Merete Thune Wiiger

  • Principal engineer; PhD
  • +47 2278 1324

Publications 2023

Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ (2023)
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
J Immunol, 211 (9), 1348-1358
DOI 10.4049/jimmunol.2300406, PubMed 37737664

Lachota M, Zielniok K, Palacios D, Kanaya M, Penna L, Hoel HJ, Wiiger MT, Kveberg L, Hautz W, Zagożdżon R, Malmberg KJ (2023)
Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation
EBioMedicine, 96, 104811
DOI 10.1016/j.ebiom.2023.104811, PubMed 37741009

Publications 2022

Haroun-Izquierdo A, Vincenti M, Netskar H, van Ooijen H, Zhang B, Bendzick L, Kanaya M, Momayyezi P, Li S, Wiiger MT, Hoel HJ, Krokeide SZ, Kremer V, Tjonnfjord G, Berggren S, Wikström K, Blomberg P, Alici E, Felices M, Önfelt B, Höglund P, Valamehr B, Ljunggren HG, Björklund A, Hammer Q et al. (2022)
Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
J Immunother Cancer, 10 (11)
DOI 10.1136/jitc-2022-005577, PubMed 36319065

Publications 2020

Ask EH, Tschan-Plessl A, Gjerdingen TJ, Sætersmoen ML, Hoel HJ, Wiiger MT, Olweus J, Wahlin BE, Lingjærde OC, Horowitz A, Cashen AF, Watkins M, Fehniger TA, Holte H, Kolstad A, Malmberg KJ (2020)
A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Med, 2 (2), 180-195.e5
DOI 10.1016/j.medj.2020.10.006, PubMed 35590201

Publications 2019

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279

Publications 2018

Jacobs B, Pfefferle A, Clement D, Berg-Larsen A, Saetersmoen ML, Lorenz S, Wiiger MT, Goodridge JP, Malmberg KJ (2018)
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
J Immunol, 202 (3), 736-746
DOI 10.4049/jimmunol.1801146, PubMed 30578306

Publications 2014

Wiiger MT, Bideli H, Fodstad O, Flatmark K, Andersson Y (2014)
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
J Ovarian Res, 7, 23
DOI 10.1186/1757-2215-7-23, PubMed 24528603

Publications 2010

Wiiger MT, Gehrken HB, Fodstad Ø, Maelandsmo GM, Andersson Y (2010)
A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
Cancer Immunol Immunother, 59 (11), 1665-74
DOI 10.1007/s00262-010-0892-3, PubMed 20635083

Publications 2008

Collingwood MA, Rose SD, Huang L, Hillier C, Amarzguioui M, Wiiger MT, Soifer HS, Rossi JJ, Behlke MA (2008)
Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs
Oligonucleotides, 18 (2), 187-200
DOI 10.1089/oli.2008.0123, PubMed 18637735

Publications 2007

Wiiger MT, Prydz H (2007)
The changing faces of tissue factor biology. A personal tribute to the understanding of the "extrinsic coagulation activation"
Thromb Haemost, 98 (1), 38-42
DOI 10.1160/Th07-04-0289, PubMed 17597988

Publications 2006

Amarzguioui M, Peng Q, Wiiger MT, Vasovic V, Babaie E, Holen T, Nesland JM, Prydz H (2006)
Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells
Clin Cancer Res, 12 (13), 4055-61
DOI 10.1158/1078-0432.CCR-05-2482, PubMed 16818705

Publications 2004

Kavlie A, Wiiger MT, Husbyn M, Stormorken H, Prydz H (2004)
A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk
Thromb Haemost, 91 (1), 28-37
DOI 10.1160/TH03-05-0258, PubMed 14691565

Wiiger MT (2004)
Tissue factor and factor VII in coagulation and signal transduction
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 243, 1 b. (flere pag.)
BIBSYS 050048953, ISBN 82-8072-178-9

Wiiger MT, Prydz H (2004)
The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells
Thromb Haemost, 92 (1), 13-22
DOI 10.1160/TH03-08-0549, PubMed 15213840

Publications 2002

Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H (2002)
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor
Nucleic Acids Res, 30 (8), 1757-66
DOI 10.1093/nar/30.8.1757, PubMed 11937629

Publications 2000

Camerer E, Gjernes E, Wiiger M, Pringle S, Prydz H (2000)
Binding of factor VIIa to tissue factor on keratinocytes induces gene expression
J Biol Chem, 275 (9), 6580-5
DOI 10.1074/jbc.275.9.6580, PubMed 10692465

Wiiger MT, Pringle S, Pettersen KS, Narahara N, Prydz H (2000)
Effects of binding of ligand (FVIIa) to induced tissue factor in human endothelial cells
Thromb Res, 98 (4), 311-21
DOI 10.1016/s0049-3848(00)00183-3, PubMed 10822078

Wiiger MT, Prydz H (2000)
Cellular effects of initiation of the extrinsic pathway of blood coagulation
Trends Cardiovasc Med, 10 (8), 360-5
DOI 10.1016/s1050-1738(01)00074-3, PubMed 11369263

Publications 1999

Prydz H, Camerer E, Røttingen JA, Wiiger MT, Gjernes E (1999)
Cellular consequences of the initiation of blood coagulation
Thromb Haemost, 82 (2), 183-92
PubMed 10605703

Publications 1998

Martin DM, Wiiger MT, Prydz H (1998)
Tissue factor and biotechnology
Thromb Res, 90 (1), 1-25
DOI 10.1016/s0049-3848(98)00015-2, PubMed 9678673

Publications 1996

Camerer E, Pringle S, Skartlien AH, Wiiger M, Prydz K, Kolstø AB, Prydz H (1996)
Opposite sorting of tissue factor in human umbilical vein endothelial cells and Madin-Darby canine kidney epithelial cells
Blood, 88 (4), 1339-49
DOI 10.1182/blood.V88.4.1339.bloodjournal8841339, PubMed 8695852

Publications 1994

Narahara N, Enden T, Wiiger M, Prydz H (1994)
Polar expression of tissue factor in human umbilical vein endothelial cells
Arterioscler Thromb, 14 (11), 1815-20
DOI 10.1161/01.atv.14.11.1815, PubMed 7947608

Publications 1992

Pettersen KS, Wiiger MT, Narahara N, Andoh K, Gaudernack G, Prydz H (1992)
Induction of tissue factor synthesis in human umbilical vein endothelial cells involves protein kinase C
Thromb Haemost, 67 (4), 473-7
PubMed 1631796

Publications 1990

Wiiger MT (1990)
Stimulering av murine miltceller IN VITRO og IN VIVO med det konserverte kjerneproteinet P1 som antigen
[M. T. Wiiger], Oslo, 108 s.
BIBSYS 900161981

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