SOP103 List of Approved Locations for Handling and Storage Facilities for Genetically Modified Microbes and Organisms (GMMs/GMOs)

Standard Operating Procedure (SOP)

Title: List of Approved Locations for Handling and Storage Facilities for Genetically Modified Microbes and Organisms (GMMs/GMOs)

ID: SOP103
Section: Section for Research
Department: Department of Microbiology
Division: Division of Laboratory Medicine (KLM), Oslo University Hospital (OUH)
Written by: Mari Kaarbø
Date: 01.06.2019
Approved by: Hilde Loge Nilsen
Date: 15.02.2022
Updated: 16.09.2025

 

1. Purpose and Scope

This SOP lists the currently approved locations for handling and storage facilities for safe and correct handling of genetically modified microbes (GMMs) or organisms (GMOs) within the Section for Research, Department of Microbiology, OUH.

Several laboratories at Section for Research at MIK are approved for contained use of GMMs/GMOs (GMM/GMO Risk Group 1 and 2) at laboratory scale.

 

2. GMMs and GMOs to be used

  • Viruses: Bacteriophages, Baculovirus, Cytomegalovirus, Adenovirus (Adenovirus based vectors), Lentivirus (Lentivirus based vectors).
  • Prokaryotes: Bacteria - non-pathogenic strains of Escherichia coli with and without plasmids, Helicobakter pylori, Borrelia burgdorferi, Mycobacterium, Pseudomonas, Staphylococcus, Bacillus, Acinetobacter, Neisseriaceae, Simonsiella, Kingae, Eikenella, Moraxella, Suttonella and Cardiobacterium.
  • Eukaryotes: Fungi – Saccharomyces cerevisiae og Schizosaccharomyses pombe.
  • Mammalian cell lines: Human, monkey, rat and mouse, and derived cell lines.
  • Insect cells and Caenorhabditis elegans.

 

3. Responsibilities

  • All employees and researchers working with GMMs/GMOs in the section laboratories are responsible for following this SOP.
  • GMO responsible must ensure that all staff are trained and familiar with the different biosafety levels and restrictions of each location.

 

4. Approved Locations

4.1. Biosafety Level 1

4.1.1. Domus Medica 4, DM4

Mikroskopirom L-220, Massespektroskopilab L-221, Isotoplab L-222, Liten generell lab L-223, Forrom cellelab L-225, Cellelab L-226 , Kjølerom L-244, FPLC-rom L-243, Fryserrom L-245, Instrumentrom L-246, Kjemikalierom L-247, Stor generell lab L-248, Sentrifugerom L-249, Inkubatorrom L-250, Vaskerom L-251

4.1.2. Forskningsveien 1, MIK SINTEF

Instrument- og inkubatorrom E489A/B, Generell lab E490, Instrumentrom F487, Generell lab F489 A/B.

4.2. Biosafety Level 2

4.2.1. Domus Medica 4, DM4

Neisserialab L-224, Cellelab: L-226, Vaskerom: L-251, Mikroskopirom: L-220.

4.2.2. Forskningsveien 1, MIK SINTEF

Cellelab E486, Cellelab E487B, Cellelab F486, Cellelab F488, Cellelab F491, Cellelab, F494, Vaskerom E494, Instrumentrom F490A/B, Mikroskopirom F492A/B, Mikroskopirom F493.

4.2.3. Rikshospitalet

Hj. Lab sonikator A3.3052, Laboratorium A3.3047, Cellelab B2.3008, Cellelab B2.3013, Avfallsrom B2.3014, Cellelab B2.3016, Sentrifugerom B2.3033, Ultrafrysere B2.3113.

 

5. Structural Safety Measures

  • GMO/GMM work at Biosafety Level 2 must be conducted in aerosol-protected biosafety cabinets (LAF benches). 
  • Laboratory access is restricted outside of normal working hours.

 

6. Definitions 

  • GMM – Genetically Modified Microbe: A microbial unit with altered genetic material. 
  • GMO – Genetically Modified Organism: Any organism whose genetic material has been altered using gene or cell technology.

 

7. References

  • Regulation on Contained Use of Genetically Modified Animals (Dyreforskriften):
    👉 Forskrift om innesluttet bruk av genmodifiserte dyr 
  • Related eHandbook Documents: 
    • Genetically Modified Organisms – Quality and Safety Requirements under the Gene Technology Act

 

 
Oct 3, 2025
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