Publications from OUS - NK Cell Biology and Cell Therapy (Malmberg)

86 publications found

Publications 2024

  1. Ask EH, Tschan-Plessl A, Hoel HJ, Kolstad A, Holte H, Malmberg KJ (2024)
    MetaGate: Interactive analysis of high-dimensional cytometry data with metadata integration
    Patterns (N Y), 5 (7), 100989
    DOI 10.1016/j.patter.2024.100989, PubMed 39081571
  2. Fein JA, Shouval R, Krieger E, Spellman SR, Wang T, Baldauf H, Fleischhauer K, Kröger N, Horowitz M, Maiers M, Miller JS, Mohty M, Nagler A, Weisdorf D, Malmberg KJ, Toor AA, Schetelig J, Romee R, Koreth J (2024)
    Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
    Blood Adv, 8 (3), 581-590
    DOI 10.1182/bloodadvances.2023011622, PubMed 38052043
  3. Hammer Q, Perica K, Mbofung RM, van Ooijen H, Martin KE, Momayyezi P, Varady E, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide SZ, Lee T, Williams A, Goodridge JP, Valamehr B, Önfelt B, Sadelain M, Malmberg KJ (2024)
    Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies
    Cell Stem Cell, 31 (9), 1376-1386.e8
    DOI 10.1016/j.stem.2024.06.011, PubMed 38981470
  4. Martin KE, Hammer Q, Perica K, Sadelain M, Malmberg KJ (2024)
    Engineering immune-evasive allogeneic cellular immunotherapies
    Nat Rev Immunol, 24 (9), 680-693
    DOI 10.1038/s41577-024-01022-8, PubMed 38658708
  5. Netskar H, Pfefferle A, Goodridge JP, Sohlberg E, Dufva O, Teichmann SA, Brownlie D, Michaëlsson J, Marquardt N, Clancy T, Horowitz A, Malmberg KJ (2024)
    Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
    Nat Immunol, 25 (8), 1445-1459
    DOI 10.1038/s41590-024-01884-z, PubMed 38956379
  6. Palacios D, Majhi RK, Szabo EK, Clement D, Lachota M, Netskar H, Penna L, Krokeide SZ, Vincenti M, Kveberg L, Malmberg KJ (2024)
    The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration
    J Immunol, 213 (9), 1349-1357
    DOI 10.4049/jimmunol.2400228, PubMed 39320215
  7. Pfefferle A, Phuyal S, Netskar H, Malmberg KJ (2024)
    Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer
    EMBO J, 43 (13), 2527-2529
    DOI 10.1038/s44318-024-00144-y, PubMed 38886578
  8. Rebuffet L, Melsen JE, Escalière B, Basurto-Lozada D, Bhandoola A, Björkström NK, Bryceson YT, Castriconi R, Cichocki F, Colonna M, Davis DM, Diefenbach A, Ding Y, Haniffa M, Horowitz A, Lanier LL, Malmberg KJ, Miller JS, Moretta L, Narni-Mancinelli E, O'Neill LAJ, Romagnani C, Ryan DG, Sivori S, Sun D et al. (2024)
    High-dimensional single-cell analysis of human natural killer cell heterogeneity
    Nat Immunol, 25 (8), 1474-1488
    DOI 10.1038/s41590-024-01883-0, PubMed 38956378
  9. Strunz B, Momayyezi P, Bilev E, Muvva JR, Chen P, Bister J, Schaffer M, Akber M, Cornillet M, Karolinska KI/K COVID-19 Study Group, Horowitz A, Malmberg KJ, Rooyackers O, Aleman S, Ljunggren HG, Björkström NK, Strålin K, Hammer Q (2024)
    The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19
    Genes Immun (in press)
    DOI 10.1038/s41435-024-00302-6, PubMed 39487235
  10. Sætersmoen M, Kotchetkov IS, Torralba-Raga L, Mansilla-Soto J, Sohlberg E, Krokeide SZ, Hammer Q, Sadelain M, Malmberg KJ (2024)
    Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor
    Med (in press)
    DOI 10.1016/j.medj.2024.09.010, PubMed 39423821
  11. Vo DN, Yuan O, Kanaya M, Telliam-Dushime G, Li H, Kotova O, Caglar E, Honnens de Lichtenberg K, Rahman SH, Soneji S, Scheding S, Bryder D, Malmberg KJ, Sitnicka E (2024)
    A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis
    Blood Adv, 8 (11), 2933-2951
    DOI 10.1182/bloodadvances.2023011909, PubMed 38484189

Publications 2023

  1. Ask EH, Tschan-Plessl A, Hoel HJ, Kolstad A, Holte H, Malmberg KJ (2023)
    MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration
    bioRxiv
    DOI 10.1101/2023.10.27.564454, PubMed 37961421
  2. Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ (2023)
    The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
    J Immunol, 211 (9), 1348-1358
    DOI 10.4049/jimmunol.2300406, PubMed 37737664
  3. Giang KA, Boxaspen T, Diao Y, Nilvebrant J, Kosugi-Kanaya M, Kanaya M, Krokeide SZ, Lehmann F, Svensson Gelius S, Malmberg KJ, Nygren PÅ (2023)
    Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells
    N Biotechnol, 77, 139-148
    DOI 10.1016/j.nbt.2023.09.002, PubMed 37673373
  4. Hammer Q, Perica K, van Ooijen H, Mbofung R, Momayyezi P, Varady E, Martin KE, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide S, Lee T, Williams A, Goodridge JP, Valamehr B, Önfelt B, Sadelain M, Malmberg KJ (2023)
    Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells
    bioRxiv
    DOI 10.1101/2023.10.09.557143, PubMed 37873468
  5. Haroun-Izquierdo A, Lanuza PM, Pfefferle A, Netskar H, Ask EH, Törlén J, Björklund A, Sohlberg E, Malmberg KJ (2023)
    Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
    Transplant Cell Ther, 29 (6), 376.e1-376.e11
    DOI 10.1016/j.jtct.2023.03.023, PubMed 36966873
  6. Humbert M, Olofsson A, Wullimann D, Niessl J, Hodcroft EB, Cai C, Gao Y, Sohlberg E, Dyrdak R, Mikaeloff F, Neogi U, Albert J, Malmberg KJ, Lund-Johansen F, Aleman S, Björkhem-Bergman L, Jenmalm MC, Ljunggren HG, Buggert M, Karlsson AC (2023)
    Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
    Proc Natl Acad Sci U S A, 120 (12), e2220320120
    DOI 10.1073/pnas.2220320120, PubMed 36917669
  7. Lachota M, Zielniok K, Palacios D, Kanaya M, Penna L, Hoel HJ, Wiiger MT, Kveberg L, Hautz W, Zagożdżon R, Malmberg KJ (2023)
    Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation
    EBioMedicine, 96, 104811
    DOI 10.1016/j.ebiom.2023.104811, PubMed 37741009
  8. Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, Önfelt B, Norman PJ, Malmberg KJ (2023)
    Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
    Blood Adv, 7 (16), 4492-4504
    DOI 10.1182/bloodadvances.2023009827, PubMed 37327114
  9. Sandoz PA, Kuhnigk K, Szabo EK, Thunberg S, Erikson E, Sandström N, Verron Q, Brech A, Watzl C, Wagner AK, Alici E, Malmberg KJ, Uhlin M, Önfelt B (2023)
    Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
    Nat Commun, 14 (1), 6035
    DOI 10.1038/s41467-023-41634-7, PubMed 37758698

Publications 2022

  1. Bajor M, Graczyk-Jarzynka A, Marhelava K, Burdzinska A, Muchowicz A, Goral A, Zhylko A, Soroczynska K, Retecki K, Krawczyk M, Klopotowska M, Pilch Z, Paczek L, Malmberg KJ, Wälchli S, Winiarska M, Zagozdzon R (2022)
    PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
    J Immunother Cancer, 10 (1)
    DOI 10.1136/jitc-2021-002500, PubMed 35078921
  2. Cichocki F, Bjordahl R, Goodridge JP, Mahmood S, Gaidarova S, Abujarour R, Davis ZB, Merino A, Tuininga K, Wang H, Kumar A, Groff B, Witty A, Bonello G, Huffman J, Dailey T, Lee TT, Malmberg KJ, Walcheck B, Höpken U, Rehm A, Valamehr B, Miller JS (2022)
    Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
    Nat Commun, 13 (1), 7341
    DOI 10.1038/s41467-022-35127-2, PubMed 36446823
  3. Hammer Q, Dunst J, Christ W, Picarazzi F, Wendorff M, Momayyezi P, Huhn O, Netskar HK, Maleki KT, García M, Sekine T, Sohlberg E, Azzimato V, Aouadi M, Karolinska COVID-19 Study Group, Severe COVID-19 GWAS Group, Degenhardt F, Franke A, Spallotta F, Mori M, Michaëlsson J, Björkström NK, Rückert T, Romagnani C, Horowitz A et al. (2022)
    SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
    Cell Rep, 38 (10), 110503
    DOI 10.1016/j.celrep.2022.110503, PubMed 35235832
  4. Haroun-Izquierdo A, Vincenti M, Netskar H, van Ooijen H, Zhang B, Bendzick L, Kanaya M, Momayyezi P, Li S, Wiiger MT, Hoel HJ, Krokeide SZ, Kremer V, Tjonnfjord G, Berggren S, Wikström K, Blomberg P, Alici E, Felices M, Önfelt B, Höglund P, Valamehr B, Ljunggren HG, Björklund A, Hammer Q et al. (2022)
    Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
    J Immunother Cancer, 10 (11)
    DOI 10.1136/jitc-2022-005577, PubMed 36319065
  5. Ljunggren HG, Ask EH, Cornillet M, Strunz B, Chen P, Rao Muvva J, Akber M, Buggert M, Chambers BJ, Cuapio A, Dzidic M, Filipovic I, Flodström-Tullberg M, Garcia M, Gorin JB, Gredmark-Russ S, Hertwig L, Klingström J, Kokkinou E, Kvedaraite E, Lourda M, Mjösberg J, Maucourant C, Norrby-Teglund A, Palma Medina LM et al. (2022)
    The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes
    Scand J Immunol, 96 (1), e13195 (in press)
    DOI 10.1111/sji.13195, PubMed 35652743
  6. Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, Miele MM, Zhao Z, Giavridis T, van der Stegen SJC, Tamzalit F, Rivière I, Huse M, Hendrickson RC, Hivroz C, Sadelain M (2022)
    HLA-independent T cell receptors for targeting tumors with low antigen density
    Nat Med, 28 (2), 345-352
    DOI 10.1038/s41591-021-01621-1, PubMed 35027758
  7. Momayyezi P, Malmberg KJ, Hammer Q (2022)
    Small Interfering RNA Delivery Into Primary Human Natural Killer Cells for Functional Gene Analyses
    Curr Protoc, 2 (11), e613
    DOI 10.1002/cpz1.613, PubMed 36440989
  8. Palacios D, Momayyezi P, Huhn O, Ask EH, Dunst J, Malmberg KJ, Hammer Q (2022)
    An optimized platform for efficient siRNA delivery into human NK cells
    Eur J Immunol, 52 (7), 1190-1193
    DOI 10.1002/eji.202149710, PubMed 35416292
  9. Salomé B, Sfakianos JP, Ranti D, Daza J, Bieber C, Charap A, Hammer C, Banchereau R, Farkas AM, Ruan DF, Izadmehr S, Geanon D, Kelly G, de Real RM, Lee B, Beaumont KG, Shroff S, Wang YA, Wang YC, Thin TH, Garcia-Barros M, Hegewisch-Solloa E, Mace EM, Wang L, O'Donnell T et al. (2022)
    NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
    Cancer Cell, 40 (9), 1027-1043.e9
    DOI 10.1016/j.ccell.2022.08.005, PubMed 36099881
  10. Shapiro RM, Birch GC, Hu G, Vergara Cadavid J, Nikiforow S, Baginska J, Ali AK, Tarannum M, Sheffer M, Abdulhamid YZ, Rambaldi B, Arihara Y, Reynolds C, Halpern MS, Rodig SJ, Cullen N, Wolff JO, Pfaff KL, Lane AA, Lindsley RC, Cutler CS, Antin JH, Ho VT, Koreth J, Gooptu M et al. (2022)
    Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse
    J Clin Invest, 132 (11)
    DOI 10.1172/JCI154334, PubMed 35349491

Publications 2021

  1. Klopotowska M, Bajor M, Graczyk-Jarzynka A, Kraft A, Pilch Z, Zhylko A, Firczuk M, Baranowska I, Lazniewski M, Plewczynski D, Goral A, Soroczynska K, Domagala J, Marhelava K, Slusarczyk A, Retecki K, Ramji K, Krawczyk M, Temples MN, Sharma B, Lachota M, Netskar H, Malmberg KJ, Zagozdzon R, Winiarska M (2021)
    PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
    Cancer Immunol Res, 10 (2), 228-244
    DOI 10.1158/2326-6066.CIR-20-1023, PubMed 34853030
  2. Lachota M, Lennikov A, Malmberg KJ, Zagozdzon R (2021)
    Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression
    J Immunol Res, 2021, 9920234
    DOI 10.1155/2021/9920234, PubMed 34195299
  3. Mazzarella L, Enblad G, Olweus J, Malmberg KJ, Jerkeman M (2021)
    Advances in immune therapies in hematological malignancies
    J Intern Med, 292 (2), 205-220
    DOI 10.1111/joim.13395, PubMed 34624160
  4. Sullivan LC, Nguyen THO, Harpur CM, Stankovic S, Kanagarajah AR, Koutsakos M, Saunders PM, Cai Z, Gray JA, Widjaja JML, Lin J, Pietra G, Mingari MC, Moretta L, Samir J, Luciani F, Westall GP, Malmberg KJ, Kedzierska K, Brooks AG (2021)
    Natural killer cell receptors regulate responses of HLA-E-restricted T cells
    Sci Immunol, 6 (58)
    DOI 10.1126/sciimmunol.abe9057, PubMed 33893172
  5. Woan KV, Kim H, Bjordahl R, Davis ZB, Gaidarova S, Goulding J, Hancock B, Mahmood S, Abujarour R, Wang H, Tuininga K, Zhang B, Wu CY, Kodal B, Khaw M, Bendzick L, Rogers P, Ge MQ, Bonello G, Meza M, Felices M, Huffman J, Dailey T, Lee TT, Walcheck B et al. (2021)
    Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
    Cell Stem Cell, 28 (12), 2062-2075.e5
    DOI 10.1016/j.stem.2021.08.013, PubMed 34525347

Publications 2020

  1. Ask EH, Tschan-Plessl A, Gjerdingen TJ, Sætersmoen ML, Hoel HJ, Wiiger MT, Olweus J, Wahlin BE, Lingjærde OC, Horowitz A, Cashen AF, Watkins M, Fehniger TA, Holte H, Kolstad A, Malmberg KJ (2020)
    A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
    Med, 2 (2), 180-195.e5
    DOI 10.1016/j.medj.2020.10.006, PubMed 35590201
  2. Clement D, Goodridge JP, Grimm C, Patel S, Malmberg KJ (2020)
    TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
    Front Immunol, 11, 753
    DOI 10.3389/fimmu.2020.00753, PubMed 32411146
  3. Goldenson BH, Zhu H, Wang YM, Heragu N, Bernareggi D, Ruiz-Cisneros A, Bahena A, Ask EH, Hoel HJ, Malmberg KJ, Kaufman DS (2020)
    Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
    Front Immunol, 11, 561553
    DOI 10.3389/fimmu.2020.561553, PubMed 33178188
  4. Jacobs B, Schlögl S, Strobl CD, Völkl S, Stoll A, Mougiakakos D, Malmberg KJ, Mackensen A, Aigner M (2020)
    The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
    Front Immunol, 11, 2128
    DOI 10.3389/fimmu.2020.02128, PubMed 33123121
  5. Lachota M, Vincenti M, Winiarska M, Boye K, Zagożdżon R, Malmberg KJ (2020)
    Prospects for NK Cell Therapy of Sarcoma
    Cancers (Basel), 12 (12)
    DOI 10.3390/cancers12123719, PubMed 33322371
  6. Maucourant C, Filipovic I, Ponzetta A, Aleman S, Cornillet M, Hertwig L, Strunz B, Lentini A, Reinius B, Brownlie D, Cuapio A, Ask EH, Hull RM, Haroun-Izquierdo A, Schaffer M, Klingström J, Folkesson E, Buggert M, Sandberg JK, Eriksson LI, Rooyackers O, Ljunggren HG, Malmberg KJ, Michaëlsson J, Marquardt N et al. (2020)
    Natural killer cell immunotypes related to COVID-19 disease severity
    Sci Immunol, 5 (50)
    DOI 10.1126/sciimmunol.abd6832, PubMed 32826343
  7. Patel S, Malmberg KJ (2020)
    Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
    Cell Calcium, 92, 102289
    DOI 10.1016/j.ceca.2020.102289, PubMed 33027744
  8. Pfefferle A, Jacobs B, Haroun-Izquierdo A, Kveberg L, Sohlberg E, Malmberg KJ (2020)
    Deciphering Natural Killer Cell Homeostasis
    Front Immunol, 11, 812
    DOI 10.3389/fimmu.2020.00812, PubMed 32477340
  9. Tschan-Plessl A, Kalberer CP, Wieboldt R, Stern M, Siegler U, Wodnar-Filipowicz A, Gerull S, Halter J, Heim D, Tichelli A, Tsakiris DA, Malmberg KJ, Passweg JR, Bottos A (2020)
    Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma
    Cytotherapy, 23 (4), 329-338
    DOI 10.1016/j.jcyt.2020.09.009, PubMed 33268029
  10. Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS (2020)
    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
    Cell Stem Cell, 27 (2), 224-237.e6
    DOI 10.1016/j.stem.2020.05.008, PubMed 32531207

Publications 2019

  1. Cornillet M, Jansson H, Schaffer M, Hertwig L, Berglin L, Zimmer CL, Johansson H, Ellis E, Isaksson B, Gonzalez-Galarza FF, Middleton D, Malmberg KJ, Sparrelid E, Björkström NK (2019)
    Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
    Gastroenterology, 157 (4), 1067-1080.e9
    DOI 10.1053/j.gastro.2019.06.023, PubMed 31229495
  2. Enqvist M, Jacobs B, Junlén HR, Schaffer M, Melén CM, Friberg D, Wahlin BE, Malmberg KJ (2019)
    Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
    Front Immunol, 10, 2085
    DOI 10.3389/fimmu.2019.02085, PubMed 31572357
  3. Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
    Remodeling of secretory lysosomes during education tunes functional potential in NK cells
    Nat Commun, 10 (1), 514
    DOI 10.1038/s41467-019-08384-x, PubMed 30705279
  4. Pfefferle A, Jacobs B, Netskar H, Ask EH, Lorenz S, Clancy T, Goodridge JP, Sohlberg E, Malmberg KJ (2019)
    Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
    Cell Rep, 29 (8), 2284-2294.e4
    DOI 10.1016/j.celrep.2019.10.058, PubMed 31747601

Publications 2018

  1. Björklund AT, Carlsten M, Sohlberg E, Liu LL, Clancy T, Karimi M, Cooley S, Miller JS, Klimkowska M, Schaffer M, Watz E, Wikström K, Blomberg P, Wahlin BE, Palma M, Hansson L, Ljungman P, Hellström-Lindberg E, Ljunggren HG, Malmberg KJ (2018)
    Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
    Clin Cancer Res, 24 (8), 1834-1844
    DOI 10.1158/1078-0432.CCR-17-3196, PubMed 29444931
  2. De Santis F, Del Vecchio M, Castagnoli L, De Braud F, Di Cosimo S, Franceschini D, Fucà G, Hiscott J, Malmberg KJ, McGranahan N, Pietrantonio F, Rivoltini L, Sangaletti S, Tagliabue E, Tripodo C, Vernieri C, Zitvogel L, Pupa SM, Di Nicola M (2018)
    Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
    Cytokine Growth Factor Rev, 44, 1-10
    DOI 10.1016/j.cytogfr.2018.10.005, PubMed 30393044
  3. Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ (2018)
    Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
    J Immunol, 202 (3), 736-746
    DOI 10.4049/jimmunol.1801146, PubMed 30578306
  4. Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte JA, Malmberg KJ (2018)
    Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
    Cancer Immunol Res, 6 (4), 467-480
    DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477
  5. Saetersmoen ML, Hammer Q, Valamehr B, Kaufman DS, Malmberg KJ (2018)
    Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
    Semin Immunopathol, 41 (1), 59-68
    DOI 10.1007/s00281-018-0721-x, PubMed 30361801
  6. Tutturen AEV, Dørum S, Clancy T, Reims HM, Christophersen A, Lundin KEA, Sollid LM, de Souza GA, Stamnaes J (2018)
    Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
    Am J Pathol, 188 (7), 1563-1579
    DOI 10.1016/j.ajpath.2018.03.017, PubMed 29684362

Publications 2017

  1. Clancy T, Dannenfelser R, Troyanskaya O, Malmberg KJ, Hovig E, Kristensen V (2017)
    Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
    Curr Pharm Des, 23 (32), 4716-4725
    DOI 10.2174/1381612823666170710154936, PubMed 28699527
  2. Liu LL, Béziat V, Oei VYS, Pfefferle A, Schaffer M, Lehmann S, Hellström-Lindberg E, Söderhäll S, Heyman M, Grandér D, Malmberg KJ (2017)
    Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
    Cancer Immunol Res, 5 (8), 654-665
    DOI 10.1158/2326-6066.CIR-16-0296, PubMed 28637877
  3. Malmberg KJ, Carlsten M, Björklund A, Sohlberg E, Bryceson YT, Ljunggren HG (2017)
    Natural killer cell-mediated immunosurveillance of human cancer
    Semin Immunol, 31, 20-29
    DOI 10.1016/j.smim.2017.08.002, PubMed 28888619
  4. Malmberg KJ, Sohlberg E, Goodridge JP, Ljunggren HG (2017)
    Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
    Immunogenetics, 69 (8-9), 547-556
    DOI 10.1007/s00251-017-1011-9, PubMed 28699110
  5. Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA, Becker-Hapak M, Schappe T, Abdel-Latif S, Ireland AR, Jaishankar D, King JA, Vij R, Clement D, Goodridge J, Malmberg KJ, Wong HC, Fehniger TA (2017)
    CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
    J Clin Invest, 127 (11), 4042-4058
    DOI 10.1172/JCI90387, PubMed 28972539

Publications 2016

  1. Björklund AT, Clancy T, Goodridge JP, Béziat V, Schaffer M, Hovig E, Ljunggren HG, Ljungman PT, Malmberg KJ (2016)
    Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
    J Immunol, 196 (3), 1400-11
    DOI 10.4049/jimmunol.1501434, PubMed 26746188
  2. Clancy T, Hovig E (2016)
    Profiling networks of distinct immune-cells in tumors
    BMC Bioinformatics, 17 (1), 263
    DOI 10.1186/s12859-016-1141-3, PubMed 27377892
  3. Horowitz A, Djaoud Z, Nemat-Gorgani N, Blokhuis J, Hilton HG, Béziat V, Malmberg KJ, Norman PJ, Guethlein LA, Parham P (2016)
    Class I HLA haplotypes form two schools that educate NK cells in different ways
    Sci Immunol, 1 (3)
    DOI 10.1126/sciimmunol.aag1672, PubMed 27868107
  4. Landtwing V, Raykova A, Pezzino G, Béziat V, Marcenaro E, Graf C, Moretta A, Capaul R, Zbinden A, Ferlazzo G, Malmberg KJ, Chijioke O, Münz C (2016)
    Cognate HLA absence in trans diminishes human NK cell education
    J Clin Invest, 126 (10), 3772-3782
    DOI 10.1172/JCI86923, PubMed 27571408
  5. Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VYS, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V (2016)
    Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
    Cell Rep, 15 (5), 1088-1099
    DOI 10.1016/j.celrep.2016.04.005, PubMed 27117418
  6. Mensali N, Ying F, Sheng VO, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J (2016)
    Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
    Oncoimmunology, 5 (5), e1138199
    DOI 10.1080/2162402X.2016.1138199, PubMed 27467957

Publications 2015

  1. Béziat V, Sleiman M, Goodridge JP, Kaarbø M, Liu LL, Rollag H, Ljunggren HG, Zimmer J, Malmberg KJ (2015)
    Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients
    Front Immunol, 6, 507
    DOI 10.3389/fimmu.2015.00507, PubMed 26500647
  2. Enqvist M, Ask EH, Forslund E, Carlsten M, Abrahamsen G, Béziat V, Andersson S, Schaffer M, Spurkland A, Bryceson Y, Önfelt B, Malmberg KJ (2015)
    Coordinated expression of DNAM-1 and LFA-1 in educated NK cells
    J Immunol, 194 (9), 4518-27
    DOI 10.4049/jimmunol.1401972, PubMed 25825444
  3. Forslund E, Sohlberg E, Enqvist M, Olofsson PE, Malmberg KJ, Önfelt B (2015)
    Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells
    J Immunol, 195 (7), 3374-81
    DOI 10.4049/jimmunol.1500171, PubMed 26320254
  4. Goodridge JP, Önfelt B, Malmberg KJ (2015)
    Newtonian cell interactions shape natural killer cell education
    Immunol Rev, 267 (1), 197-213
    DOI 10.1111/imr.12325, PubMed 26284479
  5. Liu LL, Pfefferle A, Yi Sheng VO, Björklund AT, Béziat V, Goodridge JP, Malmberg KJ (2015)
    Harnessing adaptive natural killer cells in cancer immunotherapy
    Mol Oncol, 9 (10), 1904-17
    DOI 10.1016/j.molonc.2015.10.001, PubMed 26604011
  6. Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, Han H, Chiang SC, Foley B, Mattsson K, Larsson S, Schaffer M, Malmberg KJ, Ljunggren HG, Miller JS, Bryceson YT (2015)
    Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
    Immunity, 42 (3), 443-56
    DOI 10.1016/j.immuni.2015.02.008, PubMed 25786176
  7. Sobecks RM, Wang T, Askar M, Gallagher MM, Haagenson M, Spellman S, Fernandez-Vina M, Malmberg KJ, Müller C, Battiwalla M, Gajewski J, Verneris MR, Ringdén O, Marino S, Davies S, Dehn J, Bornhäuser M, Inamoto Y, Woolfrey A, Shaw P, Pollack M, Weisdorf D, Milller J, Hurley C, Lee SJ et al. (2015)
    Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
    Biol Blood Marrow Transplant, 21 (9), 1589-96
    DOI 10.1016/j.bbmt.2015.05.002, PubMed 25960307
  8. Sohlberg E, Pfefferle A, Andersson S, Baumann BC, Hellström-Lindberg E, Malmberg KJ (2015)
    Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
    Oncotarget, 6 (33), 34178-90
    DOI 10.18632/oncotarget.6213, PubMed 26497557
  9. von Bahr L, Blennow O, Alm J, Björklund A, Malmberg KJ, Mougiakakos D, Le Blanc A, Oefner PJ, Labopin M, Ljungman P, Le Blanc K (2015)
    Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation
    Bone Marrow Transplant, 50 (9), 1217-23
    DOI 10.1038/bmt.2015.123, PubMed 26030049

Publications 2014

  1. Azzi T, Lünemann A, Murer A, Ueda S, Béziat V, Malmberg KJ, Staubli G, Gysin C, Berger C, Münz C, Chijioke O, Nadal D (2014)
    Role for early-differentiated natural killer cells in infectious mononucleosis
    Blood, 124 (16), 2533-43
    DOI 10.1182/blood-2014-01-553024, PubMed 25205117
  2. Béziat V, Traherne J, Malmberg JA, Ivarsson MA, Björkström NK, Retière C, Ljunggren HG, Michaëlsson J, Trowsdale J, Malmberg KJ (2014)
    Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
    Eur J Immunol, 44 (7), 2192-6
    DOI 10.1002/eji.201444464, PubMed 24723455
  3. Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, Malmberg KJ, Manns MP, Sandberg JK, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK (2014)
    Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
    Gut, 64 (3), 469-82
    DOI 10.1136/gutjnl-2014-306767, PubMed 24721903
  4. Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD (2014)
    Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
    Blood, 124 (5), 812-21
    DOI 10.1182/blood-2013-11-536888, PubMed 24855210

Publications 2013

  1. Bengnér M, Béziat V, Ernerudh J, Nilsson BO, Löfgren S, Wikby A, Malmberg KJ, Strindhall J (2013)
    Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
    Age (Dordr), 36 (2), 571-82
    DOI 10.1007/s11357-013-9587-y, PubMed 24065293
  2. Béziat V, Liu LL, Malmberg JA, Ivarsson MA, Sohlberg E, Björklund AT, Retière C, Sverremark-Ekström E, Traherne J, Ljungman P, Schaffer M, Price DA, Trowsdale J, Michaëlsson J, Ljunggren HG, Malmberg KJ (2013)
    NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
    Blood, 121 (14), 2678-88
    DOI 10.1182/blood-2012-10-459545, PubMed 23325834
  3. Béziat V, Traherne JA, Liu LL, Jayaraman J, Enqvist M, Larsson S, Trowsdale J, Malmberg KJ (2013)
    Influence of KIR gene copy number on natural killer cell education
    Blood, 121 (23), 4703-7
    DOI 10.1182/blood-2012-10-461442, PubMed 23637128
  4. Sternberg-Simon M, Brodin P, Pickman Y, Onfelt B, Kärre K, Malmberg KJ, Höglund P, Mehr R (2013)
    Natural killer cell inhibitory receptor expression in humans and mice: a closer look
    Front Immunol, 4, 65
    DOI 10.3389/fimmu.2013.00065, PubMed 23532016
  5. Vanherberghen B, Olofsson PE, Forslund E, Sternberg-Simon M, Khorshidi MA, Pacouret S, Guldevall K, Enqvist M, Malmberg KJ, Mehr R, Önfelt B (2013)
    Classification of human natural killer cells based on migration behavior and cytotoxic response
    Blood, 121 (8), 1326-34
    DOI 10.1182/blood-2012-06-439851, PubMed 23287857

Publications 2012

  1. Björkström NK, Béziat V, Cichocki F, Liu LL, Levine J, Larsson S, Koup RA, Anderson SK, Ljunggren HG, Malmberg KJ (2012)
    CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
    Blood, 120 (17), 3455-65
    DOI 10.1182/blood-2012-03-416867, PubMed 22968455
  2. Malmberg KJ (2012)
    Toward a prime-boost regime for NK cells?
    Blood, 120 (24), 4663-4
    DOI 10.1182/blood-2012-09-457184, PubMed 23223209

 
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