Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
From major journals, first or last author from the Institute for Cancer Research
Sohlberg E, Malmberg KJ(2025) The innate power of natural killer cells in cancer therapy Nat Med(in press) DOI 10.1038/s41591-025-03712-9, PubMed 40355615
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Yin Y, Xu H, He L, Brown JR, Mato AR, Aittokallio T, Skånland SS(2025) Protein Profiles Predict Treatment Responses to the PI3K Inhibitor Umbralisib in Patients with Chronic Lymphocytic Leukemia Clin Cancer Res, 31(10), 1943-1955 DOI 10.1158/1078-0432.CCR-24-2911, PubMed 40085050
Sohlberg E, Malmberg KJ(2025) The innate power of natural killer cells in cancer therapy Nat Med(in press) DOI 10.1038/s41591-025-03712-9, PubMed 40355615
Kotkowska ZK, Haunerdinger V, Waeckerle-Men Y, Kolm-Djamei I, Duda A, Hausammann L, Schineis P, Fischer H, Sella F, Li N, Selbo PK, Høgset A, Kündig TM, Halin C, Johansen P(2025) Inflammatory cutaneous reactions with systemic CD8+ T-cell responses upon photochemical internalization of antigens in mice J Invest Dermatol(in press) DOI 10.1016/j.jid.2025.04.020, PubMed 40348329