
DOI 10.1016/s0162-3109(99)00008-9, PubMed 10408384

Fiane AE, Videm V, Mollnes TE, Høgâsen K, Hovig T (1999)
Inhibition of platelet aggregation by the GPIIb/IIIa antagonist reopro does not significantly prolong xenograft survival in an ex vivo model
Transpl Int, 12 (5), 323-33
DOI 10.1007/s001470050235, PubMed 10551997

Krohn CD, Reikerås O, Mollnes TE (1999)
Complement activation and increased systemic and pulmonary vascular resistance indices during infusion of postoperatively drained untreated blood
Br J Anaesth, 82 (1), 47-51
DOI 10.1093/bja/82.1.47, PubMed 10325835

Mollnes TE, Fiane AE (1999)
Xenotransplantation: how to overcome the complement obstacle?
Mol Immunol, 36 (4-5), 269-76
DOI 10.1016/s0161-5890(99)00050-4, PubMed 10403480

Mollnes TE, Haga HJ, Brun JG, Nielsen EW, Sjöholm A, Sturfeldt G, Mårtensson U, Bergh K, Rekvig OP (1999)
Complement activation in patients with systemic lupus erythematosus without nephritis
Rheumatology (Oxford), 38 (10), 933-40
DOI 10.1093/rheumatology/38.10.933, PubMed 10534542

Mollnes TE, Videm V, Christiansen D, Bergseth G, Riesenfeld J, Hovig T (1999)
Platelet compatibility of an artificial surface modified with functionally active heparin
Thromb Haemost, 82 (3), 1132-6
PubMed 10494777

Neeleman C, Geelen SP, Aerts PC, Daha MR, Mollnes TE, Roord JJ, Posthuma G, van Dijk H, Fleer A (1999)
Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H
Infect Immun, 67 (9), 4517-24
DOI 10.1128/IAI.67.9.4517-4524.1999, PubMed 10456894

Videm V, Mollnes TE, Bergh K, Fosse E, Mohr B, Hagve TA, Aasen AO, Svennevig JL (1999)
Heparin-coated cardiopulmonary bypass equipment. II. Mechanisms for reduced complement activation in vivo
J Thorac Cardiovasc Surg, 117 (4), 803-9
DOI 10.1016/S0022-5223(99)70302-8, PubMed 10096977

Videm V, Mollnes TE, Fosse E, Mohr B, Bergh K, Hagve TA, Aasen AO, Svennevig JL (1999)
Heparin-coated cardiopulmonary bypass equipment. I. Biocompatibility markers and development of complications in a high-risk population
J Thorac Cardiovasc Surg, 117 (4), 794-802
DOI 10.1016/s0022-5223(99)70301-6, PubMed 10096976

Publications 1998

Arnestad JP, Hyllner M, Bengtson JP, Tylman M, Mollnes TE, Bengtsson A (1998)
Removal of activated complement from shed blood: comparison of high- and low-dilutional haemofiltration
Acta Anaesthesiol Scand, 42 (7), 811-5
DOI 10.1111/j.1399-6576.1998.tb05327.x, PubMed 9698958

Baksaas ST, Videm V, Mollnes TE, Tølløfsrud S, Hetland G, Pedersen T, Svennevig JL (1998)
Leucocyte filtration during cardiopulmonary bypass hardly changed leucocyte counts and did not influence myeloperoxidase, complement, cytokines or platelets
Perfusion, 13 (6), 429-36
DOI 10.1177/026765919801300606, PubMed 9881390

Bengtsson A, Redl H, Schlag G, Högåsen K, Götze O, Mollnes TE (1998)
Anti-TNF treatment of baboons with sepsis reduces TNF-alpha, IL-6 and IL-8, but not the degree of complement activation
Scand J Immunol, 48 (5), 509-14
DOI 10.1046/j.1365-3083.1998.00433.x, PubMed 9822260

Fiane AE, Videm V, Foerster A, Scholz T, Perdersen TH, Karlsen H, Svennevig JL, Geiran OR, Aasen AO, Mollnes TE (1998)
An ex vivo perfusion model to evaluate hyperacute rejection in a discordant pig-to-human combination
Eur Surg Res, 30 (5), 341-51
DOI 10.1159/000008597, PubMed 9731103

Fiane AE, Videm V, Mellbye OJ, Foerster A, Geiran OR, Gladhaug IP, Svennevig JL, Mollnes TE (1998)
Immunoglobulin prolongs survival of pig kidneys perfused ex vivo with human blood
Scand J Immunol, 47 (6), 568-74
DOI 10.1046/j.1365-3083.1998.00341.x, PubMed 9652825

Fosse E, Pillgram-Larsen J, Svennevig JL, Nordby C, Skulberg A, Mollnes TE, Abdelnoor M (1998)
Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma
Injury, 29 (7), 509-14
DOI 10.1016/s0020-1383(98)00113-2, PubMed 10193492

Hetland G, Mollnes TE, Bergh K, Høgåsen K, Bergerud UE, Solheim BG (1998)
Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4
Transfusion, 38 (1), 16-23
DOI 10.1046/j.1537-2995.1998.38198141493.x, PubMed 9482389

Høgåsen K, Mollnes TE, Nürnberger W, Pausa M, Fukumori Y, Tedesco F (1998)
Characterization of soluble terminal complement complex assembled in C8beta-deficient plasma and serum
Scand J Immunol, 48 (3), 261-8
DOI 10.1046/j.1365-3083.1998.00390.x, PubMed 9743210

Krohn CD, Reikerås O, Mollnes TE, Aasen AO (1998)
Complement activation and release of interleukin-6 and tumour necrosis factor-alpha in drained and systemic blood after major orthopaedic surgery
Eur J Surg, 164 (2), 103-8
DOI 10.1080/110241598750004742, PubMed 9537716

Mollnes TE (1998)
Complement and biocompatibility
Vox Sang, 74 Suppl 2, 303-7
DOI 10.1111/j.1423-0410.1998.tb05435.x, PubMed 9704460

Mollnes TE, Høgåsen K, De Carolis C, Vaquero E, Nielsen EW, Fontana L, Perricone R (1998)
High-dose intravenous immunoglobulin treatment activates complement in vivo
Scand J Immunol, 48 (3), 312-7
DOI 10.1046/j.1365-3083.1998.00386.x, PubMed 9743219

Nielsen EW, Fure H, Winge P, Mollnes TE (1998)
Identification of a C-->T mutation in the reactive-site coding region of the C1-inhibitor gene and its detection by an improved mutation-specific polymerase chain reaction method
Scand J Immunol, 47 (3), 273-6
DOI 10.1046/j.1365-3083.1998.00290.x, PubMed 9519866

Nordang L, Laurent C, Mollnes TE (1998)
Complement activation in sudden deafness
Arch Otolaryngol Head Neck Surg, 124 (6), 633-6
DOI 10.1001/archotol.124.6.633, PubMed 9639471

Solheim BG, Bergerud UE, Kjeldsen-Kragh J, Brosstad F, Mollnes TE, Högman CF, Eriksson L, Schutz R (1998)
Improved blood preservation with 0.5CPD erythro-sol. Coagulation factor VIII activity and erythrocyte quality after delayed separation of blood
Vox Sang, 74 (3), 168-75
DOI 10.1046/j.1423-0410.1998.7430168.x, PubMed 9595644

Publications 1997

Baksaas ST, Videm V, Mollnes TE, Pedersen T, Karlsen H, Svennevig JL (1997)
Effects on complement, granulocytes and platelets of a leukocyte-depletion filter during in vitro extracorporeal circulation
Scand Cardiovasc J, 31 (2), 73-7
DOI 10.3109/14017439709058072, PubMed 9211593

Fosse E, Thelin S, Svennevig JL, Jansen P, Mollnes TE, Hack E, Venge P, Moen O, Brockmeier V, Dregelid E, Haldén E, Hagman L, Videm V, Pedersen T, Mohr B (1997)
Duraflo II coating of cardiopulmonary bypass circuits reduces complement activation, but does not affect the release of granulocyte enzymes : a European multicentre study
Eur J Cardiothorac Surg, 11 (2), 320-7
DOI 10.1016/s1010-7940(96)01062-7, PubMed 9080162

Fure H, Nielsen EW, Hack CE, Mollnes TE (1997)
A neoepitope-based enzyme immunoassay for quantification of C1-inhibitor in complex with C1r and C1s
Scand J Immunol, 46 (6), 553-7
DOI 10.1046/j.1365-3083.1997.d01-168.x, PubMed 9420617

Garred P, Mollnes TE (1997)
Immobilized heparin inhibits the increase in leukocyte surface expression of adhesion molecules
Artif Organs, 21 (4), 293-9
DOI 10.1111/j.1525-1594.1997.tb00364.x, PubMed 9096801

Hetland G, Moen O, Bergh K, Högäsen K, Hack CE, Mollnes TE, Fosse E (1997)
Both plasma- and leukocyte-associated C5a are essential for assessment of C5a generation in vivo
Ann Thorac Surg, 63 (4), 1076-80
DOI 10.1016/s0003-4975(96)01255-6, PubMed 9124908

Homann C, Varming K, Høgåsen K, Mollnes TE, Graudal N, Thomsen AC, Garred P (1997)
Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality
Gut, 40 (4), 544-9
DOI 10.1136/gut.40.4.544, PubMed 9176087

Moen O, Høgåsen K, Fosse E, Dregelid E, Brockmeier V, Venge P, Harboe M, Mollnes TE (1997)
Attenuation of changes in leukocyte surface markers and complement activation with heparin-coated cardiopulmonary bypass
Ann Thorac Surg, 63 (1), 105-11
DOI 10.1016/s0003-4975(96)00743-6, PubMed 8993250

Mollnes TE (1997)
Biocompatibility: complement as mediator of tissue damage and as indicator of incompatibility
Exp Clin Immunogenet, 14 (1), 24-9
PubMed 9187920

Mollnes TE, Andreassen IH, Høgåsen K, Hack CE, Harboe M (1997)
Effect of whole and fractionated intravenous immunoglobulin on complement in vitro
Mol Immunol, 34 (10), 719-29
DOI 10.1016/s0161-5890(97)00091-6, PubMed 9430199

Pedersen TH, Videm V, Svennevig JL, Karlsen H, Ostbakk RW, Jensen O, Mollnes TE (1997)
Extracorporeal membrane oxygenation using a centrifugal pump and a servo regulator to prevent negative inlet pressure
Ann Thorac Surg, 63 (5), 1333-9
DOI 10.1016/s0003-4975(97)00098-2, PubMed 9146324

Samdal F, Mollnes TE, Amland PF, Truedsson L (1997)
Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique
Plast Reconstr Surg, 99 (6), 1591-4; discussion 1595-6
DOI 10.1097/00006534-199705000-00017, PubMed 9145127

Publications 1996

Bengtsson A, Redl H, Schlag G, Mollnes TE, Högåsen K (1996)
Effects on complement activation and cytokine (TNF-alpha and IL-8) release of infusion of anti-TNF-antibodies or a xanthine derivative (HWA 138) in septic baboons
Acta Anaesthesiol Scand, 40 (2), 244-9
DOI 10.1111/j.1399-6576.1996.tb04427.x, PubMed 8848926

Brandtzaeg P, Høgåsen K, Kierulf P, Mollnes TE (1996)
The excessive complement activation in fulminant meningococcal septicemia is predominantly caused by alternative pathway activation
J Infect Dis, 173 (3), 647-55
DOI 10.1093/infdis/173.3.647, PubMed 8627028

Bringeland EA, Ramstad K, Nielsen EW, Andersen L, Amundsen W, Mollnes TE (1996)
[Reduced blood utilization in hip arthroplasty. Introduction of a blood preservation program]
Tidsskr Nor Laegeforen, 116 (1), 30-3
PubMed 8553331

Gong J, Larsson R, Ekdahl KN, Mollnes TE, Nilsson U, Nilsson B (1996)
Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model
J Clin Immunol, 16 (4), 222-9
DOI 10.1007/BF01541228, PubMed 8840224

Høgåsen K, Homann C, Mollnes TE, Graudal N, Høgåsen AK, Hasselqvist P, Thomsen AC, Garred P (1996)
Serum clusterin and vitronectin in alcoholic cirrhosis
Liver, 16 (2), 140-6
DOI 10.1111/j.1600-0676.1996.tb00719.x, PubMed 8740849

Mellbye OJ, Shen Y, Høgåsen K, Mollnes TE, Førre O (1996)
Adhesion molecule expression and complement activation in vessel walls in synovial tissue from patients with chronic inflammatory joint disease
Clin Rheumatol, 15 (5), 441-7
DOI 10.1007/BF02229640, PubMed 8894356

Moen O, Fosse E, Bråten J, Andersson C, Høgåsen K, Mollnes TE, Venge P, Kierulf P (1996)
Differences in blood activation related to roller/centrifugal pumps and heparin-coated/uncoated surfaces in a cardiopulmonary bypass model circuit
Perfusion, 11 (2), 113-23
DOI 10.1177/026765919601100205, PubMed 8740352

Moen O, Fosse E, Dregelid E, Brockmeier V, Andersson C, Høgåsen K, Venge P, Mollnes TE, Kierulf P (1996)
Centrifugal pump and heparin coating improves cardiopulmonary bypass biocompatibility
Ann Thorac Surg, 62 (4), 1134-40
DOI 10.1016/0003-4975(96)00492-4, PubMed 8823102

Mollnes TE, Harboe M (1996)
Clinical immunology
BMJ, 312 (7044), 1465-9
DOI 10.1136/bmj.312.7044.1465, PubMed 8664630

Nielsen EW, Gran JT, Straume B, Mellbye OJ, Johansen HT, Mollnes TE (1996)
Hereditary angio-oedema: new clinical observations and autoimmune screening, complement and kallikrein-kinin analyses
J Intern Med, 239 (2), 119-30
DOI 10.1046/j.1365-2796.1996.418764000.x, PubMed 8568479

Nielsen EW, Johansen HT, Høgåsen K, Wuillemin W, Hack CE, Mollnes TE (1996)
Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema
Scand J Immunol, 44 (2), 185-92
DOI 10.1046/j.1365-3083.1996.d01-298.x, PubMed 8711433

Nielsen EW, Johansen HT, Høgåsen K, Wuillemin W, Hack CE, Mollnes TE (1996)
Activation of the complement, coagulation, fibrinolytic and kallikrein-kinin systems during attacks of hereditary angioedema
Immunopharmacology, 33 (1-3), 359-60
DOI 10.1016/0162-3109(96)00085-9, PubMed 8856186

Ovrum E, Fosse E, Mollnes TE, Am Holen E, Tangen G, Abdelnoor M, Ringdal MA, Oystese R, Venge P (1996)
Complete heparin-coated cardiopulmonary bypass and low heparin dose reduce complement and granulocyte activation
Eur J Cardiothorac Surg, 10 (1), 54-60
DOI 10.1016/s1010-7940(96)80266-1, PubMed 8776186

Radillo O, Nocera A, Leprini A, Barocci S, Mollnes TE, Pocecco M, Pausa M, Valente U, Betterle C, Tedesco F (1996)
Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic
Clin Immunol Immunopathol, 79 (3), 217-23
DOI 10.1006/clin.1996.0071, PubMed 8635278

Svennevig JL, Tølløfsrud S, Kongsgaard U, Noddeland H, Mohr B, Ozer M, Mollnes TE (1996)
Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement
Perfusion, 11 (4), 326-32
DOI 10.1177/026765919601100405, PubMed 8884861

Saatvedt K, Lindberg H, Geiran OR, Michelsen S, Pedersen T, Seem E, Mollnes TE (1996)
Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement
Cardiovasc Res, 31 (4), 596-602
PubMed 8689651

Saatvedt K, Lindberg H, Michelsen S, Mollnes TE (1996)
Release of interleukin 6 and activation of complement during and after paediatric cardiopulmonary bypass. Effect of autotransfusion of shed mediastinal blood and ultrafiltration
Cytokine, 8 (5), 417-20
DOI 10.1006/cyto.1996.0057, PubMed 8726671

Publications 1995

Abrahamsen TG, Mollnes TE, Vandvik B (1995)
Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis
Biol Neonate, 68 (2), 153-6
DOI 10.1159/000244231, PubMed 8534775

Fiane AE, Videm V, Scholz T, Pedersen T, Karlsen H, Geiran O, Foerster A, Mollnes T, Aasen AO, Svennevig J (1995)
Ex vivo model for xenotransplantation
Transplant Proc, 27 (6), 3560-1
PubMed 8540102

Høgåsen K, Jansen JH, Mollnes TE, Hovdenes J, Harboe M (1995)
Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency
J Clin Invest, 95 (3), 1054-61
DOI 10.1172/JCI117751, PubMed 7883953

Høgåsen K, Mollnes TE, Harboe M, Götze O, Hammer HB, Oppermann M (1995)
Terminal complement pathway activation and low lysis inhibitors in rheumatoid arthritis synovial fluid
J Rheumatol, 22 (1), 24-8
PubMed 7535360

Kjeldsen-Kragh J, Mellbye OJ, Haugen M, Mollnes TE, Hammer HB, Sioud M, Førre O (1995)
Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet
Scand J Rheumatol, 24 (2), 85-93
DOI 10.3109/03009749509099290, PubMed 7747149

Kuroki K, Roy S, Laerum F, Mollnes TE, Solheim BG, Videm V (1995)
Complement activation by angiographic catheters in vitro
J Vasc Interv Radiol, 6 (5), 819-26
DOI 10.1016/s1051-0443(95)71193-9, PubMed 8541691

Moen O, Fosse E, Brockmeier V, Andersson C, Mollnes TE, Høgåsen K, Venge P (1995)
Disparity in blood activation by two different heparin-coated cardiopulmonary bypass systems
Ann Thorac Surg, 60 (5), 1317-23
DOI 10.1016/0003-4975(95)00777-i, PubMed 8526620

Mollnes TE, Høgåsen K, Hoaas BF, Michaelsen TE, Garred P, Harboe M (1995)
Inhibition of complement-mediated red cell lysis by immunoglobulins is dependent on the IG isotype and its C1 binding properties
Scand J Immunol, 41 (5), 449-56
DOI 10.1111/j.1365-3083.1995.tb03591.x, PubMed 7725063

Mollnes TE, Riesenfeld J, Garred P, Nordström E, Høgåsen K, Fosse E, Götze O, Harboe M (1995)
A new model for evaluation of biocompatibility: combined determination of neoepitopes in blood and on artificial surfaces demonstrates reduced complement activation by immobilization of heparin
Artif Organs, 19 (9), 909-17
DOI 10.1111/j.1525-1594.1995.tb02450.x, PubMed 8687297

Nielsen EW, Johansen HT, Gaudesen O, Osterud B, Olsen JO, Høgåsen K, Hack CE, Mollnes TE (1995)
C3 is activated in hereditary angioedema, and C1/C1-inhibitor complexes rise during physical stress in untreated patients
Scand J Immunol, 42 (6), 679-85
DOI 10.1111/j.1365-3083.1995.tb03711.x, PubMed 8552992

Ovrum E, Mollnes TE, Fosse E, Holen EA, Tangen G, Abdelnoor M, Ringdal MA, Oystese R, Venge P (1995)
Complement and granulocyte activation in two different types of heparinized extracorporeal circuits
J Thorac Cardiovasc Surg, 110 (6), 1623-32
DOI 10.1016/s0022-5223(95)70023-4, PubMed 8523872

Ovrum E, Mollnes TE, Fosse E, Holen EA, Tangen G, Ringdal MA, Videm V (1995)
High and low heparin dose with heparin-coated cardiopulmonary bypass: activation of complement and granulocytes
Ann Thorac Surg, 60 (6), 1755-61
DOI 10.1016/0003-4975(95)00763-6, PubMed 8787476

Riesenfeld J, Olsson P, Sanchez J, Mollnes TE (1995)
Surface modification with functionally active heparin
Med Device Technol, 6 (2), 24-31
PubMed 10155375

Røger M, Høgåsen K, Holme PA, Halstensen TS, Mollnes TE, Hovig T (1995)
The Fluid-phase SC5b-9 Terminal Complement Complex Binds to the GPIIb/IIIa Complex of Thrombin-stimulated Human Blood Platelets Inhibiting Platelet Aggregation
Platelets, 6 (3), 160-8
DOI 10.3109/09537109509013269, PubMed 21043620

Samdal F, Aasen AO, Mollnes TE, Høgåsen K, Amland PF (1995)
Effect of syringe-assisted liposuction on activation of cascade systems and circulating cells when using the superwet or tumescent technique
Ann Plast Surg, 35 (3), 242-8
DOI 10.1097/00000637-199509000-00004, PubMed 7503516

Saatvedt K, Lindberg H, Geiran OR, Michelsen S, Aasen AO, Pedersen T, Mollnes TE (1995)
Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass in children
Scand J Clin Lab Invest, 55 (1), 79-86
DOI 10.3109/00365519509075381, PubMed 7624740

Publications 1994

Busund R, Rønning G, Lindsetmo RO, Busund LT, Mollnes TE, Konopski Z, Revhaug A (1994)
The effects of plasma and albumin infusion on organ function and sepsis markers in experimental gram-negative sepsis
Shock, 2 (6), 402-7
DOI 10.1097/00024382-199412000-00003, PubMed 7743369

Fosse E, Moen O, Johnson E, Semb G, Brockmeier V, Mollnes TE, Fagerhol MK, Venge P (1994)
Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass
Ann Thorac Surg, 58 (2), 472-7
DOI 10.1016/0003-4975(94)92231-4, PubMed 8067851

Høgåsen K, Mollnes TE, Brandtzaeg P (1994)
Low levels of vitronectin and clusterin in acute meningococcal disease are closely associated with formation of the terminal-complement complex and the vitronectin-thrombin-antithrombin complex
Infect Immun, 62 (11), 4874-80
DOI 10.1128/iai.62.11.4874-4880.1994, PubMed 7523299

Mellbye OJ, Mollnes TE, Steen LS (1994)
IgG subclass distribution and complement activation ability of autoantibodies to neutrophil cytoplasmic antigens (ANCA)
Clin Immunol Immunopathol, 70 (1), 32-9
DOI 10.1006/clin.1994.1007, PubMed 8261667

Moen O, Fosse E, Bråten J, Andersson C, Fagerhol MK, Venge P, Høgåsen K, Mollnes TE (1994)
Roller and centrifugal pumps compared in vitro with regard to haemolysis, granulocyte and complement activation
Perfusion, 9 (2), 109-17
DOI 10.1177/026765919400900205, PubMed 7919596

Mollnes TE, Fosse E (1994)
The complement system in trauma-related and ischemic tissue damage: a brief review
Shock, 2 (4), 301-10
DOI 10.1097/00024382-199410000-00012, PubMed 7757525

Nielsen EW, Johansen HT, Holt J, Mollnes TE (1994)
C1 inhibitor and diagnosis of hereditary angioedema in newborns
Pediatr Res, 35 (2), 184-7
DOI 10.1203/00006450-199402000-00012, PubMed 8165053

Nielsen EW, Johansen HT, Straume B, Mollnes TE (1994)
Effect of time, temperature and additives on a functional assay of C1 inhibitor
J Immunol Methods, 173 (2), 245-51
DOI 10.1016/0022-1759(94)90303-4, PubMed 8046257

Nielsen EW, Stenberg PA, Einarsen E, Johansen HT, Mollnes TE (1994)
[Angioedema associated with ACE inhibitors]
Tidsskr Nor Laegeforen, 114 (7), 804-6
PubMed 8009499

Røger M, Høgåsen K, Mollnes TE, Hovig T (1994)
The Membrane Glycoprotein IIb/IIIa Complex Mediates Deposition of Thrombin-stimulated Blood Platelets on Polystyrene Plastic Under Static Conditions
Platelets, 5 (2), 96-104
DOI 10.3109/09537109409005519, PubMed 21043610

Verduin CM, Jansze M, Hol C, Mollnes TE, Verhoef J, van Dijk H (1994)
Differences in complement activation between complement-resistant and complement-sensitive Moraxella (Branhamella) catarrhalis strains occur at the level of membrane attack complex formation
Infect Immun, 62 (2), 589-95
DOI 10.1128/iai.62.2.589-595.1994, PubMed 8300216

Videm V, Mollnes TE (1994)
Human complement activation by polygeline and dextran 70
Scand J Immunol, 39 (3), 314-20
DOI 10.1111/j.1365-3083.1994.tb03377.x, PubMed 7510416

Publications 1993

Bengtsson A, Redl H, Paul E, Schlag G, Mollnes TE, Davies J (1993)
Complement and leukocyte activation in septic baboons
Circ Shock, 39 (2), 83-8
PubMed 8490996

Garred P, Fosse E, Fagerhol MK, Videm V, Mollnes TE (1993)
Calprotectin and complement activation during major operations with or without cardiopulmonary bypass
Ann Thorac Surg, 55 (3), 694-9
DOI 10.1016/0003-4975(93)90277-o, PubMed 8452432

Garred P, Lyon H, Christoffersen P, Mollnes TE, Tranum-Jensen J (1993)
Deposition of C3, the terminal complement complex and vitronectin in primary biliary cirrhosis and primary sclerosing cholangitis
Liver, 13 (6), 305-10
DOI 10.1111/j.1600-0676.1993.tb00650.x, PubMed 7507546

Hetland G, Mollnes TE, Garred P (1993)
The B chain, but not the A chain, of Ricinus communis activates human complement
Cancer Lett, 75 (1), 59-63
DOI 10.1016/0304-3835(93)90208-q, PubMed 8287382

Høgåsen K, Mollnes TE, Tschopp J, Harboe M (1993)
Quantitation of vitronectin and clusterin. Pitfalls and solutions in enzyme immunoassays for adhesive proteins
J Immunol Methods, 160 (1), 107-15
DOI 10.1016/0022-1759(93)90014-x, PubMed 7680696

Jansen JH, Høgåsen K, Mollnes TE (1993)
Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease)
Am J Pathol, 143 (5), 1356-65
PubMed 8238252

Jensen ET, Kharazmi A, Garred P, Kronborg G, Fomsgaard A, Mollnes TE, Høiby N (1993)
Complement activation by Pseudomonas aeruginosa biofilms
Microb Pathog, 15 (5), 377-88
DOI 10.1006/mpat.1993.1087, PubMed 8015418

Mollnes TE, Nielsen EW, Høgåsen K, Mellbye OJ (1993)
[Complement analysis tests]
Tidsskr Nor Laegeforen, 113 (2), 211-3
PubMed 8430403

Mollnes TE, Redl H, Høgåsen K, Bengtsson A, Garred P, Speilberg L, Lea T, Oppermann M, Götze O, Schlag G (1993)
Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC)
Clin Exp Immunol, 91 (2), 295-300
DOI 10.1111/j.1365-2249.1993.tb05898.x, PubMed 7679061

Opdahl H, Mollnes TE, Naess O (1993)
Effects of high dose E. coli lipopolysaccharide on rabbit lung function, and of subsequent addition of chemotactic granulocyte activators to their isolated, blood-perfused lungs
Acta Anaesthesiol Scand, 37 (4), 334-42
DOI 10.1111/j.1399-6576.1993.tb03725.x, PubMed 8322560

Røger M, Høgåsen K, Solum NO, Mollnes TE, Hovig T (1993)
Vitronectin inhibits blood platelet aggregation
Platelets, 4 (4), 225-9
DOI 10.3109/09537109309013222, PubMed 21043846

Svennevig JL, Geiran OR, Karlsen H, Pedersen T, Mollnes TE, Kongsgard U, Frøysaker T (1993)
Complement activation during extracorporeal circulation. In vitro comparison of Duraflo II heparin-coated and uncoated oxygenator circuits
J Thorac Cardiovasc Surg, 106 (3), 466-72
PubMed 8361189

Publications 1992

Halstensen TS, Mollnes TE, Garred P, Fausa O, Brandtzaeg P (1992)
Surface epithelium related activation of complement differs in Crohn's disease and ulcerative colitis
Gut, 33 (7), 902-8
DOI 10.1136/gut.33.7.902, PubMed 1379568

Hetland G, Mollnes TE, Larsen J, Garred P (1992)
Biocompatibility of white cell filters as evaluated by complement activation
Transfusion, 32 (6), 557-61
DOI 10.1046/j.1537-2995.1992.32692367201.x, PubMed 1502709

Høgåsen K, Mollnes TE, Harboe M (1992)
Heparin-binding properties of vitronectin are linked to complex formation as illustrated by in vitro polymerization and binding to the terminal complement complex
J Biol Chem, 267 (32), 23076-82
PubMed 1385412

Røger M, Halstensen TS, Høgåsen K, Mollnes TE, Solum NO, Hovig T (1992)
Platelets and vitronectin: immunocytochemical localization and platelet interaction with exogenously added vitronectin
Nouv Rev Fr Hematol (1978), 34 (1), 47-54
PubMed 1381819

Videm V, Fosse E, Mollnes TE, Garred P, Svennevig JL (1992)
Time for new concepts about measurement of complement activation by cardiopulmonary bypass?
Ann Thorac Surg, 54 (4), 725-31
DOI 10.1016/0003-4975(92)91018-5, PubMed 1417231

Videm V, Svennevig JL, Fosse E, Semb G, Osterud A, Mollnes TE (1992)
Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations
J Thorac Cardiovasc Surg, 103 (4), 806-13
PubMed 1548925

Publications 1991

Brandtzaeg P, Waage A, Mollnes TE, Oktedalen O, Kierulf P (1991)
Severe human septic shock involves more than tumor necrosis factor
Prog Clin Biol Res, 367, 25-42
PubMed 1924430

Hetland G, Garred P, Mollnes TE, Størvold G (1991)
The use of flow cytometry to detect the biosynthesis of complement components
J Immunol Methods, 140 (2), 167-71
DOI 10.1016/0022-1759(91)90367-o, PubMed 2066563

Hetland G, Mollnes TE, Garred P (1991)
Activation of complement during apheresis
Clin Exp Immunol, 84 (3), 535-8
PubMed 1904328

Mellbye OJ, Førre O, Mollnes TE, Kvarnes L (1991)
Immunopathology of subcutaneous rheumatoid nodules
Ann Rheum Dis, 50 (12), 909-12
DOI 10.1136/ard.50.12.909, PubMed 1768157

Mollnes TE, Videm V, Götze O, Harboe M, Oppermann M (1991)
Formation of C5a during cardiopulmonary bypass: inhibition by precoating with heparin
Ann Thorac Surg, 52 (1), 92-7
DOI 10.1016/0003-4975(91)91426-v, PubMed 2069469

Mollnes TE, Videm V, Riesenfeld J, Garred P, Svennevig JL, Fosse E, Hogasen K, Harboe M (1991)
Complement activation and bioincompatibility. The terminal complement complex for evaluation and surface modification with heparin for improvement of biomaterials
Clin Exp Immunol, 86 Suppl 1, 21-6
PubMed 1934602

Olmez U, Garred P, Mollnes TE, Harboe M, Berntzen HB, Munthe E (1991)
C3 activation products, C3 containing immune complexes, the terminal complement complex and native C9 in patients with rheumatoid arthritis
Scand J Rheumatol, 20 (3), 183-9
DOI 10.3109/03009749109103019, PubMed 2068540

Siemssen PA, Garred P, Olsen J, Aasen AO, Mollnes TE (1991)
Activation of complement, kallikrein-kinin, fibrinolysis and coagulation systems by urinary catheters. Effect of time and temperature in biocompatibility studies
Br J Urol, 67 (1), 83-7
DOI 10.1111/j.1464-410x.1991.tb15075.x, PubMed 1993281

Videm V, Mollnes TE, Garred P, Svennevig JL (1991)
Biocompatibility of extracorporeal circulation. In vitro comparison of heparin-coated and uncoated oxygenator circuits
J Thorac Cardiovasc Surg, 101 (4), 654-60
PubMed 2008104

Publications 1990

Garred P, Hetland G, Mollnes TE, Stoervold G (1990)
Synthesis of C3, C5, C6, C7, C8, and C9 by human fibroblasts
Scand J Immunol, 32 (5), 555-60
DOI 10.1111/j.1365-3083.1990.tb03196.x, PubMed 2270435

Garred P, Michaelsen TE, Aase A, Mollnes TE (1990)
C3, C4, and the terminal complement complex differ from C1q by binding predominantly to the antigenic part of solid phase immune complexes
J Immunol, 144 (1), 198-203
PubMed 2295791

Garred P, Mollnes TE, Thorsteinsson L, Erlendsson K, Steinsson K (1990)
Increased amounts of C4-containing immune complexes and inefficient activation of C3 and the terminal complement pathway in a patient with homozygous C2 deficiency and systemic lupus erythematosus
Scand J Immunol, 31 (1), 59-64
DOI 10.1111/j.1365-3083.1990.tb02743.x, PubMed 2300790

Garred P, Våge DI, Mollnes TE, Harboe M (1990)
Latex gloves as a cause of inflammation and eczema
Lancet, 335 (8703), 1469
DOI 10.1016/0140-6736(90)91502-2, PubMed 1972244

Halstensen TS, Mollnes TE, Garred P, Fausa O, Brandtzaeg P (1990)
Epithelial deposition of immunoglobulin G1 and activated complement (C3b and terminal complement complex) in ulcerative colitis
Gastroenterology, 98 (5 Pt 1), 1264-71
DOI 10.1016/0016-5085(90)90343-y, PubMed 1691118

Hetland G, Garred P, Pettersen HB, Mollnes TE, Johnson E (1990)
S protein binds to serum-treated agarose beads independently of complement activation and the formation of the terminal complement complex on the beads
Clin Exp Immunol, 79 (3), 459-62
DOI 10.1111/j.1365-2249.1990.tb08112.x, PubMed 1690618

Mellbye OJ, Vartdal F, Pahle J, Mollnes TE (1990)
IgG and IgA subclass distribution of total immunoglobulin and rheumatoid factors in rheumatoid tissue plasma cells
Scand J Rheumatol, 19 (5), 333-40
DOI 10.3109/03009749009096788, PubMed 2218430

Monaco S, Bonetti B, Ferrari S, Moretto G, Nardelli E, Tedesco F, Mollnes TE, Nobile-Orazio E, Manfredini E, Bonazzi L (1990)
Complement-mediated demyelination in patients with IgM monoclonal gammopathy and polyneuropathy
N Engl J Med, 322 (10), 649-52
DOI 10.1056/NEJM199003083221002, PubMed 1689461

Pettersen HB, Johnson E, Garred P, Hetland G, Osen SS, Mollnes TE (1990)
Quantification of non-activated (native) complement component C9 synthesized by alveolar macrophages from patients with sarcoidosis
Scand J Immunol, 31 (5), 657-63
DOI 10.1111/j.1365-3083.1990.tb02816.x, PubMed 2189215

Pettersen HB, Johnson E, Mollnes TE, Garred P, Hetland G, Osen SS (1990)
Synthesis of complement by alveolar macrophages from patients with sarcoidosis
Scand J Immunol, 31 (1), 15-23
DOI 10.1111/j.1365-3083.1990.tb02738.x, PubMed 1689072

Roeise O, Garred P, Mollnes TE, Stadaas JO, Aasen AO (1990)
Methylprednisolone in high doses gives different effects on the early and the late part of complement
Eur Surg Res, 22 (1), 41-9
DOI 10.1159/000129081, PubMed 2199200

Tedesco F, Radillo O, Candussi G, Nazzaro A, Mollnes TE, Pecorari D (1990)
Immunohistochemical detection of terminal complement complex and S protein in normal and pre-eclamptic placentae
Clin Exp Immunol, 80 (2), 236-40
DOI 10.1111/j.1365-2249.1990.tb05240.x, PubMed 2357851

Videm V, Fosse E, Mollnes TE, Garred P, Svennevig JL (1990)
Complement activation with bubble and membrane oxygenators in aortocoronary bypass grafting
Ann Thorac Surg, 50 (3), 387-91
DOI 10.1016/0003-4975(90)90480-t, PubMed 2205161

Våge DI, Garred P, Lea T, Mollnes TE (1990)
Elutable factors from latex-containing materials activate complement and inhibit cell proliferation. An in vitro biocompatibility study of medical devices
Complement Inflamm, 7 (2), 63-70
DOI 10.1159/000463130, PubMed 2225794

Publications 1989

Brandtzaeg P, Mollnes TE, Kierulf P (1989)
Complement activation and endotoxin levels in systemic meningococcal disease
J Infect Dis, 160 (1), 58-65
DOI 10.1093/infdis/160.1.58, PubMed 2471750

Garred P, Mollnes TE, Kazatchkine MD (1989)
Activation-dependent antigenic changes of human C3
Complement Inflamm, 6 (3), 205-18
DOI 10.1159/000463094, PubMed 2472922

Garred P, Mollnes TE, Lea T, Lachmann PJ (1989)
Enzyme immunoassay detection of circulating immune complexes by monoclonal antibodies to C3 neoepitopes with special reference to IgG concentration and to interfering anti-immunoglobulin antibodies
J Immunol Methods, 117 (1), 59-66
DOI 10.1016/0022-1759(89)90119-1, PubMed 2464039

Garred P, Olsen J, Mollnes TE, Bilde T, Glahn BE (1989)
Biocompatibility of urinary catheters. Effect on complement activation
Br J Urol, 63 (4), 367-71
DOI 10.1111/j.1464-410x.1989.tb05219.x, PubMed 2713618

Halstensen TS, Mollnes TE, Brandtzaeg P (1989)
Persistent complement activation in submucosal blood vessels of active inflammatory bowel disease: immunohistochemical evidence
Gastroenterology, 97 (1), 10-9
DOI 10.1016/0016-5085(89)91409-1, PubMed 2498144

Halstensen TS, Mollnes TE, Fausa O, Brandtzaeg P (1989)
Deposits of terminal complement complex (TCC) in muscularis mucosae and submucosal vessels in ulcerative colitis and Crohn's disease of the colon
Gut, 30 (3), 361-6
DOI 10.1136/gut.30.3.361, PubMed 2707635

Hetland G, Pettersen HB, Mollnes TE, Johnson E (1989)
S-protein is synthesized by human monocytes and macrophages in vitro
Scand J Immunol, 29 (1), 15-21
DOI 10.1111/j.1365-3083.1989.tb01094.x, PubMed 2466326

Høgevold HE, Aasen AO, Kierulf P, Garred P, Mollnes TE, Reikerås O (1989)
High doses of corticosteroids in total hip replacement. Effects on components of coagulation, fibrinolytic, plasma kallikrein-kinin and complement systems
Acta Chir Scand, 155 (4-5), 247-50
PubMed 2678856

Kongsgaard UE, Smith-Erichsen N, Geiran O, Amundsen E, Mollnes TE, Garred P (1989)
Different activation patterns in the plasma kallikrein-kinin and complement systems during coronary bypass surgery
Acta Anaesthesiol Scand, 33 (5), 343-7
DOI 10.1111/j.1399-6576.1989.tb02921.x, PubMed 2800971

Mollnes TE (1989)
Antigenic changes of complement components: relevance for the analysis of complement activation
Complement Inflamm, 6 (3), 134-41
DOI 10.1159/000463090, PubMed 2472919

Mollnes TE (1989)
[The complement system--a fascinating biological cascade. 1--physiologic aspects]
Tidsskr Nor Laegeforen, 109 (27), 2782-8
PubMed 2815011

Mollnes TE (1989)
[The complement system--a fascinating biological cascade. 2--clinical aspects]
Tidsskr Nor Laegeforen, 109 (28), 2891-6
PubMed 2815029

Mollnes TE, Abrahamsen TG, Garred P (1989)
Alterations in the terminal complement pathway in leukopenic children with malignant diseases during episodes with evidence of infection
Complement Inflamm, 6 (6), 460-9
DOI 10.1159/000463115, PubMed 2598645

Mollnes TE, Lea T, Tschopp J (1989)
Activation-dependent epitopes in the terminal complement pathway
Complement Inflamm, 6 (3), 223-35
DOI 10.1159/000463096, PubMed 2472924

Roeise O, Garred P, Mollnes TE, Aasen AO (1989)
Studies on the dose dependence of endotoxin-induced in vitro activation of the complement system
Eur Surg Res, 21 (1), 34-41
DOI 10.1159/000129001, PubMed 2714308

Videm V, Fosse E, Mollnes TE, Ellingsen O, Pedersen T, Karlsen H (1989)
Different oxygenators for cardiopulmonary bypass lead to varying degrees of human complement activation in vitro
J Thorac Cardiovasc Surg, 97 (5), 764-70
PubMed 2709867

Publications 1988

Bhakdi S, Käflein R, Halstensen TS, Hugo F, Preissner KT, Mollnes TE (1988)
Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes
Clin Exp Immunol, 74 (3), 459-64
PubMed 2466593

Brandtzaeg P, Kierulf P, Gaustad P, Dobloug J, Mollnes TE, Sirnes K (1988)
Systemic meningococcal disease: a model infection to study acute endotoxinemia in man
Prog Clin Biol Res, 272, 263-71
PubMed 3393567

Garred P, Mollnes TE, Lea T (1988)
Quantification in enzyme-linked immunosorbent assay of a C3 neoepitope expressed on activated human complement factor C3
Scand J Immunol, 27 (3), 329-35
DOI 10.1111/j.1365-3083.1988.tb02354.x, PubMed 2451274

Garred P, Mollnes TE, Lea T, Fischer E (1988)
Characterization of a monoclonal antibody MoAb bH6 reacting with a neoepitope of human C3 expressed on C3b, iC3b, and C3c
Scand J Immunol, 27 (3), 319-27
DOI 10.1111/j.1365-3083.1988.tb02353.x, PubMed 2451273

Halstensen TS, Mollnes TE, Brandtzaeg P (1988)
Terminal complement complex (TCC) and S-protein (vitronectin) on follicular dendritic cells in human lymphoid tissues
Immunology, 65 (2), 193-7
PubMed 2461343

Halstensen TS, Mollnes TE, Garred P, Brandtzaeg P (1988)
Deposits of terminal complement complex and S-protein on follicular dendritic cells in human lymphoid tissue
Adv Exp Med Biol, 237, 185-9
DOI 10.1007/978-1-4684-5535-9_27, PubMed 2978199

Heideman M, Norder-Hansson B, Bengtson A, Mollnes TE (1988)
Terminal complement complexes and anaphylatoxins in septic and ischemic patients
Arch Surg, 123 (2), 188-92
DOI 10.1001/archsurg.1988.01400260068008, PubMed 3277584

Hunziker T, Mollnes TE, Misiano G, Späth PJ (1988)
Complement in chronic cutaneous lupus erythematosus
Br J Dermatol, 118 (1), 131-3
DOI 10.1111/j.1365-2133.1988.tb01762.x, PubMed 3257702

Mellbye OJ, Frøland SS, Lilleaasen P, Svennevig JL, Mollnes TE (1988)
Complement activation during cardiopulmonary bypass: comparison between the use of large volumes of plasma and dextran 70
Eur Surg Res, 20 (2), 101-9
DOI 10.1159/000128748, PubMed 2455645

Mollnes TE, Garred P, Bergseth G (1988)
Effect of time, temperature and anticoagulants on in vitro complement activation: consequences for collection and preservation of samples to be examined for complement activation
Clin Exp Immunol, 73 (3), 484-8
PubMed 2463123

Mollnes TE, Klos A, Tschopp J (1988)
Identification of a human C5 beta-chain epitope exposed in the native complement component but concealed in the SC5b-9 complex
Scand J Immunol, 28 (3), 307-12
DOI 10.1111/j.1365-3083.1988.tb01453.x, PubMed 2461581

Mollnes TE, Lachmann PJ (1988)
Regulation of complement
Scand J Immunol, 27 (2), 127-42
DOI 10.1111/j.1365-3083.1988.tb02331.x, PubMed 3277261

Mollnes TE, Tambs KE, Myreng Y, Engebretsen LF (1988)
Acute phase reactants and complement activation in patients with acute myocardial infarction
Complement, 5 (1), 33-9
DOI 10.1159/000463029, PubMed 2448082

Pettersen HB, Johnson E, Mollnes TE, Garred P (1988)
Synthesis of soluble C3 and C9 neoepitopes by human alveolar macrophages in vitro
Scand J Immunol, 28 (4), 431-4
DOI 10.1111/j.1365-3083.1988.tb01472.x, PubMed 2461585

Sandberg G, Stenvinkel C, Mollnes TE (1988)
Demonstration of C3d and the terminal complement complex on thymic large granular lymphocytes and common thymocytes after incubation with naturally thymocytotoxic serum
Int Arch Allergy Appl Immunol, 87 (3), 239-46
DOI 10.1159/000234679, PubMed 3264545

Thorlacius S, Mollnes TE, Garred P, Aarli JA, Matre R, Tönder O, Halvorsen K (1988)
Plasma exchange in myasthenia gravis: changes in serum complement and immunoglobulins
Acta Neurol Scand, 78 (3), 221-7
DOI 10.1111/j.1600-0404.1988.tb03650.x, PubMed 3227807

Videm V, Fosse E, Mollnes TE, Garred P (1988)
Complement activation by extracorporeal circulation: effects of precoating a membrane oxygenator circuit with human whole blood
Scand J Thorac Cardiovasc Surg, 22 (3), 251-6
DOI 10.3109/14017438809106071, PubMed 3227328

Publications 1987

Fosse E, Mollnes TE, Ingvaldsen B (1987)
Complement activation during major operations with or without cardiopulmonary bypass
J Thorac Cardiovasc Surg, 93 (6), 860-6
PubMed 3494886

Fosse E, Mollnes TE, Osterud A, Aasen AO (1987)
Effects of methylprednisolone on complement activation and leukocyte counts during cardiopulmonary bypass
Scand J Thorac Cardiovasc Surg, 21 (3), 255-61
DOI 10.3109/14017438709106035, PubMed 2964081

Fosse E, Mollnes TE, Aasen AO, Trumpy JH, Stokke T (1987)
Complement activation following multiple injuries
Acta Chir Scand, 153 (5-6), 325-30
PubMed 3499041

Mollnes TE, Harboe M (1987)
Immunohistochemical detection of the membrane and fluid-phase terminal complement complexes C5b-9(m) and SC5b-9. Consequences for interpretation and terminology
Scand J Immunol, 26 (4), 381-6
DOI 10.1111/j.1365-3083.1987.tb02270.x, PubMed 3685888

Mollnes TE, Lachmann PJ (1987)
Activation of the third component of complement (C3) detected by a monoclonal anti-C3'g' neoantigen antibody in a one-step enzyme immunoassay
J Immunol Methods, 101 (2), 201-7
DOI 10.1016/0022-1759(87)90151-7, PubMed 2440954

Mollnes TE, Tschopp J (1987)
A unique epitope exposed in native complement component C9 and hidden in the terminal SC5b-9 complex enables selective detection and quantification of non-activated C9
J Immunol Methods, 100 (1-2), 215-21
DOI 10.1016/0022-1759(87)90192-x, PubMed 2439601

Mollnes TE, Vandvik B, Lea T, Vartdal F (1987)
Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex
J Neurol Sci, 78 (1), 17-28
DOI 10.1016/0022-510x(87)90074-8, PubMed 3572448

Publications 1986

Mollnes TE, Lea T, Mellbye OJ, Pahle J, Grand O, Harboe M (1986)
Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex
Arthritis Rheum, 29 (6), 715-21
DOI 10.1002/art.1780290603, PubMed 3718564

Mollnes TE, Lea T, Rogde S, Tedesco F (1986)
The terminal complement complex in sera deficient in the eighth component of complement (C8)
Scand J Immunol, 24 (3), 307-12
DOI 10.1111/j.1365-3083.1986.tb02098.x, PubMed 3749815

Mollnes TE, Ng YC, Peters DK, Lea T, Tschopp J, Harboe M (1986)
Effect of nephritic factor on C3 and on the terminal pathway of complement in vivo and in vitro
Clin Exp Immunol, 65 (1), 73-9
PubMed 3641694

Mollnes TE, Paus A (1986)
Complement activation in synovial fluid and tissue from patients with juvenile rheumatoid arthritis
Arthritis Rheum, 29 (11), 1359-64
DOI 10.1002/art.1780291108, PubMed 3778542

Tschopp J, Mollnes TE (1986)
Antigenic crossreactivity of the alpha subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor
Proc Natl Acad Sci U S A, 83 (12), 4223-7
DOI 10.1073/pnas.83.12.4223, PubMed 2424021

Publications 1985

Mollnes TE (1985)
Early- and late-phase activation of complement evaluated by plasma levels of C3d,g and the terminal complement complex
Complement, 2 (2-3), 156-64
DOI 10.1159/000467856, PubMed 3878764

Mollnes TE (1985)
Quantification of the C3d split products of human complement by a sensitive enzyme-linked immunosorbent assay
Scand J Immunol, 21 (6), 607-13
DOI 10.1111/j.1365-3083.1985.tb01851.x, PubMed 3895396

Mollnes TE (1985)
The human terminal complement complex
[T. E. Mollnes], Oslo, 1 b. (flere pag.)
BIBSYS 852180004, ISBN 82-90522-03-7

Mollnes TE, Frøland SS, Harboe M (1985)
Increased plasma levels of the terminal complement complex in patients with evidence of complement activation
Complement, 2 (2-3), 175-84
DOI 10.1159/000467858, PubMed 3878765

Mollnes TE, Lea T, Frøland SS, Harboe M (1985)
Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex
Scand J Immunol, 22 (2), 197-202
DOI 10.1111/j.1365-3083.1985.tb01871.x, PubMed 2412280

Mollnes TE, Lea T, Harboe M, Tschopp J (1985)
Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma
Scand J Immunol, 22 (2), 183-95
DOI 10.1111/j.1365-3083.1985.tb01870.x, PubMed 4035298

Publications 1984

Mollnes TE, Lea T, Harboe M (1984)
Detection and quantification of the terminal C5b-9 complex of human complement by a sensitive enzyme-linked immunosorbent assay
Scand J Immunol, 20 (2), 157-66
DOI 10.1111/j.1365-3083.1984.tb00989.x, PubMed 6474098

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