Malmberg Lab partner in a Project:
Translating mechanisms of cytotoxicity in natural killer cells and gamma-delta T cells into next generation cell-based cancer immunotherapy
Malmberg Lab partner in a Project: “Translating mechanisms of cytotoxicity in natural killer cells and gamma-delta T cells into next generation cell-based cancer immunotherapy”
Grant: SEK 31,200,000 over five years Principal investigator: Professor Björn Önfelt, KTH Royal Institute of Technology
Karl-Johan Malmberg, head of the "Natural Killer Cell Biology and Cell Therapy" group at the Department of Cancer Immunology, has recently been awarded a prestigious “FRIPRO Toppforsk” grant from the Research Council for the project "Programming natural killer cell function through the organelle communication".
The Norwegian government is aiming for long-term efforts to build research communities on the highest level. In total 24 Norwegian projects, all disciplines included, receive between 15 and 25 mill NOK. The grants are aimed at research communities that have the potential to become international leaders within their fields.
Two of the 24 selected projects are led by group leaders at the Institute for Cancer Research. The other is Tor Erik Rusten from the Department of Molecular Cell Biology.
Rea A, Santana-Hernández S, Villanueva J, Sanvicente-García M, Cabo M, Suarez-Olmos J, Quimis F, Qin M, Llorens E, Blasco-Benito S, Torralba-Raga L, Perez L, Bhattarai B, Alari-Pahissa E, Georgoudaki AM, Balaguer F, Juan M, Pardo J, Celià-Terrassa T, Rovira A, Möker N, Zhang C, Colonna M, Spanholtz J, Malmberg KJet al.(2025) Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression Nat Immunol, 26(4), 582-594 DOI 10.1038/s41590-025-02103-z, PubMed 40119192
Torralba-Raga L, Malmberg KJ(2025) The NKG2/HLA-E Axis Influence Outcomes of Haploidentical Transplantation Transplant Cell Ther, 31(3), 118-120 DOI 10.1016/j.jtct.2025.02.008, PubMed 40023657
Weiss L, Schluck M, Classens R, de Jonge PKJD, van der Waart A, Nguyen KG, Nguyen TT, Zaharoff DA, Malmberg KJ, Dolstra H, Figdor CG, Sohlberg E, Hammink R(2024) Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells Acta Biomater, 191, 386-397 DOI 10.1016/j.actbio.2024.11.012, PubMed 39528061