
Mariaserena Giliberto
- Postdoc; PhD
- +47 2278 1957
Room: K06.062
Projects
The primary objective of the PhD project is to develop a new approach to personalized cancer therapy. Differently from other approaches, a transdisciplinary strategy will be applied to implement today’s cancer therapy. The project aims to establish a new pipeline to identify drugs and drug combinations effective in personalized therapy of individual cancer patients, in whom other treatment options are exhausted or ineffective. Novel in-silico mathematical models and simulations will also be applied to investigate the current challenges of tumor heterogeneity and drug resistance mechanisms.
To date, ex vivo drug sensitivity and resistance testing are performed in our lab, with patient cancer cells and patient-derived cell lines for multiple myeloma (MM) and chronic lymphatic leukemia (CLL). The drug sensitivity responses are measured by cell viability and death readouts along with relevant cell signaling analysis.

Publications 2022
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457
Publications 2021
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096
Publications 2018
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303
Publications 2017
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss
Blood Adv, 1 (27), 2656-2666
DOI 10.1182/bloodadvances.2017010801, PubMed 29296919