Santosh Phuyal

  • Scientist; PhD
 

Publications 2024

Pfefferle A, Phuyal S, Netskar H, Malmberg KJ (2024)
Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer
EMBO J, 43 (13), 2527-2529
DOI 10.1038/s44318-024-00144-y, PubMed 38886578

Publications 2023

Ghannoum S, Fantini D, Zahoor M, Reiterer V, Phuyal S, Leoncio Netto W, Sørensen Ø, Iyer A, Sengupta D, Prasmickaite L, Mælandsmo GM, Köhn-Luque A, Farhan H (2023)
A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression
PLoS Comput Biol, 19 (4), e1010995
DOI 10.1371/journal.pcbi.1010995, PubMed 37068117

Phuyal S, Romani P, Dupont S, Farhan H (2023)
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction
Trends Cell Biol, 33 (12), 1049-1061
DOI 10.1016/j.tcb.2023.05.001, PubMed 37236902

Publications 2022

Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh SJ, Reiterer V, Parizadeh A, Felder E, Kahlhofer JC, Teis D, Kazanietz MG, Geley S, Eriksson L, Roca-Cusachs P, Farhan H (2022)
Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1
EMBO J, 41 (18), e110596
DOI 10.15252/embj.2022110596, PubMed 35938214

Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H (2022)
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828

Publications 2021

Alswady-Hoff M, Erdem JS, Phuyal S, Knittelfelder O, Sharma A, Fonseca DM, Skare Ø, Slupphaug G, Zienolddiny S (2021)
Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells
Int J Mol Sci, 22 (10)
DOI 10.3390/ijms22105349, PubMed 34069552

Besse L, Besse A, Stolze SC, Sobh A, Zaal EA, van der Ham AJ, Ruiz M, Phuyal S, Büchler L, Sathianathan M, Florea BI, Borén J, Ståhlman M, Huber J, Bolomsky A, Ludwig H, Hannich JT, Loguinov A, Everts B, Berkers CR, Pilon M, Farhan H, Vulpe CD, Overkleeft HS, Driessen C (2021)
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
Cancer Res, 81 (17), 4581-4593
DOI 10.1158/0008-5472.CAN-20-3323, PubMed 34158378

Phuyal S, Farhan H (2021)
Want to leave the ER? We offer vesicles, tubules, and tunnels
J Cell Biol, 220 (6)
DOI 10.1083/jcb.202104062, PubMed 33999114

Publications 2020

Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C (2020)
ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis
J Cell Sci, 133 (18)
DOI 10.1242/jcs.243477, PubMed 32843575

Phuyal S, Baschieri F (2020)
Endomembranes: Unsung Heroes of Mechanobiology?
Front Bioeng Biotechnol, 8, 597721
DOI 10.3389/fbioe.2020.597721, PubMed 33195167

Publications 2019

Phuyal S, Farhan H (2019)
Multifaceted Rho GTPase Signaling at the Endomembranes
Front Cell Dev Biol, 7, 127
DOI 10.3389/fcell.2019.00127, PubMed 31380367

Publications 2018

Phuyal S, Kasem M, Knittelfelder O, Sharma A, Fonseca DM, Vebraite V, Shaposhnikov S, Slupphaug G, Skaug V, Zienolddiny S (2018)
Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes
Nanotoxicology, 12 (2), 138-152
DOI 10.1080/17435390.2018.1425500, PubMed 29350075

Publications 2017

Moen A, Jacobsen D, Phuyal S, Legfeldt A, Haugen F, Røe C, Gjerstad J (2017)
MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation
J Transl Med, 15 (1), 89
DOI 10.1186/s12967-017-1194-8, PubMed 28460630

Phuyal S, Kasem M, Rubio L, Karlsson HL, Marcos R, Skaug V, Zienolddiny S (2017)
Effects on human bronchial epithelial cells following low-dose chronic exposure to nanomaterials: A 6-month transformation study
Toxicol In Vitro, 44, 230-240
DOI 10.1016/j.tiv.2017.07.016, PubMed 28746895

Vestad B, Llorente A, Neurauter A, Phuyal S, Kierulf B, Kierulf P, Skotland T, Sandvig K, Haug KBF, Øvstebø R (2017)
Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study
J Extracell Vesicles, 6 (1), 1344087
DOI 10.1080/20013078.2017.1344087, PubMed 28804597

Publications 2014

Phuyal S, Hessvik NP, Skotland T, Sandvig K, Llorente A (2014)
Regulation of exosome release by glycosphingolipids and flotillins
FEBS J, 281 (9), 2214-27
DOI 10.1111/febs.12775, PubMed 24605801

Phuyal S, Skotland T, Hessvik NP, Simolin H, Øverbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A (2014)
The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
J Biol Chem, 290 (7), 4225-37
DOI 10.1074/jbc.M114.593962, PubMed 25519911

Publications 2012

Hessvik NP, Phuyal S, Brech A, Sandvig K, Llorente A (2012)
Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
Biochim Biophys Acta, 1819 (11-12), 1154-63
DOI 10.1016/j.bbagrm.2012.08.016, PubMed 22982408

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