The multidisciplinary team of the K.G.Jebsen Colorectal Cancer Research Centre publishes a novel gene expression-based classification of metastatic colorectal cancer.
PhD student S. Hossein Moosavi in Anita Sveen’s project group at the Dept. of Molecular Oncology at the Institute for Cancer Research is 1st author of this paper published in Genome Medicine.
This is the first large study of multi-metastatic gene expression profiling of colorectal cancer liver metastases, and the new metastasis-oriented subtyping framework showed prognostic relevance in the context of tumor heterogeneity.
The five biologically distinct liver metastasis subtypes (LMS1-5) originated from different progenitor cell types, and a subtype expressing biological features of cancer aggressiveness was also an independent predictor of a poor patient survival. The aim of a recent innovation project with the TTO Inven2 is to develop the subtypes into a framework for biology-guided treatment of metastatic colorectal cancers.
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
Seyed H. Moosavi, Peter W. Eide, Ina A. Eilertsen, Tuva H. Brunsell, Kaja C. G. Berg, Bård I. Røsok, Kristoffer W. Brudvik, Bjørn A. Bjørnbeth, Marianne G. Guren, Arild Nesbakken, Ragnhild A. Lothe & Anita Sveen
Genome Medicine volume 13, Article number: 143 (2021)